1. Synthesis of Polyfluorinated Thia- and Oxathiacalixarenes Based on Perfluoro-m-xylene
- Author
-
Yuri V. Gatilov, Roman A. Bredikhin, Pavel V. Nikul’shin, and Vladimir N. Kovtonyuk
- Subjects
tetraoxadithiacalix[6]arene ,Pharmaceutical Science ,Resorcinol ,Sulfides ,Xylenes ,Orcinol ,Medicinal chemistry ,Article ,Analytical Chemistry ,lcsh:QD241-441 ,perfluoro-m-xylene ,chemistry.chemical_compound ,lcsh:Organic chemistry ,Phenols ,dioxadithiacalix[4]arenes ,Drug Discovery ,Benzene Derivatives ,Physical and Theoretical Chemistry ,thiourea ,Fluorocarbons ,Trifluoromethyl ,X-ray analyses ,perfluorinated tetrathiacalix[4]arene ,Organic Chemistry ,Benzene ,m-Xylene ,Biodegradation, Environmental ,chemistry ,Thiourea ,Chemistry (miscellaneous) ,Molecular Medicine ,2,5-difluoro-4,6-bis(trifluoromethyl)benzene-1,3-dithiol ,Calixarenes ,Toluene - Abstract
Perfluorinated tetrathiacalix[4]arene was obtained by heating perfluoro-m-xylene with thiourea or 2,5-difluoro-4,6-bis(trifluoromethyl)benzene-1,3-dithiol at 90 °, C. Interaction of perfluoro-m-xylene with resorcinol or orcinol under mild conditions and subsequent heating of the mixture with 2,5-difluoro-4,6-bis(trifluoromethyl)benzene-1,3-dithiol leads to polyfluorinated dioxadithiacalix[4]arenes. Triphenyl and pentaphenyl ethers formed by the interaction of perfluoro-m-xylene with resorcinol under heating with thiourea gives polyfluorinated oxathiacalixarenes containing six and five aromatic nuclei, respectively.
- Published
- 2021