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Pipeline leakage seriously threatens the efficient and safe gas drainage in coal mines. To achieve the accurate detection and localization of gas drainage pipeline leakages, this study proposes a gas drainage pipeline leakage detection and localization approach based on the pressure gradient method. Firstly, the basic law of gas flow in the drainage pipeline was analyzed, and a pipeline network resistance correction formula was deduced based on the pressure gradient method. Then, a drainage pipeline model was established based on the realizable k - ε turbulence model, and the pressure and flow velocity distribution during pipeline leakage under different leakage degrees, leakage locations, and pipeline negative pressures were simulated and analyzed, thus verifying the feasibility of the pipeline leakage detection and localization method. It is concluded that the positioning errors of pipeline leakage points under different leakage degrees, different leakage positions, and different pipeline negative pressures were 0.88~1.08%, 0.88~1.49%, and 0.68~0.88%, respectively. Finally, field tests were conducted in the highly located drainage roadway 8421 of the Fifth Mine of Yangquan Coal Industry Group to verify the accuracy of the proposed pipeline leakage detection and localization method, and the relative error was about 8.2%. The results show that with increased pipeline leakage hole diameters, elevated pipeline negative pressures, and closer leakage positions to the pipeline center, the relative localization error was smaller, the localization accuracy was higher, and the stability was greater. The research results could lay the foundation for the fault diagnosis and localization of coal mine gas drainage pipeline networks and provide technical support for safe and efficient coal mine gas drainage. [ABSTRACT FROM AUTHOR]

Background: Iron plays an important role in neuronal injury and edema formation after intracranial hemorrhage. However, the role of serum iron in aneurysmal subarachnoid hemorrhage (aSAH) is yet to be well-established. This study aims to identify whether serum iron could predict postoperative global cerebral edema (GCE) and poor outcome in aSAH. Methods: 847 patients' aSAH clinical data were retrospectively collected at the First Affiliated Hospital of Fujian Medical University. Data on demographics, clinical characteristics, and laboratory values were collected and analyzed through univariate and multivariate analyses. Propensity score matching (PSM) analysis was performed to balance the baseline differences between the groups. Results: The incidence of high-grade global cerebral edema (H-GCE) following aSAH was 12.99% (110/847). Serum iron levels [odds ratio (OR) = 1.143; 95% confidence interval (CI), (1.097–1.191); p < 0.001] were associated with the occurrence of H-GCE following aSAH in the univariate analysis. This association remained statistically significant even after adjusting for other variables in the multivariate model, with serum iron having an OR of 1.091 (95% CI, 1.043–1.141; p < 0.001) for GCE. After 1:1 PSM, serum iron levels ≤ 10.7 µmol/L remained a significant independent predictor of GCE (p = 0.002). The receiver operating characteristic (ROC) curve analysis determined that a serum iron cut-off value of ≤ 10.7 µmol/L was optimal for predicting H-GCE [Areas under the ROC curves (AUC) = 0.701, 95% CI, (0.669–0.732), p < 0.001; sensitivity, 67.27%; specificity, 63.77%] in patients with aSAH. Additionally, a trend was observed in which higher Hunt-Hess grades (HH grade) were associated with lower serum iron levels, and higher modified Fisher grades (mFisher grade) were associated with lower serum iron levels. In addition, the serum iron level was also associated with a 3-month functional neurological outcome (p < 0.001). Conclusions: The results of this study indicate that a decreased serum iron level serves as a clinically significant biomarker for the prediction of postoperative GCE and a poor outcome at 3-months in patients with aSAH. [ABSTRACT FROM AUTHOR]

Predictable logistics disruptions due to scheduled lockdowns for large-scale events such as the Olympic Games may not only reduce supply chain profits, but also increase carbon emissions. To help solve these problems, an emergency transit policy to be applied to the logistics path is an effective solution. However, optimal inventory control is needed. This paper proposes an optimization model to control ordering and inventory policies for decentralized and centralized supply chains. The model considers the logistics path damping coefficient, the logistics path acceleration coefficient, and the vehicle loading capacity ratio in emergency transit. Our major findings include the following. First, supply chain profits under centralization are confirmed to be higher than under decentralization. Second, a price discount mechanism can achieve supply chain coordination. Third, the manufacturers in a centralized supply chain are more inclined to choose a logistics path with a high acceleration coefficient in order to let their cargo arrive quickly and to reduce the impact of the lead time demand fluctuations. Finally, the implications of our research results for carbon emission reductions are discussed. [ABSTRACT FROM AUTHOR]

Mechanical fault prediction is one of the main problems in condition-based maintenance, and its purpose is to predict the future working status of the machine based on the collected status information of the machine. However, on one hand, the model health indices based on the information collected by the sensors will directly affect the evaluation results of the system. On the other hand, because the model health index is a continuous time series, the effect of feature learning on continuous data also affects the results of fault prognosis. This paper makes full use of the autonomous information fusion capability of the stacked autoencoder and the strong feature learning capability of continuous deep belief networks for continuous data, and proposes a novel fault prognosis method. Firstly, a stacked autoencoder is used to construct the model health index through the feature learning and information fusion of the vibration signals collected by the sensors. To solve the local fluctuations in the health indices, the exponentially weighted moving average method is used to smooth the index data to reduce the impact of noise. Then, a continuous deep belief network is used to perform feature learning on the constructed health index to predict future performance changes in the model. Finally, a fault prognosis experiment based on bearing data was performed. The experimental results show that the method combines the advantages of stacked autoencoders and continuous deep belief networks, and has a lower prediction error than traditional intelligent fault prognosis methods. [ABSTRACT FROM AUTHOR]

Highlights: A new method is proposed to quantitatively assess the equilibrium between primary education facilities and primary students from the perspective of the living circle. The spatial equilibrium of primary education services across Zhangjiakou City was evaluated based on four living circle scenarios. We establish a site selection path to optimize the spatial equilibrium of primary education based on the living circle. Primary education services are a key component of public infrastructure. These services exert significant impacts on public activity, sustainability, and healthy socio-economic development. This research applies the concept of a 'living circle' in order to evaluate the spatial equilibrium of education services in existing primary schools. This has enabled equilibrium planning schemes to be proposed for primary schools as well as the promotion and construction of livable and defensible living spaces. This area remains a key issue, however, one that urgently needs to be addressed in terms of the layout of public infrastructural services to facilitate livable living space construction. Thus, from the perspective of livable and defensible living space construction, the aim of this study was to construct a primary education equalization assessment method based on the walking living circle method. An equilibrium index was also designed based on the number of primary school students; this was then combined with the standard construction of new primary schools to optimize the spatial equilibrium of these education services. The city of Zhangjiakou City was then used as a case study; the spatial equilibrium of primary education services was evaluated across four living circle scenarios (i.e., 15 min, 20 min, 25 min, and 30 min). Results reveal that the city of Zhangjiakou currently offers dramatically spatially negative non-equilibrium primary education services (i.e., supply < demand) across four living circle scenarios, but most notably in rural areas away from urban areas and towns, especially in the counties of Shangyi, Chicheng, Chongli, Kangbao, and Guyuan. It is interesting to note that all living circle scenarios could enable positive non-equilibrium primary education services (i.e., supply > demand), mainly within the urban districts of Qiaodong, Xuanhua, Qiaoxi, Wanquan, and Xiahuayuan. It is also clear that equilibrium living circles are distributed across all counties. A spatial optimization proposal for primary school services should therefore be presented that alleviates the issues inherent to non-equilibrium primary education services. The results of this study offer a number of suggestions for education service optimization across the city of Zhangjiakou as well as for other cities in China. We also provide further scientific foundations for research on livable space and defensible unit construction as well as the spatial equilibrium evaluation of other public infrastructural service facilities [ABSTRACT FROM AUTHOR]

Objective: In this study, we assessed the correlation between the lactate dehydrogenase (LDH) to phosphate ratio and the prognosis of microsurgical clippings for ruptured intracranial aneurysm (rIA) to test the hypothesis that the serum LDH to phosphate ratio could be a predictor of the outcome of microsurgical clipping for rIA. Methods: Records of rIA patients between 2012 and 2018 were retrospectively collected. Age, sex, Hunt-Hess grade, Fisher grade, medical history, aneurysm location, hydrocephalus, laboratory data including serum LDH, phosphate, and LDH to phosphate ratio, related complications, and the outcomes in 3 months were recorded. Results: A total of 1608 rIA patients in our institution were collected, and 856 patients treated by microsurgical clipping were enrolled. On admission, a significantly higher LDH-phosphate ratio was observed in patients with poor outcomes at 3 months (median ± SD, 200.175 ± 107.290 for mRS 0–2 vs. 323.826 ± 219.075 for mRS score 3–6; p = 0.000). An LDH to phosphate ratio of 226.25 in the receiver operating characteristic (ROC) curve was the optimal cutoff value to discriminate between good and poor outcomes at 3 months. The LDH to phosphate ratio ≥ 226.25 on admission was independently correlated with poor outcomes in rIA patients. In addition, Hunt and Hess grade, Fisher grade, pneumonia, and DIND were also independently correlated with poor outcomes. After removing the bias in essential clinical variables between patients with LDH to phosphate, ratio ≥ 226.25 versus <226.25 by PSM, the number of patients with poor outcomes at 3 months increased in patients with an LDH to phosphate ratio of ≥226.25 (p = 0.005). Conclusions: The LDH to phosphate ratio was a potential biomarker and could predict the unfavorable outcome of microsurgical clipping for rIA in 3 months, related to neuronal damage, cerebral hypoxia, and early brain injury after aneurysm ruptures. [ABSTRACT FROM AUTHOR]

Dual-layer-offset or multi-layer-offset design of a PET detector can improve spatial resolution while maintaining high sensitivity. In this study, three dual-layer-offset LYSO detectors with three different reflectors (ESR, Toray, and BaSO4) were developed. The top layer consisted of a 17 × 17 array of crystals 1 × 1 × 6.5 mm3 in size and the bottom layer consisted of an 18 × 18 array of crystals 1 × 1 × 9.5 mm3 in size. Neither light guides nor optical glue were used between the two layers of crystals. A custom-designed electronics system, composed of a 6 × 6 SiPM array, two FPC cables, and a custom-designed data processing module, was used to read out signals. An optimized interaction-decoding algorithm using the center of gravity to determine the position and threshold of analog signals for timing methods was applied to generate decoding flood histograms. The detector performances, in terms of peak to valley ratio of the flood histograms and energy resolutions, were calculated and compared. The dual-layer-offset PET detector constructed with BaSO4 reflectors performed much better than the other two reflectors in both crystal identification and energy resolution. The average peak-to-valley ratio and the energy resolution were approximately 7 and 11%, respectively. In addition, the crystals in the bottom layer showed better performance at crystal identification than those in the top layer. This study can act as a reference providing guidance in choosing scintillator reflectors for multi-layer dedicated DOI detectors designed for small-animal PET imaging. [ABSTRACT FROM AUTHOR]

As a commonly used solution, the multi-ended readout can measure the depth-of-interaction (DOI) for positron emission tomography (PET) detectors. In the present study, the effects of the multi-ended readout design were investigated using the leading-edge discriminator (LED) triggers on the timing performance of time-of-flight (TOF) PET detectors. At the very first, the photon transmission model of the four detectors, namely, single-ended readout, dual-ended readout, side dual-ended readout, and triple-ended readout, was established in Tracepro. The optical simulation revealed that the light output of the multi-ended readout was higher. Meanwhile, the readout circuit could be triggered earlier. Especially, in the triple-ended readout, the light output at 0.5 ns was observed to be nearly twice that of the single-ended readout after the first scintillating photon was generated. Subsequently, a reference detector was applied to test the multi-ended readout detectors that were constructed from a 6 × 6 × 25 mm3 LYSO crystal. Each module is composed of a crystal coupled with multiple SiPMs. Accordingly, its timing performance was improved by approximately 10% after the compensation of fourth-order polynomial fitting. Finally, the compensated full-width-at-half-maximum (FWHM) coincidence timing resolutions (CTR) of the dual-ended readout, side dual-ended readout, and triple-ended readout were 216.9 ps, 231.0 ps, and 203.6 ps, respectively. [ABSTRACT FROM AUTHOR]

Ratiometric near-infrared fluorescent probes (AH+ and BH+) have been prepared for pH determination in mitochondria by attaching dithioacetal and formal residues onto a hemicyanine dye. The reactive formyl group on probe BH+ allows for retention inside mitochondria as it can react with a protein primary amine residue to form an imine under slightly basic pH 8.0. Probes AH+ and BH+ display ratiometric fluorescent responses to pH changes through the protonation and deprotonaton of a hydroxy group in hemicyanine dyes with experimentally determined pKa values of 6.85 and 6.49, respectively. Calculated pKa values from a variety of theoretical methods indicated that the SMDBONDI method of accounting for solvent and van der Waals radii plus including a water molecule located near the site of protonation produced the closest overall agreement with the experimental values at 7.33 and 6.14 for AH+ and BH+ respectively. [ABSTRACT FROM AUTHOR]

The performance of radiation detectors used in positron-emission tomography (PET) is determined by the intrinsic properties of the scintillators, the geometry and surface treatment of the scintillator crystals and the electrical and optical characteristics of the photosensors. Experimental studies were performed to assess the timing resolution and energy resolution of detectors constructed with samples of different scintillator materials (LaBr3, CeBr3, LFS, LSO, LYSO: Ce, Ca and GAGG) that were fabricated into different shapes with various surface treatments. The saturation correction of SiPMs was applied for tested detectors based on a Tracepro simulation. Overall, we tested 28 pairs of different forms of scintillators to determine the one with the best CTR and light output. Two common high-performance silicon photomultipliers (SiPMs) provided by SensL (J-series, 6 mm) or AdvanSiD (NUV, 6 mm) were used for photodetectors. The PET detector constructed with 6 mm CeBr3 cubes achieved the best CTR with a FWHM of 74 ps. The 4 mm co-doped LYSO: Ce, Ca pyramid crystals achieved 88.1 ps FWHM CTR. The 2 mm, 4 mm and 6 mm 0.2% Ce, 0.1% Ca co-doped LYSO cubes achieved 95.6 ps, 106 ps and 129 ps FWHM CTR, respectively. The scintillator crystals with unpolished surfaces had better timing than those with polished surfaces. The timing resolution was also improved by using certain geometric factors, such as a pyramid shape, to improve light transportation in the scintillator crystals. [ABSTRACT FROM AUTHOR]

A fluorescence resonance energy transfer (FRET)-based near-infrared fluorescent probe (B+) for double-checked sensitive detection of intracellular pH changes has been synthesized by binding a near-infrared rhodamine donor to a near-infrared cyanine acceptor through robust C-N bonds via a nucleophilic substitution reaction. To demonstrate the double-checked advantages of probe B+, a near-infrared probe (A) was also prepared by modification of a near-infrared rhodamine dye with ethylenediamine to produce a closed spirolactam residue. Under basic conditions, probe B+ shows only weak fluorescence from the cyanine acceptor while probe A displays nonfluorescence due to retention of the closed spirolactam form of the rhodamine moiety. Upon decrease in solution pH level, probe B+ exhibits a gradual fluorescence increase from rhodamine and cyanine constituents at 623 nm and 743 nm respectively, whereas probe A displays fluorescence increase at 623 nm on the rhodamine moiety as acidic conditions leads to the rupture of the probe spirolactam rings. Probes A and B+ have successfully been used to monitor intracellular pH alternations and possess pKa values of 5.15 and 7.80, respectively. [ABSTRACT FROM AUTHOR]