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20 results on '"Kim,Sang Ryong"'

13. p47phox siRNA-Loaded PLGA Nanoparticles Suppress ROS/Oxidative Stress-Induced Chondrocyte Damage in Osteoarthritis

Author

Shin, Hyo Jung, primary, Park, Hyewon, additional, Shin, Nara, additional, Kwon, Hyeok Hee, additional, Yin, Yuhua, additional, Hwang, Jeong-Ah, additional, Kim, Song I, additional, Kim, Sang Ryong, additional, Kim, Sooil, additional, Joo, Yongbum, additional, Kim, Youngmo, additional, Kim, Jinhyun, additional, Beom, Jaewon, additional, and Kim, Dong Woon, additional

Published
2020
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15. Characterization of Mesenchymal Stem Cells Derived from Patients with Cerebellar Ataxia: Downregulation of the Anti-Inflammatory Secretome Profile

Author

Kim, Jong-Heon, primary, Han, Jin, additional, Seo, Donggun, additional, Yoon, Jong Hyuk, additional, Yoon, Dongyeong, additional, Hong, Jungwan, additional, Kim, Sang Ryong, additional, Kim, Min Sung, additional, Lee, Tae Yong, additional, Kim, Kyung Suk, additional, Ko, Pan-Woo, additional, Lee, Ho-Won, additional, and Suk, Kyoungho, additional

Published
2020
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16. DRG2 Deficient Mice Exhibit Impaired Motor Behaviors with Reduced Striatal Dopamine Release

Author

Lim, Hye Ryeong, primary, Vo, Mai-Tram, additional, Kim, Dong Jun, additional, Lee, Unn Hwa, additional, Yoon, Jong Hyuk, additional, Kim, Hyung-Jun, additional, Kim, Jeongah, additional, Kim, Sang Ryong, additional, Lee, Jun Yeon, additional, Yang, Chae Ha, additional, Kim, Hee Young, additional, Choi, June-Seek, additional, Kim, Kijeong, additional, Yang, Esther, additional, Kim, Hyun, additional, Lee, Seongsoo, additional, Lee, Byung Ju, additional, Kim, Kyungjin, additional, Park, Jeong Woo, additional, and Ha, Chang Man, additional

Published
2019
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18. Role of Oxidative Stress in Blood-Brain Barrier Disruption and Neurodegenerative Diseases.

Author

Kim S, Jung UJ, and Kim SR

Abstract

Upregulation of reactive oxygen species (ROS) levels is a principal feature observed in the brains of neurodegenerative diseases such as Parkinson's disease (PD) and Alzheimer's disease (AD). In these diseases, oxidative stress can disrupt the blood-brain barrier (BBB). This disruption allows neurotoxic plasma components, blood cells, and pathogens to enter the brain, leading to increased ROS production, mitochondrial dysfunction, and inflammation. Collectively, these factors result in protein modification, lipid peroxidation, DNA damage, and, ultimately, neural cell damage. In this review article, we present the mechanisms by which oxidative damage leads to BBB breakdown in brain diseases. Additionally, we summarize potential therapeutic approaches aimed at reducing oxidative damage that contributes to BBB disruption in neurodegenerative diseases.

Published
2024
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19. Alpha-Synuclein and Microglia in Parkinson's Disease: From Pathogenesis to Therapeutic Prospects.

Author

Eo H, Kim S, Jung UJ, and Kim SR

Abstract

Parkinson's disease (PD) is a neurodegenerative disorder characterized by both motor symptoms and non-motor features. A hallmark of PD is the misfolding and accumulation of alpha-synuclein (α-syn), which triggers neuroinflammation and drives neurodegeneration. Microglia, brain cells that play a central role in neuroinflammatory responses and help clear various unnecessary molecules within the brain, thus maintaining the brain's internal environment, respond to α-syn through mechanisms involving inflammation, propagation, and clearance. This review delves into the complex interplay between α-syn and microglia, elucidating how these interactions drive PD pathogenesis. Furthermore, we discuss emerging therapeutic strategies targeting the α-syn-microglia axis, with a focus on modulating microglial functions to mitigate neuroinflammation, enhance clearance, and prevent α-syn propagation, emphasizing their potential to slow PD progression.

Published
2024
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20. The Potential of Mesenchymal Stem Cells in Treating Spinocerebellar Ataxia: Advances and Future Directions.

Author

Lee GB, Park SM, Jung UJ, and Kim SR

Abstract

Spinocerebellar ataxia (SCA) is a heterogeneous disorder characterized by impaired balance and coordination caused by cerebellar dysfunction. The absence of treatments approved by the U.S. Food and Drug Administration for SCA has driven the investigation of alternative therapeutic strategies, including stem cell therapy. Mesenchymal stem cells (MSCs), known for their multipotent capabilities, have demonstrated significant potential in treating SCA. This review examines how MSCs may promote neuronal growth, enhance synaptic connectivity, and modulate brain inflammation. Recent findings from preclinical and clinical studies are also reviewed, emphasizing the promise of MSC therapy in addressing the unmet needs of SCA patients. Furthermore, ongoing clinical trials and future directions are proposed to address the limitations of the current approaches.

Published
2024
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