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Alzheimer’s disease (AD) is a progressive neurodegenerative disease and the most common form of dementia globally. Although the direct cause of AD remains under debate, neuroinflammation and oxidative stress are critical components in its pathogenesis and progression. As a result, compounds like cannabidiol (CBD) are being increasingly investigated for their ability to provide antioxidant and anti-inflammatory neuroprotection. CBD is the primary non-psychotropic phytocannabinoid derived from Cannabis sativa. It has been found to provide beneficial outcomes in a variety of medical conditions and is gaining increasing attention for its potential therapeutic application in AD. CBD is not psychoactive and its lipophilic nature allows its rapid distribution throughout the body, including across the blood–brain barrier (BBB). CBD also possesses anti-inflammatory, antioxidant, and neuroprotective properties, making it a viable candidate for AD treatment. This review outlines CBD’s mechanism of action, the role of oxidative stress and neuroinflammation in AD, and the effectiveness and limitations of CBD in preclinical models of AD.

Based on a sample of 8271 mothers, this study explored a set of psychological and sociodemographic factors associated with their vocabulary, drawing on data from a large, nationally representative sample of children born in 2000. The dependent variable was maternal vocabulary assessed when cohort members were at fourteen years of age, and the mothers were in their mid-forties. Data were also collected when cohort members were at birth, 9 months old, and at ages 3, 7, 11 and 14 years. Correlational analysis showed that family income at birth, parent–child relationship quality at age 3, maternal educational qualifications at age 11, and maternal personality trait Openness at age 14 were significantly and positively associated with maternal vocabulary. It also showed maternal malaise at 9 months and children’s behavioral adjustment at age 7, and maternal traits Neuroticism and Agreeableness at age 14 were significantly and negatively associated with maternal vocabulary. Maternal age was also significantly and positively associated with vocabulary. Regression analysis showed that maternal age, malaise, parent–child relationship quality, children’s behavioral adjustment, maternal educational qualifications, and traits Openness and Agreeableness were significant predictors of maternal vocabulary, accounting for 33% of total variance. The implications and limitations are discussed.

This study explored a longitudinal data set of over 10,663 children at age 7 years to examine various psychological and sociological factors that possibly influenced their behavioural problems. Data were collected when cohort members were born, then 9 months old, and later at later at ages 3 and 7 years. Structural equation modelling showed that the family income, maternal psychological distress, the parent-child relationship, and maternal personality traits all had direct significant effects on children’s behavioural problems, accounting for 42 percent of the total variance. The strongest predictor was parent-child relationship, followed by maternal emotional stability (low neuroticism) and the family poverty indicator.

This study explored a longitudinal data set of 4361 adults (2119 males and 2239 females) to examine factors that influence adult vocabulary task performance. Data were collected at birth, in childhood (age 10 years), during teenage years (age 16 years), and in adulthood (ages 30, 34, and 42 years) to examine the effects of family social status, childhood cognitive ability, teenager locus of control, psychological distress, educational qualifications, and occupational prestige in adulthood on an adult vocabulary task—an index of crystallized intelligence. Structural equation modeling showed that childhood cognitive ability, teenager locus of control, education, and occupation were all significant and direct predictors of adult vocabulary task performance. Parental social status affected the outcome variable mediated through educational qualifications. The strongest predictor of adult vocabulary task performance was childhood cognitive ability, followed by educational qualifications and locus of control. Finally, limitations were acknowledged.

This paper reports on a longitudinal study of over 12,000 people based on the UK Household Longitudinal Study data. We were interested in their monthly income (as the criterion variable) as it related to their gender, age, education, occupation, personality, intelligence, and region where they lived (as the predictor variables). Correlations showed that, after occupation and education, gender and cognitive ability (particularly numeric ability) were the strongest correlates of income. Hierarchical regressions showed that age and gender accounted for 9% of the variance, intelligence and personality added another 5%, and education and occupation added a further 15%, while region added a further 1%. All four models were statistically significant (p < 0.001). The study suggests that, in future research of this kind on the personal correlates of income, social-demographic, psychological, and regional factors all need to be considered. Limitations are acknowledged.

The current study investigated a longitudinal data set of 4790 adults examining a set of socio-demographic and psychological factors that influence adult financial well-being. Parental social status (at birth), childhood intelligence and self-esteem (at age 10), locus of control (at age 16), psychological distress (age 30), educational qualifications (age 34), current occupation, weekly net income, house ownership status, and number of rooms (all measured at age 38 years) were examined. Structural Equation Modelling showed that childhood intelligence, locus of control, education and occupation were all independent predictors of adult financial well-being for both men and women. Parental social status and psychological distress were also significant predictors of the outcome variable for men, but not for women. Whereas for women, in comparison to men, the effects of current occupation and childhood intelligence on the outcome variable appeared to be stronger. The strongest predictor of adult financial well-being was current occupational prestige, followed by educational achievement. The gender deferential of financial well-being indicators and its implications are discussed.

This study set out to investigate to what extent childhood cognitive ability, along with personality traits, education and occupational status, as well as marital status influence adult financial success. Data were drawn from a large, prospective birth cohort in the UK, the National Child Development Study (NCDS). The analytic sample was comprised of 4537 cohort members with data on parental social class (at birth), cognitive ability (at age 11), educational qualifications (at age 33), personality traits (at age 50), current marital status and occupational prestige, and salary/wage earning level (all measured at age 54). Correlational results showed that parental social class, childhood cognitive ability, traits extraversion, emotional stability, conscientiousness, and openness, being married positively, being divorced or separated negatively, education and occupation as well as gender were all significantly associated with adult earning ability (p < 0.05 to p < 0.001). Effect sizes for the relationship between intelligence and income was moderate. Results of a multiple regression analysis showed that childhood cognitive ability, traits conscientiousness and openness, educational qualifications and occupational prestige were significant and independent predictors of adult earning ability accounting for 30% of the total variance. There was also a gender effect on the outcome variable. Numerous limitations are noted.

Massachusetts began newborn screening (NBS) for Spinal Muscular Atrophy (SMA) following the availability of new treatment options. The New England Newborn Screening Program developed, validated, and implemented a screening algorithm for the detection of SMA-affected infants who show absent SMN1 Exon 7 by Real-Time™ quantitative PCR (qPCR). We screened 179,467 neonates and identified 9 SMA-affected infants, all of whom were referred to a specialist by day of life 6 (average and median 4 days of life). Another ten SMN1 hybrids were observed but never referred. The nine referred infants who were confirmed to have SMA were entered into treatment protocols. Early data show that some SMA-affected children have remained asymptomatic and are meeting developmental milestones and some have mild to moderate delays. The Massachusetts experience demonstrates that SMA NBS is feasible, can be implemented on a population basis, and helps engage infants for early treatment to maximize benefit.