1. <em>68</em>Ga-Labeled Cyclic NGR Peptide for MicroPET Imaging of CD13 Receptor Expression.
- Author
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Yahui Shao, Wansheng Liang, Fei Kang, Weidong Yang, Xiaowei Ma, Guiyu Li, Shu Zong, Kai Chen, and Jing Wang
- Subjects
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PEPTIDES , *NEOVASCULARIZATION inhibitors , *ARGININE , *AMINOPEPTIDASES , *BIOMARKERS - Abstract
Peptides containing the asparagines-glycine-arginine (NGR) motif have been identified as specific ligands binding to CD13/aminopeptidase N (APN) receptor, a tumor neovascular biomarker. In this study, we synthesized a novel NGR-containing peptide (NOTA-G3-NGR), and labeled NOTA-G3-NGR with 68Ga (t1/2 = 67.7 min). The resulting 68Ga-NOTA-G3-NGR peptide was subject to in vitro and in vivo characterization. The microPET imaging results revealed that the 68Ga-NOTA-G3-NGR peptide exhibits rapid and specific tumor uptake, and high tumor-to-background contrast in a subcutaneous HT-1080 fibrosarcoma mouse model. We concluded that the 68Ga-NOTA-G3-NGR peptide has potential in the diagnosis of CD13-targeted tumor angiogenesis. [ABSTRACT FROM AUTHOR]
- Published
- 2014
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