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Simple Summary: The incidence of obstructive sleep apnea in children is increasing year by year, and its occurrence and related metabolic and endocrine lesions may be related to hypothalamic dysfunction. Lysine acetylation is a common post-translational modification that is essential for metabolism. The aim of this study was to determine the effects of chronic intermittent hypoxia-induced lysine acetylation on hypothalamic function in an infant mice model, simulating pediatric obstructive sleep apnoea patients. Our study revealed the lysine acetylome and proteomic profile of the hypothalamus induced by chronic intermittent hypoxia in juvenile mice. Differentially acetylated proteins were involved in endocrine metabolism, the citrate cycle (TCA cycle), synapse function, and circadian entrainment. Our findings suggest that chronic intermittent hypoxia may induce metabolic and endocrine dysregulation through modulation of hypothalamic lysine acetylation. Paediatric obstructive sleep apnoea (OSA) is a highly prevalent sleep disorder resulting in chronic intermittent hypoxia (CIH) that has been linked to metabolism and endocrine impairment. Protein acetylation, which is a frequently occurring posttranslational modification, plays pivotal roles in the regulation of hypothalamic processes. However, the effects of CIH-induced global protein acetylation on hypothalamic function and endocrine metabolism remain poorly understood. To bridge this knowledge gap, we conducted a study utilizing liquid chromatography–mass spectrometry to analyse the lysine acetylome and proteome of the hypothalamus in healthy infantile mice exposed to 3 weeks of intermittent hypoxia (as a CIH model) compared to normoxic mice (as controls). Our analysis identified and quantified 2699 Kac sites in 2453 proteins. These acetylated proteins exhibited disruptions primarily in endocrine metabolism, the citrate cycle (TCA cycle), synapse function, and circadian entrainment. Additionally, we observed significant down-regulation of proteins that are known to be involved in endocrine hormone secretion. This study aimed to elucidate the molecular mechanisms underlying CIH-induced alterations in protein acetylation within the hypothalamus. By providing valuable insights into the pathophysiological processes associated with CIH and their impacts on hypothalamic function, our findings contribute to a deeper understanding of the consequences stemming from CIH-induced changes in protein acetylation within the hypothalamus as well as its potential role in endocrine impairment. [ABSTRACT FROM AUTHOR]

The proper supplementation of boron, an essential trace element, can enhance animal immune function. We utilized the method of TMT peptide labeling in conjunction with LC-MS/MS quantitative proteomics for the purpose of examining the effects of boric acid on a rat model and analyzing proteins from the duodenum. In total, 5594 proteins were obtained from the 0, 10, and 320 mg/L boron treatment groups. Two hundred eighty-four proteins that exhibit differential expression were detected. Among the comparison, groups of 0 vs. 10 mg/L, 0 vs. 320 mg/L, and 10 vs. 320 mg/L of boron, 110, 32, and 179 proteins, respectively, demonstrated differential expression. The results revealed that these differential expression proteins (DEPs) mainly clustered into two profiles. GO annotations suggested that most of the DEPs played a role in the immune system process, in which 2′-5′-oligoadenylate synthetase-like, myxovirus resistance 1, myxovirus resistance 2, dynein cytoplasmic 1 intermediate chain 1, and coiled-coil domain containing 88B showed differential expression. The DEPs had demonstrated an augmentation in the signaling pathways, which primarily include phagosome, antigen processing, and presentation, as well as cell adhesion molecules (CAMs). Our study found that immune responses in the duodenum were enhanced by lower doses of boron and that this effect is likely mediated by changes in protein expression patterns in related signaling pathways. It offers an in-depth understanding of the underlying molecular mechanisms that lead to immune modulation in rats subjected to dietary boron treatment. [ABSTRACT FROM AUTHOR]

GaN-based μLEDs with superior properties have enabled outstanding achievements in emerging micro-display, high-quality illumination, and communication applications, especially white-light visible light communication (WL-VLC). WL-VLC systems can simultaneously provide white-light solid-state lighting (SSL) while realizing high-speed wireless optical communication. However, the bandwidth of conventional white-light LEDs is limited by the long-lifetime yellow yttrium aluminum garnet (YAG) phosphor, which restricts the available communication performance. In this paper, white-light GaN-μLEDs combining blue InGaN-μLEDs with green/red perovskite quantum dots (PQDs) are proposed and experimentally demonstrated. Green PQDs (G-PQDs) and red PQDs (R-PQDs) with narrow emission spectrum and short fluorescence lifetime as color converters instead of the conventional slow-response YAG phosphor are mixed with high-bandwidth blue InGaN-μLEDs to generate white light. The communication and illumination performances of the WL-VLC system based on the white-light GaN-based μLEDs are systematically investigated. The VLC properties of monochromatic light (green/red) from G-PQDs or R-PQDs are studied in order to optimize the performance of the white light. The modulation bandwidths of blue InGaN-μLEDs, G-PQDs, and R-PQDs are up to 162 MHz, 64 MHz, and 90 MHz respectively. Furthermore, the white-light bandwidth of 57.5 MHz and the Commission Internationale de L'Eclairage (CIE) of (0.3327, 0.3114) for the WL-VLC system are achieved successfully. These results demonstrate the great potential and the direction of the white-light GaN-μLEDs with PQDs as color converters to be applied for VLC and SSL simultaneously. Meanwhile, these results contribute to the implementation of full-color micro-displays based on μLEDs with high-quality PQDs as color-conversion materials. [ABSTRACT FROM AUTHOR]

Modulo-scheduled coarse-grained reconfigurable array (CGRA) processors have shown their potential for exploiting loop-level parallelism at high energy efficiency. However, these CGRAs need frequent reconfiguration during their execution, which makes them suffer from large area and power overhead for context memory and context-fetching. To tackle this challenge, this paper uses an architecture/compiler co-designed method for context reduction. From an architecture perspective, we carefully partition the context into several subsections and only fetch the subsections that are different to the former context word whenever fetching the new context. We package each different subsection with an opcode and index value to formulate a context-fetching primitive (CFP) and explore the hardware design space by providing the centralized and distributed CFP-fetching CGRA to support this CFP-based context-fetching scheme. From the software side, we develop a similarity-aware tuning algorithm and integrate it into state-of-the-art modulo scheduling and memory access conflict optimization algorithms. The whole compilation flow can efficiently improve the similarities between contexts in each PE for the purpose of reducing both context-fetching latency and context footprint. Experimental results show that our HW/SW co-designed framework can improve the area efficiency and energy efficiency to at most 34% and 21% higher with only 2% performance overhead. [ABSTRACT FROM AUTHOR]

The incidence of obesity and colorectal cancer (CRC) has risen rapidly in recent decades. More than 650 million obese and 2 billion overweight individuals are currently living in the world. CRC is the third most common cancer. Obesity is regarded as one of the key environmental risk factors for the pathogenesis of CRC. In the present review, we mainly focus on the epidemiology of obesity and CRC in the world, the United States, and China. We also summarize the molecular mechanisms linking obesity to CRC in different aspects, including nutriology, adipokines and hormones, inflammation, gut microbiota, and bile acids. The unmet medical needs for obesity-related CRC are still remarkable. Understanding the molecular basis of these associations will help develop novel therapeutic targets and approaches for the treatment of obesity-related CRC. [ABSTRACT FROM AUTHOR]

This paper presents two new models for solving image the deblurring problem in the presence of impulse noise. One involves a high-order total variation (TV) regularizer term in the corrected total variation L1 (CTVL1) model and is named high-order corrected TVL1 (HOCTVL1). This new model can not only suppress the defects of the staircase effect, but also improve the quality of image restoration. In most cases, the regularization parameter in the model is a fixed value, which may influence processing results. Aiming at this problem, the spatially adapted regularization parameter selection scheme is involved in HOCTVL1 model, and spatially adapted HOCTVL1 (SAHOCTVL1) model is proposed. When dealing with corrupted images, the regularization parameter in SAHOCTVL1 model can be updated automatically. Many numerical experiments are conducted in this paper and the results show that the two models can significantly improve the effects both in visual quality and signal-to-noise ratio (SNR) at the expense of a small increase in computational time. Compared to HOCTVL1 model, SAHOCTVL1 model can restore more texture details, though it may take more time. [ABSTRACT FROM AUTHOR]