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Anderson–Fabry disease (AFD) is a rare X-linked lysosomal storage disorder characterized by the accumulation of globotriaosylceramide, leading to multi-organ involvement and significant morbidity. Cardiovascular manifestations, particularly arrhythmias, are common and pose a considerable risk to affected individuals. This overview examines current approaches to arrhythmic risk stratification in AFD, focusing on the identification, assessment, and management of cardiac arrhythmias associated with the disease. We explore advancements in diagnostic techniques, including echocardiography, cardiac MRI, and ambulatory ECG monitoring, to enhance the detection of arrhythmogenic substrate. Furthermore, we discuss the role of genetic and biochemical markers in predicting arrhythmic risk and the implications for personalized treatment strategies. Current therapeutic interventions, including enzyme replacement therapy and antiarrhythmic medications, are reviewed in the context of their efficacy and limitations. Finally, we highlight ongoing research and future directions with the aim of improving arrhythmic risk assessment and management in AFD. This overview underscores the need for a multidisciplinary approach to optimize care and outcomes for patients with AFD.

Acute fulminant myocarditis is a rare event in children, accounting for about 10% of all cases of acute myocarditis. Its lack of specific onset patterns and unpredictable evolution make diagnosis and prompt treatment challenging. We observed six cases of fulminant myocarditis admitted to our Pediatric Emergency Unit (Campania region, Sothern Italy) within a very short timeframe (50 days, from July to September 2024). Three of them died, and two are still under treatment in a Pediatric Cardiologic Intensive Care Unit in critical condition. In only one case, cardiac function improved. The described cases were not geographically linked, belonging to different areas of Southern Italy. No common etiological agent was found. Given the relatively low incidence of the condition, the occurrence of six pediatric myocarditis within approximately two months should be considered exceptional. Careful monitoring of further cases in the next few months should be warranted.

The study of the physical properties of the topside ionosphere is fundamental to investigating the energy balance of the ionosphere and developing accurate models to predict relevant phenomena, which are often at the root of Space Weather effects in the near-Earth environment. One of the most important physical parameters characterising the ionospheric medium is electrical conductivity, which is crucial for the onset and amplification of ionospheric currents and for calculating the power density dissipated by such currents. We characterise, for the first time, electrical conductivity in the direction perpendicular to the geomagnetic field, namely Pedersen and Hall conductivities, in the topside ionosphere at an altitude of about 450 km. For this purpose, we use eight years of in situ simultaneous measurements of electron density, electron temperature and geomagnetic field strength acquired by the Swarm A satellite. We present global statistical maps of perpendicular electrical conductivity and study their variations depending on magnetic latitude and local time, seasons, and solar activity. Our findings indicate that the most prominent features of perpendicular electrical conductivity are located at low latitudes and are probably driven by the complex dynamics of the Equatorial Ionisation Anomaly. At higher latitudes, perpendicular conductivity is a few orders of magnitude lower than that at low latitudes. Nevertheless, conductivity features are modulated by solar activity and seasonal variations at all latitudes.

Ionospheric plasma density irregularities, which are one of the primary sources of disturbance for the Global Navigation Satellite System, significantly impact the propagation of electromagnetic signals, leading to signal degradation and potential interruptions. In the equatorial ionospheric F region after sunset, certain plasma density irregularities, identified as equatorial plasma bubbles, encounter optimal conditions for their formation and development. The energy spectra of electron density fluctuations associated with these irregularities exhibit a power-law scaling behavior qualitatively similar to the Kolmogorov power law observed in fluid turbulence theory. This intriguing similarity raises the possibility that these plasma density irregularities may possess turbulent characteristics. In this study, we analyzed electron density, temperature, and pressure data obtained from the China Seismo-Electromagnetic Satellite (CSES-01) to delve into the spectral properties of equatorial plasma depletions in the ionospheric F region at an altitude of about 500 km. This research marks the first exploration of these properties utilizing CSES-01 data and focuses on 14 semi-orbits that crossed the equator after midnight (01:00–03:00 LT), characterized by a geomagnetic quiet condition (Kp < 1). The analysis of electron temperature, density and pressure within equatorial plasma depletions revealed power-law scaling behavior for all the selected parameters. Notably, the spectral index values of these parameters are different from each other. The significance of these findings in terms of investigating plasma depletions via magnetic field signatures, as well as their relationship to the occurrence of Rayleigh–Taylor convective turbulence, is examined and discussed.

Cardiac amyloidosis is the most frequent infiltrative disease caused by the deposition of misfolded proteins in the cardiac tissue, leading to heart failure, brady- and tachyarrhythmia and death. Conduction disorders, atrial fibrillation (AF) and ventricular arrhythmia (VA) significantly impact patient outcomes and demand recognition. However, several issues remain unresolved regarding early diagnosis and optimal management. Extreme bradycardia is the most common cause of arrhythmic death, while fast and sustained VAs can be found even in the early phases of the disease. Risk stratification and the prevention of sudden cardiac death are therefore to be considered in these patients, although the time for defibrillator implantation is still a subject of debate. Moreover, atrial impairment due to amyloid fibrils is associated with an increased risk of AF resistant to antiarrhythmic therapy, as well as recurrent thromboembolic events despite adequate anticoagulation. In the last few years, the aging of the population and progressive improvements in imaging methods have led to increases in the diagnosis of cardiac amyloidosis. Novel therapies have been developed to improve patients’ functional status, quality of life and mortality, without data regarding their effect on arrhythmia prevention. In this review, we consider the latest evidence regarding the arrhythmic risk stratification of cardiac amyloidosis, as well as the available therapeutic strategies.

Unveiling the physical properties of the Earth’s ionosphere is crucial for the comprehension of the dynamic processes that occur within it across various spatial and temporal scales [...]

High levels of serum uric acid (SUA) and triglycerides (TG) might promote high-cardiovascular-risk phenotypes, including subclinical atherosclerosis. An interaction between plaques xanthine oxidase (XO) expression, SUA, and HDL-C has been recently postulated. Subjects from the URic acid Right for heArt Health (URRAH) study with carotid ultrasound and without previous cardiovascular diseases (CVD) (n = 6209), followed over 20 years, were included in the analysis. Hypertriglyceridemia (hTG) was defined as TG ≥ 150 mg/dL. Higher levels of SUA (hSUA) were defined as ≥5.6 mg/dL in men and 5.1 mg/dL in women. A carotid plaque was identified in 1742 subjects (28%). SUA and TG predicted carotid plaque (HR 1.09 [1.04–1.27], p < 0.001 and HR 1.25 [1.09–1.45], p < 0.001) in the whole population, independently of age, sex, diabetes, systolic blood pressure, HDL and LDL cholesterol and treatment. Four different groups were identified (normal SUA and TG, hSUA and normal TG, normal SUA and hTG, hSUA and hTG). The prevalence of plaque was progressively greater in subjects with normal SUA and TG (23%), hSUA and normal TG (31%), normal SUA and hTG (34%), and hSUA and hTG (38%) (Chi-square, 0.0001). Logistic regression analysis showed that hSUA and normal TG [HR 1.159 (1.002 to 1.341); p = 0.001], normal SUA and hTG [HR 1.305 (1.057 to 1.611); p = 0.001], and the combination of hUA and hTG [HR 1.539 (1.274 to 1.859); p = 0.001] were associated with a higher risk of plaque. Our findings demonstrate that SUA is independently associated with the presence of carotid plaque and suggest that the combination of hyperuricemia and hypertriglyceridemia is a stronger determinant of carotid plaque than hSUA or hTG taken as single risk factors. The association between SUA and CVD events may be explained in part by a direct association of UA with carotid plaques.

The objective of this study was to investigate the longitudinal association of metabolically healthy overweight/obese adults with major adverse cardiovascular events (MACE) and the effect of LDL-cholesterol levels on this association. This study was conducted with 15,904 participants from the URRAH study grouped according to BMI and metabolic status. Healthy metabolic status was identified with and without including LDL-cholesterol. The risk of MACE during 11.8 years of follow-up was evaluated with multivariable Cox regressions. Among the participants aged p = 0.012). However, when LDL-cholesterol < 130 mg/dL was included in the definition of healthy metabolic status, no increase in risk was found in the overweight/obese adults compared to the normal weight individuals (hazard ratio 0.70 (0.07–6.71, p = 0.75). The present data show that the risk of MACE is increased in metabolically healthy overweight/obese individuals identified according to standard criteria. However, when LDL-cholesterol is included in the definition, metabolically healthy individuals who are overweight/obese have no increase in risk.

Over the past decade, remote monitoring (RM) has become an increasingly popular way to improve healthcare and health outcomes. Modern cardiac implantable electronic devices (CIEDs) are capable of recording an increasing amount of data related to CIED function, arrhythmias, physiological status and hemodynamic parameters, providing in-depth and updated information on patient cardiovascular function. The extensive use of RM for patients with CIED allows for early diagnosis and rapid assessment of relevant issues, both clinical and technical, as well as replacing outpatient follow-up improving overall management without compromise safety. This approach is recommended by current guidelines for all eligible patients affected by different chronic cardiac conditions including either brady- and tachy-arrhythmias and heart failure. Beyond to clinical advantages, RM has demonstrated cost-effectiveness and is associated with elevated levels of patient satisfaction. Future perspectives include improving security, interoperability and diagnostic power as well as to engage patients with digital health technology. This review aims to update existing data concerning clinical outcomes in patients managed with RM in the wide spectrum of cardiac arrhythmias and Hear Failure (HF), disclosing also about safety, effectiveness, patient satisfaction and cost-saving.

Space plasma turbulence plays a relevant role in several plasma environments, such as solar wind and the Earth’s magnetosphere–ionosphere system, and is essential for describing their complex coupling. This interaction gives rise to various phenomena, including ionospheric irregularities and the amplification of magnetospheric and ionospheric currents. The structure and dynamics of these currents have relevant implications, for example, in studying ionospheric heating and the nature of electric and magnetic field fluctuations in the auroral and polar environments. In this study, we investigate the nature of small-scale fluctuations characterizing the ionospheric magnetic field in response to different geomagnetic conditions. We use high-resolution (50 Hz) magnetic data from the ESA’s Swarm mission, collected during a series of high-latitude crossings, to probe the scaling features of magnetic field fluctuations in auroral and polar cap regions at spatial scales still poorly explored. Our findings reveal that magnetic field fluctuations in field-aligned currents (FACs) and polar cap regions across both hemispheres are characterized by different scaling properties, suggesting a distinct driver of turbulence. Furthermore, we find that geomagnetic activity significantly influences the nature of energy dissipation in FAC regions, leading to more localized filamentary structures toward smaller scales.

This study focuses on the open question of the electron temperature (Te) variation with solar activity in the topside ionosphere at mid- and high latitudes. It takes advantage of in situ observations taken over a decade (2014–2023) from Langmuir probes on board the low-Earth-orbit Swarm B satellite and spanning an altitude range of 500–530 km. The study also includes a comparison with Te values modeled using the International Reference Ionosphere (IRI) model and with Millstone Hill (42.6° N. 71.5° W) incoherent scatter radar observations. The largest Te variation with solar activity was found at high latitudes in the winter season, where Te shows a marked decreasing trend with solar activity in the polar cusp and auroral regions and, more importantly, at sub-auroral latitudes in the nightside sector. Differently, in the summer season, Te increases with solar activity in the polar cusp and auroral regions, while for equinoxes, variations are smaller and less clear. Mid-latitudes generally show negligible Te variations with solar activity, which are mostly within the natural dispersion of Te observations. The comparison between measured and modeled values highlighted that future implementations of the IRI model would benefit from an improved description of the Te dependence on solar activity, especially at high latitudes.

Several studies have detected a direct association between serum uric acid (SUA) and cardiovascular (CV) risk. In consideration that SUA largely depends on kidney function, some studies explored the role of the serum creatinine (sCr)-normalized SUA (SUA/sCr) ratio in different settings. Previously, the URRAH (URic acid Right for heArt Health) Study has identified a cut-off value of this index to predict CV mortality at 5.35 Units. Therefore, given that no SUA/sCr ratio threshold for CV risk has been identified for patients with diabetes, we aimed to assess the relationship between this index and CV mortality and to validate this threshold in the URRAH subpopulation with diabetes; the URRAH participants with diabetes were studied (n = 2230). The risk of CV mortality was evaluated by the Kaplan–Meier estimator and Cox multivariate analysis. During a median follow-up of 9.2 years, 380 CV deaths occurred. A non-linear inverse association between baseline SUA/sCr ratio and risk of CV mortality was detected. In the whole sample, SUA/sCr ratio > 5.35 Units was not a significant predictor of CV mortality in diabetic patients. However, after stratification by kidney function, values > 5.35 Units were associated with a significantly higher mortality rate only in normal kidney function, while, in participants with overt kidney dysfunction, values of SUA/sCr ratio > 7.50 Units were associated with higher CV mortality. The SUA/sCr ratio threshold, previously proposed by the URRAH Study Group, is predictive of an increased risk of CV mortality in people with diabetes and preserved kidney function. While, in consideration of the strong association among kidney function, SUA, and CV mortality, a different cut-point was detected for diabetics with impaired kidney function. These data highlight the different predictive roles of SUA (and its interaction with kidney function) in CV risk, pointing out the difference in metabolic- and kidney-dependent SUA levels also in diabetic individuals.

Among the effects of space weather, the degradation of air traffic communications and satellite-based navigation systems are the most notable. For this reason, it is of uttermost importance to understand the nature and origin of ionospheric irregularities that are at the base of the observed communication outages. Here we focus on polar cap patches (PCPs) that constitute a special class of ionospheric irregularities observed at very high latitudes in the F region. To this purpose we use the so-called PCP flag, a Swarm Level 2 product, that allows for identifying PCPs. We relate the presence of PCPs to the values of the first- and second-order scaling exponents and intermittency estimated from Swarm A electron density fluctuations and to the values of the Rate Of change of electron Density Index (RODI) for two different levels of geomagnetic activity, over a time span of approximately 3.5 years starting on 16 July 2014. Our findings show that values of RODI, first- and second-order scaling exponents and intermittency corresponding to measurements taken inside PCPs differ from those corresponding to measurements taken outside PCPs. Additionally, the values of the first- and second-order scaling exponents and of intermittency indicate that PCPs are in a turbulent state. Investigation of the coincidence of loss of lock (LoL) events with PCPs displayed that approximately 57.4% of LoLs in the Northern hemisphere and 45.7% in the Southern hemisphere occur in coincidence of PCPs when disturbed geomagnetic activity is considered. During quiet geomagnetic conditions these percentages decrease to 51.4% in the Northern hemisphere and to 20.1% in the Southern hemisphere.

This report presents the first case of Brugada pattern complicated by a supraventricular arrhythmia in a child with SARS-CoV-2 related Multisystem Inflammatory Syndrome in Children (MIS-C). A 7-year-old boy came to our Emergency Department with 7 days of abdominal pain and fever. MIS-C was diagnosed on the basis of the clinical, laboratory and instrumental tests. On admission, ECG showed type 1 Brugada pattern in the right precordial leads. During hospitalization the onset of supraventricular arrhythmias complicated the clinical picture. This case underlines management complexity of supraventricular arrhythmic events, different from atrial fibrillation, in patients with Brugada pattern in the context of a systemic inflammatory condition with significant cardiac involvement. All potential therapeutic choices should be considered to ensure the best outcomes.

In this work, we aim to characterize the effective scale height at the ionosphere F2-layer peak (H0) by using in situ electron density (Ne) observations by Langmuir Probes (LPs) onboard the China Seismo-Electromagnetic Satellite (CSES—01). CSES—01 is a sun-synchronous satellite orbiting at an altitude of ~500 km, with descending and ascending nodes at ~14:00 local time (LT) and ~02:00 LT, respectively. Calibrated CSES—01 LPs Ne observations for the years 2019–2021 provide information in the topside ionosphere, whereas the International Reference Ionosphere model (IRI) provides Ne values at the F2-layer peak altitude for the same time and geographical coordinates as CSES—01. CSES—01 and IRI Ne datasets are used as anchor points to infer H0 by assuming a linear scale height in the topside representation given by the NeQuick model. COSMIC/FORMOSAT—3 (COSMIC—1) radio occultation (RO) data are used to constrain the vertical gradient of the effective scale height in the topside ionosphere in the linear approximation. With the CSES—01 dataset, we studied the global behavior of H0 for daytime (~14:00 LT) and nighttime (~02:00 LT) conditions, different seasons, and low solar activity. Results from CSES—01 observations are compared with those obtained through Swarm B satellite Ne-calibrated measurements and validated against those from COSMIC—1 RO for similar diurnal, seasonal, and solar activity conditions. H0 values modeled by using CSES—01 and Swarm B-calibrated observations during daytime both agree with corresponding values obtained directly from COSMIC—1 RO profiles. Differently, H0 modeling for nighttime conditions deserves further investigation because values obtained from both CSES—01 and Swarm B-calibrated observations show remarkable and spatially localized differences compared to those obtained through COSMIC—1. Most of the H0 mismodeling for nighttime conditions can probably to be attributed to a sub-optimal spatial representation of the F2-layer peak density made by the underlying IRI model. For comparison, H0 values obtained with non-calibrated CSES—01 and Swarm B Ne observations are also calculated and discussed. The methodology developed in this study for the topside effective scale height modeling turns out to be applicable not only to CSES—01 satellite data but to any in situ Ne observation by low-Earth-orbit satellites orbiting in the topside ionosphere.

Hyponatremia is associated with adverse outcomes in hospitalized patients. An elevated value of the serum urea-to-creatinine ratio (UCR) has been proposed as a proxy of hypovolemia. The aim of this study was to investigate the relationship between the UCR and in-hospital death in patients hospitalized with COVID-19 and hyponatremia. We studied 258 patients admitted for COVID-19 between January 2020 and May 2021 with serum sodium at < 135 mmol/L. The primary end-point was all-cause mortality. A 5-unit increase in the serum UCR during hospital stays was associated with an 8% increase in the hazard of all-cause death (HR = 1.08, 95% CI: 1.03–1.14, p = 0.001) after adjusting for potential confounders. In patients with a UCR > 40 at baseline, a > 10 mmol/L increase in serum sodium values within the first week of hospitalization was associated with higher odds of in-hospital death (OR = 2.93, 95% CI: 1.03–8.36, p = 0.044) compared to patients who experienced a < 10 mmol/L change. This was not observed in patients with a UCR < 40. Hypovolemia developing during hospital stays in COVID-19 patients with hyponatremia detected at hospital admission bears an adverse prognostic impact. Moreover, in hypovolemic patients, a > 10 mmol/L increase in serum sodium within the first week of hospital stays may further worsen the in-hospital prognosis.

The diagnosis of Kawasaki disease (KD) is challenging and often delayed mainly in case of young infants and in presence of an incomplete disease and atypical features. Facial nerve palsy is one of the rare neurologic symptoms of KD, associated with a higher incidence of coronary arteries lesions and may be an indicator of a more severe disease. Here, we describe a case of lower motor neuron facial nerve palsy complicating KD and perform an extensive literature review to better characterize clinical features and treatment of patients with KD-associated facial nerve palsy. The patient was diagnosed at the sixth day of disease and presented extensive coronary artery lesions. A prompt treatment with intravenous immunoglobulins, aspirin and steroids obtained a good clinical and laboratory response, with resolution of facial nerve palsy and improvement of coronary lesions. The incidence of facial nerve palsy is 0.9–1.3%; it is often unilateral, transient, more frequent on the left and seemingly associated with coronary impairment. Our literature review showed coronary artery involvement in the majority of reported cases (27/35, 77%) of KD with facial nerve palsy. Unexplained facial nerve palsy in young children with a prolonged febrile illness should prompt consideration of echocardiography to exclude KD and start the appropriate treatment.

At its introduction in the management of pediatric asthma, montelukast was regarded as a potentially revolutionary drug due to its mechanism of action and easy clinical applicability. Nevertheless, its use in daily practice and evidence from clinical trials have shown that, rather than a radical change in the approach to asthmatic children, montelukast more likely represents a second-line medication that is useful when inhaled steroids alone fail in providing adequate symptom control. Furthermore, increasingly reported side effects have raised concerns regarding its safety. In the last decade, several studies have tried to better define the strengths and drawbacks of montelukast both in preschool wheezing and school-age asthma. The present review summarizes the literature published on this topic since 2010, highlighting the often-controversial results and the unanswered questions regarding the role of montelukast in pediatric asthma. Moreover, advances in the understanding of the mechanisms of action of montelukast are reported. The main finding emerging from the present analysis is that montelukast application is likely to be useful in a subset of asthmatic children rather than in large groups of patients. Future studies should focus on the identification of biomarkers able to predict which patients will benefit from montelukast to achieve a more tailored prescription.

High serum uric acid (SUA) and triglyceride (TG) levels might promote high-cardiovascular risk phenotypes across the cardiometabolic spectrum. However, SUA predictive power in the presence of normal and high TG levels has never been investigated. We included 8124 patients from the URic acid Right for heArt Health (URRAH) study cohort who were followed for over 20 years and had no established cardiovascular disease or uncontrolled metabolic disease. All-cause mortality (ACM) and cardiovascular mortality (CVM) were explored by the Kaplan–Meier estimator and Cox multivariable regression, adopting recently defined SUA cut-offs for ACM (≥4.7 mg/dL) and CVM (≥5.6 mg/dL). Exploratory analysis across cardiometabolic subgroups and a sensitivity analysis using SUA/serum creatinine were performed as validation. SUA predicted ACM (HR 1.25 [1.12–1.40], p < 0.001) and CVM (1.31 [1.11–1.74], p < 0.001) in the whole study population, and according to TG strata: ACM in normotriglyceridemia (HR 1.26 [1.12–1.43], p < 0.001) and hypertriglyceridemia (1.31 [1.02–1.68], p = 0.033), and CVM in normotriglyceridemia (HR 1.46 [1.23–1.73], p < 0.001) and hypertriglyceridemia (HR 1.31 [0.99–1.64], p = 0.060). Exploratory and sensitivity analyses confirmed our findings, suggesting a substantial role of SUA in normotriglyceridemia and hypertriglyceridemia. In conclusion, we report that SUA can predict ACM and CVM in cardiometabolic patients without established cardiovascular disease, independent of TG levels.

This paper presents the project Comprehensive spAce wEather Studies for the ASPIS prototype Realization (CAESAR), which aims to tackle the relevant aspects of Space Weather (SWE) science and develop a prototype of the scientific data centre for Space Weather of the Italian Space Agency (ASI) called ASPIS (ASI SPace Weather InfraStructure). To this end, CAESAR involves the majority of the SWE Italian community, bringing together 10 Italian institutions as partners, and a total of 92 researchers. The CAESAR approach encompasses the whole chain of phenomena from the Sun to Earth up to planetary environments in a multidisciplinary, comprehensive, and unprecedented way. Detailed and integrated studies are being performed on a number of well-observed “target SWE events”, which exhibit noticeable SWE characteristics from several SWE perspectives. CAESAR investigations synergistically exploit a great variety of different products (datasets, codes, models), both long-standing and novel, that will be made available in the ASPIS prototype: this will consist of a relational database (DB), an interface, and a wiki-like documentation structure. The DB will be accessed through both a Web graphical interface and the ASPIS.py module, i.e., a library of functions in Python, which will be available for download and installation. The ASPIS prototype will unify multiple SWE resources through a flexible and adaptable architecture, and will integrate currently available international SWE assets to foster scientific studies and advance forecasting capabilities.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may present with a wide variety of symptoms, including neurological manifestations. We investigated clinical, demographic, laboratory, neurophysiological and imaging characteristics of SARS-CoV-2-positive children with seizures and analyzed differences between children admitted during the periods with prevalent circulation of the Alpha/Delta and Omicron variants, respectively. Patients’ characteristics were analyzed according to the presence or absence of seizures and then according to the SARS-CoV-2 variants. Five-hundred and four SARS-CoV-2-positive patients were included: 93 (18.4%) with seizures and 411 (81.6%) without. Patients with seizures were older, had more commonly an underlying epilepsy and had more frequently altered C-reactive protein than those without seizures. Electroencephalography was abnormal in 5/38 cases. According to the SARS-CoV-2 variant, seizures were recorded in 4.7% of the total number of hospitalized patients during the Alpha/Delta period, and in 16.9% of patients admitted during the Omicron period. During the Alpha/Delta variants, seizures were more commonly observed in patients with epilepsy compared to those observed during the Omicron period. Our findings suggest that although SARS-CoV-2 may potentially trigger seizures, they are generally not severe and do not require intensive care admission.

Complexity is a typical feature of space plasmas that may involve the formation of multiscale coherent magnetic and plasma structures. The winding features (pseudo-polarization) of magnetic field fluctuations at different spatial scales are a useful quantity in this framework for investigating complexity in space plasma. Indeed, a strong link between pseudo-polarization, magnetic/plasma structures, turbulence and dissipation exists. We present some preliminary results on the link between the polarization of the magnetic field fluctuations and the structure of field-aligned currents in the high-latitude ionosphere. This study is based on high-resolution (50 Hz) magnetic field data collected on board the European Space Agency Swarm constellation. The results show the existence of a clear link between the multiscale coarse-grained structure of pseudo-polarization and intensity of the field-aligned currents, supporting the recent findings according to which turbulence may be capable of generating multiscale filamentary current structures in the auroral ionosphere. This feature is also examined theoretically, along with its significance for the rate of energy deposition and heating in the polar regions.

The study of electrical currents in the topside ionosphere is of great importance, as it may allow a better understanding of the processes involved in the Sun–Earth interaction and magnetosphere–ionosphere–thermosphere coupling, two crucial aspects debated by the Space Weather scientific community. In this context, investigating the electrical conductivity parallel to the geomagnetic field in the topside ionosphere is of primary importance because: (1) it provides information on the capability of the ionosphere to conduct currents; (2) it relates current density and electric field through Ohm’s law; (3) it can help to quantify the dissipation of currents; (4) it is generally modeled and not locally measured by in situ missions. In this work, we used in situ measurements of electron density and temperature recorded between 2019 and 2021 by the China Seismo-Electromagnetic Satellite (CSES-01) flying with an orbital inclination of 97.4° and at an altitude of about 500 km to compute the parallel electrical conductivity in the topside ionosphere at low and middle latitudes at the two fixed local times (LT) characterizing the CSES-01 mission: around 02 and 14 LT. The results, which are discussed in light of previous literature, highlight the dependence of conductivity on latitude and longitude and are compared with those obtained using values both measured by the Swarm B satellite (flying at a similar altitude) and modeled by the International Reference Ionosphere in the same time period. In particular, we found a diurnal variation in parallel electrical conductivity, with a slight hemispheric asymmetry. Daytime features are compatible with Sq and equatorial electrojet current systems, containing “anomalous” low values of conductivity in correspondence with the South Atlantic region that could be physical in nature.

Characterising the physical properties of the Earth’s ionosphere is fundamental to shed light on the dynamic processes occurring therein on a wide range of both spatial and temporal scales and to understand several phenomena relevant to Space Weather [...]

The China Seismo-Electromagnetic Satellite (CSES-01) provides in situ electron density (Ne) observations through Langmuir probes (LPs) in the topside ionosphere since February 2018. CSES-01 is a sun-synchronous satellite probing the ionosphere around two fixed local times (LTs), 14 LT in the daytime sector and 02 LT in the night-time sector, at an altitude of about 500 km. Previous studies evidenced that CSES-01 seems to underestimate Ne measurements with respect to those acquired by similar satellites or obtained from different instruments. To overcome this issue, we calibrated CSES-01 LP Ne observations through Swarm B satellite data, which flies approximately at CSES-01 altitude. As a first step, Swarm B LP Ne observations were calibrated through Faceplate (FP) Ne observations from the same satellite. Such calibration allowed solving the Ne overestimation made by Swarm LP during nighttime for low solar activity. Then, the calibrated Swarm B LP Ne observations were used to calibrate CSES-01 Ne observations on a statistical basis. Finally, the goodness of the proposed calibration procedure was statistically assessed through a comparison with Ne observations by incoherent scatter radars (ISRs) located at Jicamarca, Arecibo, and Millstone Hill. The proposed calibration procedure allowed solving the CSES-01 Ne underestimation issue for both daytime and nighttime sectors and brought CSES-01 Ne observations in agreement with corresponding ones measured by Swarm B, ISRs, and with those modelled by the International Reference Ionosphere (IRI). This is a first fundamental step towards a possible future inclusion of CSES-01 Ne observations in the dataset underlying IRI for the purpose of improving the description of the topside ionosphere made by IRI.

Endothelial dysfunction (ED) is frequently found in patients with heart failure (HF). Among several pharmacological agents reported to improve endothelial function, levosimendan seems to be a promising one, even though, to date, only two previously published studies have evaluated its effects on ED in these patients. The aim of our pilot study was to further investigate the role of periodic levosimendan infusion on endothelial function in patients affected by advanced HF. In this cross-sectional study, three different groups were enrolled: 20 patients with advanced HF treated with periodic levosimendan (LEVO), 20 patients with HF on optimal medical therapy (OMT), and 20 healthy subjects (control group). ED was evaluated through flow-mediated dilation (FMD) at the level of the brachial artery. The three groups presented similar ages with significant differences in gender distribution, systolic blood pressure, and chronic kidney disease (eGFR < 30 mL/min). In HF patients, ischaemic aetiology was more prevalent in the LEVO group than in the OMT group (60 vs. 40%, p < 0.001). The New York Heart Association (NYHA) functional class was worse in the LEVO group, as well as in NT-proBNP (5636.7 ± 6164.6 ng/dL and 1243.7 ± 1487.2 ng/dL, in the LEVO and OMT groups, respectively, p = 0.005). The FMD was significantly higher in the healthy control group compared to that of the OMT group (15.7 ± 6.4 vs. 9.1 ± 6.0%, p = 0.007) while it showed an intermediate value in LEVO patients (12.4 ± 7.1%) (ANOVA p = 0.010). In conclusion, levosimendan therapy seems to ameliorate endothelial dysfunction related to heart failure. Longitudinal studies in patients on periodic therapy are needed in order to confirm the long-term effects of levosimendan on ED.

Several reports highlighted how public health measures aimed at limiting severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2) circulation have likely contributed to reducing the circulation of other respiratory viruses, particularly during the first year of the COVID-19 pandemic. We evaluated the epidemiology of acute respiratory infections in a large cohort of hospitalized children during the third year of the pandemic (2021–2022). We retrospectively analyzed data from the health records of children (

(1) Background: Among the different cardiovascular (CV) manifestations of the coronavirus disease 2019 (COVID-19), arrhythmia and atrial fibrillation (AF) in particular have recently received special attention. The aims of our study were to estimate the incidence of AF in patients hospitalized for COVID-19, and to evaluate its role as a possible predictor of in-hospital all-cause mortality. (2) Methods: We enrolled 3435 people with SARS-CoV2 infection admitted to three hospitals in Northern Italy from February 2020 to May 2021. We collected data on their clinical history, laboratory tests, pharmacological treatment and intensive care unit (ICU) admission. Incident AF and all-cause in-hospital mortality were considered as outcomes. (3) Results: 145 (4.2%) patients developed AF during hospitalization, with a median time since admission of 3 days (I-III quartile: 0, 12). Patients with incident AF were admitted more frequently to the ICU (39.3 vs. 12.4%, p < 0.001), and more frequently died (37.2 vs. 16.9%, p < 0.001). In the Cox regression model, the significant determinants of incident AF were age (HR: 1.041; 95% CI: 1.022, 1.060 per year), a history of AF (HR: 2.720; 95% CI: 1.508, 4.907), lymphocyte count (HR: 0.584; 95% CI: 0.384, 0.888 per 103/µL), estimated glomerular filtration rate (eGFR, HR: 0.988; 95% CI: 0.980, 0.996 per mL/min) and ICU admission (HR: 5.311; 95% CI: 3.397, 8.302). Incident AF was a predictor of all-cause mortality (HR: 1.405; 95% CI: 1.027, 1.992) along with age (HR: 1.057; 95% CI: 1.047, 1.067), male gender (HR: 1.315; 95% CI: 1.064; 1.626), dementia (HR: 1.373; 95% CI: 1.045, 1.803), lower platelet (HR: 0.997; 95% CI: 0.996, 0.998 per 103/µL) and lymphocyte counts (HR: 0.843; 95% CI: 0.725, 0.982 per 103/µL), C-Reactive protein values (HR: 1.004; 95% CI: 1.003, 1.005 per mg/L), eGFR (HR: 0.990; 95% CI: 0.986, 0.994 per mL/min), and ICU admission (HR: 1.759; 95% CI: 1.292, 2.395). (4) Conclusions: Incident AF is a common complication in COVID-19 patients during hospitalization, and its occurrence strongly predicts in-hospital mortality.

Current technology has produced a wide range of advanced micro-structured surfaces, designed for achieving the best wettability and adhesion performances for each specific application. In the context of in-flight icing simulations, this opens new challenges since the current most popular and successful ice accretion prediction tools neglect the details of the droplet behavior opting for a continuous film model. Here, a phenomenological model, following, in a Lagrangian approach, the evolution of the single droplets from the impinging to the onset of rivulets, is developed to simulate the performances of super-hydrophobic surfaces in icing application. Possible rebound and droplet spread on the impact, coalescence, single ice bead formation and droplet to rivulet transition are taken into account. The first validation shows how the models are able to predict the anti-icing capability of a super-hydrophobic surface coupled with a heating system.

Endothelial hyperinflammation and vasculitis are known hallmarks of acute COVID-19 and multisystem inflammatory syndrome in children (MIS-C). They are due to the direct effect of the virus on endothelial cells enhanced by pro-inflammatory modulators and may cause venous/arterial thrombosis. Therefore, it is essential to identify patients with endothelial damage early in order to establish specific therapies. We studied the monocyte chemoattractant protein 1 (MCP-1), the perinuclear anti-neutrophil cytoplasmic antibodies (pANCA), and the vascular endothelial growth factor A (VEGF-A) in serum from 45 MIS-C patients at hospital admission and 24 healthy controls (HC). For 13/45 MIS-C patients, we measured the three serum biomarkers also after one week from hospitalization. At admission, MIS-C patients had significantly higher levels of MCP-1 and VEGF-A than the HC, but no significant differences were observed for pANCA. While after one week, MCP-1 was significantly lower, pANCA was higher and VEGF-A levels were not significantly different from the admission values. These findings suggest an involvement of epithelium in MIS-C with an acute phase, showing high MCP-1 and VEGF-A, followed by an increase in pANCA that suggests a vasculitis development. The serum biomarker levels may help to drive personalized therapies in these phases with anticoagulant prophylaxis, immunomodulators, and/or anti-angiogenic drugs.

Liver and pancreatic involvement in children with Multisystem Inflammatory Syndrome related to SARS-CoV-2 (MIS-C) has been poorly investigated so far. We reviewed a cohort of MIS-C patients to analyze the prevalence of acute liver injury (ALI) and pancreatic injury and their correlation with clinical outcomes. Demographic, clinical, laboratory and imaging features of children with MIS-C at admission and during hospital stay were prospectively collected. Fifty-five patients (mean age 6.5 ± 3.7 years) were included. At admission, 16 patients showed ALI and 5 had increased total serum lipase. During observation, 10 more patients developed ALI and 19 more subjects presented raised pancreatic enzymes. In comparison to those with normal ALT, subjects with ALI were significantly older (p = 0.0004), whereas pancreatic involvement was associated to a longer duration of hospital stay compared with patients with normal pancreatic enzymes (p = 0.004). Time between hospital admission and onset of ALI was shorter compared to the onset of raised pancreatic enzymes (3.2 ± 3.9 versus 5.3 ± 2.7 days, respectively; p = 0.035). Abdominal ultrasound showed liver steatosis in 3/26 (12%) and hepatomegaly in 6/26 (16%) patients with ALI; 2 patients presented enlarged pancreas. Although liver and pancreatic involvement is commonly observed in MIS-C patients, it is mild in most cases with a complete recovery.

Background: Multisystem inflammatory syndrome in children (MIS-C) is a disease temporally related to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and it is characterized by fever, conjunctival injections, rash, gastrointestinal symptoms, and cardiovascular complications. We evaluated the clinical presentation, laboratory findings, imaging features, therapeutic interventions, and hospital course of a monocentric cohort, and we analyzed these findings according to two age groups. Methods: Patients with MIS-C admitted to a Tertiary Care Pediatric Hospital from November 2020 to November 2021 were considered for the enrollment. Results: Overall, 35 consecutive patients were included. Most of the children did not require intensive care unit at the admission. The clinical presentation of MIS-C slightly differs according to age groups. Mucocutaneus involvement was more frequent in younger patients, while abdominal symptoms were present in 54% of patients aged less than 5 years and in 95% of patients aged more than 5 years (p < 0.05). In addition, the number of cases with troponin above the normal reference value was significantly higher in older patients (77%) compared to younger cases (15%) (p < 0.01). Conclusions: MIS-C is a new emerging condition and represents a challenge to pediatricians due to the severity of presentation. Further studies to better characterize the long-term outcome of MIS-C patients are mandatory.

The ionospheric plasma density irregularities are known to play a role in the propagation of electromagnetic signals and to be one of the most important sources of disturbance for the Global Navigation Satellite System, being responsible for degradation and, sometimes, interruptions of the signals received by the system. In the equatorial ionospheric F region, these plasma density irregularities, known as plasma bubbles, find the suitable conditions for their development during post-sunset hours. In recent years, important features of plasma bubbles such as their dependence on latitude, longitude, and solar and geomagnetic activities have been inferred indirectly using their magnetic signatures. Here, we study the scaling properties of both the electron density and the magnetic field inside the plasma bubbles using measurements on board the Swarm A satellite from 1 April 2014 to 31 January 2016. We show that the spectral features of plasma irregularities cannot be directly inferred from their magnetic signatures. A relation more complex than the linear one is necessary to properly describe the role played by the evolution of plasma bubbles with local time and by the development of turbulent phenomena.

The global statistical median behavior of the electron temperature (Te) in the topside ionosphere was investigated through in-situ data collected by Langmuir Probes on-board the European Space Agency Swarm satellites constellation from the beginning of 2014 to the end of 2020. This is the first time that such an analysis, based on such a large time window, has been carried out globally, encompassing more than half a solar cycle, from the activity peak of 2014 to the minimum of 2020. The results show that Swarm data can help in understanding the main features of Te in the topside ionosphere in a way never achieved before. Te data measured by Swarm satellites were also compared to data modeled by the empirical climatological International Reference Ionosphere (IRI) model and data measured by Jicamarca (12.0°S, 76.8°W), Arecibo (18.2°N, 66.4°W), and Millstone Hill (42.6°N, 71.5°W) Incoherent Scatter Radars (ISRs). Moreover, the correction of Swarm Te data recently proposed by Lomidze was applied and evaluated. These analyses were performed for two main reasons: (1) to understand how the IRI model deviates from the measurements; and (2) to test the reliability of the Swarm dataset as a new possible dataset to be included in the underlying empirical dataset layer of the IRI model. The results show that the application of the Lomidze correction improved the agreement with ISR data above all at mid latitudes and during daytime, and it was effective in reducing the mismatch between Swarm and IRI Te values. This suggests that future developments of the IRI Te model should include the Swarm dataset with the Lomidze correction. However, the existence of a quasi-linear relation between measured and modeled Te values was well verified only below about 2200 K, while for higher values it was completely lost. This is an important result that IRI Te model developers should properly consider when using the Swarm dataset.

Mitochondrial RTG-dependent retrograde signaling, whose regulators have been characterized in Saccharomyces cerevisiae, plays a recognized role under various environmental stresses. Of special significance, the activity of the transcriptional complex Rtg1/3 has been shown to be modulated by Hog1, the master regulator of the high osmolarity glycerol pathway, in response to osmotic stress. The present work focuses on the role of RTG signaling in salt-induced osmotic stress and its interaction with HOG1. Wild-type and mutant cells, lacking HOG1 and/or RTG genes, are compared with respect to cell growth features, retrograde signaling activation and mitochondrial function in the presence and in the absence of high osmostress. We show that RTG2, the main upstream regulator of the RTG pathway, contributes to osmoadaptation in an HOG1-dependent manner and that, with RTG3, it is notably involved in a late phase of growth. Our data demonstrate that impairment of RTG signaling causes a decrease in mitochondrial respiratory capacity exclusively under osmostress. Overall, these results suggest that HOG1 and the RTG pathway may interact sequentially in the stress signaling cascade and that the RTG pathway may play a role in inter-organellar metabolic communication for osmoadaptation.

The electron temperature (Te) behavior at small scales (both spatial and temporal) in the topside ionosphere is investigated through in situ observations collected by Langmuir Probes on-board the European Space Agency Swarm satellites from the beginning of 2014 to the end of 2020. Te observations are employed to calculate the Rate Of change of electron TEmperature Index (ROTEI), which represents the standard deviation of the Te time derivative calculated over a window of fixed width. As a consequence, ROTEI provides a description of the small-scale variations of Te along the Swarm satellites orbit. The extension of the dataset and the orbital configuration of the Swarm satellites allowed us to perform a statistical analysis of ROTEI to unveil its mean spatial, diurnal, seasonal, and solar activity variations. The main ROTEI statistical trends are presented and discussed in the light of the current knowledge of the phenomena affecting the distribution and dynamics of the ionospheric plasma, which play a key role in triggering Te small-scale variations. The appearance of unexpected high values of ROTEI at mid and low latitudes for specific magnetic local time sectors is revealed and discussed in association with the presence of Te spikes recorded by Swarm satellites under very specific conditions.

A multi-parametric approach that involves the use of different geophysical methods coupled with geochemical data allowed us to identify undiscovered archeological burials in a funerary area of the Grotte di Castro Etruscan settlement. In particular, we tested the suitability of the capacitive resistivity method and the presence of Radon in soil for the identification of burials calibrating their outcomes over coincident survey profiles with standard geophysical techniques routinely applied for archaeological prospections. Soil Radon data were acquired both in a grid and along a profile to highlight anomalous gas concentrations, whereas electrical resistivity and ground-penetrating radar measurements were conducted on overlapping profiles to depict the electrical and electromagnetic subsurface distribution. Data integration showed a series of anomalies, suggesting the presence of multiple burials starting from a depth of approximately 1.5 m below the terrain surface. Slight anomalies of Radon in the soil were found to correspond to most of the recovered geophysical ones. Our results pointed out the effectiveness of geophysical method integration in archeological prospecting with the novelty of the joint use of Radon in soil measurements and capacitive resistivity tomography. The latter provided reliable results and can be considered as a standalone technique in archaeological surveys.

This paper discusses the occurrence of Global Positioning System (GPS) loss of lock events obtained by considering total electron content (TEC) measurements carried out by the three satellites of the European Space Agency Swarm constellation from December 2013 to December 2020, which represents the longest dataset ever used to perform such an analysis. After describing the approach used to classify a GPS loss of lock, the corresponding occurrence is analyzed as a function of latitude, local time, season, and solar activity to identify well-defined patterns. Moreover, the strict relation of the occurrence of the GPS loss of lock events with defined values of both the rate of change of electron density index (RODI) and the rate of change of TEC index (ROTI) is highlighted. The scope of this study is, on one hand, to characterize the background conditions of the ionosphere for such events and, on the other hand, to pave the way for their possible future modeling. The results shown, especially the fact that GPS loss of lock events tend to happen for well-defined values of both RODI and ROTI, are of utmost importance in the light of Space Weather effects mitigation.