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Mobility as a Service (MaaS), which integrates public and shared transportation into a single service, is drawing attention as a travel demand management strategy aimed at reducing automobile dependency and encouraging public transit. In particular, there have been few studies that recognize traffic congestion during peak hours and identify related factors for practical application. The purpose of this study is to explore what factors affect Seoul commuters’ mode choice including MaaS. A web-based survey that 161 commuters participated in was conducted to collect information about personal, household, and travel attributes, together with their mode preference for MaaS. A latent class model was developed to classify unobserved latent groups based on trip frequency by means and to identify factors influencing mode-specific utilities (in particular, MaaS service) for each class. The result shows that latent classes are divided into two groups (public transit-oriented commuters and balanced mode commuters). Most variables have significant impacts on choice for MaaS. The coefficient of MaaS choice of Class 1 and Class 2 were different. These findings suggest there is a difference between the classes according to trip frequency by means as an influencing factor in MaaS choice.

Salvia Miltiorrhizae Radix (SMR) is a widely-used herbal medicine for the treatment of various blood stasis-related diseases (mainly circulatory system). It has been extensively studied in the field of pharmacology over the last few decades. In addition, several reviews concerning the effect of SMR are available. The purpose of this study was to review the pharmacological activities of SMC based on the 10th revision of the international disease classification (ICD-10). After an analysis of the literatures in the Medline database between January 1988 and August 2018, 691 eligible articles were chosen and 971 results were obtained (395 in vitro, 536 in vivo, and 40 human). The extracted data were categorized into the disease chapters of the ICD-10 and the major chapters were: IX Diseases of the circulatory system, II Neoplasms, XI Diseases of the digestive system, XIX Injury, poisoning and certain other consequences of external causes, IV Endocrine, nutritional, and metabolic diseases, VI Diseases of the nervous system, V Mental and behavioral disorders, etc. The major diseases and the pharmacological results of each chapter of the ICD-10 were described assiduously, along with the statistical details. The current study provided a comprehensive understanding and insight of SMR in terms of pharmacological activities.

Objective: Itch is an unpleasant sensation associated with an urge to scratch and is a major health care issue associated with atopic dermatitis (AD). Contagious itch, i.e., subjective feelings of itchiness induced by watching others’ scratching behavior, is common in patients with AD. Using electroencephalography, we examined alpha (8–13 Hz) oscillations in sensorimotor areas associated with the desire to scratch in patients with AD. Methods: Thirty-six patients with AD and 34 healthy controls (HCs) participated in this study. They evaluated their itch levels after watching short videos of a model scratching or tapping parts of his body. Neural oscillations were recorded from nine electrodes, including those placed over sensorimotor areas. Time–frequency analysis was used to compare mu rhythm suppression over the sensorimotor areas in response to these videos between patients with AD and HCs. Results: The behavioral test showed that the visual stimuli induced increased feelings of itchiness in patients with AD relative to HCs under the tapping and scratching conditions. The time–frequency analysis revealed that mu rhythm suppression in response to scratching images was significantly prominent in patients with AD, but not in HCs. Conclusion: Patients with AD exhibited increased susceptibility to contagious itch. This phenomenon might be related to enhanced mu rhythm suppression in sensorimotor areas of the brain in these patients. Our findings provide new insight into the neurophysiological basis of itch sensations in patients with AD.

Antibody&ndash, drug conjugate (ADC) linkers play an important role in determining the safety and efficacy of ADC. The Ortho Hydroxy-Protected Aryl Sulfate (OHPAS) linker is a newly developed linker in the form of a di-aryl sulfate structure consisting of phenolic payload and self-immolative group (SIG). In this study, using two bioanalytical approaches (namely &ldquo, bottom-up&rdquo, and &ldquo, middle-up&rdquo, approaches) via the liquid chromatography-quadrupole time-of-flight mass spectrometric (LC-qTOF-MS) method, in vitro and in vivo linker stability experiments were conducted for the OHPAS linker. For comparison, the valine-citrulline-p-aminobenzyloxycarbonyl (VC-PABC) linker was also evaluated under the same experimental conditions. In addition, the catabolite identification experiments at the subunit intact protein level were simultaneously performed to evaluate the catabolic fate of ADCs. As a result, the OHPAS linker was stable in the in vitro mouse/human plasma as well as in vivo pharmacokinetic studies in mice, whereas the VC-PABC linker was relatively unstable in mice in vitro and in vivo. This is because the VC-PABC linker was sensitive to a hydrolytic enzyme called carboxylesterase 1c (Ces1c) in mouse plasma. In conclusion, the OHPAS linker appears to be a good linker for ADC, and further experiments would be warranted to demonstrate the efficacy and toxicity related to the OHPAS linker.

Due to increases in truck traffic, truck traffic safety has become an unavoidable societal issue in Korea. Truck traffic accidents were responsible for 24% of all traffic deaths in 2019, and the fatality rate was significantly higher than that of other forms of traffic. This study analyzes not only the driver and environmental factors, but also the traffic condition factors which are considered to contribute to the severity of truck traffic accidents, and presents practical truck safety solutions based on the findings. This study examines the fatal and serious injury truck traffic accidents in Incheon, which has large logistics facilities and the highest fatality rate (3.3) in Korea’s capital area. According to the regression analysis results, ‘Nighttime’, ‘Vehicle-single’, ‘Vehicle to Pedestrian’, ‘Lane violation’, and ‘Signal violation’ contribute to the severity of truck traffic accidents. Furthermore, truck traffic accidents in the logistics influencing area are more likely to be serious than in the non-influencing area. In terms of the traffic condition factors, the number of lanes, the maximum speed, and the number of road property-changing nodes were significant. The results of this study will provide useful data for establishing traffic safety policies in urban areas.

Nowadays, maritime air pollution is regarded as a severe threat to coastal communities&rsquo, health. Therefore, many policies to reduce air pollution have been established worldwide. Moreover, there has been a shift in policy and research attention from greenhouse gases, especially CO2, to other air pollutants. To address the current local environmental challenges, this research analyzes the non-greenhouse gas emissions inventory (CO, NOx, SOx, PM, VOC, and NH3) from ships in the second biggest port in Korea, the Port of Incheon (POI). A bottom-up activity-based methodology with real-time vessel activity data produced by the Vessel Traffic Service (VTS) is applied to obtain reliable estimations. NOx and SOx dominated the amount of emission emitted from ships. Tankers, general cargo ships, cruise ships, and container ships were identified as the highest sources of pollution. Based on the above results, this study discusses the need for long-term policies, such as the designation of a local emission control area (ECA) and the establishment of an emission management platform to reduce ship-source emissions. Furthermore, this study elucidates that significant emissions come from the docking process, ranging from 33.9% to 42.0% depending on the type of pollutant when only the auxiliary engines were being operated. Therefore, short-term solutions like applying exhausted gas cleaning systems, using on-shore power supplies, reducing docking time, or using greener alternative fuels (e.g., liquefied natural gas or biofuels) should be applied and motivated at the POI. These timely results could be useful for air quality management decision-making processes for local port operators and public agencies.

© 2017 by the authors; licensee MDPI, Basel, Switzerland. Atopic dermatitis (AD) and stress create a vicious cycle: stress exacerbates atopic symptoms, and atopic disease elicits stress and anxiety. Targeting multiple pathways including stress and allergic inflammation is, therefore, important for treating AD. In this study, we investigated the remedial value of Polygala tenuifoliaWilld. (PTW) for treating immobilization (IMO) stress-exacerbated atopy-like skin dermatitis and its underlying mechanism. Trimellitic anhydride (TMA) was applied to dorsal skin for sensitization and subsequently both ears for eliciting T-cell-dependent contact hypersensitivity in mice, which underwent 2 h-IMO stress and PTW administration for the latter 6 and 9 days in the ear exposure period of TMA, respectively. To elicit in vitro degranulation of human mast cell line-1 (HMC-1), 10 μM substance P (SP) and 200 nM corticotrophin-releasing factor (CRF) were sequentially added with 48 h-interval. PTW extract (500 μg/mL) was added 30 min before CRF treatment. IMO stress exacerbated TMA-induced scratching behavior by 252%, and increased their blood corticosterone levels by two-fold. Treatment with 250 mg/kg PTW significantly restored IMO stress-exacerbated scratching behavior and other indicators such as skin inflammation and water content, lymph node weights, and serum histamine and immunoglobulin E (lgE) levels. Furthermore, it also reversed TMA-stimulated expression of tumor necrosis factor (TNF)-α and interleukin (IL)-4 mRNAs in ear tissues. PTW significantly inhibited SP/CRF-stimulated degranulation of HMC-1 cells, subsequent tryptase secretion, and protein kinase A (PKA) activity. PTW also selectively inhibited p38 mitogen-activated protein kinase (MAPK) phosphorylation in SP/CRF-treated HMC-1 cells. PTW significantly inhibited HMC-1 cell degranulation and alleviated IMO stress-exacerbated atopic dermatitis symptoms by modulating the PKA/p38 MAPK signaling pathway.