1. Identification of N-Acetyldopamine Dimers from the Dung Beetle Catharsius molossus and Their COX-1 and COX-2 Inhibitory Activities
- Author
-
Juan Lu, Qin Sun, Pi-Xian Shui, Qing Lv, Zhengchao Tu, and Yong-Xian Cheng
- Subjects
Dopamine ,Catharsius molossus ,Pharmaceutical Science ,Inhibitory postsynaptic potential ,N-acetyldopamine dimers ,Article ,Analytical Chemistry ,Cell Line ,Madin Darby Canine Kidney Cells ,lcsh:QD241-441 ,Dogs ,lcsh:Organic chemistry ,Drug Discovery ,N-acetyldopamine ,Insect Proteins ,Animals ,Humans ,Physical and Theoretical Chemistry ,Enzyme Inhibitors ,Dung beetle ,biology ,Traditional medicine ,Molecular Structure ,Chemistry ,COX-1 ,Organic Chemistry ,Madin Darby canine kidney cell ,COX-2 ,biology.organism_classification ,Coleoptera ,Biochemistry ,Chemistry (miscellaneous) ,Cell culture ,Cyclooxygenase 2 ,Cyclooxygenase 1 ,MCF-7 Cells ,Molecular Medicine ,Identification (biology) ,HeLa Cells - Abstract
Recent studies focusing on identifying the biological agents of Catharsius molossus have led to the identification of three new N-acetyldopamine dimers molossusamide A-C (1-3) and two known compounds 4 and 5. The structures of the new compounds were identified by comprehensive spectroscopic evidences. Compound 4 was found to have inhibitory effects towards COX-1 and COX-2.
- Published
- 2015