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24 results on '"Fracassi, Francesco"'

8. Potential Relation between Plasma BDNF Levels and Human Coronary Plaque Morphology

Author

Amadio, Patrizia, primary, Cosentino, Nicola, additional, Eligini, Sonia, additional, Barbieri, Simone, additional, Tedesco, Calogero Claudio, additional, Sandrini, Leonardo, additional, Zarà, Marta, additional, Fabiocchi, Franco, additional, Niccoli, Giampaolo, additional, Magnani, Giulia, additional, Fracassi, Francesco, additional, Crea, Filippo, additional, Veglia, Fabrizio, additional, Marenzi, Giancarlo, additional, and Barbieri, Silvia Stella, additional

Published
2021
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11. Netrin-1 in Atherosclerosis: Relationship between Human Macrophage Intracellular Levels and In Vivo Plaque Morphology

Author

Fiorelli, Susanna, primary, Cosentino, Nicola, additional, Porro, Benedetta, additional, Fabbiocchi, Franco, additional, Niccoli, Giampaolo, additional, Fracassi, Francesco, additional, Capra, Nicolò, additional, Barbieri, Simone, additional, Crea, Filippo, additional, Marenzi, Giancarlo, additional, Cavalca, Viviana, additional, Tremoli, Elena, additional, and Eligini, Sonia, additional

Published
2021
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18. TiO2@PEI-Grafted-MWCNTs Hybrids Nanocomposites Catalysts for CO2 Photoreduction

Author

Fusco, Caterina, primary, Casiello, Michele, additional, Catucci, Lucia, additional, Comparelli, Roberto, additional, Cotugno, Pietro, additional, Falcicchio, Aurelia, additional, Fracassi, Francesco, additional, Margiotta, Valerio, additional, Moliterni, Anna, additional, Petronella, Francesca, additional, D’Accolti, Lucia, additional, and Nacci, Angelo, additional

Published
2018
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22. Activation of Nrf2/HO-1 Pathway and Human Atherosclerotic Plaque Vulnerability: An In Vitro and In Vivo Study

Author

Franco Fabbiocchi, Chiara Maria Manega, Simone Barbieri, Benedetta Porro, Susanna Fiorelli, Francesco Fracassi, Sonia Eligini, Elena Tremoli, Giancarlo Marenzi, Nicola Cosentino, Alessandro Di Minno, Giampaolo Niccoli, Filippo Crea, Viviana Cavalca, Fiorelli, Susanna, Porro, Benedetta, Cosentino, Nicola, Di Minno, Alessandro, Manega, Chiara Maria, Fabbiocchi, Franco, Niccoli, Giampaolo, Fracassi, Francesco, Barbieri, Simone, Marenzi, Giancarlo, Crea, Filippo, Cavalca, Viviana, Tremoli, Elena, and Eligini, Sonia

Subjects
0301 basic medicine, Male, NF-E2-Related Factor 2, macrophage, Coronary Artery Disease, 030204 cardiovascular system & hematology, medicine.disease_cause, Article, Antioxidants, Coronary artery disease, 03 medical and health sciences, 0302 clinical medicine, In vivo, hemic and lymphatic diseases, medicine, Macrophage, Humans, oxidative stress, lcsh:QH301-705.5, nuclear factor erythroid 2–related factor 2, Aged, chemistry.chemical_classification, oxidative stre, Reactive oxygen species, optical coherence tomography, Chemistry, Fibrous cap, Membrane Proteins, General Medicine, heme-oxygenase-1, Middle Aged, medicine.disease, Atherosclerosis, GA-Binding Protein Transcription Factor, In vitro, Plaque, Atherosclerotic, macrophages, 030104 developmental biology, medicine.anatomical_structure, lcsh:Biology (General), Cancer research, Female, plaque vulnerability, Signal transduction, Reactive Oxygen Species, Oxidative stress, Heme Oxygenase-1, Tomography, Optical Coherence, Signal Transduction
Abstract

Reactive oxygen species (ROS) induce nuclear factor erythroid 2&ndash, related factor 2 (Nrf2) activation as an adaptive defense mechanism, determining the synthesis of antioxidant molecules, including heme-oxygenase-1 (HO-1). HO-1 protects cells against oxidative injury, degrading free heme and inhibiting ROS production. HO-1 is highly expressed in macrophages during plaque growth. Macrophages are morpho-functionally heterogeneous, and the prevalence of a specific phenotype may influence the plaque fate. This heterogeneity has also been observed in monocyte-derived macrophages (MDMs), a model of macrophages infiltrating tissue. The study aims to assess oxidative stress status and Nrf2/HO-1 axis in MDM morphotypes obtained from healthy subjects and coronary artery disease (CAD) patients, in relation to coronary plaque features evaluated in vivo by optical coherence tomography (OCT). We found that MDMs of healthy subjects exhibited a lower oxidative stress status, lower Nrf2 and HO-1 levels as compared to CAD patients. High HO-1 levels in MDMs were associated with the presence of a higher macrophage content, a thinner fibrous cap, and a ruptured plaque with thrombus formation, detected by OCT analysis. These findings suggest the presence of a relationship between in vivo plaque characteristics and in vitro MDM profile, and may help to identify patients with rupture-prone coronary plaque.

Published
2019

23. Preparation of Heterojunctions Based on Cs 3 Bi 2 Br 9 Nanocrystals and g-C 3 N 4 Nanosheets for Photocatalytic Hydrogen Evolution.

Author

Medina-Llamas M, Speltini A, Profumo A, Panzarea F, Milella A, Fracassi F, Listorti A, and Malavasi L

Abstract

Heterojunctions based on metal halide perovskites (MHPs) are promising systems for the photocatalytic hydrogen evolution reaction (HER). In this work, we coupled Cs 3 Bi 2 Br 9 nanocrystals (NCs), obtained by wet ball milling synthesis, with g-C 3 N 4 nanosheets (NSs), produced by thermal oxidation of bulk g-C 3 N 4, in air. These methods are reproducible, inexpensive and easy to scale up. Heterojunctions with different loadings of Cs 3 Bi 2 Br 9 NCs were fully characterised and tested for the HER. A relevant improvement of H 2 production with respect to pristine carbon nitride was achieved at low NCs levels reaching values up to about 4600 µmol g -1 h -1 . This work aims to provide insights into the synthesis of inexpensive and high-performing heterojunctions using MHP for photocatalytic applications.

Published
2023
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24. Photocatalytic Investigation of Aerosol-Assisted Atmospheric Pressure Plasma Deposited Hybrid TiO 2 Containing Nanocomposite Coatings.

Author

Lo Porto C, Dell'Edera M, De Pasquale I, Milella A, Fracassi F, Curri ML, Comparelli R, and Palumbo F

Abstract

We report on the aerosol-assisted atmospheric-pressure plasma deposition onto a stainless-steel woven mesh of a thin nanocomposite coating based on TiO2 nanoparticles hosted in a hybrid organic−inorganic matrix, starting from nanoparticles dispersed in a mixture of hexamethyldisiloxane and isopropyl alcohol. The stainless-steel mesh was selected as an effective support for the possible future technological application of the coating for photocatalytically assisted water depollution. The prepared coatings were thoroughly investigated from the chemical and morphological points of view and were demonstrated to be photocatalytically active in the degradation of an organic molecule, used as a pollutant model, in water upon UV light irradiation. In order to optimize the photocatalytic performance, different approaches were investigated for the coating’s realization, namely (i) the control of the deposition time and (ii) the application of a postdeposition O2 plasma treatment on the pristine coatings. Both strategies were found to be able to increase the photocatalytic activity, and, remarkably, their combination resulted in a further enhancement of the photoactivity. Indeed, the proposed combined approach allowed a three-fold increase in the kinetic constant of the degradation reaction of the model dye methylene blue with respect to the pristine coating. Interestingly, the chemical and morphological characterizations of all the prepared coatings were able to account for the enhancement of the photocatalytic performance. Indeed, the presence of the TiO2 nanoparticles on the outmost surface of the film confirmed the accessibility of the photocatalytic sites in the nanocomposite and reasonably explained the enhanced photocatalytic performance. In addition, the sustained photoactivity (>5 cycles of use) of the nanocomposites was demonstrated.

Published
2022
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