1. Development of Magnetic Particle Distribution Imaging Using Magnetic Field Reconstruction for Biopsy of the Sentinel Lymph Node.
- Author
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Akari Inagaki, Tomoko Suzuki, Yuki Mima, and Kenjiro Kimura
- Subjects
LYMPH node cancer ,SENTINEL lymph node biopsy ,MAGNETIC fields ,MAGNETIC resonance imaging of cancer ,RADIOACTIVE tracers - Abstract
The sentinel lymph node is the first lymph-node-draining cancer metastasis. The identification of the sentinel lymph node using magnetic particles and a magnetic sensor has attracted attention in recent years, as this method is less invasive than the conventional method of radiotracer injection. However, the development of a two-dimensional measurement method for sentinel lymph nodes using magnetic nanoparticles remains an issue. In the present study, a method and apparatus for the two-dimensional imaging of magnetic particle distribution were developed to detect a lymph node with magnetic particles concentrated within lymphoid tissues. The method comprises the reconstruction of the magnetic field measured with a high-sensitivity magnetic sensor and with a magnetic detection ability of 2 nT/pHz at 100 Hz (5 nT/pHz at 1 Hz). The proposed system measures the two-dimensional magnetic field distribution in an area of up to 25 x 25 mm² using a coil generating a 0.77 mT external magnetic field applied to the measurement target. The improved spatial resolution of the images makes it possible to use two-dimensional imaging for diagnostics of breast cancer metastases. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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