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The objective was to evaluate the metabolic and performance differences in primiparous Nellore cows, which became pregnant at 14 or 24 months. Thirty-eight primiparous Nellore cows, which were bred for first pregnancy at 14 or 24-mo of age, with 202 ± 5 days of gestation were divided into two treatments according to breeding age: 14 or 24 months in the breeding season. Cows were evaluated for weight, body condition score (BCS), carcass characteristics, milk yield and blood parameters: glucose, total proteins, albumin, urea, beta-hydroxybutyrate (β-OHB), non-esterified fatty acids (NEFA), progesterone, and for insulin-like growth factor-1 (IGF-1). There was an in-teraction (p < 0.01) between age at first pregnancy and time for body weight, where 24-mo cows were heavier, but both categories loss weight at parturition which concomitant decrease in the BCS (p < 0,01). However, BW of 24-mo remained stable (p > 0.05) after parturition. Milk yield was higher in 24-mo cows (p < 0.01). Interaction between sampling time and breading age was observed for Longissimus muscle area (p < 0.01) and tended for Longissimus muscle depth, where 24-mo cows had greater values in prepartum. Calves born from the cows bred at 24-mo, where was higher (p < 0.01) from 160 days of age until weaning at 240 days. Glucose, urea, total proteins, albumin and NEFA were affected (p < 0.01) by the parturition data-point. There was an interaction (p < 0.01) between breading age and sampling period for β-OHB. Progesterone concentration was greater in 24-mo cows (p < 0.01). It was concluded that primiparous cows that became pregnant at 14 or 24 months of age have different nutritional and metabolic responses.

The study of phytotherapy in dentistry is relevant due to the low occurrence of research in the treatment of oral pathologies, such as caries and periodontal disease. Thus, the aim of this research was to characterize the chemical composition of extracts from the leaves of Couroupita guianensis Aubl, including toxicological evaluation and the antioxidant and antimicrobial potential against Staphylococcus aureus, Streptococcus mutans and Candida albicans. Three extracts were prepared using assisted ultrasound, originating the Crude Ultrasound Extract (CUE) and Soxhlet apparatus, originating the Crude Soxhlet Extract (CSE) and the Ethanol Soxhlet Extract (ESE). In the analysis of the chemical composition, the presence of flavonoids, tannins and saponins were detected. LC-DAD analysis revealed the presence of caffeic acid, sinapic acid, rutin, quercetin, luteolin, kaempferol and apigenin in all extracts. In the GC-MS analysis, stigmasterol and β-sitosterol were identified in CUE and CSE. The antioxidant potentials, determined by the DPPH• and ABTS•+ methods, the ESE showed higher antioxidant activity (2.98 ± 0.96 and 4.93 ± 0.90, respectively). In the evaluation of toxicity, the CUE 50µg/mL and the ESE 50 µg/mL presented growth stimulation of Allium cepa roots. At a concentration of 750µg/mL, all extracts inhibited root growth. None of the extracts showed toxicity against Artemia salina. Antibacterial action was detected in all extracts, mainly against the microorganisms S. aureus and S. mutans; however, the antifungal action against C. albicans was not detected. From the results, the extracts of C. guianensis have therapeutic potential for use in the control of microorganisms in the oral microbiota.

The development of new joint configurations suitable for dissimilar materials enables a wider range of applications and allows for an accelerated replacement of traditional structural construction materials by lightweight materials. The T-configuration is a joint configuration that has not been sufficiently studied for use with dissimilar materials, especially when created using the friction stir welding (FSW) process. In this study, a combined lap/butt design was introduced and implemented, seeking to create a T-joint between aluminum and steel. Characterization of the joints showed that FSW could be successfully used to join aluminum and steel in a T-configuration. The formation of intermetallic bonds and kissing bonds was carefully analyzed, and their contribution to the fracture behavior during loading in the skin and stringer directions was studied. Finite element simulation was used to determine the stress state at the interface during loading. The characterization results showed that the intermetallic, as an indicator of metallurgical bonding, is formed when special features are observed in the pattern of material flow. The fractography images showed that the stress state has a major impact on the fracture. The results of the present study can be effectively used to design and fabricate dissimilar joints, taking into account the loading condition.

It has been demonstrated that a possible solution to reducing delamination in a unidirectional composite laminate lies in the replacement of conventional carbon-fibre-reinforced polymer layers with optimized thin-ply layers, thus creating hybrid laminates. This leads to an increase in the transverse tensile strength of the hybrid composite laminate. This study investigates the performance of a hybrid composite laminate reinforced by thin plies used as adherends in bonded single lap joints. Two different composites with the commercial references Texipreg HS 160 T700 and NTPT-TP415 were used as the conventional composite and thin-ply material, respectively. Three configurations were considered in this study: two reference single lap joints with a conventional composite or thin ply used as the adherends and a hybrid single lap. The joints were quasi-statically loaded and recorded with a high-speed camera, allowing for the determination of damage initiation sites. Numerical models of the joints were also created, allowing for a better understanding of the underlying failure mechanisms and the identification of the damage initiation sites. The results show a significant increase in tensile strength for the hybrid joints compared to the conventional ones as a result of changes in the damage initiation sites and the level of delamination present in the joint.

The main drawback of friction stir welding (FSW) dissimilar metals is the formation of intermetallic compounds (IMCs), which are brittle and affect the strength of the joint. The formation of these compounds is inevitable due to their low enthalpy of formation; however, their emergence is an indication of metallurgical bonding between dissimilar metals. This means that the determining factors of intermetallics should be optimal to ensure the formation of the joint and, at the same time, the performance of the joint. It is known that various parameters such as welding parameters, joint configuration, and tool geometry have an influence on the formation of these compounds. However, the influence of the base metal is not adequately addressed in the literature. The current review paper focuses on intermetallic formation during the friction stir welding of aluminum/steel (Al/St) alloys to explore how the types of alloys affect the thicknesses and morphologies of the intermetallics. Different structural steels and stainless steels were considered to see how they affect intermetallic formation when welded to different types of aluminum alloys. The thicknesses of the IMCs in the FSW of different aluminum/steel alloys were taken from the literature and averaged to provide insight into the contribution of the elements to IMC formation. Thermodynamic and kinetic analyses were used to explain this effect. Finally, the mechanism of intermetallic formation is explained to provide a useful guide for selecting dissimilar metals for welding using friction stir welding.

Epoxy adhesives, widely used in multiple structural applications, are used in the milling tool industry to replace brazing and mechanical fastening when joining the cutting bits to the tool body; though their durability is still a concern. This work aims to evaluate and characterise the effect of environmental factors associated with a tool’s life cycle on the performance of these bonded joints. A gravimetric analysis was conducted on bulk adhesive plates for water, cutting emulsion and dielectric fluid to obtain diffusion and relaxation rates. Novel real joint shear specimens were developed to enable strength testing on joints which are comparable with the final application. These specimens were immersed in fluids and subjected to thermal cycles or a corrosive finishing surface treatment to simulate the tool’s life cycle. The joint’s resistance was then benchmarked. Lastly, a dimensional variation test was carried out on tool prototypes before and after ageing, showing no significant dimensional variation which could compromise the cutting performance of the tool. Overall, though it was possible to identify a decrease in strength of around 20% in most tests, joint strength was still within the values necessary for safe operation, with a large safety factor still being retained.

Self-adhesive resin cements (SARCs) are used because of their mechanical properties, ease of cementation protocols, and lack of requirements for acid conditioning or adhesive systems. SARCs are generally dual-cured, photoactivated, and self-cured, with a slight increase in acidic pH, allowing self-adhesiveness and increasing resistance to hydrolysis. This systematic review assessed the adhesive strength of SARC systems luted to different substrates and computer-aided design and manufacturing (CAD/CAM) ceramic blocks. The PubMed/MedLine and Science Direct databases were searched using the Boolean formula [((dental or tooth) AND (self-adhesive) AND (luting or cement) AND CAD-CAM) NOT (endodontics or implants)]. Of the 199 articles obtained, 31 were selected for the quality assessment. Lava Ultimate (resin matrix filled with nanoceramic) and Vita Enamic (polymer-infiltrated ceramic) blocks were the most tested. Rely X Unicem 2 was the most tested resin cement, followed by Rely X Unicem > Ultimate > U200, and μTBS was the test most used. The meta-analysis confirmed the substrate-dependent adhesive strength of SARCs, with significant differences between them and between SARCs and conventional resin-based adhesive cement (α < 0.05). SARCs are promising. However, one must be aware of the differences in the adhesive strengths. An appropriate combination of materials must be considered to improve the durability and stability of restorations.

Adhesives are increasingly being employed in industrial applications as a replacement for traditional mechanical joining methods, since they enable improvements in the strength-to-weight ratio and lower the cost of the overall structures. This has led to a need for adhesive mechanical characterisation techniques that can provide the data needed to build advanced numerical models, allowing structural designers to expedite the adhesive selection process and grant precise optimisation of bonded connection performance. However, mechanically mapping the behaviour of an adhesive involves numerous different standards resulting in a complex network of various specimens, testing procedures and data reduction methods that concern techniques which are exceedingly complex, time-consuming, and expensive. As such, and to address this problem, a novel fully integrated experimental characterisation tool is being developed to significantly reduce all the issues associated with adhesive characterisation. In this work, a numerical optimisation of the unified specimen’s fracture toughness components, comprising the combined mode I (modified double cantilever beam) and II (end-loaded split) test, was performed. This was achieved by computing the desired behaviour as a function of the apparatus’ and specimens’ geometries, through several dimensional parameters, and by testing different adhesives, widening the range of applications of this tool. In the end, a custom data reduction scheme was deduced and set of design guidelines was defined.

A Finite Element (FE) based macro–element is described for the mechanical response of masonry structures within different ranges of analysis. The macro–element is composed of discrete rigid quadrilateral FE plates whose adjoining interfaces are connected through FE trusses. It allows representing both elasticity and strength orthotropy, full material nonlinearity and damage through a scalar–based model. The possibility of coupling with a so–called FE2 (multi–scale) strategy is also addressed. Validation of the macro–element is conducted within linear static, vibration, and cyclic (nonlinear) problems, in which both static and dynamic ranges are explored. Results are compared with those retrieved from traditional FE continuous models. Advantages are highlighted, as well as its robustness to cope with convergence issues and suitability to be applied within more general and larger–scale scenarios, such as the analysis of anisotropic materials subjected to static and dynamic loading. Formal details are given for its reproducibility by academics and practitioners—eventually within other FE platforms—as the improved running times may be of utmost importance in dynamic problems or highly nonlinear (material) quasi–static analysis.

In the present paper, an exploratory study on the creep behavior of a pressure sensitive adhesive (PSA) is performed. After the determination of the quasi-static behavior of the adhesive for bulk specimens and single lap joints (SLJ), SLJs were subjected to creep tests at 80%, 60%, and 30% of their respective failure load. It was verified that the durability of the joints increases under static creep conditions as the load level decreases, with the second phase of the creep curve becoming more pronounced, where the strain rate is close to zero. In addition, cyclic creep tests were performed for the 30% load level at a frequency of 0.04 Hz. Finally, an analytical model was applied to the experimental results in order to reproduce the values obtained for both static and cyclic tests. The model was found to be effective, reproducing the three phases of the curves which allowed for the characterization of the full creep curve, something not commonly found in the literature, especially for PSAs.

Water vapor sorption is a powerful tool for the analysis of cement paste, one of the most used substances by mankind. The monitoring of cementitious materials is fundamental for the improvement of infrastructure resilience, which has a deep impact on the economy, the environment, and on society. In this work, a multimode fiber was embedded in cement paste for real-time monitoring of cement paste water vapor sorption. Changes in the reflected light intensity due to the build-up of water in the cement paste’s pores were exploited for this purpose. The sample was 7-day moist cured, and the relative humidity was controlled between 8.9% and 97.6%. Reflected light intensity was converted into a specific surface area of cement paste (133 m2/g) and thickness of water through the Brunauer-Emmett-Teller (BET) method and into a pore size distribution through the Barret-Joyner-Halenda (BJH) method. The results achieved through reflected light intensity agree with those found in the literature, validating the usage of this setup for the monitoring of water vapor sorption, breaking away from standard gravimetric measurements.

Friction stir welding (FSW) is a process by which a joint can be made in a solid state. The complexity of the process due to metallurgical phenomena necessitates the use of models with the ability to accurately correlate the process parameters with the joint properties. In the present study, a multilayer perceptron (MLP) artificial neural network (ANN) was used to model and predict the ultimate tensile strength (UTS) of the joint between the AA2024 and AA7075 aluminum alloys. Three pin geometries, pyramidal, conical, and cylindrical, were used for welding. The rotation speed varied between 800 and 1200 rpm and the welding speed varied between 10 and 50 mm/min. The obtained ANN model was used in a simulated annealing algorithm (SA algorithm) to optimize the process to attain the maximum UTS. The SA algorithm yielded the cylindrical pin and rotational speed of 1110 rpm to achieve the maximum UTS (395 MPa), which agreed well with the experiment. Tensile testing and scanning electron microscopy (SEM) were used to assess the joint strength and the microstructure of the joints, respectively. Various defects were detected in the joints, such as a root kissing bond and unconsolidated banding structures, whose formations were dependent on the tool geometry and the rotation speed.

The use of carbon fibre reinforced polymer (CFRP) materials is increasing in many different industries, such as those operating in the aviation, marine, and automotive sectors. In these applications, composite parts are often joined with other composite or metallic parts, where adhesive bonding plays a key role. Unlike conventional joining methods, adhesive bonding does not add weight or require the drilling of holes, both of which are major sources of stress concentration. The performance of a composite joint is dependent on multiple factors and can be improved by modifying the adhesive layer or the composite layup of the adherend. Moreover, joint geometry, surface preparation, and the manufacturing methods used for production are also important factors. The present work reviews recent developments on the design and manufacture of adhesively bonded joints with composite substrates, with particular interest in adherend modification techniques. The effects of stacking sequence, use of thin-plies, composite metal laminates and its specific surface preparations, and the use of toughened surface layers in the composite adherends are described for adhesively bonded CFRP structures.

Background: Education is believed to contribute positively to brain structure and function, as well as to cognitive reserve. One of the brain regions most impacted by education is the medial temporal lobe (MTL), a region that houses the hippocampus, which has an important role in learning processes and in consolidation of memories, and is also known to undergo neurogenesis in adulthood. We aimed to investigate the influence of education on the absolute cell numbers of the MTL (comprised by the hippocampal formation, amygdala, and parahippocampal gyrus) of men without cognitive impairment. Methods: The Isotropic Fractionator technique was used to allow the anisotropic brain tissue to be transformed into an isotropic suspension of nuclei, and therefore assess the absolute cell composition of the MTL. We dissected twenty-six brains from men aged 47 to 64 years, with either low or high education. Results: A significant difference between groups was observed in brain mass, but not in MTL mass. No significant difference was found between groups in the number of total cells, number of neurons, and number of non-neuronal cells. Regression analysis showed that the total number of cells, number of neurons, and number of non-neuronal cells in MTL were not affected by education. Conclusions: The results indicate a resilience of the absolute cellular composition of the MTL of typical men to low schooling, suggesting that the cellularity of brain regions is not affected by formal education.

One of the most common loading conditions that bonded joints experience in service is repeated impact. Despite the destructive effects of impact fatigue, the behavior of metal-composite bonded joints subjected to repeated impact loads has rarely been studied in the literature. Therefore, it is of utmost importance to pay attention to this phenomenon on the one hand and to find solutions to improve the impact fatigue life of bonded composite metal components on the other hand. Accordingly, in this study, the use of the bi-adhesive technique is proposed to improve the durability of composite-metal single-lap joints (SLJs) under impact fatigue loading conditions. J-N (energy-life) method is also used to analyze the experimental data obtained. Accordingly, in the present study, the impact fatigue behavior of single adhesive metal to composite joints was analyzed experimentally based on the J-N method and also numerically using the finite element method (FEM). By using two adhesives along a single overlap, the impact fatigue life of joints between dissimilar composite and metal joints was also analyzed experimentally. The results show that the double adhesives technique can significantly improve the impact fatigue life of the tested joints. It was also found that the optimum length ratio of the adhesives (the length covered by the ductile adhesive relative to the total overlap size) is a function of the stiffness of the joint and is more pronounced for less stiff bonded joints. A linear elastic numerical analysis was also conducted to evaluate the stress state along the bloodline of the bonded joints. Results show that the compressive peel stress made at the boundary of the two adhesives can be a possible reason behind the different results observed.

Viral infections inflict many serious human diseases, being responsible for remarkably high mortality rates. In this sense, both the academy and the pharmaceutical industry are continuously searching for new compounds with antiviral activity, and in addition, face the challenge of developing greener and more efficient methods to synthesize these compounds. This becomes even more important with drugs possessing stereogenic centers as highly enantioselective processes are required. In this minireview, the advances achieved to improve synthetic routes efficiency and sustainability of important commercially antiviral chiral drugs are discussed, highlighting the use of organocatalytic methods.

Traditional agriculture represents the most-extensive food-producing segment in the world. However, these agroecosystems are widely and closely associated with rural poverty, reflecting the dualism between the subsistence and the commodity-producing sector in the peripheric countries. Therefore, socially adapted technologies may be a reliable and helpful methodology to enhance subsistence crop production. Humic substances are natural organic biostimulants extractable as water suspensions from renewable sources such as agricultural biomass and farming residues. These easy-to-handle extracts may be mixed with plant-growth-promoting bacteria (PGPB) and used as biostimulants within a low-cost technological application in the circular economy strategy. Few investigations have been focused on the use of biostimulant practices on marginal or subsistence crops. Cassava (Manihot esculenta Crantz) and okra (Abelmoschus esculentus) are two essential foods for poor communities of rural territories in tropical and subtropical countries. The aim of this study was to evaluate the effect of the foliar application of a humic/PGPB mixed biostimulant on cassava and okra crops grown in an agricultural soil with very low natural fertility. In pot trials, the applied biostimulant improved the plant development with a 200% increase of the root weight in cassava, while the preservation of active diazotrophic bacteria was improved by 10- and 100-times in cassava and okra in the mixed formulation with humic acid. In real field systems, the plant treatment increased the yield of cassava and okra by 70% and 50%, respectively thereby allowing a simultaneous nitrogen savings with the best yield performance obtained at the lower N fertilization rate. The use of biostimulants can play a role in the transition process, helping the food security and the autonomy of impoverished farmers. Combining the elements of traditional knowledge and modern science is essential to create innovative technologies enabling the sustainable management of agroecosystems.

Over recent decades, the need to comply with environmental standards has become a concern in many industrial sectors. As a result, manufacturers have increased their use of eco-friendly, recycled, recyclable, and, overall, more sustainable materials and industrial techniques. One technique highly dependent on petroleum-based products, and at the edge of a paradigm change, is adhesive bonding. Adhesive bonding is often used to join composite materials and depends upon an adhesive to achieve the connection. However, the matrices of the composite materials and the adhesives used, as well as, in some cases, the composite fibres, are manufactured from petrochemical products. Efforts to use natural composites and adhesives are therefore ongoing. One composite that has proven to be promising is wood due to its high strength and stiffness (particularly when it is densified), formability, and durability. However, wood must be very carefully characterised since its properties can be variable, depending on the slope of the grains, irregularities (such as knots, shakes, or splits), and on the location and climate of each individual tree. Therefore, in addition to neat wood, wood composites may also be a promising option to increase sustainability, with more predictable properties. To bond wood or wooden composite substrates, bio-adhesives can be considered. These adhesives are now formulated with increasingly enhanced mechanical properties and are becoming promising alternatives at the structural application level. In this paper, wooden adhesive joints are surveyed considering bio-adhesives and wood-based substrates, taking into consideration the recent approaches to improve these base materials, accurately characterise them, and implement them in adhesive joints.

Although clean energy generation utilizing the Oxygen Reduction Reaction (ORR) can be considered a promising strategy, this approach remains challenging by the dependence on high loadings of noble metals, mainly Platinum (Pt). Therefore, efforts have been directed to develop new and efficient electrocatalysts that could decrease the Pt content (e.g., by nanotechnology tools or alloying) or replace them completely in these systems. The present investigation shows that high catalytic activity can be reached towards the ORR by employing 1.8 ± 0.7 nm Ir nanoparticles (NPs) deposited onto MnO2 nanowires surface under low Ir loadings (1.2 wt.%). Interestingly, we observed that the MnO2-Ir nanohybrid presented high catalytic activity for the ORR close to commercial Pt/C (20.0 wt.% of Pt), indicating that it could obtain efficient performance using a simple synthetic procedure. The MnO2-Ir electrocatalyst also showed improved stability relative to commercial Pt/C, in which only a slight activity loss was observed after 50 reaction cycles. Considering our findings, the superior performance delivered by the MnO2-Ir nanohybrid may be related to (i) the significant concentration of reduced Mn3+ species, leading to increased concentration of oxygen vacancies at its surface; (ii) the presence of strong metal-support interactions (SMSI), in which the electronic effect between MnOx and Ir may enhance the ORR process; and (iii) the unique structure comprised by Ir ultrasmall sizes at the nanowire surface that enable the exposure of high energy surface/facets, high surface-to-volume ratios, and their uniform dispersion.

The worldwide increase in serious infections caused by multidrug-resistant (MDR) K. pneumoniae emphasizes the urgent need of new therapeutic strategies for the control of this pathogen. There is growing interest in the use of bacteriophages (or phages) to treat K. pneumoniae infections, and newly isolated phages are needed. Here, we report the isolation and physical/biological/molecular characterization of a novel lytic phage and its efficacy in the control of MDR K. pneumoniae. The phage vB_KpnS_Uniso31, referred to hereafter as phage Kpn31, was isolated from hospital wastewater using K. pneumoniae CCCD-K001 as the host. Phage Kpn31 presents a siphovirus-like morphotype and was classified as Demerecviridae; Sugarlandvirus based on its complete genome sequence. The 113,444 bp Kpn31 genome does not encode known toxins or antimicrobial resistance genes, nor does it encode depolymerases related sequences. Phage Kpn31 showed an eclipse time of 15 min and a burst size of 9.12 PFU/host cell, allowing us to conclude it replicates well in K. pneumoniae CCCD-K001 with a latency period of 30 min. Phage Kpn31 was shown to be effective against at least six MDR K. pneumoniae clinical isolates in in vitro antibacterial activity assays. Based on its features, phage Kpn31 has potential for controlling infections caused by MDR K. pneumoniae.

Xylella fastidiosa causes diseases in many plant species. Originally confined to the Americas, infecting mainly grapevine, citrus, and coffee, X. fastidiosa has spread to several plant species in Europe causing devastating diseases. Many pathogenicity and virulence factors have been identified, which enable the various X. fastidiosa strains to successfully colonize the xylem tissue and cause disease in specific plant hosts, but the mechanisms by which this happens have not been fully elucidated. Here we present thorough comparative analyses of 94 whole-genome sequences of X. fastidiosa strains from diverse plant hosts and geographic regions. Core-genome phylogeny revealed clades with members sharing mostly a geographic region rather than a host plant of origin. Phylogenetic trees for 1605 orthologous CDSs were explored for potential candidates related to host specificity using a score of mapping metrics. However, no candidate host-specificity determinants were strongly supported using this approach. We also show that X. fastidiosa accessory genome is represented by an abundant and heterogeneous mobilome, including a diversity of prophage regions. Our findings provide a better understanding of the diversity of phylogenetically close genomes and expand the knowledge of X. fastidiosa mobile genetic elements and immunity systems.

Buriti (Mauritia flexuosa L.) oil (BO) is a byproduct that can be incorporated into the diet of lambs, thus increasing the energy density. The study aimed to evaluate the optimum BO inclusion level in lamb diets. Sixty-five Santa Ines lambs were distributed in two completely randomized experiments with five treatments each (BO inclusion at 0 (control), 12, 24, 36 and 48 g/kg dry matter (DM) total). The BO supplementation to partially replace ground corn linearly decreased the nutrient intake and digestibility of DM, ether extract and neutral detergent fiber (NDF), N&deg, chews/bolus, DM and NDF rumination or eating efficiencies, the N intake and N balance, carcass weights and yields, and dressing content of lamb carcasses (p &lt, 0.05). The addition of BO responded quadratically to DM eating efficiency and N-fecal and N-urinary excretion (p &lt, 0.05). The linear response plateau (LRP) analysis demonstrated that the levels of 0 and 12 g/kg of BO were similar, and improved intake and digestibility and consequently performance (p &lt, 0.001). There was a linear increase in feed efficiency and shrinkage after chilling with the BO inclusion replacing ground corn. The inclusion of 12 g/kg BO in the total DM of diet is recommended, because it improves feeding intake, digestibility and performance of lambs.

Corn grown as second-crop (safrinha) immediately after soybeans contributes to Brazil’s recent sustainable intensification of efforts to land spare and reduce deforestation. Brazil’s Mato Grosso state is very important for corn production with a large number of available hybrids for producers with different characteristics. Evaluating as many hybrids as possible increases the likelihood of identifying those that are more productive. Our experiment used a randomized block design to evaluate 20 corn hybrids for yield and quality in the western Cerrado savannah region of Mato Grosso state. There were significant differences in silage quality and grain yield between hybrids. Silage quality was correlated with higher grain yield. Corn grain yields for 10 higher-yielding hybrids (average = 11,425 kg/hectare) were significantly greater than the two lowest yielding hybrids (6974 and 8207 kg/hectare) and 64% more than the 2020 average in Mato Grosso. Precipitation was not limiting during our experiment but may be in the drier Cerrado area and during other years. Higher silage quality with lower lignin content and higher in vitro digestibility can improve beef productivity as Brazil transitions from extensive grazing to more intensified systems such as pasture supplementation. Increasing corn grain yields in Mato Grosso can hedge against lower crop yields elsewhere.

A point source interferometer (PSI) is a device where atoms are split and recombined by applying a temporal sequence of Raman pulses during the expansion of a cloud of cold atoms behaving approximately as a point source. The PSI can work as a sensitive multi-axes gyroscope that can automatically filter out the signal from accelerations. The phase shift arising from the rotations is proportional to the momentum transferred to each atom from the Raman pulses. Therefore, by increasing the momentum transfer, it should be possible to enhance the sensitivity of the PSI. Here, we investigate the degree of enhancement in sensitivity that could be achieved by augmenting the PSI with large momentum transfer (LMT) employing a sequence of many Raman pulses with alternating directions. We analyze how factors such as Doppler detuning, spontaneous emission, and the finite initial size of the atomic cloud compromise the advantage of LMT and how to find the optimal momentum transfer under these limitations, with both the semi-classical model and a model under which the motion of the center of mass of each atom is described quantum mechanically. We identify a set of realistic parameters for which LMT can improve the PSI by a factor of nearly 40.

Considering the challenges of urea administration due to the high ureolytic activity of the rumen and the importance of its use, as well as taking into account the relevance of sustainably exploiting the technological potential of biodiversity, this research studies the encapsulation of urea in different clay minerals (palygorskite (Pal), sepiolite (Sep), and Veegum&reg, (V)) as an alternative for use as nonprotein nitrogen (NNP) sources. A method of incorporation was developed in which the encapsulation of urea was proven by X-ray diffraction, fibrous materials, Pal and Sep had similar characteristics due to the decrease in the relative plane intensity (011), suggesting a decrease in the order of their stacking due to the presence of urea on the surface or inside channels. By contrast, V showed a 7.74&deg, reflection shift, suggesting an increase in basal spacing from 11.45 &Aring, in V to 14.88 &Aring, in the sample after urea encapsulation. By thermogravimetry, it was observed that the presence of urea did not change the mass-loss profiles but only increased the percentage of loss in respective events, indicating urea incorporation in the clay minerals. These results provide a promising alternative for administering NNP sources in the ruminant diet.

This review aims to assess the current modelling and experimental achievements in the design for additive manufacturing of bonded joints, providing a summary of the current state of the art. To limit its scope, the document is focused only on polymeric additive manufacturing processes. As a result, this review paper contains a structured collection of the tailoring methods adopted for additively manufactured adherends and adhesives with the aim of maximizing bonded joint performance. The intent is, setting the state of the art, to produce an overview useful to identify the new opportunities provided by recent progresses in the design for additive manufacturing, additive manufacturing processes and materials’ developments.

International audience; Mono and bimetallic catalysts based on Pt and Pd were prepared by a co-precipitation method. They were tested in liquid phase hydrogenation reactions of glucose and furfural at low temperature and pressure. The bimetallic PtPd/TiO2 catalyst proved to be an efficient material in selectively hydrogenating glucose to sorbitol. Moreover, high furfural conversion was attained under relatively soft conditions, and the furfuryl alcohol selectivity was strongly affected by the chemical composition of the catalysts. Furfuryl alcohol (FA) was the major product in most cases, along with side products such as methylfuran (MF), furan, and traces of tetrahydrofuran (THF). These results showed that the PtPd bimetallic sample was more active relative to the monometallic counterparts. A correlation between the catalytic results and the physicochemical properties of the supported nanoparticles identified key factors responsible for the synergetic behavior of the PtPd system. The high activity and selectivity were due to the formation of ultra-small particles, alloy formation, and the Pt-rich surface composition of the bimetallic particles supported on the TiO2 nanowires.

Made available in DSpace on 2014-12-03T13:11:43Z (GMT). No. of bitstreams: 0 Previous issue date: 2014-05-01Bitstream added on 2014-12-03T13:22:28Z : No. of bitstreams: 1 WOS000337113000034.pdf: 224463 bytes, checksum: ee28e88c1d3cb36be99cd5321f6a56c5 (MD5) Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) NPQ-Glaxo PROPE Tuberculosis is an ancient disease that is still present as a global public health problem. Our group has been investigating new molecules with anti-TB activity. In this context, inorganic chemistry has been a quite promising source of such molecules, with excellent results seen with ruthenium compounds. Nanostructured lipid systems may potentiate the action of drugs by reducing the required dosage and side effects and improving the antimicrobial effects. The aim of this study was to develop a nanostructured lipid system and then characterize and apply these encapsulated compounds (SCARs 1, 2 and 4) with the goal of improving their activity by decreasing the Minimum Inhibitory Concentration (MIC90) and reducing the cytotoxicity (IC50). The nanostructured system was composed of 10% phase oil (cholesterol), 10% surfactant (soy oleate, soy phosphatidylcholine and Eumulgin (R)) and 80% aqueous phase (phosphate buffer pH = 7.4). Good activity against Mycobacterium tuberculosis was maintained after the incorporation of the compounds into the nanostructured lipid system, while the cytotoxicity decreased dramatically, in some cases up to 20 times less toxic than the unencapsulated drug. Univ Estadual Paulista, Fac Ciencias Farmaceut, Dept Ciencias Biol, BR-14801902 Sao Paulo, Brazil Univ Estadual Paulista, Fac Ciencias Farmaceut, Dept Farmacos & Medicamentos, BR-14801902 Sao Paulo, Brazil Univ Fed Sao Carlos, Dept Quim, BR-13565905 Sao Paulo, Brazil Univ Estadual Paulista, Fac Ciencias Farmaceut, Dept Ciencias Biol, BR-14801902 Sao Paulo, Brazil Univ Estadual Paulista, Fac Ciencias Farmaceut, Dept Farmacos & Medicamentos, BR-14801902 Sao Paulo, Brazil FAPESP: 13/09265-7 FAPESP: 13/14957-5 NPQ-Glaxo406827/2012-5 PROPE0102/004/43