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Polymer Ca-alginate capsules with rejuvenator bring a high healing level for asphalt concrete under dry healing environments; however, the healing levels of bituminous mixtures containing capsules under water healing conditions are still unknown. In view of this, this study aimed at exploring the healing levels of asphalt concrete containing polymer capsules under various solution healing conditions following cyclic loads. This study involved the preparation of capsules, followed by the evaluation of their morphological characteristics, resilience to compression, thermal endurance, and rejuvenator content. The assessment of the healing properties of asphalt concrete utilizing capsules was conducted through a fracture–heal–refracture examination. This study conducted Fourier transform infrared spectrum experiments to determine the rejuvenator release ratio of capsules under dry conditions and the remaining rejuvenator content in extracted bituminous binder from capsule–asphalt concrete after solution treatment. Meanwhile, a dynamic shear rheometer was utilized to investigate the rheological characteristics of asphalt binder. Results revealed that the healing ratios of capsule–asphalt concrete beams under a dry healing environment were significantly higher than that of beams under various solution healing conditions, and the alkali solution has the worst effect on the improvement in healing ratio. The coupled impact of moisture intrusion and ion erosion resulted in an enhancement of complex modulus of asphalt binder while concurrently reducing its phase angle. Consequently, the restorative capacity of the asphalt binder was weakened. [ABSTRACT FROM AUTHOR]

Chitosan belongs to the group of biopolymers with increasing range of potential applications therefore searching for new raw materials as well as new techniques of obtaining of this polysaccharide are currently a subject of interest of many scientists. Presented manuscript describes preparation of chitosan from crickets. Obtainment of final product required a number of processes aimed at removal of undesirable substances such as waxes, mineral salts, proteins or pigments from above-mentioned insects. Chemical structure of fractions obtained after each step was compared with the structure of commercial chitosan by means of techniques such as X-ray diffraction and FT-IR spectroscopy. Final product was subsequently used for preparation of polymer capsules that were modified with active substance characterized by antibacterial and anticancer activity—nisin. Next, sorption capacity of obtained materials was evaluated as well as a release profile of active substance in different environments. Based on the conducted research it can be concluded that crickets constitute an alternative for shellfish and other conventional sources of chitosan. Furthermore, obtained capsules on the basis of such prepared chitosan can be considered as drug delivery systems which efficiency of release of active substance is bigger in alkaline environments. [ABSTRACT FROM AUTHOR]

In the past few decades, enormous efforts have been made to synthesize covalent polymer nano/microstructured materials with specific morphologies, due to the relationship between their structures and functions. Up to now, the formation of most of these structures often requires either templates or preorganization in order to construct a specific structure before, and then the subsequent removal of previous templates to form a desired structure, on account of the lack of "self-error-correcting" properties of reversible interactions in polymers. The above processes are time-consuming and tedious. A template-free, self-assembled strategy as a "bottom-up" route to fabricate well-defined nano/microstructures remains a challenge. Herein, we introduce the recent progress in template-free, self-assembled nano/microstructures formed by covalent two-dimensional (2D) polymers, such as polymer capsules, polymer films, polymer tubes and polymer rings. [ABSTRACT FROM AUTHOR]

To reduce nonspecific interactions and circumvent biological barriers, low-fouling material of poly(ethylene glycol) (PEG) is most used for the modification of drug nanocarriers. Herein, we report the fabrication of PEG capsules via the free-radical polymerization of linear PEG or 8-arm-PEG using an emulsion templating method for targeted drug delivery. Doxorubicin (DOX) could be loaded in capsules via electrostatic interactions. The obtained capsules composed of 8-arm-PEG result in a lower cell association (2.2%) compared to those composed of linear PEG (7.3%) and, therefore, demonstrate the stealth property. The functionalization of cyclic peptides containing Arg-Gly-Asp (cRGD) on PEG capsules induce high cell targeting to U87 MG cells. A cell cytotoxicity assay demonstrates the biocompatibility of PEG capsules and high drug delivery efficacy of the targeted capsules. The reported capsules with the stealth and targeting property provide a potential platform for improved drug delivery. [ABSTRACT FROM AUTHOR]