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9 results on '"Gaspari, Valeria"'

1. Molecular Typing of Leishmania spp. Causing Tegumentary Leishmaniasis in Northeastern Italy, 2014–2020

Author

Gritti, Tommaso, primary, Carra, Elena, additional, Van der Auwera, Gert, additional, Solana, José Carlos, additional, Gaspari, Valeria, additional, Trincone, Silvana, additional, Ortalli, Margherita, additional, Rabitti, Alice, additional, Reggiani, Alessandro, additional, Rugna, Gianluca, additional, Varani, Stefania, additional, and The Skin_Leish_RER Network, The Skin_Leish_RER Network, additional

Published
2023
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2. Visits to Sexually Transmitted Infection Clinics in Italy from January 2016 to November 2021: A Multicenter, Retrospective Study

Author

Borghi, Alessandro, primary, Flacco, Maria Elena, additional, Pacetti, Lucrezia, additional, Orioni, Gionathan, additional, Marzola, Elisa, additional, Cultrera, Rosario, additional, Guerra, Valentina, additional, Manfredini, Roberto, additional, Gaspari, Valeria, additional, Segala, Daniela, additional, and Corazza, Monica, additional

Published
2023
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5. First-Void Urine Microbiome in Women with Chlamydia trachomatis Infection

Author

Gaspari, Valeria, primary, Ceccarani, Camilla, additional, Severgnini, Marco, additional, Orioni, Gionathan, additional, Camboni, Tania, additional, Laghi, Luca, additional, Morselli, Sara, additional, Foschi, Claudio, additional, Marangoni, Antonella, additional, Consolandi, Clarissa, additional, and Piraccini, Bianca Maria, additional

Published
2022
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8. First-Void Urine Microbiome in Women with Chlamydia trachomatis Infection

Author

Valeria Gaspari, Camilla Ceccarani, Marco Severgnini, Gionathan Orioni, Tania Camboni, Luca Laghi, Sara Morselli, Claudio Foschi, Antonella Marangoni, Clarissa Consolandi, Bianca Maria Piraccini, Gaspari, Valeria, Ceccarani, Camilla, Severgnini, Marco, Orioni, Gionathan, Camboni, Tania, Laghi, Luca, Morselli, Sara, Foschi, Claudio, Marangoni, Antonella, Consolandi, Clarissa, and Piraccini, Bianca Maria

Subjects
Organic Chemistry, Chlamydia trachomatis, urine, urobiome, microbiome, metabolome, urethritis, urethriti, General Medicine, Catalysis, Computer Science Applications, Inorganic Chemistry, Chlamydia trachomati, Physical and Theoretical Chemistry, Molecular Biology, Spectroscopy
Abstract

Background: Chlamydia trachomatis (CT) is the agent of the most common bacterial sexually transmitted infection worldwide. Until now, little information is available about the microbial composition of urine samples during CT urethritis. Therefore, in this study, we characterized the microbiome and metabolome profiles of first-void urines in a cohort of women with CT urethral infection attending an STI clinic. Methods: Based on CT positivity by nucleic acid amplification techniques on urine samples, the enrolled women were divided into two groups, i.e., “CT-negative” (n = 21) and “CT-positive” (n = 11). Urine samples were employed for (i) the microbiome profile analysis by means of 16s rRNA gene sequencing and (ii) the metabolome analysis by 1H-NMR. Results: Irrespective of CT infection, the microbiome of first-void urines was mainly dominated by Lactobacillus, L. iners and L. crispatus being the most represented species. CT-positive samples were characterized by reduced microbial biodiversity compared to the controls. Moreover, a significant reduction of the Mycoplasmataceae family—in particular, of the Ureaplasma parvum species—was observed during CT infection. The Chlamydia genus was positively correlated with urine hippurate and lactulose. Conclusions: These data can help elucidate the pathogenesis of chlamydial urogenital infections, as well as to set up innovative diagnostic and therapeutic approaches.

Published
2022
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9. Screening of Anal HPV Precancerous Lesions: A Review after Last Recommendations.

Author

Natale A, Brunetti T, Orioni G, and Gaspari V

Abstract

Over the last decades, the incidence of anal cancer has increased worldwide. The discovery of the HPV virus as its primary cause and the natural progression of the disease, involving precancerous lesions, have resulted in significant interest in screening for anal cancer. The use of cytology testing, high-risk HPV DNA research, high-resolution anoscopy, and their combination has been adopted with variable success in detecting anal HPV precancerous lesions. Various studies have been carried out to evaluate the sensitivity and specificity of these techniques in different populations. High-risk populations for developing anal cancer have been identified through study of incidence and prevalence. Therefore, different scientific societies and experts worldwide have provided different recommendations for screening, but a universal approach has not yet been established. The inhomogeneity of different risk groups, the variable accessibility to specifical techniques, and the lack of data regarding the cost-benefit ratio of screening are the main problems to address in order to define a consensus guideline acceptable worldwide. The purpose of this paper is to provide a comprehensive review of the literature on HPV precancerous lesions and its screening, particularly after the release of recent recommendations.

Published
2024
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