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Your search keyword '"Guo, Xiaoquan"' showing total 13 results
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13 results on '"Guo, Xiaoquan"'

6. PRRSV Elimination in a Farrow-to-Finish Pig Herd Using Herd Closure and Rollover Approach

Author

Hu, Ruiming, primary, Zhang, Tiansheng, additional, Lai, Rongbin, additional, Ding, Zhen, additional, Zhuang, Yu, additional, Liu, Hao, additional, Cao, Huabin, additional, Gao, Xiaona, additional, Luo, Junrong, additional, Chen, Zheng, additional, Zhang, Caiying, additional, Liu, Ping, additional, Guo, Xiaoquan, additional, Hu, Guoliang, additional, Ding, Nengshui, additional, and Deng, Shunzhou, additional

Published
2023
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11. Preparation of the RIPK3 Polyclonal Antibody and Its Application in Immunoassays of Nephropathogenic Infectious Bronchitis Virus-Infected Chickens

Author

Tian, Guanming, primary, Shi, Yan, additional, Cao, Xianhong, additional, Chen, Wei, additional, Gu, Yueming, additional, Li, Ning, additional, Huang, Cheng, additional, Zhuang, Yu, additional, Li, Guyue, additional, Liu, Ping, additional, Hu, Guoliang, additional, Gao, Xiaona, additional, and Guo, Xiaoquan, additional

Published
2022
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13. Mechanism of Mitochondrial Kinetic Imbalance and Nrf2 Signaling Pathway-Mediated Oxidative Stress in Nickel and/or Chromium-Induced Kidney Injury in Mice.

Author

Du J, Li Z, Cao X, Qi Q, Wang L, Liu P, Chen Y, Hu G, Guo X, and Gao X

Abstract

Nickel and chromium are both common heavy metals that pose serious environmental and health hazards. However, the exact mechanism by which nickel and/or chromium cause renal injury is unclear. Therefore, we explored the molecular mechanisms of renal injury caused by nickel and/or chromium poisoning from the perspective of mitochondrial dynamics and the Nrf2 antioxidant pathway. In this study, eighty 6-week-old C57BL/6J mice were randomly divided into four groups: control (Con, untreated), nickel (Ni, 110 mg/L Ni 2+ ), chromium (Cr, 50 mg/L Cr 6+ ), and combined nickel-chromium (Ni + Cr, 110 mg/L Ni 2+ , 50 mg/L Cr 6+ ). The results showed that chronic nickel and/or chromium exposure inhibited body weight gain and impaired kidney function and structure in mice. Chronic nickel and/or chromium exposure led to the disruption of mitochondrial dynamics and thus induced oxidative stress. On the other hand, the Nrf2 antioxidant pathway may play an important regulatory role in mitigating oxidative stress-induced oxidative damage in kidney. The present study partially elucidated the molecular mechanism of renal injury induced by nickel and/or chromium exposure in mice and the regulatory role of the Nrf2 pathway in inducing oxidative injury from the perspective of mitochondrial dynamics. This provides a theoretical basis for the development of prevention and control strategies, and environmental protection measures.

Published
2024
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