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Your search keyword '"Grassi, Gabriele"' showing total 27 results
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27 results on '"Grassi, Gabriele"'

1. In Vitro and In Vivo Evaluation of the Effects of Drug 2c and Derivatives on Ovarian Cancer Cells

Author

Maddaloni, Marianna, primary, Farra, Rossella, additional, Dapas, Barbara, additional, Felluga, Fulvia, additional, Benedetti, Fabio, additional, Berti, Federico, additional, Drioli, Sara, additional, Vidali, Mattia, additional, Cemazar, Maja, additional, Kamensek, Urska, additional, Brancolini, Claudio, additional, Murano, Erminio, additional, Maremonti, Francesca, additional, Grassi, Mario, additional, Biasin, Alice, additional, Rizzolio, Flavio, additional, Cavarzerani, Enrico, additional, Scaggiante, Bruna, additional, Bulla, Roberta, additional, Balduit, Andrea, additional, Ricci, Giuseppe, additional, Zito, Gabriella, additional, Romano, Federico, additional, Bonin, Serena, additional, Azzalini, Eros, additional, Baj, Gabriele, additional, Tierno, Domenico, additional, and Grassi, Gabriele, additional

Published
2024
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4. BCG-Unresponsive Non-Muscle-Invasive Bladder Cancer: Current Treatment Landscape and Novel Emerging Molecular Targets

Author

Claps, Francesco, primary, Pavan, Nicola, additional, Ongaro, Luca, additional, Tierno, Domenico, additional, Grassi, Gabriele, additional, Trombetta, Carlo, additional, Tulone, Gabriele, additional, Simonato, Alchiede, additional, Bartoletti, Riccardo, additional, Mertens, Laura S., additional, van Rhijn, Bas W. G., additional, Mir, Maria Carmen, additional, and Scaggiante, Bruna, additional

Published
2023
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6. A Case–Control Study by ddPCR of ALU 260/111 and LINE-1 266/97 Copy Number Ratio in Circulating Cell-Free DNA in Plasma Revealed LINE-1 266/97 as a Potential Biomarker for Early Breast Cancer Detection

Author

Bortul, Marina, primary, Giudici, Fabiola, additional, Tierno, Domenico, additional, Generali, Daniele, additional, Scomersi, Serena, additional, Grassi, Gabriele, additional, Bottin, Cristina, additional, Cappelletti, Maria Rosa, additional, Zanconati, Fabrizio, additional, and Scaggiante, Bruna, additional

Published
2023
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7. Targeting Non-Coding RNAs for the Development of Novel Hepatocellular Carcinoma Therapeutic Approaches

Author

Jesenko, Tanja, primary, Brezar, Simona Kranjc, additional, Cemazar, Maja, additional, Biasin, Alice, additional, Tierno, Domenico, additional, Scaggiante, Bruna, additional, Grassi, Mario, additional, Grassi, Chiara, additional, Dapas, Barbara, additional, Truong, Nhung Hai, additional, Abrami, Michela, additional, Zanconati, Fabrizio, additional, Bonazza, Deborah, additional, Rizzolio, Flavio, additional, Parisi, Salvatore, additional, Pastorin, Giorgia, additional, and Grassi, Gabriele, additional

Published
2023
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11. Potential Application of Small Interfering RNA in Gastro-Intestinal Tumors

Author

Losurdo, Pasquale, primary, de Manzini, Nicolò, additional, Palmisano, Silvia, additional, Grassi, Mario, additional, Parisi, Salvatore, additional, Rizzolio, Flavio, additional, Tierno, Domenico, additional, Biasin, Alice, additional, Grassi, Chiara, additional, Truong, Nhung Hai, additional, and Grassi, Gabriele, additional

Published
2022
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12. High eEF1A1 Protein Levels Mark Aggressive Prostate Cancers and the In Vitro Targeting of eEF1A1 Reveals the eEF1A1–Actin Complex as a New Potential Target for Therapy

Author

Bosutti, Alessandra, primary, Dapas, Barbara, additional, Grassi, Gabriele, additional, Bussani, Rossana, additional, Zanconati, Fabrizio, additional, Giudici, Fabiola, additional, Bottin, Cristina, additional, Pavan, Nicola, additional, Trombetta, Carlo, additional, and Scaggiante, Bruna, additional

Published
2022
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14. 5-Azacytidine Downregulates the Proliferation and Migration of Hepatocellular Carcinoma Cells In Vitro and In Vivo by Targeting miR-139-5p/ROCK2 Pathway

Author

Tonon, Federica, primary, Cemazar, Maja, additional, Kamensek, Urska, additional, Zennaro, Cristina, additional, Pozzato, Gabriele, additional, Caserta, Sergio, additional, Ascione, Flora, additional, Grassi, Mario, additional, Guido, Stefano, additional, Ferrari, Cinzia, additional, Cansolino, Laura, additional, Trotta, Francesco, additional, Kuzmanov, Biljana Grcar, additional, Forte, Giancarlo, additional, Martino, Fabiana, additional, Perrone, Francesca, additional, Bomben, Riccardo, additional, Gattei, Valter, additional, Elvassore, Nicola, additional, Murano, Erminio, additional, Truong, Nhung Hai, additional, Olson, Michael, additional, Farra, Rossella, additional, Grassi, Gabriele, additional, and Dapas, Barbara, additional

Published
2022
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15. Xenograft Zebrafish Models for the Development of Novel Anti-Hepatocellular Carcinoma Molecules

Author

Tonon, Federica, primary, Farra, Rossella, additional, Zennaro, Cristina, additional, Pozzato, Gabriele, additional, Truong, Nhung, additional, Parisi, Salvatore, additional, Rizzolio, Flavio, additional, Grassi, Mario, additional, Scaggiante, Bruna, additional, Zanconati, Fabrizio, additional, Bonazza, Deborah, additional, Grassi, Gabriele, additional, and Dapas, Barbara, additional

Published
2021
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17. The Extracellular Matrix Influences Ovarian Carcinoma Cells’ Sensitivity to Cisplatinum: A First Step towards Personalized Medicine

Author

Balduit, Andrea, primary, Agostinis, Chiara, additional, Mangogna, Alessandro, additional, Maggi, Veronica, additional, Zito, Gabriella, additional, Romano, Federico, additional, Romano, Andrea, additional, Ceccherini, Rita, additional, Grassi, Gabriele, additional, Bonin, Serena, additional, Bonazza, Deborah, additional, Zanconati, Fabrizio, additional, Ricci, Giuseppe, additional, and Bulla, Roberta, additional

Published
2020
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18. Strategies for Delivery of siRNAs to Ovarian Cancer Cells

Author

Farra, Rossella, primary, Maruna, Matea, additional, Perrone, Francesca, additional, Grassi, Mario, additional, Benedetti, Fabio, additional, Maddaloni, Marianna, additional, El Boustani, Maguie, additional, Parisi, Salvo, additional, Rizzolio, Flavio, additional, Forte, Giancarlo, additional, Zanconati, Fabrizio, additional, Cemazar, Maja, additional, Kamensek, Urska, additional, Dapas, Barbara, additional, and Grassi, Gabriele, additional

Published
2019
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20. Polymer-Mediated Delivery of siRNAs to Hepatocellular Carcinoma: Variables Affecting Specificity and Effectiveness

Author

Farra, Rossella, primary, Musiani, Francesco, additional, Perrone, Francesca, additional, Čemažar, Maja, additional, Kamenšek, Urška, additional, Tonon, Federica, additional, Abrami, Michela, additional, Ručigaj, Aleš, additional, Grassi, Mario, additional, Pozzato, Gabriele, additional, Bonazza, Deborah, additional, Zanconati, Fabrizio, additional, Forte, Giancarlo, additional, El Boustani, Maguie, additional, Scarabel, Lucia, additional, Garziera, Marica, additional, Russo Spena, Concetta, additional, De Stefano, Lucia, additional, Salis, Barbara, additional, Toffoli, Giuseppe, additional, Rizzolio, Flavio, additional, Grassi, Gabriele, additional, and Dapas, Barbara, additional

Published
2018
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21. Potential Applications of Nanocellulose-Containing Materials in the Biomedical Field

Author

Halib, Nadia, primary, Perrone, Francesca, additional, Cemazar, Maja, additional, Dapas, Barbara, additional, Farra, Rossella, additional, Abrami, Michela, additional, Chiarappa, Gianluca, additional, Forte, Giancarlo, additional, Zanconati, Fabrizio, additional, Pozzato, Gabriele, additional, Murena, Luigi, additional, Fiotti, Nicola, additional, Lapasin, Romano, additional, Cansolino, Laura, additional, Grassi, Gabriele, additional, and Grassi, Mario, additional

Published
2017
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22. Polysaccharides for the Delivery of Antitumor Drugs

Author

Posocco, Bianca, primary, Dreussi, Eva, additional, de Santa, Jacopo, additional, Toffoli, Giuseppe, additional, Abrami, Michela, additional, Musiani, Francesco, additional, Grassi, Mario, additional, Farra, Rossella, additional, Tonon, Federica, additional, Grassi, Gabriele, additional, and Dapas, Barbara, additional

Published
2015
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24. An Overview of Circulating Cell-Free Nucleic Acids in Diagnosis and Prognosis of Triple-Negative Breast Cancer

Author

Domenico Tierno, Gabriele Grassi, Fabrizio Zanconati, Marina Bortul, Bruna Scaggiante, Tierno, Domenico, Grassi, Gabriele, Zanconati, Fabrizio, Bortul, Marina, and Scaggiante, Bruna

Subjects
liquid biopsy, Organic Chemistry, circulating cell-free nucleic acid, General Medicine, circulating cell-free tumor miRNA, Catalysis, Computer Science Applications, Inorganic Chemistry, circulating cell-free tumor DNA, circulating cell-free tumor lncRNA, Physical and Theoretical Chemistry, TNBC, Molecular Biology, Spectroscopy
Abstract

Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer due to its molecular heterogeneity and poor clinical outcomes. Analysis of circulating cell-free tumor nucleic acids (ctNAs) can improve our understanding of TNBC and provide efficient and non-invasive clinical biomarkers that may be representative of tumor heterogeneity. In this review, we summarize the potential of ctNAs to aid TNBC diagnosis and prognosis. For example, tumor fraction of circulating cell-free DNA (TFx) may be useful for molecular prognosis of TNBC: high TFx levels after neoadjuvant chemotherapy have been associated with shorter progression-free survival and relapse-free survival. Mutations and copy number variations of TP53 and PIK3CA/AKT genes in plasma may be important markers of TNBC onset, progression, metastasis, and for clinical follow-up. In contrast, the expression profile of circulating cell-free tumor non-coding RNAs (ctncRNAs) can be predictive of molecular subtypes of breast cancer and thus aid in the identification of TBNC. Finally, dysregulation of some circulating cell-free tumor miRNAs (miR17, miR19a, miR19b, miR25, miR93, miR105, miR199a) may have a predictive value for chemotherapy resistance. In conclusion, a growing number of efforts are highlighting the potential of ctNAs for future clinical applications in the diagnosis, prognosis, and follow-up of TNBC.

Published
2023
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25. The Extracellular Matrix Influences Ovarian Carcinoma Cells’ Sensitivity to Cisplatinum: A First Step towards Personalized Medicine

Author

Serena Bonin, Roberta Bulla, Giuseppe Ricci, Fabrizio Zanconati, Alessandro Mangogna, A. Romano, Gabriele Grassi, Federico Romano, Andrea Balduit, Gabriella Zito, Deborah Bonazza, Rita Ceccherini, Veronica Maggi, Chiara Agostinis, Balduit, Andrea, Agostinis, Chiara, Mangogna, Alessandro, Maggi, Veronica, Zito, Gabriella, Romano, Federico, Romano, Andrea, Ceccherini, Rita, Grassi, Gabriele, Bonin, Serena, Bonazza, Deborah, Zanconati, Fabrizio, Ricci, Giuseppe, and Bulla, Roberta

Subjects
0301 basic medicine, Cancer Research, endocrine system diseases, medicine.medical_treatment, spheroids, macromolecular substances, lcsh:RC254-282, Article, 03 medical and health sciences, 0302 clinical medicine, In vivo, fibronectin, Ovarian carcinoma, hyaluronic acid, Medicine, HGSOC, chemoresistance, ovarian cancer, personalized medicine, Chemotherapy, business.industry, medicine.disease, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Primary tumor, 3. Good health, Serous fluid, 030104 developmental biology, Oncology, 030220 oncology & carcinogenesis, Cancer cell, Cancer research, Personalized medicine, business, Ovarian cancer
Abstract

The development of personalized therapies for ovarian carcinoma patients is still hampered by several limitations, mainly the difficulty of predicting patients&rsquo, responses to chemotherapy in tumor cells isolated from peritoneal fluids. The main reason for the low predictive power of in vitro assays is related to the modification of the cancer cells&rsquo, phenotype induced by the culture conditions, which results in changes to the activation state and drug sensitivity of tumor cells compared to their in vivo properties. We have defined the optimal culture conditions to set up a prognostic test to predict high-grade serous ovarian carcinoma (HGSOC) patients&rsquo, responses to platinum chemotherapy. We evaluated the effects of hyaluronic acid (HA) and fibronectin matrices and the contribution of freezing/thawing processes to the cell response to platinum-based treatment, collecting spheroids from the ascitic fluids of 13 patients with stage II or III HGSOC. Our findings indicated that an efficient model used to generate predictive data for in vivo sensitivity to platinum is culturing fresh spheroids on HA, avoiding the use of previously frozen primary tumor cells. The establishment of this easy, reproducible and standardized testing method can significantly contribute to an improvement in therapeutic effectiveness, thus bringing the prospect of personalized therapy closer for ovarian carcinoma patients.

Published
2020

26. Agarose Cryogels: Production Process Modeling and Structural Characterization.

Author

Mancino R, Caccavo D, Barba AA, Lamberti G, Biasin A, Cortesi A, Grassi G, Grassi M, and Abrami M

Abstract

A cryogel is a cross-linked polymer network with different properties that are determined by its manufacturing technique. The formation of a cryogel occurs at low temperatures and results in a porous structure whose pore size is affected by thermal conditions. The adjustable pore sizes of cryogels make them attractive for diverse applications. In this study, the influence of the external operational temperature, which affects the cooling and freezing rates, on the production of cryogels with 2% w / w agarose is investigated. Moreover, a mathematical model is developed to simulate the cryogel production process and provide an initial estimate of the pore size within the structure. The predictions of the model, supported by qualitative light microscopy images, demonstrate that cryogels produced at higher process temperatures exhibit larger pore sizes. Moreover, the existence of pore size distribution within the gel structure is confirmed. Finally, stress relaxation tests, coupled with an image analysis, validates that cryogels produced at lower temperatures possess a higher stiffness and slower water release rates.

Published
2023
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27. Theoretical Importance of PVP-Alginate Hydrogels Structure on Drug Release Kinetics.

Author

Abrami M, Marizza P, Zecchin F, Bertoncin P, Marson D, Lapasin R, de Riso F, Posocco P, Grassi G, and Grassi M

Abstract

Background: The new concepts of personalized and precision medicine require the design of more and more refined delivery systems. In this frame, hydrogels can play a very important role as they represent the best surrogate of soft living tissues for what concerns rheological properties. Thus, this paper focusses on a global theoretical approach able to describe how hydrogel polymeric networks can affect the release kinetics of drugs characterized by different sizes. The attention is focused on a case study dealing with an interpenetrated hydrogel made up by alginate and poly( N -vinyl-2-pyrrolidone)., Methods: Information about polymeric network characteristics (mesh size distribution and polymer volume fraction) is deduced from the theoretical interpretation of the rheological and the low field Nuclear Magnetic Resonance (NMR) characterization of hydrogels. This information is then, embodied in the mass balance equation whose resolution provides the release kinetics., Results: Our simulations indicate the influence of network characteristics on release kinetics. In addition, the reliability of the proposed approach is supported by the comparison of the model outcome with experimental release data., Conclusions: This study underlines the necessity of a global theoretical approach in order to design reliable delivery systems based on hydrogels., Competing Interests: The authors declare no conflict of interest.

Published
2019
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