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2 results on '"Elisabetta Cagni"'

1. Evaluating the Quality of Patient-Specific Deformable Image Registration in Adaptive Radiotherapy Using a Digitally Enhanced Head and Neck Phantom

Author

Elisabetta Cagni, Andrea Botti, Matteo Orlandi, Marco Galaverni, Cinzia Iotti, Mauro Iori, Geraint Lewis, and Emiliano Spezi

Subjects
deformable image registration, multimodal image registration, adaptive radiotherapy, head and neck, verification, Technology, Engineering (General). Civil engineering (General), TA1-2040, Biology (General), QH301-705.5, Physics, QC1-999, Chemistry, QD1-999
Abstract

Despite the availability of national and international guidelines, an accurate and efficient, patient-specific, deformable image registration (DIR) validation methodology is not yet established, and several groups have found an incompatibility of the various digital phantoms with the commercial systems. To evaluate the quality of the computed tomography (CT) and on-board cone-beam CT (CBCT) DIRs, a novel methodology was developed and tested on 10 head and neck (HN) patients, using CT and CBCT anthropomorphic HN phantom images, digitally reprocessed to include the common organs at risk. Reference DVFs (refDVFs) were generated from the clinical patient CT-CBCT fused images using an independent registration software. The phantom CT images were artificially deformed, using the refDVFs, and registered with the phantom CBCT images, using the clinical registration software, generating a test DVF (testDVF) dataset. The clinical plans were recalculated on the daily patient ‘deformed’ CTs, and the dose maps transferred to the patient-planning CT, using both the refDVF and testDVF. The spatial and dosimetric errors were quantified and the DIR performance evaluated using an established operative tolerance level. The method showed the ability to quantify the DIR spatial errors and assess their dose impact at the voxel level and could be applied to patient-specific DIR evaluation during adaptive HN radiotherapy in routine practice.

Published
2022
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2. Sharing Patient and Clinician Experiences of Moderate-to-Severe Psoriasis: A Nationwide Italian Survey and Expert Opinion to Explore Barriers Impacting upon Patient Wellbeing

Author

Francesca Prignano, Alexandra M. G. Brunasso, Gabriella Fabbrocini, Giuseppe Argenziano, Federico Bardazzi, Riccardo G. Borroni, Martina Burlando, Anna Elisabetta Cagni, Elena Campione, Elisa Cinotti, Aldo Cuccia, Stefano Dastoli, Rocco De Pasquale, Clara De Simone, Vito Di Lernia, Valentina Dini, Maria Concetta Fargnoli, Elisa Faure, Alfredo Giacchetti, Claudia Giofrè, Giampiero Girolomoni, Claudia Lasagni, Serena Lembo, Francesco Loconsole, Maria Antonia Montesu, Paolo Pella, Paolo Pigatto, Antonio Giovanni Richetta, Elena Stroppiana, Marina Venturini, Leonardo Zichichi, Stefano Piaserico, Prignano, F., Brunasso, A. M. G., Fabbrocini, G., Argenziano, G., Bardazzi, F., Borroni, R. G., Burlando, M., Cagni, A. E., Campione, E., Cinotti, E., Cuccia, A., Dastoli, S., De Pasquale, R., De Simone, C., Di Lernia, V., Dini, V., Fargnoli, M. C., Faure, E., Giacchetti, A., Giofre, C., Girolomoni, G., Lasagni, C., Lembo, S., Loconsole, F., Montesu, M. A., Pella, P., Pigatto, P., Richetta, A. G., Stroppiana, E., Venturini, M., Zichichi, L., and Piaserico, S.

Subjects
physician, physicians, perspective, psoriasis, General Medicine, patients, health-related quality of life, wellbeing, surveys and questionnaires, surveys and questionnaire, patient, psoriasi
Abstract

A nationwide survey was conducted in adult patients with psoriasis (PsO) across Italy to obtain their real-world perspective of the impact of PsO on their wellbeing. Patients completed a 26-question survey (based on the patient benefit index; PBI, The Dermatology Life Quality Index; DLQI and the World Health Organization-five; WHO-5 wellbeing index) and workshop discussion sessions were undertaken by dermatologists to interpret results from the survey. 392 patients with PsO completed the survey. Analysis of results was restricted to patients who had moderate-to-severe plaque psoriasis (assessed by patients; n = 252; 64.3%). Dermatologists (n = 32) completed one question from the survey related to wellbeing and rated social, physical and mental domains as contributing to a similar extent, with comparable scores also observed by patients. For treatment, biologics yielded higher scores on average, whereas little difference was observed between topical and conventional systemic treatments. Only 23.8% of patients felt that their dermatologist was taking into consideration their wellbeing and 32.6% of the patients considered their therapy as inadequate in improving signs and symptoms of the disease. This survey identified key factors contributing to barriers impacting on patient wellbeing. Simple, but comprehensive questionnaires can provide important insight to patients’ needs that may significantly increase clinician awareness during visits leading to tailored treatment.

Published
2022
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