1. Neuroparacoccidioidomycosis: A 13-Year Cohort Study, Rio de Janeiro, Brazil
- Author
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Priscila Marques de Macedo, Eduardo Mastrangelo Marinho Falcão, Dayvison Francis Saraiva Freitas, Andréa d’Avila Freitas, Ziadir Francisco Coutinho, Mauro de Medeiros Muniz, Rosely Maria Zancopé-Oliveira, Rodrigo Almeida-Paes, Marcus Tulius Teixeira da Silva, and Antonio Carlos Francesconi do Valle
- Subjects
neuroparacoccidioidomycosis ,paracoccidioidomycosis ,neglected diseases ,Paracoccidioides ,central nervous system ,Biology (General) ,QH301-705.5 - Abstract
Neuroparacoccidioidomycosis (NPCM) is a rare and severe clinical presentation of paracoccidioidomycosis (PCM). We performed a retrospective cohort study at the Evandro Chagas National Institute of Infectious Diseases (INI/Fiocruz), a reference center for PCM in the state of Rio de Janeiro, Brazil. All cases of PCM admitted to the INI/Fiocruz from January 2007 to December 2019 were reviewed. Eight (3.9%) among 207 patients met the diagnostic criteria for NPCM. The mean age was 44.6 years and the male:female ratio was 7:1. All cases presented multifocal disease, 5 (62.5%) the chronic form and 3 (37.5%) the acute/subacute form. All patients presented the pseudotumoral pattern and 6 (75.0%) had multiple lesions in the cerebral hemispheres. Seizures and motor symptoms were the most frequent clinical manifestations (50.0%, each). The treatment of choice was sulfamethoxazole/trimethoprim (SMZ-TMP) and fluconazole, in association (87.5%). Most patients responded well to the treatment. Sequela and death occurred in one (12.5%) patient, each.
- Published
- 2020
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