Search

Your search keyword '"Iossa, Susanna"' showing total 12 results
Start Over Author "Iossa, Susanna" Publisher mdpi ag
12 results on '"Iossa, Susanna"'

10. Fat Quality Influences the Obesogenic Effect of High Fat Diets

Author

Crescenzo, Raffaella, primary, Bianco, Francesca, additional, Mazzoli, Arianna, additional, Giacco, Antonia, additional, Cancelliere, Rosa, additional, di Fabio, Giovanni, additional, Zarrelli, Armando, additional, Liverini, Giovanna, additional, and Iossa, Susanna, additional

Published
2015
Full Text
View/download PDF

12. Sweet but Bitter: Focus on Fructose Impact on Brain Function in Rodent Models

Author

Luisa Cigliano, Maria Stefania Spagnuolo, Susanna Iossa, Stefania Spagnuolo, Maria, Iossa, Susanna, and Cigliano, Luisa

Subjects
0301 basic medicine, Aging, brain insulin resistance, Review, medicine.disease_cause, neuroinflammation, Eating, chemistry.chemical_compound, 0302 clinical medicine, Insulin, Nutrition and Dietetics, biology, brain mitochondria, Brain, Neurodegenerative Diseases, brain oxidative stre, Mitochondria, Corn syrup, Liver, Taste, brain oxidative stress, Carbohydrate Metabolism, fructose diet, lcsh:Nutrition. Foods and food supply, medicine.medical_specialty, food.ingredient, lcsh:TX341-641, Rodentia, Fructose, 03 medical and health sciences, food, Insulin resistance, Metabolic Diseases, Memory, Internal medicine, medicine, Animals, Cognitive Dysfunction, Obesity, Neuroinflammation, cognitive impairment, Inflammation, medicine.disease, Oxidative Stress, Insulin receptor, GLUT5, 030104 developmental biology, Endocrinology, chemistry, Sweetening Agents, Fructolysis, biology.protein, Insulin Resistance, High Fructose Corn Syrup, 030217 neurology & neurosurgery, Oxidative stress, Food Science
Abstract

Fructose consumption has drastically increased during the last decades due to the extensive commercial use of high-fructose corn syrup as a sweetener for beverages, snacks and baked goods. Fructose overconsumption is known to induce obesity, dyslipidemia, insulin resistance and inflammation, and its metabolism is considered partially responsible for its role in several metabolic diseases. Indeed, the primary metabolites and by-products of gut and hepatic fructolysis may impair the functions of extrahepatic tissues and organs. However, fructose itself causes an adenosine triphosphate (ATP) depletion that triggers inflammation and oxidative stress. Many studies have dealt with the effects of this sugar on various organs, while the impact of fructose on brain function is, to date, less explored, despite the relevance of this issue. Notably, fructose transporters and fructose metabolizing enzymes are present in brain cells. In addition, it has emerged that fructose consumption, even in the short term, can adversely influence brain health by promoting neuroinflammation, brain mitochondrial dysfunction and oxidative stress, as well as insulin resistance. Fructose influence on synaptic plasticity and cognition, with a major impact on critical regions for learning and memory, was also reported. In this review, we discuss emerging data about fructose effects on brain health in rodent models, with special reference to the regulation of food intake, inflammation, mitochondrial function and oxidative stress, insulin signaling and cognitive function.

Published
2020
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results