1. When Oxidative Stress Meets Epigenetics: Implications in Cancer Development
- Author
-
Alvaro García-Guede, Inmaculada Ibanez-de-caceres, and Olga Vera
- Subjects
0301 basic medicine ,Physiology ,Clinical Biochemistry ,miR7/MAFG/Nrf2 axe ,Review ,medicine.disease_cause ,Biochemistry ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Gene expression ,medicine ,cancer ,oxidative stress ,Epigenetics ,Molecular Biology ,Organism ,biology ,epigenetics ,lcsh:RM1-950 ,Cancer ,chemoresistance ,Cell Biology ,Methylation ,medicine.disease ,Cell biology ,030104 developmental biology ,Histone ,lcsh:Therapeutics. Pharmacology ,chemistry ,030220 oncology & carcinogenesis ,biology.protein ,cancer therapy ,DNA ,Oxidative stress - Abstract
Cancer is one of the leading causes of death worldwide and it can affect any part of the organism. It arises as a consequence of the genetic and epigenetic changes that lead to the uncontrolled growth of the cells. The epigenetic machinery can regulate gene expression without altering the DNA sequence, and it comprises methylation of the DNA, histones modifications, and non-coding RNAs. Alterations of these gene-expression regulatory elements can be produced by an imbalance of the intracellular environment, such as the one derived by oxidative stress, to promote cancer development, progression, and resistance to chemotherapeutic treatments. Here we review the current literature on the effect of oxidative stress in the epigenetic machinery, especially over the largely unknown ncRNAs and its consequences toward cancer development and progression.
- Published
- 2020