1. Novel Insights into the Role of Long Noncoding RNA in Ocular Diseases
- Author
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Xuyang Wen, Fang Li, Xianqun Fan, and He Zhang
- Subjects
0301 basic medicine ,Proliferative vitreoretinopathy ,genetic structures ,Eye Diseases ,Glaucoma ,Detailed data ,Review ,Biology ,Bioinformatics ,Catalysis ,lcsh:Chemistry ,Inorganic Chemistry ,03 medical and health sciences ,medicine ,Humans ,Epigenetics ,long noncoding RNA ,Physical and Theoretical Chemistry ,Ocular disease ,lcsh:QH301-705.5 ,Molecular Biology ,Spectroscopy ,Diabetic Retinopathy ,epigenetics ,Organic Chemistry ,Vitreoretinopathy, Proliferative ,ocular disease ,General Medicine ,Diabetic retinopathy ,medicine.disease ,Long non-coding RNA ,eye diseases ,Computer Science Applications ,030104 developmental biology ,lcsh:Biology (General) ,lcsh:QD1-999 ,RNA, Long Noncoding ,sense organs ,Biomarkers - Abstract
Recent advances have suggested that long noncoding RNAs (lncRNAs) are differentially expressed in ocular tissues and play a critical role in the pathogenesis of different types of eye diseases. Here, we summarize the functions and mechanisms of known aberrantly-expressed lncRNAs and present a brief overview of relevant reports about lncRNAs in such ocular diseases as glaucoma, proliferative vitreoretinopathy (PVR), diabeticretinopathy (DR), and ocular tumors. We intend to highlight comprehensive studies that provide detailed data about the mechanisms of lncRNAs, their applications as diagnostic or prognostic biomarkers, and their potential therapeutic targets. Although our understanding of lncRNAs is still in its infancy, these examples may provide helpful insights into the methods by which lncRNAs interfere with ocular diseases.
- Published
- 2016