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10 results on '"Comai, Stefano"'

1. Probing the Association between Cognition, Suicidal Behavior and Tryptophan Metabolism in a Sample of Individuals Living with Bipolar Disorder: A Secondary Analysis

Author

Paribello, Pasquale, primary, Squassina, Alessio, additional, Pisanu, Claudia, additional, Meloni, Anna, additional, Dall’Acqua, Stefano, additional, Sut, Stefania, additional, Nasini, Sofia, additional, Bertazzo, Antonella, additional, Congiu, Donatella, additional, Garzilli, Mario, additional, Guiso, Beatrice, additional, Suprani, Federico, additional, Pulcinelli, Vittoria, additional, Iaselli, Maria Novella, additional, Pinna, Ilaria, additional, Somaini, Giulia, additional, Arru, Laura, additional, Corrias, Carolina, additional, Pinna, Federica, additional, Carpiniello, Bernardo, additional, Comai, Stefano, additional, and Manchia, Mirko, additional

Published
2023
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3. Investigation of Genetic Variants Associated with Tryptophan Metabolite Levels via Serotonin and Kynurenine Pathways in Patients with Bipolar Disorder

Author

Pisanu, Claudia, primary, Squassina, Alessio, additional, Paribello, Pasquale, additional, Dall’Acqua, Stefano, additional, Sut, Stefania, additional, Nasini, Sofia, additional, Bertazzo, Antonella, additional, Congiu, Donatella, additional, Meloni, Anna, additional, Garzilli, Mario, additional, Guiso, Beatrice, additional, Suprani, Federico, additional, Pulcinelli, Vittoria, additional, Iaselli, Maria Novella, additional, Pinna, Ilaria, additional, Somaini, Giulia, additional, Arru, Laura, additional, Corrias, Carolina, additional, Pinna, Federica, additional, Carpiniello, Bernardo, additional, Comai, Stefano, additional, and Manchia, Mirko, additional

Published
2022
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4. Is Poor Lithium Response in Individuals with Bipolar Disorder Associated with Increased Degradation of Tryptophan along the Kynurenine Pathway? Results of an Exploratory Study

Author

Fellendorf, Frederike T., primary, Manchia, Mirko, additional, Squassina, Alessio, additional, Pisanu, Claudia, additional, Dall’Acqua, Stefano, additional, Sut, Stefania, additional, Nasini, Sofia, additional, Congiu, Donatella, additional, Reininghaus, Eva Z., additional, Garzilli, Mario, additional, Guiso, Beatrice, additional, Suprani, Federico, additional, Paribello, Pasquale, additional, Pulcinelli, Vittoria, additional, Iaselli, Maria Novella, additional, Pinna, Ilaria, additional, Somaini, Giulia, additional, Arru, Laura, additional, Corrias, Carolina, additional, Pinna, Federica, additional, Carpiniello, Bernardo, additional, and Comai, Stefano, additional

Published
2022
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5. Tryptophan Metabolites, Cytokines, and Fatty Acid Binding Protein 2 in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

Author

Simonato, Manuela, primary, Dall’Acqua, Stefano, additional, Zilli, Caterina, additional, Sut, Stefania, additional, Tenconi, Romano, additional, Gallo, Nicoletta, additional, Sfriso, Paolo, additional, Sartori, Leonardo, additional, Cavallin, Francesco, additional, Fiocco, Ugo, additional, Cogo, Paola, additional, Agostinis, Paolo, additional, Aldovini, Anna, additional, Bruttomesso, Daniela, additional, Marcolongo, Renzo, additional, Comai, Stefano, additional, and Baritussio, Aldo, additional

Published
2021
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6. Early Dysfunction of Substantia Nigra Dopamine Neurons in the ParkinQ311X Mouse

Author

Regoni, Maria, primary, Zanetti, Letizia, additional, Comai, Stefano, additional, Mercatelli, Daniela, additional, Novello, Salvatore, additional, Albanese, Federica, additional, Croci, Laura, additional, Consalez, Gian Giacomo, additional, Ciammola, Andrea, additional, Valtorta, Flavia, additional, Morari, Michele, additional, and Sassone, Jenny, additional

Published
2021
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10. D-Lysergic Acid Diethylamide (LSD) as a model of psychosis: Mechanism of action and pharmacology

Author

Gabriella Gobbi, Stefano Comai, Luca Posa, Danilo De Gregorio, De Gregorio, Danilo, Comai, Stefano, Posa, Luca, and Gobbi, Gabriella

Subjects
Dopamine, Drug Evaluation, Preclinical, Review, Atypical antipsychotic, Pharmacology, Synaptic Transmission, Receptors, Dopamine, Receptors, G-Protein-Coupled, Catalysi, lcsh:Chemistry, LSD, 0302 clinical medicine, Receptor, Serotonin, 5-HT2A, lcsh:QH301-705.5, Spectroscopy, Behavior, Animal, Dopaminergic, Computer Science Applications1707 Computer Vision and Pattern Recognition, General Medicine, Serotonin Receptor Agonists, Computer Science Applications, Receptors, Glutamate, Receptor, Serotonin, 5-HT1A, Hallucinogen, medicine.symptom, Antipsychotic Agents, Dorsal Raphe Nucleus, Agonist, Psychosis, Serotonin, medicine.drug_class, TAAR1, Psychosi, Serotonergic, Partial agonist, Catalysis, Inorganic Chemistry, Atypical antipsychotics, 03 medical and health sciences, Dopamine receptor D2, medicine, Animals, Humans, Hallucinogens, TAAR, 1, Physical and Theoretical Chemistry, Molecular Biology, business.industry, Ventral Tegmental Area, Organic Chemistry, medicine.disease, Rats, 030227 psychiatry, Disease Models, Animal, Lysergic Acid Diethylamide, lcsh:Biology (General), lcsh:QD1-999, Psychotic Disorders, Mechanism of action, business, 030217 neurology & neurosurgery
Abstract

d-Lysergic Acid Diethylamide (LSD) is known for its hallucinogenic properties and psychotic-like symptoms, especially at high doses. It is indeed used as a pharmacological model of psychosis in preclinical research. The goal of this review was to understand the mechanism of action of psychotic-like effects of LSD. We searched Pubmed, Web of Science, Scopus, Google Scholar and articles’ reference lists for preclinical studies regarding the mechanism of action involved in the psychotic-like effects induced by LSD. LSD’s mechanism of action is pleiotropic, primarily mediated by the serotonergic system in the Dorsal Raphe, binding the 5-HT2A receptor as a partial agonist and 5-HT1A as an agonist. LSD also modulates the Ventral Tegmental Area, at higher doses, by stimulating dopamine D2, Trace Amine Associate receptor 1 (TAAR1) and 5-HT2A. More studies clarifying the mechanism of action of the psychotic-like symptoms or psychosis induced by LSD in humans are needed. LSD’s effects are mediated by a pleiotropic mechanism involving serotonergic, dopaminergic, and glutamatergic neurotransmission. Thus, the LSD-induced psychosis is a useful model to test the therapeutic efficacy of potential novel antipsychotic drugs, particularly drugs with dual serotonergic and dopaminergic (DA) mechanism or acting on TAAR1 receptors.

Published
2016

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