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2. Impacts of Environmental Pollution on Brain Tumorigenesis

Author

Pagano, Cristina, primary, Navarra, Giovanna, additional, Coppola, Laura, additional, Savarese, Beatrice, additional, Avilia, Giorgio, additional, Giarra, Antonella, additional, Pagano, Giovanni, additional, Marano, Alessandra, additional, Trifuoggi, Marco, additional, Bifulco, Maurizio, additional, and Laezza, Chiara, additional

Published
2023
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4. N6-Isopentenyladenosine Impairs Mitochondrial Metabolism through Inhibition of EGFR Translocation on Mitochondria in Glioblastoma Cells

Author

Pagano, Cristina, primary, Coppola, Laura, additional, Navarra, Giovanna, additional, Avilia, Giorgio, additional, Bruzzaniti, Sara, additional, Piemonte, Erica, additional, Galgani, Mario, additional, Della Monica, Rosa, additional, Chiariotti, Lorenzo, additional, Cuomo, Mariella, additional, Buonaiuto, Michela, additional, Torelli, Giovanni, additional, Caiazzo, Pasquale, additional, Laezza, Chiara, additional, and Bifulco, Maurizio, additional

Published
2022
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9. Towards an Improvement of Anticancer Activity of Benzyl Adenosine Analogs

Author

Covelli, Verdiana, primary, Grimaldi, Manuela, additional, Randino, Rosario, additional, Firoznezhad, Mohammad, additional, Proto, Maria Chiara, additional, Simone, Veronica De, additional, Matteoli, Gianluca, additional, Gazzerro, Patrizia, additional, Bifulco, Maurizio, additional, D’Ursi, Anna Maria, additional, and Rodriquez, Manuela, additional

Published
2021
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10. PRDM12 in Health and Diseases

Author

Rienzo, Monica, primary, Di Zazzo, Erika, additional, Casamassimi, Amelia, additional, Gazzerro, Patrizia, additional, Perini, Giovanni, additional, Bifulco, Maurizio, additional, and Abbondanza, Ciro, additional

Published
2021
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11. N6-Isopentenyladenosine Hinders the Vasculogenic Mimicry in Human Glioblastoma Cells through Src-120 Catenin Pathway Modulation and RhoA Activity Inhibition

Author

Pagano, Cristina, primary, Navarra, Giovanna, additional, Pastorino, Olga, additional, Avilia, Giorgio, additional, Coppola, Laura, additional, Della Monica, Rosa, additional, Chiariotti, Lorenzo, additional, Florio, Tullio, additional, Corsaro, Alessandro, additional, Torelli, Giovanni, additional, Caiazzo, Pasquale, additional, Gazzerro, Patrizia, additional, Bifulco, Maurizio, additional, and Laezza, Chiara, additional

Published
2021
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15. Ganoderma lucidum Ethanol Extracts Enhance Re-Epithelialization and Prevent Keratinocytes from Free-Radical Injury

Author

Abate, Mario, primary, Pepe, Giacomo, additional, Randino, Rosario, additional, Pisanti, Simona, additional, Basilicata, Manuela Giovanna, additional, Covelli, Verdiana, additional, Bifulco, Maurizio, additional, Cabri, Walter, additional, D’Ursi, Anna Maria, additional, Campiglia, Pietro, additional, and Rodriquez, Manuela, additional

Published
2020
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16. Multifaceted Role of PRDM Proteins in Human Cancer

Author

Casamassimi, Amelia, primary, Rienzo, Monica, additional, Di Zazzo, Erika, additional, Sorrentino, Anna, additional, Fiore, Donatella, additional, Proto, Maria Chiara, additional, Moncharmont, Bruno, additional, Gazzerro, Patrizia, additional, Bifulco, Maurizio, additional, and Abbondanza, Ciro, additional

Published
2020
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17. Cholesterol Homeostasis Modulates Platinum Sensitivity in Human Ovarian Cancer

Author

Criscuolo, Daniela, primary, Avolio, Rosario, additional, Calice, Giovanni, additional, Laezza, Chiara, additional, Paladino, Simona, additional, Navarra, Giovanna, additional, Maddalena, Francesca, additional, Crispo, Fabiana, additional, Pagano, Cristina, additional, Bifulco, Maurizio, additional, Landriscina, Matteo, additional, Matassa, Danilo Swann, additional, and Esposito, Franca, additional

Published
2020
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18. The Endocannabinoid System: A Target for Cancer Treatment

Author

Laezza, Chiara, primary, Pagano, Cristina, additional, Navarra, Giovanna, additional, Pastorino, Olga, additional, Proto, Maria Chiara, additional, Fiore, Donatella, additional, Piscopo, Chiara, additional, Gazzerro, Patrizia, additional, and Bifulco, Maurizio, additional

Published
2020
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21. Immuno-Modulatory and Anti-Inflammatory Effects of Dihydrogracilin A, a Terpene Derived from the Marine Sponge Dendrilla membranosa

Author

Ciaglia, Elena, primary, Malfitano, Anna, additional, Laezza, Chiara, additional, Fontana, Angelo, additional, Nuzzo, Genoveffa, additional, Cutignano, Adele, additional, Abate, Mario, additional, Pelin, Marco, additional, Sosa, Silvio, additional, Bifulco, Maurizio, additional, and Gazzerro, Patrizia, additional

Published
2017
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23. In Vitro Evidence of Statins’ Protective Role against COVID-19 Hallmarks

Author

Donatella Fiore, Maria Chiara Proto, Silvia Franceschelli, Maria Pascale, Maurizio Bifulco, Patrizia Gazzerro, Fiore, Donatella, Proto, Maria Chiara, Franceschelli, Silvia, Pascale, Maria, Bifulco, Maurizio, and Gazzerro, Patrizia

Subjects
lipid rafts, SARS-CoV-2, statins, COVID-19, cytokine storm, ACE2 receptor, Medicine (miscellaneous), General Biochemistry, Genetics and Molecular Biology, lipid raft
Abstract

Despite the progressions in COVID-19 understanding, the optimization of patient-specific therapies remains a challenge. Statins, the most widely prescribed lipid-lowering drugs, received considerable attention due to their pleiotropic effects, encompassing lipid metabolism control and immunomodulatory and anti-thrombotic effects. In COVID-19 patients, statins improve clinical outcomes, reducing Intensive Care Unit admission, the onset of ARDS, and in-hospital death. However, the safety of statins in COVID-19 patients has been debated, mainly for statins’ ability to induce the expression of the ACE2 receptor, the main entry route of SARS-CoV-2. Unfortunately, the dynamic of statins’ mechanism in COVID-19 disease and prevention remains elusive. Using different in vitro models expressing different levels of ACE2 receptor, we investigated the role of lipophilic and hydrophilic statins on ACE2 receptor expression and subcellular localization. We demonstrated that the statin-mediated increase of ACE2 receptor expression does not necessarily coincide with its localization in lipid rafts domains, particularly after treatments with the lipophilic atorvastatin that disrupt lipid rafts’ integrity. Through a proteomic array, we analyzed the cytokine patterns demonstrating that statins inhibit the release of cytokines and factors involved in mild to severe COVID-19 cases. The results obtained provide additional information to dissect the mechanism underlying the protective effects of statin use in COVID-19.

Published
2022

24. Cannabinoids: Therapeutic Use in Clinical Practice

Author

Cristina Pagano, Giovanna Navarra, Laura Coppola, Giorgio Avilia, Maurizio Bifulco, Chiara Laezza, Pagano, Cristina, Navarra, Giovanna, Coppola, Laura, Avilia, Giorgio, Bifulco, Maurizio, and Laezza, Chiara

Subjects
Cannabinoids, viral infections, Organic Chemistry, General Medicine, cannabinoid, skin disorder, Catalysis, Computer Science Applications, Inorganic Chemistry, neurodegenerative disease, Neoplasms, Cannabidiol, Humans, cancer, Dronabinol, Physical and Theoretical Chemistry, Molecular Biology, Spectroscopy, Cannabis, Endocannabinoids
Abstract

Medical case reports suggest that cannabinoids extracted from Cannabis sativa have therapeutic effects; however, the therapeutic employment is limited due to the psychotropic effect of its major component, Δ9-tetrahydrocannabinol (THC). The new scientific discoveries related to the endocannabinoid system, including new receptors, ligands, and mediators, allowed the development of new therapeutic targets for the treatment of several pathological disorders minimizing the undesirable psychotropic effects of some constituents of this plant. Today, FDA-approved drugs, such as nabiximols (a mixture of THC and non-psychoactive cannabidiol (CBD)), are employed in alleviating pain and spasticity in multiple sclerosis. Dronabinol and nabilone are used for the treatment of chemotherapy-induced nausea and vomiting in cancer patients. Dronabinol was approved for the treatment of anorexia in patients with AIDS (acquired immune deficiency syndrome). In this review, we highlighted the potential therapeutic efficacy of natural and synthetic cannabinoids and their clinical relevance in cancer, neurodegenerative and dermatological diseases, and viral infections.

Published
2022

25. Cholesterol Homeostasis Modulates Platinum Sensitivity in Human Ovarian Cancer

Author

Giovanna Navarra, Maurizio Bifulco, Franca Esposito, Cristina Pagano, Rosario Avolio, Daniela Criscuolo, Fabiana Crispo, Giovanni Calice, Matteo Landriscina, Danilo Swann Matassa, C. Laezza, Simona Paladino, Francesca Maddalena, Criscuolo, Daniela, Avolio, Rosario, Calice, Giovanni, Laezza, Chiara, Paladino, Simona, Navarra, Giovanna, Maddalena, Francesca, Crispo, Fabiana, Pagano, Cristina, Bifulco, Maurizio, Landriscina, Matteo, Matassa, Danilo Swann, and Esposito, Franca

Subjects
Homeòstasi, Drug resistance, Ovaris -- Càncer, Models, Biological, Article, cholesterol homeostasis, TRAP1, Mediator, Cell Line, Tumor, medicine, Homeostasis, Humans, Gene silencing, HSP90 Heat-Shock Proteins, lcsh:QH301-705.5, Inflammation, Ovarian Neoplasms, chemistry.chemical_classification, business.industry, Lipid metabolism, Lipase, General Medicine, Lipid Metabolism, medicine.disease, cholesterol homeostasi, platinum resistance, Oxidative Stress, Cholesterol, ovarian cancer, Enzyme, lcsh:Biology (General), chemistry, Drug Resistance, Neoplasm, Apoptosis, LDL receptor, Cancer research, Female, lipids (amino acids, peptides, and proteins), Cisplatin, Ovarian cancer, business, Colesterol
Abstract

Despite initial chemotherapy response, ovarian cancer is the deadliest gynecologic cancer, due to frequent relapse and onset of drug resistance. To date, there is no affordable diagnostic/prognostic biomarker for early detection of the disease. However, it has been recently shown that high grade serous ovarian cancers show peculiar oxidative metabolism, which is in turn responsible for inflammatory response and drug resistance. The molecular chaperone TRAP1 plays pivotal roles in such metabolic adaptations, due to the involvement in the regulation of mitochondrial respiration. Here, we show that platinum-resistant ovarian cancer cells also show reduced cholesterol biosynthesis, and mostly rely on the uptake of exogenous cholesterol for their needs. Expression of FDPS and OSC, enzymes involved in cholesterol synthesis, are decreased both in drug-resistant cells and upon TRAP1 silencing, whereas the expression of LDL receptor, the main mediator of extracellular cholesterol uptake, is increased. Strikingly, treatment with statins to inhibit cholesterol synthesis reduces cisplatin-induced apoptosis, whereas silencing of LIPG, an enzyme involved in lipid metabolism, or withdrawal of lipids from the culture medium, increases sensitivity to the drug. These results suggest caveats for the use of statins in ovarian cancer patients and highlights the importance of lipid metabolism in ovarian cancer treatment. This research was funded by POR CAMPANIA FESR 2014/2020 [project “SATIN” (Sviluppo di Approcci Terapeutici INnovativi per patologie neoplastiche resistenti ai trattamenti)]

Published
2020

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