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18 results on '"Gaudino, Simona"'

1. Olfactory Rehabilitation for Chronic Pain: A Multi-Dimensional Approach Supported by fMRI Insights

Author

Santantonio, Mariaconsiglia, primary, Riso, Carmela, additional, Gaudino, Simona, additional, Simonetti, Alessio, additional, Varcasia, Giuseppe, additional, Schimperna, Francesco, additional, Sergi, Bruno, additional, De Corso, Eugenio, additional, Rossi, Marco, additional, Galli, Jacopo, additional, De Spirito, Marco, additional, Maulucci, Giuseppe, additional, and Passali, Giulio Cesare, additional

Published
2024
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3. The Pathogenic RET Val804Met Variant in Acromegaly: A New Clinical Phenotype?

Author

Chiloiro, Sabrina, primary, Capoluongo, Ettore Domenico, additional, Costanza, Flavia, additional, Minucci, Angelo, additional, Giampietro, Antonella, additional, Infante, Amato, additional, Milardi, Domenico, additional, Ricciardi Tenore, Claudio, additional, De Bonis, Maria, additional, Gaudino, Simona, additional, Rindi, Guido, additional, Olivi, Alessandro, additional, De Marinis, Laura, additional, Pontecorvi, Alfredo, additional, Doglietto, Francesco, additional, and Bianchi, Antonio, additional

Published
2024
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4. Trouillas’s Grading and Post-Surgical Tumor Residue Assessment in Pituitary Adenomas: The Importance of the Multidisciplinary Approach

Author

Calandrelli, Rosalinda, primary, Mattogno, Pier Paolo, additional, Chiloiro, Sabrina, additional, Gessi, Marco, additional, D’Apolito, Gabriella, additional, Tartaglione, Tommaso, additional, Giampietro, Antonella, additional, Bianchi, Antonio, additional, Doglietto, Francesco, additional, Lauretti, Liverana, additional, and Gaudino, Simona, additional

Published
2024
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6. Unveiling the Etiopathogenic Spectrum of Hypophysitis: A Narrative Review

Author

Menotti, Sara, primary, Giampietro, Antonella, additional, Raia, Salvatore, additional, Veleno, Miriam, additional, Angelini, Flavia, additional, Tartaglione, Tommaso, additional, Gaudino, Simona, additional, Doglietto, Francesco, additional, De Marinis, Laura, additional, Pontecorvi, Alfredo, additional, Bianchi, Antonio, additional, and Chiloiro, Sabrina, additional

Published
2023
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8. Advanced Magnetic Resonance Imaging in the Evaluation of Treated Glioblastoma: A Pictorial Essay

Author

Martucci, Matia, primary, Russo, Rosellina, additional, Giordano, Carolina, additional, Schiarelli, Chiara, additional, D’Apolito, Gabriella, additional, Tuzza, Laura, additional, Lisi, Francesca, additional, Ferrara, Giuseppe, additional, Schimperna, Francesco, additional, Vassalli, Stefania, additional, Calandrelli, Rosalinda, additional, and Gaudino, Simona, additional

Published
2023
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9. Magnetic Resonance Imaging of Primary Adult Brain Tumors: State of the Art and Future Perspectives

Author

Martucci, Matia, primary, Russo, Rosellina, additional, Schimperna, Francesco, additional, D’Apolito, Gabriella, additional, Panfili, Marco, additional, Grimaldi, Alessandro, additional, Perna, Alessandro, additional, Ferranti, Andrea Maurizio, additional, Varcasia, Giuseppe, additional, Giordano, Carolina, additional, and Gaudino, Simona, additional

Published
2023
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11. Neuro-Oncology Multidisciplinary Tumor Board: The Point of View of the Neuroradiologist

Author

Gaudino, Simona, primary, Giordano, Carolina, additional, Magnani, Francesca, additional, Cottonaro, Simone, additional, Infante, Amato, additional, Sabatino, Giovanni, additional, La Rocca, Giuseppe, additional, Della Pepa, Giuseppe Maria, additional, D’Alessandris, Quintino Giorgio, additional, Pallini, Roberto, additional, Olivi, Alessandro, additional, Balducci, Mario, additional, Chiesa, Silvia, additional, Gessi, Marco, additional, Guadalupi, Pamela, additional, Russo, Rosellina, additional, Schiarelli, Chiara, additional, Ausili Cefaro, Luca, additional, Di Lella, Giuseppe Maria, additional, and Colosimo, Cesare, additional

Published
2022
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12. Reassessing the Role of Brain Tumor Biopsy in the Era of Advanced Surgical, Molecular, and Imaging Techniques—A Single-Center Experience with Long-Term Follow-Up

Author

Di Bonaventura, Rina, primary, Montano, Nicola, additional, Giordano, Martina, additional, Gessi, Marco, additional, Gaudino, Simona, additional, Izzo, Alessandro, additional, Mattogno, Pier Paolo, additional, Stumpo, Vittorio, additional, Caccavella, Valerio Maria, additional, Giordano, Carolina, additional, Lauretti, Liverana, additional, Colosimo, Cesare, additional, D’Alessandris, Quintino Giorgio, additional, Pallini, Roberto, additional, and Olivi, Alessandro, additional

Published
2021
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13. Combining magnetic resonance imaging with systemic monocyte evaluation for the implementation of gbm management

Author

Giordano, C., Sabatino, Giovanni, Romano, S., Pepa, G. M. D., Tufano, M., D'Alessandris, Quintino Giorgio, Cottonaro, S., Gessi, Marco, Balducci, Mario, Romano, M. F., Olivi, Alessandro, Gaudino, Simona, Colosimo, Cesare, Sabatino G. (ORCID:0000-0002-4227-0434), D'alessandris Q. G. (ORCID:0000-0002-2953-9291), Gessi M., Balducci M. (ORCID:0000-0003-0398-9726), Olivi A. (ORCID:0000-0002-4489-7564), Gaudino S. (ORCID:0000-0003-1681-4343), Colosimo C. (ORCID:0000-0003-3800-3648), Giordano, C., Sabatino, Giovanni, Romano, S., Pepa, G. M. D., Tufano, M., D'Alessandris, Quintino Giorgio, Cottonaro, S., Gessi, Marco, Balducci, Mario, Romano, M. F., Olivi, Alessandro, Gaudino, Simona, Colosimo, Cesare, Sabatino G. (ORCID:0000-0002-4227-0434), D'alessandris Q. G. (ORCID:0000-0002-2953-9291), Gessi M., Balducci M. (ORCID:0000-0003-0398-9726), Olivi A. (ORCID:0000-0002-4489-7564), Gaudino S. (ORCID:0000-0003-1681-4343), and Colosimo C. (ORCID:0000-0003-3800-3648)

Abstract

Magnetic resonance imaging (MRI) is the gold standard for glioblastoma (GBM) patient evaluation. Additional non‐invasive diagnostic modalities are needed. GBM is heavily infiltrated with tumor‐associated macrophages (TAMs) that can be found in peripheral blood. FKBP51s supports alternative‐macrophage polarization. Herein, we assessed FKBP51s expression in circulating monocytes from 14 GBM patients. The M2 monocyte phenotype was investigated by qPCR and flow cytometry using antibodies against PD‐L1, CD163, FKBP51s, and CD14. MRI assessed morphologic features of the tumors that were aligned to flow cytometry data. PD‐L1 expression on circulating monocytes correlated with MRI tumor necrosis score. A wider expansion in circulating CD163/monocytes was measured. These monocytes resulted in a dramatic decrease in patients with an MRI diagnosis of complete but not partial surgical removal of the tumor. Importantly, in patients with residual tumor, most of the peripheral monocytes that in the preoperative stage were CD163/FKBP51s− had turned into CD163/FKBP51s+. After Stupp therapy, CD163/FKBP51s+ monocytes were almost absent in a case of pseudoprogression, while two patients with stable or true disease progression showed sustained levels in such circulating monocytes. Our work provides preliminary but meaningful and novel results that deserve to be confirmed in a larger patient cohort, in support of potential usefulness in GBM monitoring of CD163/FKBP51s/CD14 immunophenotype in adjunct to MRI.

Published
2021

14. Combining Magnetic Resonance Imaging with Systemic Monocyte Evaluation for the Implementation of GBM Management

Author

Giordano, Carolina, primary, Sabatino, Giovanni, additional, Romano, Simona, additional, Della Pepa, Giuseppe Maria, additional, Tufano, Martina, additional, D’Alessandris, Quintino Giorgio, additional, Cottonaro, Simone, additional, Gessi, Marco, additional, Balducci, Mario, additional, Romano, Maria Fiammetta, additional, Olivi, Alessandro, additional, Gaudino, Simona, additional, and Colosimo, Cesare, additional

Published
2021
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15. A novel comprehensive clinical stratification model to refine prognosis of glioblastoma patients undergoing surgical resection

Author

Ius, T., Pignotti, Fabrizio, Pepa, G. M. D., La Rocca, Giuseppe, Somma, T., Isola, M., Battistella, C., Gaudino, Simona, Polano, M., Bo, M. D., Bagatto, D., Pegolo, E., Chiesa, Silvia, Arcicasa, M., Olivi, Alessandro, Skrap, Benjamin, Sabatino, Giovanni, Pignotti F., La Rocca G., Gaudino S. (ORCID:0000-0003-1681-4343), Chiesa S. (ORCID:0000-0003-0168-3459), Olivi A. (ORCID:0000-0002-4489-7564), Skrap M., Sabatino G. (ORCID:0000-0002-4227-0434), Ius, T., Pignotti, Fabrizio, Pepa, G. M. D., La Rocca, Giuseppe, Somma, T., Isola, M., Battistella, C., Gaudino, Simona, Polano, M., Bo, M. D., Bagatto, D., Pegolo, E., Chiesa, Silvia, Arcicasa, M., Olivi, Alessandro, Skrap, Benjamin, Sabatino, Giovanni, Pignotti F., La Rocca G., Gaudino S. (ORCID:0000-0003-1681-4343), Chiesa S. (ORCID:0000-0003-0168-3459), Olivi A. (ORCID:0000-0002-4489-7564), Skrap M., and Sabatino G. (ORCID:0000-0002-4227-0434)

Abstract

Despite recent discoveries in genetics and molecular fields, glioblastoma (GBM) prognosis still remains unfavorable with less than 10% of patients alive 5 years after diagnosis. Numerous studies have focused on the research of biological biomarkers to stratify GBM patients. We addressed this issue in our study by using clinical/molecular and image data, which is generally available to Neurosurgical Departments in order to create a prognostic score that can be useful to stratify GBM patients undergoing surgical resection. By using the random forest approach [CART analysis (classification and regression tree)] on Survival time data of 465 cases, we developed a new prediction score resulting in 10 groups based on extent of resection (EOR), age, tumor volumetric features, intraoperative protocols and tumor molecular classes. The resulting tree was trimmed according to similarities in the relative hazard ratios amongst groups, giving rise to a 5-group classification tree. These 5 groups were different in terms of overall survival (OS) (p < 0.000). The score performance in predicting death was defined by a Harrell’s c-index of 0.79 (95% confidence interval [0.76–0.81]). The proposed score could be useful in a clinical setting to refine the prognosis of GBM patients after surgery and prior to postoperative treatment.

Published
2020

16. A Novel Comprehensive Clinical Stratification Model to Refine Prognosis of Glioblastoma Patients Undergoing Surgical Resection

Author

Ius, Tamara, primary, Pignotti, Fabrizio, additional, Della Pepa, Giuseppe Maria, additional, La Rocca, Giuseppe, additional, Somma, Teresa, additional, Isola, Miriam, additional, Battistella, Claudio, additional, Gaudino, Simona, additional, Polano, Maurizio, additional, Dal Bo, Michele, additional, Bagatto, Daniele, additional, Pegolo, Enrico, additional, Chiesa, Silvia, additional, Arcicasa, Mauro, additional, Olivi, Alessandro, additional, Skrap, Miran, additional, and Sabatino, Giovanni, additional

Published
2020
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17. A Novel Comprehensive Clinical Stratification Model to Refine Prognosis of Glioblastoma Patients Undergoing Surgical Resection

Author

Simona Gaudino, Alessandro Olivi, Miran Skrap, Daniele Bagatto, Teresa Somma, Claudio Battistella, M. Arcicasa, Enrico Pegolo, Michele Dal Bo, Maurizio Polano, Silvia Chiesa, Giovanni Sabatino, Fabrizio Pignotti, Giuseppe Maria Della Pepa, Tamara Ius, Giuseppe La Rocca, Miriam Isola, Ius, Tamara, Pignotti, Fabrizio, Della Pepa, Giuseppe Maria, La Rocca, Giuseppe, Somma, Teresa, Isola, Miriam, Battistella, Claudio, Gaudino, Simona, Polano, Maurizio, Dal Bo, Michele, Bagatto, Daniele, Pegolo, Enrico, Chiesa, Silvia, Arcicasa, Mauro, Olivi, Alessandro, Skrap, Miran, and Sabatino, Giovanni

Subjects
Surgical resection, Cancer Research, medicine.medical_specialty, overall survival, Settore MED/27 - NEUROCHIRURGIA, MEDLINE, Extent of resection, lcsh:RC254-282, Article, Prognostic score, 03 medical and health sciences, 0302 clinical medicine, decision tree, Overall survival, Medicine, business.industry, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, medicine.disease, extent of resection, Confidence interval, Keywords glioblastoma prognosis, Decision tree, Glioblastoma prognosis, Personalized precision oncology, Random forest, Oncology, Relative hazard, 030220 oncology & carcinogenesis, Keywords glioblastoma prognosi, personalized precision oncology, Radiology, business, glioblastoma prognosis, random forest, 030217 neurology & neurosurgery, Glioblastoma
Abstract

Despite recent discoveries in genetics and molecular fields, glioblastoma (GBM) prognosis still remains unfavorable with less than 10% of patients alive 5 years after diagnosis. Numerous studies have focused on the research of biological biomarkers to stratify GBM patients. We addressed this issue in our study by using clinical/molecular and image data, which is generally available to Neurosurgical Departments in order to create a prognostic score that can be useful to stratify GBM patients undergoing surgical resection. By using the random forest approach [CART analysis (classification and regression tree)] on Survival time data of 465 cases, we developed a new prediction score resulting in 10 groups based on extent of resection (EOR), age, tumor volumetric features, intraoperative protocols and tumor molecular classes. The resulting tree was trimmed according to similarities in the relative hazard ratios amongst groups, giving rise to a 5-group classification tree. These 5 groups were different in terms of overall survival (OS) (p &lt, 0.000). The score performance in predicting death was defined by a Harrell&rsquo, s c-index of 0.79 (95% confidence interval [0.76&ndash, 0.81]). The proposed score could be useful in a clinical setting to refine the prognosis of GBM patients after surgery and prior to postoperative treatment.

Published
2020

18. H3 K27 -Altered Diffuse Glioma of the Spinal Cord in Adult Patients: A Qualitative Systematic Review and Peculiarity of Radiological Findings.

Author

Auricchio AM, Pennisi G, Menna G, Olivi A, Gessi M, Gielen GH, Gaudino S, Montano N, and Papacci F

Abstract

Background: Primary spinal cord diffuse gliomas (SpDG) are rare tumors that may harbor, like diffuse intrinsic pontine gliomas (DIPG), H3 K27M mutations. According to the WHO (2021), SpDGs are included in diffuse midline H3K27-altered gliomas, which occur more frequently in adults and show unusual clinical presentation, neuroradiological features, and clinical behavior, which differ from H3 G34-mutant diffuse hemispheric glioma. Currently, homogeneous adult-only case series of SpDG, with complete data and adequate follow-up, are still lacking. Methods: We conducted a qualitative systematic review, focusing exclusively on adult and young adult patients, encompassing all studies reporting cases of primitive, non-metastatic SpDG with H3 K27 mutation. We analyzed the type of treatment administered, survival, follow-up duration, and outcomes. Results: We identified 30 eligible articles published between 1990 and 2023, which collectively reported on 62 adult and young adult patients with primitive SpDG. Postoperative outcomes were assessed based on the duration of follow-up, with outcomes categorized as either survival or mortality. Patients who underwent surgery were followed up for a mean duration of 17.37 months, while those who underwent biopsy had a mean follow-up period of 14.65 months. Among patients who were still alive, the mean follow-up duration was 18.77 months. The radiological presentation of SpDG varies widely, indicating its lack of uniformity. Conclusion: Therefore, we presented a descriptive scenario where SpDG was initially suspected to be a meningioma, but was later revealed to be a malignant SpDG with H3 K27M mutation.

Published
2024
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