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To investigate pedestrian route choice mechanisms from a perspective distinct from that employed in discrete choice models (DCMs), this study utilizes machine learning models and employs SHapley Additive exPlanations (SHAP) for model interpretation. The data used in this paper come from several pedestrian flow experiments with two routes, which were recorded by UAV. Our findings indicate that logistic regression (similar to a binary logit model) exhibits good computational efficiency but falls short in predictive accuracy when compared to other machine learning models. Among the 12 machine learning models assessed, by calculating the new indicator named OP, we find that eXtreme Gradient Boosting (XGB) and Light Gradient Boosting (LGB) strike the best balance between accuracy and computational efficiency. Regarding feature contribution, our analysis reveals that bottlenecks exert the most significant influence on pedestrian route choice behavior, followed by the time it takes pedestrians to return from the end of the route to the origin (reflecting pedestrian characteristics and attitudes). While the pedestrian density of the shorter route contributes less compared to bottlenecks and return time, it exhibits a threshold effect, meaning that once the density of the shorter route surpasses a certain threshold, most pedestrians opt for the longer route. [ABSTRACT FROM AUTHOR]

Rice, a staple food for billions around the globe, is cultivated in numerous forms. Among them, soft rice is well known, which is characterized by its tender, creamy consistency and desirable texture. In this study, we examined the physicochemical properties and fine structure of starch from two soft rice varieties, Jinong Xiangruan 1 and DGR1, cultivated in different regions in China (Baodi District, Tianjin City; Liaoning Province; and Fengyang City, Anhui Province). The aim was to understand how amylopectin content (AC) influences rice quality. This research aims to bridge the knowledge gap regarding the role of amylopectin in determining rice's adhesive consistency and viscosity. Significant regional differences were observed in yield components such as the number of grains per panicle, seed setting rates and 1000-grain weight, with Liaoning generally showing higher performance metrics compared to other regions. Physicochemical analysis highlighted that though glue consistency and taste values showed little regional variation, AC significantly influenced rice hardness and viscosity. Rapid Visco Analyzer (RVA) profile analysis further demonstrated distinct differences in viscosity characteristics, underscoring the regional impacts on starch behavior. Additionally, molecular weight distribution and amylopectin chain length analysis, conducted via SEC-MALLS-RI and ICS ion chromatography, revealed notable differences in starch composition across varieties and locations. The findings suggest that environmental conditions play a crucial role in defining starch characteristics and, consequently, the eating quality of rice. This provides valuable insights for breeding high-quality japonica rice with broad adaptability. [ABSTRACT FROM AUTHOR]

In recent years, the volcanic activity of Changbai Mountain has been accompanied by several earthquakes, and the frequent human engineering activities have led to a gradual increase in the number of collapses in the region, which severely impacts residents' lives and property safety. In northeastern China, the Changbai Mountain area in the southeastern Jilin Province is a typical mountain environment. This paper selects 12 evaluation indicators to build a hazard assessment system, including slope, aspect, elevation, curvature, lithology, NDVI, land use type, distance from the fault, the river from the road, volcanic earthquake, and annual average precipitation. Using emotional weight (G1 method) and objective weight (WOE-CV method), the hazard due to collapses in the study area is evaluated too. Among them, the transcendence probability of volcanic earthquakes greater than VI degree represents the relationship between Changbai Mountain volcanic earthquakes and the assessment of geological collapse hazard. The results show that high- and very high-hazard areas are mainly distributed in densely populated areas and national and provincial trunk lines, with apparent spatial agglomeration characteristics. The low-hazard area, medium-hazard area, high-hazard area and very high-hazard area accounted for 19.33%, 44.19%, 33.85% and 2.63% of the total area of the study area, respectively. By comparing the previous geological hazard survey reports in the area with the collapse hazard zoning map in this paper, 87.72% of the known collapse hazard areas are distributed within high and very high hazard zones, indicating that the conclusions of the article are more accurate and in line with the actual situation. Results from collapse-related hazards can provide relevant guidance for preventing and controlling geological risks posed by volcanic earthquakes affecting Changbai Mountain. [ABSTRACT FROM AUTHOR]

The pathogenesis of ulcerative colitis (UC) is associated with inflammation, oxidative stress, and gut microbiota imbalance. Although most researchers have demonstrated the antioxidant bioactivity of the phenolic compounds in plants, their UC-curing ability and underlying mechanisms still need to be further and adequately explored. Herein, we studied the antioxidation–structure relationship of several common polyphenols in plants including gallic acid, proanthocyanidin, ellagic acid, and tannic acid. Furthermore, the in vivo effects of the plant polyphenols on C57BL/6 mice with dextran-sulfate-sodium-induced UC were evaluated and the action mechanisms were explored. Moreover, the interplay of several mechanisms was determined. The higher the number of phenolic hydroxyl groups, the stronger the antioxidant activity. All polyphenols markedly ameliorated the symptoms and pathological progression of UC in mice. Furthermore, inflammatory cytokine levels were decreased and the intestinal barrier was repaired. The process was regulated by the antioxidant-signaling pathway of nuclear-erythroid 2-related factor 2. Moreover, the diversity of the intestinal microbiota, Firmicutes-to-Bacteroides ratio, and relative abundance of beneficial bacteria were increased. An interplay was observed between microbiota regulation and oxidative stress, immunity, and inflammatory response. Furthermore, intestinal barrier repair was found to be correlated with inflammatory responses. Our study results can form a basis for comprehensively developing plant-polyphenol-related medicinal products. [ABSTRACT FROM AUTHOR]

Long-term antibiotic use induces drug resistance in bacteria. This has given rise to the challenge of refractory infections, which have become a global health threat. Berberine (BBR) and tannic acid (TA) from plants exhibit promising antibacterial activities and may overcome antibiotic resistance. However, poor solubility and/or low penetration capability have limited their application. Carrier-free co-assembled nanocomposites composed entirely of BBR and TA exhibit improved or new properties and produce improved efficacy. Herein, we demonstrated that an ordered nanostructure could be spontaneously co-assembled by the solvent evaporation method using the two natural products. These co-assembled berberine–tannic acid nanoparticles (BBR-TA NPs) exhibited the best antibacterial effect compared with the corresponding physical mixture, pristine BBR, and some first-line antibiotics (benzylpenicillin potassium-BP and ciprofloxacin-Cip) against Staphylococcus aureus (S. aureus) and multidrug-resistant Staphylococcus aureus (MRSA). Even if the concentration of BBR-TA NPs was as low as 15.63 μg/mL, the antibacterial rate against S. aureus and MRSA was more than 80%. In addition to the synergistic effect of the two compounds, the antibacterial mechanism underlying the nanostructures was that they strongly adhered to the surface of the bacterial cell wall, thereby inducing cell membrane damage and intracellular ATP leakage. Furthermore, the in vivo wound healing effect of BBR-TA NPs was verified using an MRSA wound infection mouse model. The BBR-TA NPs achieved the best efficacy compared with BP and Cip. Moreover, cytotoxic and histopathological evaluations of mice revealed that the nanodrug had good biological safety. This facile and green co-assembly strategy for preparing nanoparticles provides a feasible reference for the clinical treatment of bacterial infection. [ABSTRACT FROM AUTHOR]

Taking Erdaojiang and Dongchang District of Tonghua City, Jilin Province as examples, this paper studies the ecological environment restoration and governance model of their mining areas. In this paper, the vegetation cover (NDVI) data in the past ten years were selected from the study area. The Theil–Sen median and Mann–Kendall (MK) methods were used to analyze the time series of NDVI, and the vegetation cover change trend map of the study area was obtained. Then, the land use data of the study area for 4 years were selected, and the transfer matrix method was used to analyze the land use conversion between the years. Finally, according to the characteristics of the distribution of mines in the study area, for the mining area in different natural geographical locations, it was concluded that the restoration of cultivated land and the restoration of forest land and ecological reconstruction were adopted. Among them, the restoration of forest land includes natural restoration and artificial intervention. [ABSTRACT FROM AUTHOR]

Changbai Mountain is an important part of the development and opening pilot area of Changjitu. It is the birthplace of Songhua River, Yalu River, and Tumen River, and is known as the source of the three rivers. Millions of people live in the basin. A volcanic eruption accompanied by earthquakes would lead to a large number of landslides, debris flows, and show a chain effect, the formation of a secondary geological disaster chain, which is a serious threat to people's lives and property safety. This paper selected indexes from three aspects: the hazard of earthquake-induced geological disaster chain, the exposure and vulnerability of disaster-bearing bodies, and the risk assessment of earthquake-induced geological disaster chain. The sensitivity values of each influence factor were calculated by the certainty factor (CF) using the support vector machine, and then, the susceptibility assessment was obtained. The cumulative displacement calculated by the Newmark model represented the potential risk intensity. We considered the Changbai Mountain volcanic earthquake–landslide disaster chain as an example. The results of risk assessment showed that the extremely high and high risk areas were mainly located within the 12 km radius of Tianchi Lake, and the other areas in the study area were mainly associated with very low to low risk values. The verification results showed that the receiver operating characteristic (ROC) curve area was 0.8373, indicating that the method was very effective in the identification and assessment of seismic hazard chain risk. In these high-risk areas, relevant countermeasures should be formulated to prevent the risk of geological disasters, strengthen the implementation of regional disaster prevention and reduction work, and ensure the safety of residents' lives and property. [ABSTRACT FROM AUTHOR]

Due to the shortcomings of the standard bat algorithm (BA) for multi-parameter optimization, an improved bat algorithm is proposed. The benchmark function test shows that the proposed algorithm has better realization of high-dimensional function optimization by introducing multiple flight modes, adopting adaptive strategy based on group trend, and employing loudness mutation flight selection strategy based on Brownian motion. Aiming at the characteristics of complex networks structure and multiple design variables of energy harvesting non-orthogonal multiple access cognitive relay networks (EH-NOMA-CRNs), we utilize the proposed hybrid strategy improved bat algorithm (HSIBA) to optimize the performance of EH-NOMA-CRNs. At first, we construct a novel two-hop underlay power beacon assisted EH-NOMA-CRN, and derive the closed-form expressions of secondary network's outage probability and throughput. Then, the secondary network performance optimization is formulated as the throughput maximation problem with regard to EH ratio and power allocation factors. Subsequently, the HSIBA is employed to optimize the above parameters. Numerical results show that the proposed HSIBA can achieve optimization to the constructed EH-NOMA-CRN with faster convergence speed and higher stability. [ABSTRACT FROM AUTHOR]

The long-term application of sensors in a high-temperature environment needs to address several challenges, such as stability at high temperatures for a long time, better wiring interconnection of sensors, and reliable and steady connection of the sensor and its external equipment. In order to systematically investigate the reliability of thin coatings at high temperatures for a long time, Au and Cr layers were deposited on silicon substrates by magnetron sputtering. Additionally, samples with different electrode thicknesses were annealed at different temperatures for a varied duration to study the effect of electrode thickness, temperature, and duration on the reliability of samples. The results of tensile and probe tests before and after heat treatment revealed that the mechanical strength and electrical properties have changed after annealing. In addition, the bonding interface was analyzed by a cross-sectional electron microscope. The analysis showed that long-term continuous high-temperature exposure would result in thinning of the electrode, formation of pores, recrystallization, and grain growth, all of which can affect the mechanical strength and electrical properties. In addition, it was observed that increasing the thickness of the gold layer will improve reliability, and the test results show that although the thin metal layer sample is in poor condition, it is still usable. The present study provides theoretical support for the application of thin coatings in high temperatures and harsh environments. [ABSTRACT FROM AUTHOR]

Background: Various potential effect of drugs on alleviating diseases by regulating intestinal microbiome as well as the pharmaceutical excipients on gut microbiota has been revealed. However, the interaction between them is rarely investigated. Methods: Histological analysis, immunohistochemistry analysis, enzyme-linked immunosorbent assay (ELISA) analysis, RT-qPCR, and 16S rRNA analysis were utilized to explore the effect mechanism of the five excipients including hydroxypropyl methylcellulose (HPMC) F4M, Eudragit (EU) S100, chitosan (CT), pectin (PT), and rheum officinale polysaccharide (DHP) on berberine (BBR) to cure UC. Results: The combined BBR with PT and DHP group exhibited better therapeutic efficacy of UC with significantly increased colon length, and decreased hematoxylin-eosin (H&E) scores than other groups. Furthermore, the expression of tight junction ZO-1 and occludin in colon tissue were upregulated, and claudin-2 was downregulated. Ultimately, the serum content of tumor necrosis (TNF)-α, interleukin (IL)-1β, and IL-6 was decreased. Moreover, the combined BBR with PT significantly promoted the restoration of gut microbiota. The relative abundance of Firmicutes and Lactobacillus was significantly increased by the supplement of PT and DHP, and the relative abundance of Proteobacteria was downregulated. Conclusions: Our study may provide a new perspective that the selection of pharmaceutical excipients could be a crucial factor affecting the drugs' therapeutic efficiency outcome. [ABSTRACT FROM AUTHOR]

In this study, two districts, Erdaojiang District and Dongchang District, in Tonghua City, Jilin Province, were evaluated for their geological environment carrying capacity. A total of 14 evaluation indicators were selected from the three aspects of the geological environment, ecological environment, and social environment to make it more comprehensive to evaluate the carrying capacity of the geological environment. Using the AHP and CRITIC methods, the subjective weight and objective weight of each evaluation index are obtained, and the combined weight is calculated by game theory. When combined with the GIS and combined weights, the distribution map of the geological environment carrying capacity is obtained, and it is classified into four grades: excellent, good, medium, and poor. A comprehensive evaluation of the carrying capacity of the geological environment is carried out. The following conclusions are drawn: the overall carrying capacity of the geological environment in the study area is good, and the carrying capacity of individual areas is poor. The comparative analysis of the good and poor areas provides a scientific basis for future environmental governance and urban planning and provides a scientific basis for geological disasters and mines. [ABSTRACT FROM AUTHOR]

Urban waterlogging will harm economic development and people's life safety; however, the waterlogging risk zoning map provides the necessary decision support for the management of urban waterlogging, urban development and urban planning. This paper proposes an urban waterlogging risk assessment method that combines multi-criteria decision analysis (MCDA) with a geographic information system (GIS). The framework of urban waterlogging risk assessment includes four main elements: hazard, exposure, vulnerability, and emergency response and recovery capability. Therefore, we selected the urban area of Changchun City, Jilin Province as the study area. The Analytic Hierarchy Process (AHP) is a generally accepted MCDA method, it is used to calculate the weight and generate a result map of hazards, exposure, vulnerability, and emergency responses and recovery capability. Based to the principle of natural disaster risk formation, a total of 18 parameters, including spatial data and attribute data, were collected in this study. The model results are compared with the recorded waterlogging points, and the results show that the model is more reliable. [ABSTRACT FROM AUTHOR]

The urbanization rate in China has been increasing in recent years, and along with the increasing intensity of human engineering activities, ecological and geological (eco-geological) degradation have become key factors impeding sustainable urban development. Taking the concentrated mineral exploitation area of Tonghua City as an example, the distribution of mines in the area is concentrated and the spatial heterogeneity is significant. This paper includes 14 evaluation indicators in three aspects: eco-geological environment background, anthropogenic and mining engineering activities, and environmental pollution. Then, based on game theory combined with ANP-CV (Analytic Network Process and Coefficient of Variation), two empowerment methods, GIS spatial calculation is used to evaluate the eco-geological environment quality (EEQ). The results showed that the EEQ was divided into grades I–V from high to low, with areas of 21.13%, 30.35%, 27.00%, 14.30%, and 7.22%, respectively; the EEQ of the Hun River basin has a high spatial autocorrelation and low EEQ, and the EEQ grade of mines was divided on this basis; the hot spot analysis is useful for determining the EEQ, as well as for allocating mine restoration resources in a sensible manner. Finally, we propose countermeasures to improve EEQ, and this study can provide a scientific basis for ecological construction and geological environmental protection in Tonghua City. [ABSTRACT FROM AUTHOR]

Clean groundwater resources are vital to human health. To evaluate groundwater quality in the Songnen Plain (Jilin), a field investigation sampling test, multivariate statistical analysis, and spatial analysis were conducted based on a geographic information system. The main substances exceeding the standard were screened out, and the main controlling factors affecting groundwater quality were discussed. The research result showed that nine components exceeded groundwater standards by approximately 10%: Al, total hardness (TH), total dissolved solids (TDS), Mn, As, NO3−, Fe, F−, and BaP. The over-standard of TDS and TH in groundwater are mainly distributed in the geological environment conditions and unreasonable exploitation and utilization of groundwater in this area. The results of the multi-index evaluation showed that the most important factors affecting groundwater quality were general chemical indices, followed by inorganic toxicology and heavy metals. Controlling the overexploitation of water resources, controlling agricultural activities and sewage discharge, and implementing water conservation systems are the main pathways to improve water quality in the study area. The research results can provide a reference for groundwater pollution control and water resource protection in the Songnen Plain (Jilin). [ABSTRACT FROM AUTHOR]

Sparse signal processing has already been introduced to synthetic aperture radar (SAR), which shows potential in improving imaging performance based on raw data or a complex image. In this paper, the relationship between a raw data-based sparse SAR imaging method (RD-SIM) and a complex image-based sparse SAR imaging method (CI-SIM) is compared and analyzed in detail, which is important to select appropriate algorithms in different cases. It is found that they are equivalent when the raw data is fully sampled. Both of them can effectively suppress noise and sidelobes, and hence improve the image performance compared with a matched filtering (MF) method. In addition, the target-to-background ratio (TBR) or azimuth ambiguity-to-signal ratio (AASR) performance indicators of RD-SIM are superior to those of CI-SIM in down-sampling data-based imaging, nonuniform displace phase center sampling, and sparse SAR imaging model-based azimuth ambiguity suppression. [ABSTRACT FROM AUTHOR]

Wound healing is one of the major challenges in the biomedical fields. The conventional single drug treatment has unsatisfactory efficacy, and the drug delivery effectiveness is restricted by the short retention on the wound. Herein, we develop a multifunctional adhesive hydrogel that can realize robust adhesion, transdermal delivery, and combination therapy for wound healing. Multifunctional hydrogels (CS-GA-S) are mixed with chitosan-gallic acid (CS-GA), sodium periodate, and centipede peptide-scolopin2, which slowly releases scolopin2 in the layer of the dermis. The released scolopin2 induces the pro-angiogenesis of skin wounds and enables excellent antibacterial effects. Separately, GA as a natural reactive-oxygen-species-scavenger promotes antioxidation, and further enables excellent antibacterial effects and wet tissue adhesion due to a Schiff base and Michael addition reaction for accelerating wound healing. Once adhered to the wound, the precursor solution becomes both a physically and covalently cross-linked network hydrogel, which has potential advantages for wound healing with ease of use, external environment-isolating, and minimal tissue damage. The therapeutic effects of CS-GA-S on wound healing are demonstrated with the full thickness cutaneous wounds of a mouse model. The significant improvement of wound healing is achieved for mice treated with CS-GA-S. This preparation reduces wound system exposure, prolongs local drug residence time, and improves efficacy. Accordingly, with the incorporation of scolopin2 into the shape-adaptive CS-GA hydrogel, the composite hydrogel possesses multi-functions of mechanical adhesion, drug therapy, and skin wound healing. Overall, such an injectable or sprayable hydrogel plays an effective role in emergency wound treatment with the advantage of convenience and portability.