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(1) Background: Melanoma is one of the most aggressive types of neoplasia, and the management of this pathology requires a correct staging, as well as a personalized modern oncological treatment. The main objective of the study is to determine the variability of the lymphatic drainage for patients with melanomas located on the trunk and, secondarily, to determine the features of individuals who underwent sentinel lymph node biopsy (SLNB) depending on the exact location on the trunk. (2) Methods: This retrospective, observational, single-center study included 62 cases of trunk melanoma operated between July 2019 and March 2023, in which SLNB was performed and a total of 84 lymph nodes were excised. (3) Results: Patients had a median age of 54.5 (33–78) years, with 58.1% being male; the melanomas had a median Breslow index of 2.3 (0.5–12.5) mm. Approximately 64.3% of the cohort had melanoma on the upper part of the trunk (54 cases) and 35.7% had it on the lower part (30 cases). The type of anesthesia chosen was general anesthesia in 53 cases and spinal anesthesia in 9 cases (85.5% vs. 14.5%, p < 0.001). The number of sentinel lymph nodes excised was 54 for melanomas located on the upper part of the trunk (8 cervical and 46 axillary) and 30 sentinel lymph nodes for melanomas of the lower part of the trunk (16 at the axillary level and 14 at the inguinal level). Out of the 54 LNs identified in patients with melanoma on the upper part of the trunk, 13 were positive, with a total of 12 positive lymph nodes (LNs) from the axillar basin, and only one from the cervical region. Additionally, the incidence of patients with a minimum of two identified sentinel lymph nodes was 32.2%, with a total of seven having LN involvement in two basins, and only one of these cases showed positivity for malignancy. (4) Conclusions: SLNBs were more frequent in the axillary region overall, and had more positive SLNs. Moreover, melanoma on the upper part of the trunk had a higher rate of positive SLNs compared to the lower part. Tumors located on the lower part of the truck had more positive SLNs in the axillary region than in the inguinal one.

Background and Objectives: the early diagnosis of hepatocellular carcinoma (HCC) benefits from the use of alpha-fetoprotein (AFP) together with imaging diagnosis using abdominal ultrasonography, CT, and MRI, leading to improved early detection of HCC. A lot of progress has been made in the field, but some cases are missed or late diagnosed in advanced stages of the disease. Therefore, new tools (serum markers, imagistic technics) are continually being reconsidered. Serum alpha-fetoprotein (AFP), protein induced by vitamin K absence or antagonist II (PIVKA II) diagnostic accuracy for HCC (global and early disease) has been investigated (in a separate or cumulative way). The purpose of the present study was to determine the performance of PIVKA II compared to AFP. Materials and Methods: systematic research was conducted in PubMed, Web of Science, Embase, Medline and the Cochrane Central Register of Controlled Trials, taking into consideration articles published between 2018 and 2022. Results: a total number of 37 studies (5037 patients with HCC vs. 8199 patients—control group) have been included in the meta-analysis. PIVKA II presented a better diagnostic accuracy in HCC diagnostic vs. alpha-fetoprotein (global PIVKA II AUROC 0.851 vs. AFP AUROC 0.808, respectively, 0.790 vs. 0.740 in early HCC cases). The conclusion from a clinical point of view, concomitant use of PIVKA II and AFP can bring useful information, added to that brought by ultrasound examination.

The oil and gas industry is among the most affected industries as a result of war in Ukraine, on top of other economic, political, and environmental global turbulences that culminated with the coronavirus pandemic. The purpose of this qualitative, explorative study was to identify strategic changes as well as the role played by newer technologies—digital technologies in particular—in this industry. The focus is on the Romanian oil and gas industry, more specifically on the retail fuel networks of the top companies. In addition to secondary research (literature and company documents), interview-based primary research was conducted. The data were collected during spring of 2022 by conducting interviews with two groups of subjects: the strategists—consisting of top managers from the largest companies active in the oil and gas industry in Romania; and the informed consumers—selected from people working in the oil and gas industry. The interview guides were slightly different depending on the two groups targeted, and the structure of the interview guide was developed according to research questions. Among the findings, we can observe that the fuel retail market and consumer behaviour changed due to a series of factors, such as the global economic crisis, COVID-19, the Russian invasion of Ukraine, and inflation. Those factors forced fuel retail companies, at the global level, to invest in filling station shops, services development, digitalization, and divestment—selling gas station networks in countries with poor integration with refineries. Romanian fuel retail companies are following the global trends and focusing on filling station shops, alternative fuels development, and digitalization. The results are followed by discussions, and several managerial implications are suggested. The study limitations and several further research paths are also identified. Based on the data available, we can conclude that the strategic directions at the level of products and services are aligned, but at the execution level, specialists offer different solutions for customer expectations.

Currently, adipose tissue is considered an endocrine organ, however, there are still many questions regarding the roles of adipokines—leptin and ghrelin being two adipokines. The purpose of the study was to assess the relationship between the adipokines and their ratio with obesity and diabetes. Methods: Sixty patients (mean age 61.88 ± 10.08) were evaluated. Cardiovascular risk factors, leptin, ghrelin, and insulin resistance score values were assessed. The patients were classified according to their body mass index (BMI) as normal weight, overweight, and obese. Results: 20% normal weight, 51.7% overweight, 28.3% obese, and 23.3% diabetic. Obese patients had higher leptin values (in obese 34,360 pg/mL vs. overweight 18,000 pg/mL vs. normal weight 14,350 pg/mL, p = 0.0049) and leptin/ghrelin ratio (1055 ± 641 vs. 771.36 ± 921 vs. 370.7 ± 257, p = 0.0228). Stratifying the analyses according to the presence of obesity and patients’ gender, differences were found for leptin (p = 0.0020 in women, p = 0.0055 in men) and leptin/ghrelin ratio (p = 0.048 in women, p = 0.004 in men). Mean leptin/BMI and leptin/ghrelin/BMI ratios were significantly higher, and the ghrelin/BMI ratio was significantly lower in obese and diabetic patients. In conclusion, obesity and diabetes are associated with changes not only in the total amount but also in the level of adipokines/kg/m2. Changes appear even in overweight subjects, offering a basis for early intervention in diabetic and obese patients.

In this article, the yielding and plastic flow of a rapid-prototyped ABS compound was investigated for various plane stress states. The experimental procedures consisted of multiaxial tests performed on an Arcan device on specimens manufactured through photopolymerization. Numerical analyses were employed in order to determine the yield points for each stress state configuration. The results were used for the calibration of the Hosford yield criterion and flow potential. Numerical analyses performed on identical specimen models and test configurations yielded results that are in accordance with the experimental data.

Social networking sites (SNSs) are now ubiquitous communities for constant online interpersonal interactions that trigger symmetric or asymmetric effects on our everyday life. Recent studies advocate in favor of the significant role that SNSs have in promoting well-being and, more importantly, in disseminating reliable information during a global crisis, such as the current COVID-19 pandemic. Based on the growing importance of SNSs to the global framework, the main purpose of this study is to empirically assess the link between the use of symmetric social networks such as Facebook, or asymmetric social networks, like Instagram, and the level of satisfaction, employing the methodology of structural equation modeling. The results of the research validate the hypothesis that SNS activities increase the level of satisfaction, and therefore, that there is a direct link between the number of posts and comments and the level of satisfaction. Furthermore, based on the reversible and significant link between the level of satisfaction and the importance attributed to SNSs, the main conclusion of the study is that the higher the importance of the SNS, the greater the level of dissatisfaction experienced by users. Also, public activities on social networks positively affect social network satisfaction, while private activities have a direct negative relationship with the importance of social networks.