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This study explores storm floods in the Yangtze Estuary to investigate how extreme sea levels and storm surges change in the context of global warming. Previous studies focused on the long-term variations in amplitude or frequency of storm surges, with limited research conducted on the timing of extreme storm surge events. Based on the methods of non-stationary extreme value theory, we explored the last 33-year tidal levels at Xuliujing Station and found that the annual extreme water level has exhibited a slight downward trend, which is directly attributed to the decrease in mean sea level resulting from reduced upstream river flow. The storm surge season of the Yangtze Estuary experienced a significant lag in the period 2005–2018, which is not restricted to the Yangtze Estuary but is rather a large-scale climate characteristic of a broad oceanic region. The reason for this shift is the sustained increase in the intensity of the western Pacific subtropical high in the last 15 years, leading to the appearance of low-pressure channels in the East China Sea in September and October and thus causing more typhoons to enter the East China Sea during the later period of the storm surge season. [ABSTRACT FROM AUTHOR]

Telomeres are nucleoprotein complexes that cap the ends of eukaryotic linear chromosomes. Telomeric DNA is bound by shelterin protein complex to prevent telomeric chromosome ends from being recognized as damaged sites for abnormal repair. To overcome the end replication problem, cancer cells mostly preserve their telomeres by reactivating telomerase, but a minority (10–15%) of cancer cells use a homologous recombination-based pathway called alternative lengthening of telomeres (ALT). Recent studies have found that shelterin components play an important role in the ALT mechanism. The binding of TRF1, TRF2, and RAP1 to telomeres attenuates ALT activation, while the maintenance of ALT telomere requires TRF1 and TRF2. POT1 and TPP1 can also influence the occurrence of ALT. The elucidation of how shelterin regulates the initiation of ALT remains elusive. This review presents a comprehensive overview of the current findings on the regulation of ALT by shelterin components, aiming to enhance the insight into the altered functions of shelterin components in ALT cells and to identify potential targets for the treatment of ALT tumor cells. [ABSTRACT FROM AUTHOR]