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2 results on '"Célia Hitomi Yamamoto"'

1. Antinociceptive and Anti-Inflammatory Activities of the Sesame Oil and Sesamin

Author

Érika Maria Henriques Monteiro, Orlando Vieira de Sousa, Ana Lúcia Santos de Matos Araújo, Mirian Pereira Rodarte, Mônica Cecília Santana Pereira, Célia Hitomi Yamamoto, Aílson da Luz André de Araújo, Maria da Penha Henriques do Amaral, Marcelo Silva Silvério, Miriam Aparecida de Oliveira Pinto, Glauciemar Del-Vechio-Vieira, Fernanda Maria Pinto Vilela, and Lucas A. Chibli

Subjects
Male, Nociception, medicine.drug_class, Anti-Inflammatory Agents, Pain, lcsh:TX341-641, Dioxoles, Carrageenan, Anti-inflammatory, Article, Lignans, sesame oil, chemistry.chemical_compound, Mice, sesamin, Sesamin, Formaldehyde, medicine, Toxicity Tests, Acute, Animals, Edema, Food science, Hot plate, Rats, Wistar, anti-inflammatory activity, Pleurisy, Acetic Acid, Inflammation, Analgesics, Nutrition and Dietetics, antinociceptive activity, Rats, chemistry, Biochemistry, Sesame oil, lcsh:Nutrition. Foods and food supply, Leucocyte migration, Food Science, Paw edema
Abstract

Sesame oil is widely consumed as nutritious food, cooking oil, and in pharmaceuticals and food. In this study, the antinociceptive and anti-inflammatory properties of the sesame oil and sesamin were investigated. The sesame oil and sesamin reduced the number of abdominal contortions at the doses 100, 200, or 400 mg/kg. The first and second phases of the time paw licking were inhibited by sesame oil and sesamin (100, 200, or 400 mg/kg). After 90 min of treatment, sesame oil and sesamin increased the reaction time on a hot plate (200 or 400 mg/kg). Considering the tail-immersion assay, the sesame oil and sesamin produced significant effect after 60 min at the doses of 100, 200, or 400 mg/kg. After 4 h of application of the carrageenan, the sesame oil and sesamin were effective against the paw edema. The exudate volume and leucocyte migration were also reduced by sesame oil and sesamin. These results suggest that sesamin is one of the active compounds found in sesame oil and justify the antinociceptive and anti-inflammatory properties of this product.

Published
2014

2. Antinociceptive and Anti-Inflammatory Effects of Ethanol Extract from Vernonia polyanthes Leaves in Rodents

Author

José de Jesus Ribeiro Gomes de Pinho, Miriam Aparecida de Oliveira Pinto, Orlando Vieira de Sousa, Vanessa dos Santos Temponi, Célia Hitomi Yamamoto, Maria Silvana Alves, Antônia Ribeiro, Glauciemar Del-Vechio-Vieira, and Jucélia Barbosa da Silva

Subjects
Male, Leukocyte migration, Pharmacology, Carrageenan, lcsh:Chemistry, Mice, chemistry.chemical_compound, Vernonia polyanthes, antinociceptive effect, anti-inflammatory effect, Edema, Hot plate, lcsh:QH301-705.5, Spectroscopy, Pain Measurement, Analgesics, Anti-Inflammatory Agents, Non-Steroidal, General Medicine, Computer Science Applications, Nociception, medicine.symptom, Paw edema, Exudate, medicine.drug_class, Pain, Article, Catalysis, Anti-inflammatory, Inorganic Chemistry, medicine, Animals, Pain Management, Rats, Wistar, Physical and Theoretical Chemistry, Molecular Biology, Inflammation, Ethanol, Plant Extracts, business.industry, Organic Chemistry, Rats, Plant Leaves, lcsh:Biology (General), lcsh:QD1-999, chemistry, business, Vernonia
Abstract

The ethanol extract from Vernonia polyanthes leaves (EEVP) was investigated for antinociceptive and anti-inflammatory effects at the doses (p.o.) of 100, 200 and 400 mg/kg in animal models. The extract reduced the number of abdominal contortions by 16.75% and 31.44% at a dose of 200 and 400 mg/kg, respectively. The results obtained showed that EEVP exerted a significant antinociceptive effect in the two phases of formalin. The EEVP increased the reaction time on a hot plate at the doses of 100, 200 and 400 mg/kg after 90 min of treatment. The paw edema was reduced by EEVP at the doses of 100, 200 and 400 mg/kg after 4 h of application of carrageenan. Doses of 200 and 400 mg/kg, administered 4 h before the carrageenan injection, significantly reduced the exudate volume (29.25 and 45.74%, respectively) and leukocyte migration (18.19 and 27.95%, respectively). These results suggest that V. polyanthes can be an active source of substances with antinociceptive and anti-inflammatory activities.

Published
2012
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