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Sepsis-associated encephalopathy (SAE) is a common brain dysfunction, which results in severe cognitive and neurological sequelae and an increased mortality rate in patients with sepsis. Depending on the stimulus, microglia (resident macrophages in the brain that are involved in SAE pathology and physiology) can adopt two polarization states (M1/M2), corresponding to altered microglial morphology, gene expression, and function. We systematically described the pathogenesis, morphology, function, and phenotype of microglial activation in SAE and demonstrated that microglia are closely related to SAE occurrence and development, and concomitant cognitive impairment. Finally, some potential therapeutic approaches that can prime microglia and neuroinflammation toward the beneficial restorative microglial phenotype in SAE were outlined.

The power system (abbreviated as PS for convenience) is one of the indispensable infrastructures in modern society, and its stable operation is crucial for ensuring the normal operation of the national economy and society. With the continuous expansion and complexity of the power grid, power correlation analysis has become increasingly important in the operation, planning, and management of the power system. Temperature is one of the main factors affecting power load (abbreviated as PL for convenience), and how to integrate the periodic characteristics of temperature with load analysis has become a top priority. This article improved the logistic algorithm and applied it to the power correlation analysis of combined load and temperature periodic characteristics and collected four seasonal PL parameters and temperature parameters from January to December 2022. The study analyzed the correlation between PL and temperature periodic characteristics, and also compared the accuracy of PS correlation analysis using the logistic algorithm and improved logistic algorithm. According to the experimental results, it could be concluded that at 1 and 2 o’clock on 1 January 2022, the temperature was at the lowest, both of which were −3 °C, while the PS load was 1000 MW and 1100 MW, respectively. It could be seen that in winter, as the temperature was lower the PL increased. In July 2022, the load and temperature of the PS were continuously increasing, reaching their maximum at 10 o’clock and it could be observed that as the temperature increased, the PL also increased. This was because both low and high temperatures increased the operation of the power equipment, thereby increasing the PL. It was also confirmed that fusing multiple features and adopting an improved logistic algorithm could improve the accuracy of the prediction results. The improved logistic algorithm could be applied to related fields such as PL forecasting and provide a scientific decision-making basis for the power industry. This could also provide a reference for data analysis and prediction in other fields.

The bile acid sodium symporter (BASS) family plays an important role in transporting substances and coordinating plants’ salt tolerance. However, the function of BASS in Brassica rapa has not yet been elucidated. In this study, eight BrBASS genes distributed on five chromosomes were identified that belonged to four subfamilies. Expression profile analysis showed that BrBASS7 was highly expressed in roots, whereas BrBASS4 was highly expressed in flowers. The promoter element analysis also identified several typical homeopathic elements involved in abiotic stress tolerance and stress-related hormonal responses. Notably, under salt stress, the expression of BrBASS2 was significantly upregulated; under osmotic stress, that of BrBASS4 increased and then decreased; and under cold stress, that of BrBASS7 generally declined. The protein–protein interaction analysis revealed that the BrBASS2 homologous gene AtBASS2 interacted with Nhd1 (N-mediated heading date-1) to alleviate salt stress in plants, while the BrBASS4 homologous gene AtBASS3 interacted with BLOS1 (biogenesis of lysosome-related organelles complex 1 subunit 1) via co-regulation with SNX1 (sorting nexin 1) to mitigate an unfavorable growing environment for roots. Further, Bra-miR396 (Bra-microRNA396) targeting BrBASS4 and BrBASS7 played a role in the plant response to osmotic and cold stress conditions, respectively. This research demonstrates that BrBASS2, BrBASS4, and BrBASS7 harbor great potential for regulating abiotic stresses. The findings will help advance the study of the functions of the BrBASS gene family.

Catholicism during the late Ming and early Qing Dynasties is the most fascinating chapter in the development history of Christian culture in China. Apostolate through books emerged as a prominent method of Sino-West cultural exchange during that time. Apostolate through books by Catholicism was realized by means of translation practice, leading to a notable religious influence. Based on this perspective, this paper discusses the history and connotation of apostolate through books, particularly focusing on the characteristics of apostolate through books by Catholicism during the late Ming and early Qing Dynasties. In achieving this, this research shows the translation motivation and translation effect of apostolate through books during the late Ming and early Qing Dynasties. Furthermore, this paper emphasizes that the translation practice of apostolate through books by Catholicism has laid a good foundation for the sinicization and acceptance of Catholicism in China, highlighting the relationship between apostolate through books by Catholicism and the sinicization of Christian culture, so as to enlighten the internationalization of religious culture.

Leucine-rich repeat extensin (LRX) is involved in the regulation of crucial cellular processes, such as cell wall growth and development, as well as signaling. However, the presence of the LRX gene family in Brassica rapa (B. rapa) has not been previously reported. This study identified 17 BrLRXs within the Brassica rapa genome by bioinformatic analysis, and these genes were distributed on seven chromosomes. Phylogenetic and covariance analyses indicate that BrLRXs can be categorized into two distinct branches: the trophic branch and the reproductive branch, with a close relationship observed between BrLRXs and AtLRXs. According to cis-acting element analysis, this gene family is rich in hormone-responsive and stress-responsive elements such as drought-inducibility, abscisic acid, methyl jasmonate, and gibberellic acid responsive elements, suggesting a potential role in abiotic stress response. Transcriptomic, proteomic, and RT-qPCR analyses demonstrated significant up-regulation of BrLRX2 and BrLRX6 under salt stress, while BrLRX3, BrLRX6, and BrLRX8 were significantly down-regulated under osmotic stress. Our analysis of the protein tertiary structure predicts a strong association between LRX proteins and RALF. Protein–protein interaction prediction revealed that LRX interacts with the RALF protein and the receptor FER, which have been previously reported to jointly regulate plant stress responses. We propose that BrLRX6 and BrLRX8 are implicated in osmotic stress, while BrLRX2 and BrLRX6 are involved in the modulation of salt stress.

Bamei pigs, an eximious local breed reared on the Tibetan Plateau of China, are facing problems such as feed shortages, weaning stress, and antibiotic abuse. This study aimed to improve the quality of feed, growth performance, intestinal microbiota, and immunity of Bamei pigs through feeding with potentially probiotic-fermented feed. Different feeds were administered to weaned Bamei piglets for 60 days, creating the following five experimental treatment groups: basal feed group; Lactiplantibacillus plantarum-fermented-feed group; Bacillus subtilis-fermented-feed group; mixed-fermented-feed group; and antibiotic-supplemented-feed group. The results showed that the pH, neutral detergent fiber, and acid detergent fiber of the potentially probiotic-fermented feeds were significantly reduced; organic acids were produced; and Coliform bacteria, Clostridium, and aerobic bacteria were effectively inhibited. Feeding with potentially probiotic-fermented feed not only reduced the feed-conversion ratio but also improved immunity by increasing the production of anti-inflammatory cytokines, as well as decreasing pro-inflammatory cytokines and typical inflammatory pathways. The 16s rDNA high-throughput-sequencing results showed that probiotic-fermented feed improved the diversity of intestinal microbiota, inhibited the growth of the opportunistic pathogens Clostridium and Streptococcus, increased the relative abundance of Lactobacillus and Prevotella, and promoted gut health, demonstrating the promising application prospects of potentially probiotic-fermented feed.