Search

Trajectory planning is a crucial and challenging problem for research on intelligent robotic and mechatronic systems, which play a pivotal role in modern manufacturing processes, and especially within the framework of Industry 4 [...]

Lung cancer remains the leading cause of cancer deaths worldwide. International societies have promoted the molecular analysis of MET proto-oncogene, receptor tyrosine kinase (MET) exon 14 skipping for the clinical stratification of non-small cell lung cancer (NSCLC) patients. Different technical approaches are available to detect MET exon 14 skipping in routine practice. Here, the technical performance and reproducibility of testing strategies for MET exon 14 skipping carried out in various centers were evaluated. In this retrospective study, each institution received a set (n = 10) of a customized artificial formalin-fixed paraffin-embedded (FFPE) cell line (Custom METex14 skipping FFPE block) that harbored the MET exon 14 skipping mutation (Seracare Life Sciences, Milford, MA, USA), which was previously validated by the Predictive Molecular Pathology Laboratory at the University of Naples Federico II. Each participating institution managed the reference slides according to their internal routine workflow. MET exon 14 skipping was successfully detected by all participating institutions. Molecular analysis highlighted a median Cq cut off of 29.3 (ranging from 27.1 to 30.7) and 2514 (ranging from 160 to 7526) read counts for real-time polymerase chain reaction (RT-PCR) and NGS-based analyses, respectively. Artificial reference slides were a valid tool to harmonize technical workflows in the evaluation of MET exon 14 skipping molecular alterations in routine practice.

Enforcing the cessation of motion is a common action in robotic systems to avoid the damage that the robot can exert on itself, its environment or, in shared environments, people. This procedure raises two main concerns, which are addressed in this paper. On the one hand, the stopping procedure should respect the collision free path computed by the motion planner. On the other hand, a sudden stop may produce large current peaks and challenge the limits of the motor’s control capabilities, as well as degrading the mechanical performance of the system, i.e., increased wear. To address these concerns, we propose a novel method to enforce a mechanically feasible, smooth and path-consistent stop of the robot based on a time-minimization algorithm. We present a numerical implementation of the method, as well as a numerical study of its complexity and convergence. Finally, an experimental comparison with an off-the-shelf stopping scheme is presented, showing the effectiveness of the proposed method.

The construction sector is one of the major global economies and is characterised by low productivity and high inefficiencies, but could highly benefit from the introduction of robotic equipment in terms of productivity, safety, and quality. As the development and the availability of robotic solutions for the construction sector increases, the evaluation of their potential benefits compared to conventional processes that are currently adopted on construction sites becomes compelling. To this end, we exploit Bayesian decision theory and apply an axiomatic design guideline for the development of a decision-theoretic expert system that: (i) evaluates the utility of available alternatives based on evidence; (ii) accounts for uncertainty; and (iii) exploits both expert knowledge and preferences of the users. The development process is illustrated by means of exemplary use case scenarios that compare manual and robotic processes. A use case scenario that compares manual and robotic marking and spraying is chosen for describing the development process in detail. Findings show how decision making in equipment selection can be supported by means of dedicated systems for decision support, developed in collaboration with domain experts.

We develop several formal analogies between the logistic equation and the spatially homogeneous and isotropic relativistic cosmology described by the Einstein–Friedmann equations. These analogies produce an effective Lagrangian and Hamiltonian and new symmetries for the logistic equation.

Bootstrapped Newtonian gravity was developed with the purpose of estimating the impact of quantum physics in the nonlinear regime of the gravitational interaction, akin to corpuscular models of black holes and inflation. In this work, we set the ground for extending the bootstrapped Newtonian picture to cosmological spaces. We further discuss how such models of quantum cosmology can lead to a natural solution to the cosmological constant problem.

The application of robotics in construction is hindered by the site environment, which is unstructured and subject to change. At the same time, however, buildings and corresponding sites can be accurately described by Building Information Modeling (BIM). Such a model contains geometric and semantic data about the construction and operation phases of the building and it is already available at the design phase. We propose a method to leverage BIM for simple yet efficient deployment of robotic systems for construction and operation of buildings. With our proposed approach, BIM is used to provide the robot with a priori geometric and semantic information on the environment and to store information on the operation progress. We present two applications that verify the effectiveness of our proposed method. This system represents a step forward towards an easier application of robots in construction.

Decision making is a relevant task in the building construction sector, and various systems and methods for decision support are emerging. By means of a systematic literature review, this article identifies the methods for decision making in building construction and the lifecycle phases for which decision support systems are proposed. The selected articles are analyzed and grouped according to the adopted decision-making methods and the defined lifecycle phases. The findings show that multiple criteria decision analysis is the most used method for decision support in building construction and that the construction phase is the most addressed phase within the relevant existing works. The findings related to the construction phase are further refined by grouping the articles into application areas and by reviewing in detail the proposed methods therein. The scarce availability of data and project cases is identified as the most common barrier for the successful development and implementation of decision support systems in the building construction sector. This work provides a basis for scientists and practitioners for identifying suitable methods for decision-making support in a specific lifecycle phase of a building.

We study a quantum-corrected Schwarzschild black hole proposed recently in Loop Quantum Gravity. Prompted by the fact that corrections to the innermost stable circular orbit of Schwarzschild diverge, we investigate time-like and null radial geodesics. Massive particles moving radially outwards are confined, while photons make it to infinity with infinite redshift. This unsettling physics, which deviates radically from both Schwarzschild (near the horizon) and Minkowski (at infinity) is due to repulsion by the negative quantum energy density that makes the quasilocal mass vanish as one approaches spatial infinity.

The many technical and computational problems that appear to be constantly emerging in various branches of physics and engineering beg for a more detailed understanding of the fundamental mathematics that serves as the cornerstone of our way of understanding natural phenomena [...]

In this paper, after a brief review of the physical notion of quality factor in viscoelasticity, we present a complete discussion of the attenuation processes emerging in the Maxwell–Prabhakar model, recently developed by Giusti and Colombaro. Then, taking profit of some illuminating plots, we discuss some potential connections between the presented model and the modern mathematical modelling of seismic processes.