23 results on '"K. Ju"'
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2. Structural Stability Evaluation of Existing Buildings by Reverse Engineering with 3D Laser Scanner
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Arum Jang, Young K. Ju, and Min Jae Park
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BIM (building information modeling) ,safety inspection ,3D laser scanner ,structural safety assessment ,reverse engineering ,ComputingMethodologies_IMAGEPROCESSINGANDCOMPUTERVISION ,General Earth and Planetary Sciences - Abstract
In the Fourth Industrial Revolution, research and development of application technologies that combine high-tech technologies have been actively conducted. Building information modeling (BIM) technology using advanced equipment is considered promising for future construction projects. In particular, using a 3D laser scanner, LIDAR is expected to be a solution for future building safety inspections. This work proposes a new method for evaluating building stability using a 3D laser scanner. In this study, an underground parking lot was analyzed using a 3D laser scanner. Further, structural analysis was performed using the finite element method (FEM) by applying the figure and geometry data acquired from the laser scan. This process includes surveying the modeled point cloud data of the scanned building, such as identifying the relative deflection of the floor slab, and the sectional shape and inclination of the column. Consequently, safety diagnosis was performed using the original evaluation criteria. This confirms that it is precise and efficient to use a 3D laser scanner for building stability assessment. This paper presents a digital point cloud-based approach using a 3D laser scanner to evaluate the stability of buildings.
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- 2022
3. Machine Learning-Based Concrete Crack Depth Prediction Using Thermal Images Taken under Daylight Conditions
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Min Jae Park, Jihyung Kim, Sanggi Jeong, Arum Jang, Jaehoon Bae, and Young K. Ju
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crack detecting method ,machine learning ,data bias analysis ,thermal images ,General Earth and Planetary Sciences ,macrocrack - Abstract
Concrete cracks can threaten the usability of structures and degrade the aesthetics of buildings. Furthermore, minor cracks can develop into large-scale cracks that may lead to structural failure when exposed to excessive external loads. In addition, the concrete crack width and depth should be precisely measured to investigate the effects of concrete cracks on the stability of structures. Thus, a nondestructive and noncontact testing method was introduced for detecting concrete crack depth using thermal images and machine learning. The thermal images of the cracked specimens were obtained using a constant test setup for several months under daylight conditions, which provided sufficient heat for measuring the temperature distributions of the specimens, with recording parameters such as air temperature, humidity, and illuminance. From the thermal images, the crack and surface temperatures were obtained depending on the crack widths and depths using the parameters. Four machine-learning algorithms (decision tree, extremely randomized tree, gradient boosting, and AdaBoost) were selected, and the results of crack depth prediction were compared to identify the best algorithm. In addition, data bias analysis using principal component analysis, singular value decomposition, and independent component analysis were conducted to evaluate the efficiency of machine learning.
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- 2022
4. Theoretical Methane Emission Estimation from Volatile Fatty Acids in Bovine Rumen Fluid
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Sang-Ryong Lee, Yunseo Cho, Eunjeong Kim, and Hyuck K. Ju
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Technology ,QH301-705.5 ,odor ,QC1-999 ,Standard solution ,Methane ,Butyric acid ,chemistry.chemical_compound ,Rumen ,Volatile fatty acids ,General Materials Science ,Food science ,Biology (General) ,Methane production ,QD1-999 ,Instrumentation ,catalytic esterification ,Fluid Flow and Transfer Processes ,rumen ,Physics ,volatile fatty acids ,methane ,Process Chemistry and Technology ,General Engineering ,Substrate (chemistry) ,Engineering (General). Civil engineering (General) ,Computer Science Applications ,Chemistry ,Livestock farming ,chemistry ,TA1-2040 - Abstract
Methane production from livestock farming is recognized as an important contributor to global GHGs. Volatile fatty acids (VFAs) found in bovine rumen may be utilized as a substrate for methanogens to form CH4, and thus improvement of quantitative VFA measurements can help facilitate greater understanding and mitigation of CH4 production. This study aims to contribute to the development of more accurate methods for the quantification and specification of VFAs in bovine rumen. The VFAs were analyzed using the conventional method and an alternative catalytic esterification reaction (CER) method. Substantial differences in the detected concentrations of the C3+ VFAs (chain length ≥ 3) were observed between both methods, especially for butyric acid. Evaluation of the sensitivity of both methods to detecting the VFA concentrations in standard solutions confirmed that the values resulting from the CER method were closer to the known concentrations of the standard solution than those from the conventional method. The results of this study provide the first quantitative proof to show the improved accuracy of the measurements of C3+ VFAs when using the CER method compared with the conventional method. Therefore, the CER method can be recommended to analyze the VFAs found in rumen, especially butyric acid and other C3+ VFAs.
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- 2021
5. Stability Analysis of a New Class of Series Type Additive Functional Equation in Banach Spaces: Direct and Fixed Point Techniques
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P. Agilan, K. Julietraja, Mohammed M. A. Almazah, and Ammar Alsinai
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additive FE ,generalized Ulam–Hyers stability ,Banach space ,fixed point technique ,Mathematics ,QA1-939 - Abstract
In this paper, the authors introduce two new classes of series type additive functional Equations (FEs). The first class of equations is derived from the sum of the squares of the alternative series and the second one is obtained from the sum of the cubes of the series. The solution of the FE is investigated using the principle of mathematical induction. The beauty of this method lies in the fact that it satisfies the property of the additive FE as well as the series. Banach spaces are one of the widely-used spaces that are very helpful to analyse the stability results of various FEs. The Banach space conditions have been applied and the stability results are established for both of the equations. Furthermore, the Banach Contraction principle and alternative of fixed point theorem are used to derive the stability results in a fixed point technique (FPT). The relationship between the FEs and both the series is established through the principle of mathematical induction in the Application section, which adds novelty to the derived results.
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- 2023
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6. Classical and Fixed Point Approach to the Stability Analysis of a Bilateral Symmetric Additive Functional Equation in Fuzzy and Random Normed Spaces
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P. Agilan, Mohammed M. A. Almazah, K. Julietraja, and Ammar Alsinai
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random normed spaces ,fuzzy normed spaces ,additive functional equations ,Ulam–Hyers Stability ,fixed point method ,Mathematics ,QA1-939 - Abstract
In this article, a new kind of bilateral symmetric additive type functional equation is introduced. One of the interesting characteristics of the equation is the fact that it is ideal for investigating the Ulam–Hyers stabilities in two prominent normed spaces, namely fuzzy and random normed spaces simultaneously. This article analyzes the proposed equation in both spaces. The solution of this equation exhibits the property of symmetry, that is, the left of the object becomes the right of the image, and vice versa. Additionally, the stability results of this functional equation are determined in fuzzy and random normed spaces using direct and fixed point methods.
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- 2023
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7. Intuitionistic Fuzzy Stability of an Euler–Lagrange Symmetry Additive Functional Equation via Direct and Fixed Point Technique (FPT)
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P. Agilan, K. Julietraja, Nabil Mlaiki, and Aiman Mukheimer
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Euler–Lagrange symmetry additive functional equations ,generalised Hyers–Ulam–Rassias ,stability intuitionistic fuzzy normed spaces ,fixed point technique ,Mathematics ,QA1-939 - Abstract
In this article, a new class of real-valued Euler–Lagrange symmetry additive functional equations is introduced. The solution of the equation is provided, assuming the unknown function to be continuous and without any regularity conditions. The objective of this research is to derive the Hyers–Ulam–Rassias stability (HURS) in intuitionistic fuzzy normed spaces (IFNS) by applying the classical direct method and fixed point techniques (FPT). Furthermore, it is proven that the Euler–Lagrange symmetry additive functional equation and the control function, which is the IFNS of the sums and products of powers of norms, is stable. In addition, a few examples where the solution of this equation can be applied in Fourier series and Fourier transforms are demonstrated.
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- 2022
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8. Symmetric Difference Operator in Quantum Calculus
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Weidong Zhao, V. Rexma Sherine, T. G. Gerly, G. Britto Antony Xavier, K. Julietraja, and P. Chellamani
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quantum calculus ,finite differences ,inverse difference operators ,q , q(α), and h difference symmetric equations ,value stability analysis ,Mathematics ,QA1-939 - Abstract
The main focus of this paper is to develop certain types of fundamental theorems using q, q(α), and h difference operators. For several higher order difference equations, we get two forms of solutions: one is closed form and another is summation form. However, most authors concentrate only on the summation part. This motivates us to develop closed-form solutions, and we succeed. The key benefit of this research is finding the closed-form solutions for getting better results when compared to the summation form. The symmetric difference operator is the combination of forward and backward difference symmetric operators. Using this concept, we employ the closed and summation form for q, q(α), and h difference symmetric operators on polynomials, polynomial factorials, logarithmic functions, and products of two functions that act as a solution for symmetric difference equations. The higher order fundamental theorems of q and q(α) are difficult to find when the order becomes high. Hence, by inducing the h difference symmetric operator in q and q(α) symmetric operators, we find the solution easily and quickly. Suitable examples are given to validate our findings. In addition, we plot the figures to examine the value stability of q and q(α) difference equations.
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- 2022
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9. Disaster Assessment of Tall Buildings in Korea by K-Rapid Visual Screening System Focusing on Structural Safety
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Min Jae Park and Young K. Ju
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disaster assessment ,tall buildings ,rapid visual screening system ,K-RVS ,IRVS ,Building construction ,TH1-9745 - Abstract
Multiple hazards, which threaten people’s lives and property, are the main concern for engineers in preventing dangers to buildings. In particular, densely populated areas, such as capital cities and tall buildings, are exposed to higher risks owing to multiple hazards. To rapidly evaluate the disaster assessment of tall buildings, the Federal Emergency Management Agency (FEMA) in the U.S. proposed the integrated rapid visual screening system (IRVS). However, the IRVS system only considers U.S. conditions. Therefore, a Korean-oriented rapid visual screening system should be developed because the number of buildings over 200 m in Korea ranked fourth in the world with the highest density (500 people per square kilometer) among the top five countries based on the Council on Tall Buildings and Urban Habitat’s (CTBUH) database. This study describes a Korea-rapid visual screening (K-RVS) system that focuses on the structural safety of tall buildings in Korea. The K-RVS system was modified based on the IRVS, considering the Korean design standard (KDS) and Korean conditions. With the weight value for each characteristic, the scores for each hazard and final scores combined from the scores by multi-hazard can be obtained to conduct a disaster assessment of tall buildings subjected to multiple hazards.
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- 2022
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10. Bond Behavior of Concrete-Filled Steel Tube Mega Columns with Different Connectors
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Robel Wondimu Alemayehu, Jaehoon Bae, Young K. Ju, and Min Jae Park
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mega column ,concrete-filled steel tube (CFST) ,shear studs ,rib plate ,push out ,connectors ,Technology ,Electrical engineering. Electronics. Nuclear engineering ,TK1-9971 ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Microscopy ,QH201-278.5 ,Descriptive and experimental mechanics ,QC120-168.85 - Abstract
Concrete-filled steel tubes (CFSTs) are widely used in construction. To achieve composite action and take full advantage of the two materials, strain continuity at the steel–concrete interface is essential. When the concrete core and steel tube are not loaded simultaneously in regions such as beam or brace connections to the steel tubes of a CFST column, the steel–concrete bond plays a crucial role in load transfer. This study uses a validated finite-element model to investigate the bond-slip behavior between the steel tube and concrete in square CFST mega columns through a push-out analysis of eleven 1.2- × 1.2-m mega columns. The bond-slip behavior of CFST mega columns with and without mechanical connectors, including shear studs, rib plates, and connecting plates, is studied. The finite-element results indicate that the mechanical connectors substantially increased the maximum bond stress. Among the analyzed CFST mega columns, those with closely spaced shear studs and rib plate connectors with circular holes exhibited the highest bond stress, followed by plate connectors and widely spaced shear stud connectors. In the case of shear stud connectors, the stud diameter and spacing influenced the bond behavior more than the stud length. As the stud spacing decreased, the failure mode shifted from studs shearing off to outward buckling of the steel tube.
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- 2022
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11. Seismic Performance of F3D Free-Form Structures Using Small-Scale Shaking Table Tests
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Min Jae Park, Gain Cheon, Robel Wondimu Alemayehu, and Young K. Ju
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F3D ,free-form structures ,shaking table test ,small-scale ,seismic performance ,Technology ,Electrical engineering. Electronics. Nuclear engineering ,TK1-9971 ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Microscopy ,QH201-278.5 ,Descriptive and experimental mechanics ,QC120-168.85 - Abstract
In recent years, studies that can maximize irregularity have increased as technological constraints weaken owing to the development of construction technology and the increase in demand for free-form structures. Considering this, free-form structures have been constructed using various materials. Concrete is considered most suitable for realizing an atypical shape because it is highly economical and can be assembled in a free form. However, not many studies have evaluated the structural performance of free-form concrete structures using free-form formwork 3D printer (F3D) technology, a 3D printing technology. Free-form structures must be designed to secure structural stability under both dead and live loads, as well as natural hazards such as wind, snow, and earthquakes. Therefore, in this study, we tested a free-form structure constructed by F3D printing using small-scale models that satisfy the similitude law with shaking tables. Furthermore, a finite element analysis was conducted to validate the small-scale tests. Lastly, the seismic performance of free-form concrete structures was evaluated based on the test and analysis results.
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- 2022
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12. Fire Resistance Performance of Steel–Polymer Prefabricated Composite Floors Using Standard Fire Tests
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Min Jae Park, Robel Wondimu Alemayehu, and Young K. Ju
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steel–polymer prefabricated composite floor ,standard fire tests ,fire resistance performance ,stability ,finite element analysis ,Organic chemistry ,QD241-441 - Abstract
In this study, the fire resistance performance of steel–polymer prefabricated composite floors, which have a sandwich-type structure, was assessed via standard fire tests and analyzed using finite element analysis. This form of analysis should consider two aspects, namely the thermal and structural fields, so as to simulate complicated material properties and large deformations. As previous studies have already conducted analysis in the thermal field, this study entailed only the structural analysis based on the temperature distributions obtained from the thermal analysis. The variables of the specimens were the thicknesses of the top and bottom steel plates and polymers. According to the analysis results, the top steel plate thickness had no impact on the stability ratings, a criterion for fire resistance performance, whereas the bottom steel plate showed a linear correlation with the stability rating. An equation for the stability rating of composite floors was proposed, and an equation for fire resistance performance was devised based on the insulation ratings, which were obtained from the thermal analysis results.
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- 2022
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13. SMART SKY EYE System for Preliminary Structural Safety Assessment of Buildings Using Unmanned Aerial Vehicles
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Jaehoon Bae, Jonghoon Lee, Arum Jang, Young K. Ju, and Min Jae Park
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SMART SKY EYE ,unmanned aerial vehicle ,safety inspection ,thermography ,structural safety assessment ,Chemical technology ,TP1-1185 - Abstract
The development of unmanned aerial vehicles (UAVs) is expected to become one of the most commercialized research areas in the world over the next decade. Globally, unmanned aircraft have been increasingly used for safety surveillance in the construction industry and civil engineering fields. This paper presents an aerial image-based approach using UAVs to inspect cracks and deformations in buildings. A state-of-the-art safety evaluation method termed SMART SKY EYE (Smart building safety assessment system using UAV) is introduced; this system utilizes an unmanned airplane equipped with a thermal camera and programmed with various surveying efficiency improvement methods, such as thermography, machine-learning algorithms, and 3D point cloud modeling. Using this method, crack maps, crack depths, and the deformations of structures can be obtained. Error rates are compared between the proposed and conventional methods.
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- 2022
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14. Structural Behavior of a Composite Curtain Wall Fabricated by the Fused Deposition Modeling 3D Printing Method
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Min Jae Park, Jaehoon Bae, and Young K. Ju
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FDM 3D printer ,ABS-M30 ,cement cladding ,harmony search algorithm ,FEM ,Organic chemistry ,QD241-441 - Abstract
In this era of the fourth industrial revolution, the integration of big data and 3D printing technology with the construction industry has maximized productivity. Currently, there is an active effort to research the optimal cladding structure through 3D printing technology to reduce production costs. This paper proposes a new type of 3D print curtain wall, using a high-strength ABS-M30 polymer panel, which is stronger than the standard acrylonitrile butadiene styrene (ABS) polymer, as an internally reinforced structure. This structure is fabricated via fused deposition modeling, a 3D printing method, to reduce the weight of the general cement panel. In addition, the shape of the polymer board was designed; three shapes were considered—O, W, and X types—which aided in further reducing the weight of the cladding. After comparing the center deformation of the structure through a lateral load test and finite element method analysis, the optimal model was selected. The measured data of the two methods at a design wind speed of 100% showed a difference of approximately 10%; however, at 150% of the design wind speed, the difference between the two sets of data increased to 27%.
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- 2022
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15. Experimental and Finite Element Study of Polymer Infilled Tube-in-Tube Buckling Restrained Brace
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Robel Wondimu Alemayehu, Youngsik Kim, Min Jae Park, Manwoo Park, and Young K. Ju
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buckling-restrained brace ,subassembly test ,component test ,finite element analysis ,polymer infilled BRB ,slot weld ,Mining engineering. Metallurgy ,TN1-997 - Abstract
This study presents a tube-in-tube buckling-restrained brace (BRB) infilled with lightweight and rapid hardening polymer. The proposed BRB consists of a circular or square tube core encased with a tube of similar shape and polymer infill. The tube-in-tube arrangement minimizes the filler material volume and enables the use of rolled steel section as opposed to welded profiles commonly utilized when large BRB axial strength is required, although welded profiles suffer from low assembly accuracy resulting from welding deformation. The infilled polymer has a density of approximately half that of mortar and requires a curing time of 24 h, enabling weight and fabrication time reduction. The stability and inelastic deformation capability of the BRB were investigated through brace and subassembly tests of six circular and four-square full-scale specimens, followed by finite element analysis. The test results show that circular BRB designed with a Pcr/Py ratio of 1.46 exhibited a stable hysteresis up to 1.42% and 1.06% core strain in tension and compression, respectively. Circular and square specimens designed with Pcr/Py ratios ranging from 0.82 to 1.06 exhibited stable hysteresis before failing by global buckling at compressive core stains ranging from 0.86% to 1.09%. The slot weld detail adopted for welding core projection stiffener displayed a stable performance in circular BRB specimens, while it resulted in large plastic strain demand in square BRB specimens, leading to core fracture at tensile core strains ranging from 0.64% to 0.71%.
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- 2021
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16. Fire Design Equation for Steel–Polymer Composite Floors in Thermal Fields Via Finite Element Analysis
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Min Jae Park, Jaehoon Bae, Jaeho Ryu, and Young K. Ju
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steel–polymer composite floor ,insulation performance ,finite element analysis ,full-scale fire test ,fire resistance ,thermal field ,Technology ,Electrical engineering. Electronics. Nuclear engineering ,TK1-9971 ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Microscopy ,QH201-278.5 ,Descriptive and experimental mechanics ,QC120-168.85 - Abstract
Owing to the development of new materials that enhance structural members in the construction field, steel–polymer composite floors have been developed and applied to steel structures. Similar to a sandwich system, steel–polymer composite floors consist of polymers between two steel plates. The structural performance of full-scale composite floors at ambient conditions has been investigated. Additionally, experiments were conducted on analytical models to predict both thermal behavior under fire, including fire resistance based on a small-scale furnace. To evaluate the fire resistance of full-scale steel–polymer composite floors, the thermal behavior and temperature distribution of composite floors should be investigated. Therefore, the temperature distributions of the full-scale composite floors were estimated using the verified analytical model in this study. Furthermore, to determine the fire design equation of steel–polymer composite floors in the thermal field, the correlations between variables were investigated, such as the thickness of top and bottom steel plates and polymers, as well as the fire resistance in the thermal field.
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- 2020
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17. Cyclic Load Test and Finite Element Analysis of NOVEL Buckling-Restrained Brace
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Robel Wondimu Alemayehu, Youngsik Kim, Jaehoon Bae, and Young K. Ju
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buckling-restrained brace ,subassembly test ,component test ,finite element analysis ,BRB global buckling ,H-section core flange buckling ,Technology ,Electrical engineering. Electronics. Nuclear engineering ,TK1-9971 ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Microscopy ,QH201-278.5 ,Descriptive and experimental mechanics ,QC120-168.85 - Abstract
Compared to concrete or mortar-filled Buckling-Restrained Braces (BRBs), all-steel BRBs provide weight and fabrication time reductions. In particular, all-steel buckling braces with H-section cores are gaining attention in cases where large axial strength is required. In this paper, an all-steel BRB, called NOVEL (Noise, CO2 emission, Vibration, Energy dissipation and Labor), is presented. It comprises an H-section core encased in a square casing, and its behavior was studied through full-scale subassembly and brace tests, followed by a finite element parametric study. Two failure modes were observed: global buckling and flange buckling of the H-section core, which occurred in test specimens with Pcr/Py ratios of 1.68 and 4.91, respectively. Global buckling occurred when the maximum moment in the casing reached its yielding moment, although the test specimens had sufficient stiffness to prevent global buckling. Failure by core flange buckling occurred at a core strain of 1.2%. The finite element parametric study indicated that adjusting the width-to-thickness ratio of the core flange is more feasible than stiffening the flange or adjusting the unconstrained-length end stiffeners. The value of 5.06 was the minimum flange slenderness ratio that provided a stable hysteresis to the end of the loading protocol of the American Institute of Steel Construction standard.
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- 2020
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18. Cyclic Loading Performance of Radius-Cut Double Coke-Shaped Strip Dampers
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Jaehoon Bae, Chang-Hwan Lee, Minjae Park, Robel Wondimu Alemayehu, Jaeho Ryu, Youngsik Kim, and Young K. Ju
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reduced beam section ,plastic hinge ,strip damper ,energy dissipation device ,cyclic loading ,passive control system ,Technology ,Electrical engineering. Electronics. Nuclear engineering ,TK1-9971 ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Microscopy ,QH201-278.5 ,Descriptive and experimental mechanics ,QC120-168.85 - Abstract
Conventional slit dampers are widely used for the purpose of seismic retrofitting, however, the structure of these dampers is susceptible to fractures, due to stress concentration at the ends of the strips in the event of large earthquakes. To address this issue, a novel radius-cut coke-shaped strip damper featuring improved ductility is proposed herein. This damper was developed based on the moment distribution over the strip when both its ends were constrained. The height-to-width ratio of the strip was increased to induce bending rather than shear deformation, and the reduced beam section method was employed. A radius-cut section was used to intentionally focus the stress to induce the plastic hinge. This reduced the fracture fragility of the specimen, resulting in an increased inelastic deformation capacity. Cyclic loading tests were conducted to verify damping performance against earthquakes. Experiments and finite element analyses proved that the coke-shaped damper exhibits improved ductility. The final fracture occurred in the radius-cut section after sufficient energy dissipation during cyclic loading. The results also indicated further improvements in strength due to the membrane effect under cyclic loading, caused by the tensile resistance of the strip due to its constrained ends.
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- 2020
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19. Thermal Contact Conductance-Based Thermal Behavior Analytical Model for a Hybrid Floor at Elevated Temperatures
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Min Jae Park, Jeong Ki Min, Jaehoon Bae, and Young K. Ju
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polymeric material ,hybrid floor ,thermal contact conductance ,thermal behavior analytical model ,fire resistance performance ,Technology ,Electrical engineering. Electronics. Nuclear engineering ,TK1-9971 ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Microscopy ,QH201-278.5 ,Descriptive and experimental mechanics ,QC120-168.85 - Abstract
Hybrid floors infilled with polymeric materials between two steel plates were developed as a prefabricated floor system in the construction industry. However, the floor’s fire resistance performance has not been investigated. To evaluate this, fire tests suggested by the Korean Standards should be performed. As these tests are costly and time consuming, the number of variables were limited. However, many variables can be investigated in other ways such as furnace tests and finite element analysis (FEA) with less cost and time. In this study, furnace tests on heated surface areas smaller than 1 m2 were conducted to investigate the thermal behavior of the hybrid floor at elevated temperatures. To obtain the reliability of the proposed thermal behavior analytical (TBA) model, verifications were conducted by FEAs. Thermal contact conductance including interfacial thermal properties between two materials was adopted in the TBA model, and the values at elevated temperatures were suggested based on thermo-gravimetric analyses results and verified by FEA. Errors between the tests and TBA model indicated that the model was adequate in predicting the temperature distribution in small-scale hybrids. Furthermore, larger furnace tests and analysis results were compared to verify the TBA model’s application to different sized hybrid floors.
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- 2020
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20. Protective Efficacy of a Novel DNA Vaccine with a CL264 Molecular Adjuvant against Toxoplasma gondii in a Murine Model.
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Ju K, Zhang Y, Xu Z, Li L, Zhao X, and Zhou H
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Toxoplasmosis is a significant global zoonosis with devastating impacts, and an effective vaccine against toxoplasmosis for humans has not yet been developed. In this study, we designed and formulated a novel DNA vaccine encoding the inhibitor of STAT1 transcriptional activity (IST) of T. gondii utilizing the eukaryotic expression vector pEGFP-N1 for the first time, with CL264 being a molecular adjuvant. Following intramuscular injection of the vaccine into mice, the levels of antibodies and cytokines were assessed to evaluate the immune response. Additionally, mice were challenged with highly virulent RH-strain tachyzoites of T. gondii , and their survival time was observed. The results show that the levels of IgG in serum, the ratio of IgG2a/IgG1 and the levels of IFN-γ in splenocytes of mice were significantly higher in the pEGFP-TgIST group and the pEGFP-TgIST + CL264 group than in the control group. In addition, the proportion of CD4+/CD8+ T cells was higher in mice immunized with either the pEGFP-TgIST group ( p < 0.001) or the pEGFP-TgIST + CL264 group ( p < 0.05) compared to the three control groups. Notably, TgIST-immunized mice exhibited prolonged survival times after T. gondii RH strain infection ( p < 0.05). Our findings collectively demonstrate that the TgIST DNA vaccine elicits a significant humoral and cellular immune response and offers partial protection against acute T. gondii infection in the immunized mice, which suggests that TgIST holds potential as a candidate for further development as a DNA vaccine.
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- 2024
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21. Pursuing Harmony and Fulfilling Responsibility: A Qualitative Study of the Orientation to Happiness (OTH) in Chinese Culture.
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Dong R, Wang Y, Wei C, Hou X, Ju K, Liang Y, and Xi J
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Happiness is the ultimate life goal for most people, and the pursuit of happiness serves as the fundamental motivation driving human behavior. Orientation to Happiness (OTH) represents the aspect that individuals seek when making decisions or engaging in activities, including values, priorities, motivations, ideals, and goals. Nevertheless, existing research has predominantly approached OTH from an individualistic perspective, emphasizing an individual's internal emotional state and personal goals, thereby neglecting the significant influence of a collectivist cultural background on the pursuit of happiness. To address this research gap, our study employs qualitative research methods, enabling us to delve deeply into the intricate interplay between cultural context, societal influences, and individual motivations that collectively shape OTH. Our research is dedicated to understanding the structure of OTH within the Chinese cultural context. Through semi-structured interviews with 26 Chinese adults and the utilization of an inductive style of thematic analysis, we have identified two core themes within the OTH of Chinese adults: Self-focused and Other-focused. Notably, the "Other-focused" theme emphasizes the pursuit of group harmony and the fulfillment of group responsibilities, highlighting the paramount role of "relationships" in the study of happiness within collectivist cultures. This insight forms a robust foundation for future research in this area.
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- 2023
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22. A New Factor "Otherism" Added to the Hedonic and Eudaimonic Motives for Activities Scale (HEMA) in Chinese Culture.
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Dong R, Wang Y, Wei C, Hou X, Ju K, Liang Y, and Xi J
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Due to different understandings of happiness, people adopt different tendencies to act, which is called orientation to happiness (OTH). Our previous study found that OTH had two core themes, Self-focused and Other-focused in Chinese culture, which was different from OTH structures in Western culture. However, no corresponding measurement tool has been developed or revised. The Hedonic and Eudaimonic Motives for Activities Scale (HEMA) was the most commonly used measurement tool of OTH in recent years. The present study aimed to develop a Chinese version of the HEMA. A total of 1729 Chinese adults participated in this study. The exploratory factor analysis (EFA) and confirmatory factor analysis (CFA) were used to examine the underlying structure of the Chinese version of the HEMA. The results supported the 3-factor structure of the translation instrument, and the 15-item scale had good convergent and discriminant validity. The three dimensions were named Hedonism, Eudaimonism, and Otherism. Among them, Otherism is a new dimension, which means "the pursuit of the harmony of the group and achieving happiness by fulfilling their responsibilities in the group". The revised tool was named the Hedonic, Eudaimonic, and Otheristic Motives for Activities Scale-Chinese (HEOMA-C). The results showed that the HEOMA-C has good reliability and validity. Overall, the present study provided an effective tool to assess the OTH in Chinese culture., Competing Interests: The authors declare no conflict of interest.
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- 2023
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23. The Unique Role of Peer Support: Exploring the Effects of Various Sources of Social Support on the Mental Health of Unaccompanied Children in China under Residential Education.
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Dong L, Peng Y, Zhang R, Ju K, and Xi J
- Abstract
This study investigates the impact of various sources of social support on the mental health of unaccompanied children under residential education in China. Unaccompanied children refer to those whose parents are still alive but unable to raise them due to various reasons. The study utilized self-reported questionnaires administered at two time waves, with the first wave (T1) evaluating family support, teacher support, and peer support, and the second wave (T2) evaluating depression, subjective well-being, and resilience. A total of 202 participants completed both surveys. To examine the predictive effect of different sources of social support on the mental health of these children, the study used the structural equation model with depression and subjective well-being as indicators. The results show that neither family support nor teacher support (T1) had a significant effect on the mental health (T2) of the children. However, peer support (T1) had a significant positive predictive effect on mental health (T2), indicating the unique role of peer support in promoting the mental health of unaccompanied children. The study also explored the mediating role of resilience between social support and well-being, revealing that though the direct effect of teacher support (T1) on mental health (T2) was not significant, the indirect mediating effect of resilience on the relationship between teacher support and mental health was significant. Both the direct and indirect effect of family support (T1) on mental health (T2) were not significant. These findings highlight the importance of creating a positive peer environment for unaccompanied children to promote their mental health. This study has important practical implications for the development of effective intervention programs aimed at improving the mental health of this population.
- Published
- 2023
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