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Your search keyword '"Benítez-King, Gloria"' showing total 12 results
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12 results on '"Benítez-King, Gloria"'

2. Melatonin: A Neurotrophic Factor?

Author

Miranda-Riestra, Armida, primary, Estrada-Reyes, Rosa, additional, Torres-Sanchez, Erandis D., additional, Carreño-García, Silvia, additional, Ortiz, Genaro Gabriel, additional, and Benítez-King, Gloria, additional

Published
2022
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3. Antidepressant Low Doses of Ketamine and Melatonin in Combination Produce Additive Neurogenesis in Human Olfactory Neuronal Precursors

Author

Estrada-Reyes, Rosa, primary, Quero-Chávez, Daniel B., additional, Alarcón-Elizalde, Salvador, additional, Cercós, Montserrat G., additional, Trueta, Citlali, additional, Constantino-Jonapa, Luis A., additional, Oikawa-Sala, Julián, additional, Argueta, Jesús, additional, Cruz-Garduño, Ricardo, additional, Dubocovich, Margarita L., additional, and Benítez-King, Gloria A., additional

Published
2022
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5. Low Doses of Ketamine and Melatonin in Combination Produce Additive Antidepressant-like Effects in Mice

Author

Estrada-Reyes, Rosa, primary, Quero-Chávez, Daniel B., additional, Trueta, Citlali, additional, Miranda, Armida, additional, Valdés-Tovar, Marcela, additional, Alarcón-Elizalde, Salvador, additional, Oikawa-Sala, Julián, additional, Argueta, Jesús, additional, Constantino-Jonapa, Luis A., additional, Muñoz-Estrada, Jesús, additional, Dubocovich, Margarita L., additional, and Benítez-King, Gloria, additional

Published
2021
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8. Involvement of Melatonin in the Regulation of the Circadian System in Crayfish

Author

Mendoza-Vargas, Leonor, primary, Guarneros-Bañuelos, Elizabeth, additional, Báez-Saldaña, Armida, additional, Galicia-Mendoza, Fabiola, additional, Flores-Soto, Edgar, additional, Fuentes-Pardo, Beatriz, additional, Alvarado, Ramón, additional, Valdés-Tovar, Marcela, additional, Sommer, Bettina, additional, Benítez-King, Gloria, additional, and Solís-Chagoyán, Héctor, additional

Published
2018
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12. Altered PLCβ/IP 3 /Ca 2+ Signaling Pathway Activated by GPRCs in Olfactory Neuronal Precursor Cells Derived from Patients Diagnosed with Schizophrenia.

Author

Sánchez-Florentino ZA, Romero-Martínez BS, Flores-Soto E, Montaño LM, Sommer B, Valdés-Tovar M, Argueta J, Calixto E, Aquino-Gálvez A, Castillejos-López M, Serrano H, Gomez-Verjan JC, López-Riquelme GO, Benítez-King GA, Jaimez R, and Solís-Chagoyán H

Abstract

Background : Schizophrenia (SZ) is a multifactorial chronic psychiatric disorder with a worldwide prevalence of 1%. Altered expression of PLCβ occurs in SZ patients, suggesting alterations in the PLCβ/IP 3 /Ca 2+ signaling pathway. This cascade regulates critical cellular processes in all cell types, including the neuronal lineage; however, there is scarce evidence regarding the functionality of this transduction signaling in neuronal cells derived from SZ patients. Objective : We evaluated the functionality of the PLCβ/IP 3 /Ca 2+ pathway in olfactory neuronal precursor cells (hONPCs) obtained from SZ patients. Methods : Cryopreserved hONPCs isolated from SZ patients and healthy subjects (HS) were thawed. The cellular types in subcultures were corroborated by immunodetection of the multipotency and lineage markers SOX-2, Musashi-1, nestin, and β-III tubulin. The PLCβ/IP 3 /Ca 2+ pathway was activated by GPCR (G q ) ligands (ATP, UTP, serotonin, and epinephrine). In addition, PLCβ and IP 3 R were directly stimulated by perfusing cells with the activators m-3M3FBS and ADA, respectively. Cytosolic Ca 2+ was measured by microfluorometry and by Ca 2+ imaging. The amount and subcellular distribution of the PLCβ1 and PLCβ3 isoforms were evaluated by confocal immunofluorescence. IP 3 concentration was measured by ELISA. Results : The results show that the increase of cytosolic Ca 2+ triggered by GPCR ligands or directly through either PLCβ or IP 3 R activation was significantly lower in SZ-derived hONPCs, regarding HS-derived cells. Moreover, the relative amount of the PLCβ1 and PLCβ3 isoforms and IP 3 production stimulated with m-3M3FBS were reduced in SZ-derived cells. Conclusions : Our results suggest an overall functional impairment in the PLCβ/IP 3 /Ca 2+ signaling pathway in SZ-derived hONPCs.

Published
2024
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