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2 results on '"Yangyang Shang"'

1. Histone H3 Methyltransferase Suv39h1 Prevents Myogenic Terminal Differentiation by Repressing MEF2 Activity in Muscle Cells

Author

Jian Peng, Wei Jin, Siwen Jiang, and Yangyang Shang

Subjects
0301 basic medicine, Mef2, Chromatin Immunoprecipitation, epigenetic modification, histone methylation, Suv39h1, protein interaction, MEF2, myoblasts differentiation, Blotting, Western, Biology, Muscle Development, Real-Time Polymerase Chain Reaction, Catalysis, Chromatin remodeling, Article, Cell Line, Epigenesis, Genetic, lcsh:Chemistry, Inorganic Chemistry, Myoblasts, 03 medical and health sciences, Mice, medicine, Myocyte, Animals, Immunoprecipitation, MEF2C, Physical and Theoretical Chemistry, lcsh:QH301-705.5, Molecular Biology, Transcription factor, Spectroscopy, Organic Chemistry, Skeletal muscle, Cell Differentiation, General Medicine, Methyltransferases, musculoskeletal system, Molecular biology, Computer Science Applications, Repressor Proteins, 030104 developmental biology, medicine.anatomical_structure, lcsh:Biology (General), lcsh:QD1-999, Myogenic regulatory factors, Ectopic expression
Abstract

The myogenic regulatory factors (MRFs) and myocyte enhancer factor 2 (MEF2) transcription factors have been extensively studied as key transcription factors that regulate myogenic gene expression. However, few reports on the molecular mechanism that modulates chromatin remodeling during skeletal muscle differentiation are available. We reported here that the expression of the H3-K9 methyltransferase Suv39h1 was decreased during myoblast differentiation. Ectopic expression of Suv39h1 could inhibit myoblast differentiation, increasing H3-K9 methylation levels, whereas knockdown of Suv39h1 stimulated myoblast differentiation. Furthermore, Suv39h1 interacted with MEF2C directly and inhibited MEF2 transcription activity in a dose-dependent manner. Together, our studies revealed a molecular mechanism wherein Suv39h1 modulated myogenic gene expression and activation during skeletal muscle differentiation.

Published
2016

2. Histone H3 Methyltransferase Suv39h1 Prevents Myogenic Terminal Differentiation by Repressing MEF2 Activity in Muscle Cells.

Author

Wei Jin, Yangyang Shang, Jian Peng, and Siwen Jiang

Subjects
*MUSCLE cells, *TRANSCRIPTION factors, *GENE expression, *MYOBLASTS, *SKELETAL muscle
Abstract

The myogenic regulatory factors (MRFs) and myocyte enhancer factor 2 (MEF2) transcription factors have been extensively studied as key transcription factors that regulate myogenic gene expression. However, few reports on the molecular mechanism that modulates chromatin remodeling during skeletal muscle differentiation are available. We reported here that the expression of the H3-K9 methyltransferase Suv39h1 was decreased during myoblast differentiation. Ectopic expression of Suv39h1 could inhibit myoblast differentiation, increasing H3-K9 methylation levels, whereas knockdown of Suv39h1 stimulated myoblast differentiation. Furthermore, Suv39h1 interacted with MEF2C directly and inhibited MEF2 transcription activity in a dose-dependent manner. Together, our studies revealed a molecular mechanism wherein Suv39h1 modulated myogenic gene expression and activation during skeletal muscle differentiation. [ABSTRACT FROM AUTHOR]

Published
2016
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