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1. Implementation of Artificial Intelligence in Personalized Prognostic Assessment of Lung Cancer: A Narrative Review

Author

Lococo, Filippo, primary, Ghaly, Galal, additional, Chiappetta, Marco, additional, Flamini, Sara, additional, Evangelista, Jessica, additional, Bria, Emilio, additional, Stefani, Alessio, additional, Vita, Emanuele, additional, Martino, Antonella, additional, Boldrini, Luca, additional, Sassorossi, Carolina, additional, Campanella, Annalisa, additional, Margaritora, Stefano, additional, and Mohammed, Abdelrahman, additional

Published
2024
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2. Uniportal Video-Assisted Thoracoscopic Surgery Completion Lobectomy Long after Wedge Resection or Segmentectomy in the Same Lobe: A Bicenter Study

Author

Meacci, Elisa, primary, Refai, Majed, additional, Nachira, Dania, additional, Salati, Michele, additional, Kuzmych, Khrystyna, additional, Tabacco, Diomira, additional, Zanfrini, Edoardo, additional, Calabrese, Giuseppe, additional, Napolitano, Antonio Giulio, additional, Congedo, Maria Teresa, additional, Chiappetta, Marco, additional, Petracca-Ciavarella, Leonardo, additional, Sassorossi, Carolina, additional, Andolfi, Marco, additional, Xiumè, Francesco, additional, Tiberi, Michela, additional, Guiducci, Gian Marco, additional, Vita, Maria Letizia, additional, Roncon, Alberto, additional, Nanto, Anna Chiara, additional, and Margaritora, Stefano, additional

Published
2024
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3. Are the Efficacy and Safety of Chest Tubes in Uniportal Video-Assisted Thoracic Surgery Related to the Level of Intercostal Space Insertion or to the Drain Type? A Prospective Multicenter Study

Author

Nachira, Dania, primary, Bertoglio, Pietro, additional, Ismail, Mahmoud, additional, Napolitano, Antonio Giulio, additional, Calabrese, Giuseppe, additional, Kuzmych, Khrystyna, additional, Congedo, Maria Teresa, additional, Sassorossi, Carolina, additional, Meacci, Elisa, additional, Petracca Ciavarella, Leonardo, additional, Chiappetta, Marco, additional, Lococo, Filippo, additional, Solli, Piergiorgio, additional, and Margaritora, Stefano, additional

Published
2024
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4. Unsolved Issues in Thymic Epithelial Tumour Stage Classification: The Role of Tumour Dimension

Author

Sassorossi, Carolina, primary, Bertoglio, Pietro, additional, Lococo, Filippo, additional, Santoro, Gloria, additional, Meacci, Elisa, additional, Nachira, Dania, additional, Congedo, Maria Teresa, additional, Brandolini, Jury, additional, Petroncini, Matteo, additional, Nocera, Adriana, additional, Charles-Davies, Diepriye, additional, Solli, Piergiorgio, additional, Margaritora, Stefano, additional, and Chiappetta, Marco, additional

Published
2023
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6. Surgical Resection of Pulmonary Metastases from Melanoma in Oligometastatic Patients: Results from a Multicentric Study in the Era of Immunoncology and Targeted Therapy

Author

Meacci, Elisa, primary, Nachira, Dania, additional, Congedo, Maria Teresa, additional, Ibrahim, Mohsen, additional, Pariscenti, Gianluca, additional, Petrella, Francesco, additional, Casiraghi, Monica, additional, De Stefani, Alessandro, additional, del Regno, Laura del, additional, Peris, Ketty, additional, Triumbari, Elizabeth Katherine Anna, additional, Schinzari, Giovanni, additional, Rossi, Ernesto, additional, Petracca-Ciavarella, Leonardo, additional, Vita, Maria Letizia, additional, Chiappetta, Marco, additional, Siciliani, Alessandra, additional, Peritore, Valentina, additional, Manitto, Mattia, additional, Morelli, Lucia, additional, Zanfrini, Edoardo, additional, Tabacco, Diomira, additional, Calabrese, Giuseppe, additional, Bardoni, Claudia, additional, Evangelista, Jessica, additional, Spaggiari, Lorenzo, additional, and Margaritora, Stefano, additional

Published
2023
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7. Reducing Post-Operative Alveolo-Pleural Fistula by Applying PGA-Sheets (Neoveil) after Major Lung Resection: A Historical Case-Control Study

Author

Sassorossi, Carolina, primary, Congedo, Maria Teresa, additional, Nachira, Dania, additional, Tabacco, Diomira, additional, Chiappetta, Marco, additional, Evangelista, Jessica, additional, di Gioia, Adele, additional, Di Resta, Velia, additional, Sorino, Claudio, additional, Mondoni, Michele, additional, Leoncini, Fausto, additional, Calabrese, Giuseppe, additional, Napolitano, Antonio Giulio, additional, Nocera, Adriana, additional, Lococo, Achille, additional, Margaritora, Stefano, additional, and Lococo, Filippo, additional

Published
2023
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8. Is PET/CT Able to Predict Histology in Thymic Epithelial Tumours? A Narrative Review

Author

Chiappetta, Marco, primary, Mendogni, Paolo, additional, Cattaneo, Margherita, additional, Evangelista, Jessica, additional, Farina, Piero, additional, Pizzuto, Daniele Antonio, additional, Annunziata, Salvatore, additional, Castello, Angelo, additional, Congedo, Maria Teresa, additional, Tabacco, Diomira, additional, Sassorossi, Carolina, additional, Castellani, Massimo, additional, Nosotti, Mario, additional, Margaritora, Stefano, additional, and Lococo, Filippo, additional

Published
2022
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9. Clinical Stage III NSCLC Patients Treated with Neoadjuvant Therapy and Surgery: The Prognostic Role of Nodal Characteristics

Author

Chiappetta, Marco, primary, Tabacco, Diomira, additional, Iaffaldano, Amedeo Giuseppe, additional, Evangelista, Jessica, additional, Congedo, Maria Teresa, additional, Sassorossi, Carolina, additional, Meacci, Elisa, additional, D’Argento, Ettore, additional, Bria, Emilio, additional, Vita, Emanuele, additional, Tortora, Giampaolo, additional, Boldrini, Luca, additional, Charles-Davies, Diepriye, additional, Massaccesi, Mariangela, additional, Martino, Antonella, additional, Mazzarella, Ciro, additional, Valentini, Vincenzo, additional, Margaritora, Stefano, additional, and Lococo, Filippo, additional

Published
2022
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10. Risk Factors Associated with Post-Operative Complications in Multidisciplinary Treatment of Descending Necrotizing Mediastinitis

Author

Congedo, Maria Teresa, primary, Nachira, Dania, additional, Pennisi, Mariano Alberto, additional, Chiappetta, Marco, additional, Calabrese, Giuseppe, additional, Bello, Giuseppe, additional, Parrilla, Claudio, additional, Franza, Laura, additional, Covino, Marcello, additional, Petracca Ciavarella, Leonardo, additional, Porziella, Venanzio, additional, Vita, Maria Letizia, additional, Lococo, Filippo, additional, Margaritora, Stefano, additional, and Meacci, Elisa, additional

Published
2022
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11. Rate and Predictors of Unforeseen PN1/PN2-Disease in Surgically Treated cN0 NSCLC-Patients with Primary Tumor > 3 cm: Nationwide Results from Italian VATS-Group Database

Author

Lococo, Filippo, Nachira, Dania, Chiappetta, Marco, Sperduti, Isabella, Congedo, Maria Teresa, Meacci, Elisa, Leoncini, Fausto, Trisolini, Rocco, Crisci, Roberto, Curcio, Carlo, Casiraghi, Monica, Margaritora, Stefano, and On The Behalf Of The Italian Vats Group, Null

Subjects
surgery, VATS-Group, NSCLC, VATS, nodal upstaging, staging, General Medicine
Abstract

Background. Since no robust data are available on the real rate of unforeseen N1-N2 disease (uN) and the relative predictive factors in clinical-N0 NSCLC with peripheral tumours > 3 cm, the usefulness of performing a (mini)invasive mediastinal staging in this setting is debated. Herein, we investigated these issues in a nationwide database. Methods. From 01/2014 to 06/2020, 15,784 thoracoscopic major lung resections were prospectively recorded in the “Italian VATS-Group” database. Among them, 1982 clinical-N0 peripheral solid-type NSCLC > 3 cm were identified, and information was retrospectively reviewed. A mean comparison of more than two groups was made by ANOVA (Bonferroni correction for multiple comparisons), while associations between the categorical variables were estimated with a Chi-square test. The multivariate logistic regression model and Kaplan–Meyer method were used to identify the independent predictors of nodal upstaging and survival results, respectively. Results. At pathological staging, 229 patients had N1-involvement (11.6%), and 169 had uN2 disease (8.5%). Independent predictors of uN1 were SUVmax (OR: 1.98; CI 95: 1.44–2.73, p = 0.0001) and tumour-size (OR: 1.52; CI: 1.11–2.10, p = 0.01), while independent predictors of uN2 were age (OR: 0.98; CI 95: 0.96–0.99, p = 0.039), histology (OR: 0.48; CI 95: 0.30–0.78, p = 0.003), SUVmax (OR: 2.07; CI 95: 1.15–3.72, p = 0.015), and the number of resected lymph nodes (OR: 1.03; CI 95: 1.01–1.05, p = 0.002). Conclusions. The unforeseen N1-N2 disease in cN0/NSCLCs > 3 cm undergoing VATS resection is observable in between 12 and 8% of all cases. We have identified predictors that could guide physicians in selecting the best candidate for (mini)invasive mediastinal staging.

Published
2023

12. External Validation of a Prognostic Score for Survival in Lung Carcinoids

Author

Chiappetta, Marco, primary, Tabacco, Diomira, additional, Sassorossi, Carolina, additional, Sperduti, Isabella, additional, Cusumano, Giacomo, additional, Terminella, Alberto, additional, Fournel, Ludovic, additional, Alifano, Marco, additional, Guerrera, Francesco, additional, Filosso, Pier Luigi, additional, Nicosia, Samanta, additional, Gallina, Filippo, additional, Facciolo, Francesco, additional, Margaritora, Stefano, additional, and Lococo, Filippo, additional

Published
2022
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13. Current Roles of PET/CT in Thymic Epithelial Tumours: Which Evidences and Which Prospects? A Pictorial Review

Author

Lococo, Filippo, primary, Chiappetta, Marco, additional, Triumbari, Elizabeth Katherine Anna, additional, Evangelista, Jessica, additional, Congedo, Maria Teresa, additional, Pizzuto, Daniele Antonio, additional, Brascia, Debora, additional, Marulli, Giuseppe, additional, Annunziata, Salvatore, additional, and Margaritora, Stefano, additional

Published
2021
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14. Masaoka-Koga and TNM Staging System in Thymic Epithelial Tumors: Prognostic Comparison and the Role of the Number of Involved Structures

Author

Chiappetta, Marco, primary, Lococo, Filippo, additional, Pogliani, Luca, additional, Sperduti, Isabella, additional, Tabacco, Diomira, additional, Bria, Emilio, additional, D’Argento, Ettore, additional, Massaccesi, Mariangela, additional, Boldrini, Luca, additional, Meacci, Elisa, additional, Porziella, Venanzio, additional, Nachira, Dania, additional, Congedo, Maria Teresa, additional, and Margaritora, Stefano, additional

Published
2021
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15. Prognostic Factors Affecting Survival after Pulmonary Resection of Metastatic Renal Cell Carcinoma: A Multicenter Experience

Author

Meacci, Elisa, primary, Nachira, Dania, additional, Zanfrini, Edoardo, additional, Evangelista, Jessica, additional, Triumbari, Elizabeth Katherine Anna, additional, Congedo, Maria Teresa, additional, Petracca Ciavarella, Leonardo, additional, Chiappetta, Marco, additional, Vita, Maria Letizia, additional, Schinzari, Giovanni, additional, Rossi, Ernesto, additional, Tortora, Giampaolo, additional, Lucchi, Marco, additional, Ambrogi, Marcello, additional, Calabrò, Fabrizia, additional, Petrella, Francesco, additional, Spaggiari, Lorenzo, additional, Mammana, Marco, additional, Lloret Madrid, Andrea, additional, Rea, Federico, additional, Tabacco, Diomira, additional, and Margaritora, Stefano, additional

Published
2021
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17. Which Is the Best Treatment in Recurrent Thymoma? A Systematic Review and Meta-Analysis

Author

Chiappetta, Marco, primary, Grossi, Ugo, additional, Sperduti, Isabella, additional, Margaritora, Stefano, additional, Marulli, Giuseppe, additional, Fiorelli, Alfonso, additional, Sandri, Alberto, additional, Mizuno, Tetsuya, additional, Cusumano, Giacomo, additional, Hamaji, Masatsugu, additional, Cesario, Alfredo, additional, and Lococo, Filippo, additional

Published
2021
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18. Survival Analysis in Single N2 Station Lung Adenocarcinoma: The Prognostic Role of Involved Lymph Nodes and Adjuvant Therapy

Author

Chiappetta, Marco, primary, Lococo, Filippo, additional, Leuzzi, Giovanni, additional, Sperduti, Isabella, additional, Bria, Emilio, additional, Petracca Ciavarella, Leonardo, additional, Mucilli, Felice, additional, Filosso, Pier Luigi, additional, Ratto, Giovannibattista, additional, Spaggiari, Lorenzo, additional, Facciolo, Francesco, additional, and Margaritora, Stefano, additional

Published
2021
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19. Prognostic Factors and Long-Term Survival in Locally Advanced NSCLC with Pathological Complete Response after Surgical Resection Following Neoadjuvant Therapy

Author

Lococo, Filippo, primary, Sassorossi, Carolina, additional, Nachira, Dania, additional, Chiappetta, Marco, additional, Petracca Ciavarella, Leonardo, additional, Vita, Emanuele, additional, Boldrini, Luca, additional, Evangelista, Jessica, additional, Cesario, Alfredo, additional, Bria, Emilio, additional, and Margaritora, Stefano, additional

Published
2020
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20. Uniportal Laser-Assisted Video-Assisted Thoracoscopy (U-LA-VATS) for Lung Metastasectomy: Technical Description, Peri-Operative Results and Pertinent Literature Review.

Author

Sassorossi C, Chiappetta M, Nachira D, Campanella A, Santoro G, Calabrese G, Scognamiglio C, Napolitano AG, Senatore A, Petracca Ciavarella L, Vita ML, Margaritora S, and Lococo F

Abstract

Pulmonary metastasectomy (PM) is a well-established treatment that is able to contribute to the cure of oligometastatic cancer. Surgery should adopt the most lung-sparing approach possible to preserve pulmonary function (and, consequently, the quality of life) and to spare the lung for potential additional lung resections. In this framework, laser technology has been introduced in recent decades, but only few experiences combining laser technology with VATS approaches have been reported till now. The main focus of this manuscript is to report our institutional experience in performing lung-sparing laser-assisted PM by uniportal VATS (uniportal laser-assisted VATS: U-LA-VATS). The surgical technique and peri-operative results from our series of patients were herein presented and compared with the pertinent literature. Methods : Between March 2021 and November 2023, among 98 patients who underwent PM, a total of 24 patients (18 men (75%); 6 women (25%); mean age 61.4 years; age range 13-83 years) were treated with laser-assisted PM at our institution. Patients who underwent anatomical resection were excluded for the purpose of the analysis. The U-LA-VATS procedure adopted a modified laser-assisted lung resection technique for performing PM via VATS. Dedicated instruments are used, characterized by a long shape and a curved shape, with distal and proximal articulations. A surgical laser system (Thulium + Diodo OUTPUT 30-10 W, Quanta System S.p.a., Solbiate Olona, Italy) was used, and a 550-μm sterile optical fibre conducted through a specific thoracoscopic handpiece was introduced in the lowest part of the incision. Peri-operative results were analysed in all cohort and compared according to the surgical technique. Moreover, these results were compared with those reported in the literature. Comprehensive research of the literature was conducted on PubMed from 2000 to 2024. A review was performed and reported in line with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. Results : In 12 cases (50%), thulium laser-assisted resection was performed using uniportal video-assisted thoracic surgery (VATS), and in the other cases (12, 50%), a (mini)thoracotomy access was adopted. In the thoracotomy group, the mean duration of surgery was 95 ± 57.7 min; meanwhile, it was 73.5 ± 35.5 in the uniportal VATS group. At the univariate analysis, this difference resulted to be statistically significant ( p value 0.025). We did not observe intra-operative complications or remarkable malfunction of the laser system. We also did not report major complications after surgery; also the air-leak rate was 8.3% and 0% after thoracotomic and VATS procedures, respectively. Surgical margins were free from disease in all cases. Major and minor post-op complication rates were similar in both groups. The mean hospitalization after surgery was 2.9 ± 0.3 days for the uniportal VATS group and 3.7 ± 0.9 days for the thoracotomy group, this difference being statistically significant at the univariate analysis ( p value = 0.015). Conclusions : U-LA-VATS is a safe and effective procedure, able to combine a parenchymal sparing exeresis with a mini-invasive approach. This procedure is associated with a shorter hospital stay compared with PM performed by a thoracotomic approach. Compared with the selected works for the review, our series is the only one describing the use of laser resection combined with a uniportal VATS approach.

Published
2024
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21. Does Myasthenia Gravis Affect Long-Term Survival in Thymic Carcinomas? An ESTS Database Analysis.

Author

Lococo F, Nachira D, Chiappetta M, Evangelista J, Falcoz PE, Ruffini E, Van Schil P, Scarci M, Furàk J, Sollitto F, Guerrera F, Spaggiari L, Aigner C, Evangelia L, Billè A, Moser B, Thomas PA, Liberman M, Boubia S, Campisi A, Ampollini L, Toker A, Enyed A, Voltolini L, Van Raemdonck D, Margaritora S, and Ests Thymic Working Group

Abstract

Background: Thymic carcinoma is a rare and highly malignant tumor with a dismal prognosis, which occasionally coexists with myasthenia gravis (MG). This study aims to investigate the MG incidence on a surgical cohort of patients with thymic carcinoma and to explore its influence on long-term survival. Methods: the prospectively collected data from the ESTS database on thymic epithelial tumors were reviewed. Clinical, pathological, and survival information on thymic carcinoma were analyzed. Results: the analysis was conducted on 203 patients, with an equal gender distribution (96 males and 107 females). MG was detected in 22 (10.8%) patients, more frequently elderly (>60 years, p = 0.048) and male (p = 0.003). Induction therapy was performed in 22 (10.8%) cases. After surgery, 120 (59.1%) patients had a Masaoka stage II−III while complete resection (R0) was achieved in 158 (77.8%). Adjuvant therapy was performed in 68 cases. Mean follow-up was 60 (SD = 14) months. The 3-year, 5-year and 10-year survival rates were 79%, 75% and 63%, respectively. MG did not seem to influence long-term survival (5-year survival in non-MG−TCs 78% vs. 50% in MG−TCs, p = ns) as age < 60 years, female gender, early Masaoka stage, and postoperative radiotherapy did, conversely. Conclusions: myasthenia occurred in about 10% of thymic carcinomas and it did not seem to affect significantly the long-term prognosis in surgically treated thymic carcinoma-patients.

Published
2022
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