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Preeclampsia has been linked to an increased risk of cardiovascular disease (CVD), and the preeclamptic women were unaware of this link. Therefore, this study aims to assess women's knowledge and perception of future CVD after preeclampsia. This study used a cross-sectional descriptive design. Two hundred and forty-six women with a preeclampsia history were recruited from the Al Salam MCH Center and Suez Canal University Hospital. Data were collected during March 2022 using a socio-demographic questionnaire, an Adapted Coronary Heart disease knowledge tool for preeclamptic women, and The Perception of Risk of Heart Disease Scale (PRHDS). Most women (96%) were unaware of the relationship between CVD and preeclampsia. The women had a low CVD knowledge level (10.26 ± 6.08) as well as a low perception of cardiovascular disease risk (37.15 ± 7.22). There was a significant positive correlation between CVD knowledge and CVD risk perception (r = 0.434, p = 0.000). This study found that preeclampsia survivors underestimated their CVD risk. Based on these findings, preeclamptic women should receive health education sessions on CVD risk and prevention from their nurses and obstetricians. The hospital pre-discharge plan must contain these sessions in written and electronic formats to help women remember and follow CVD risk reduction measures. [ABSTRACT FROM AUTHOR]

This study presents proof of concept for designing a novel HIV-1 covalent inhibitor targeting the highly conserved Tyr318 in the HIV-1 non-nucleoside reverse transcriptase inhibitors binding pocket to improve the drug resistance profiles. The target inhibitor ZA-2 with a fluorosulfate warhead in the structure was found to be a potent inhibitor (EC50 = 11–246 nM) against HIV-1 IIIB and a panel of NNRTIs-resistant strains, being far superior to those of NVP and EFV. Moreover, ZA-2 was demonstrated with lower cytotoxicity (CC50 = 125 µM). In the reverse transcriptase inhibitory assay, ZA-2 exhibited an IC50 value of 0.057 µM with the ELISA method, and the MALDI-TOF MS data demonstrated the covalent binding mode of ZA-2 with the enzyme. Additionally, the molecular simulations have also demonstrated that compounds can form covalent binding to the Tyr318. [ABSTRACT FROM AUTHOR]

Objective: This study aimed to evaluate the efficacy and safety of Huangqi Guizhi Wuwu decoction (HGWD), which is composed of five crude drugs (Astragali Radix, Cinnamomi Ramulus, Paeoniae Radix Alba, Zingiberis Rhizoma Recens, and Jujubae Fructus), in the treatment of albumin-bound paclitaxel (nab-PTX)-induced peripheral neuropathy (PN) in Chinese patients with breast cancer (BC). Methods: This trial was conducted at the National Cancer Center in China from January 2020 to June 2022. The eligible participants were assigned randomly in a 1:1 ratio to an HGWD group or a control group. The outcome measure was EORTC QLQ-CIPN20 questionnaire. Results: 92 patients diagnosed with BC were enrolled and randomized to either HGWD group (n = 46) or control group (n = 46). There were no significant differences in baseline characteristics between the two groups (p > 0.05). A statistical analysis of the sensory and motor functions of the EORTC QLQ-CIPN20 scores showed that patients in the HGWD group reported a larger decrease in CIPN sensory scores than those in the control group (p < 0.001). The EORTC QLQ-CIPN20 autonomic scores showed no statistical significance between the two groups (p > 0.05). Conclusions: HGWD packs could significantly improve patients' nab-PTX-induced PN, increase the tolerance for nab-PTX-containing chemotherapy, and further improve the quality of life of patients with BC. [ABSTRACT FROM AUTHOR]

Municipal solid waste (MSW) has caused the increasing concern for environmental issues in recent years, and the wide engagement from all stakeholders of society has been involved in promoting integrated MSW management. Therefore, this study aims to identify the problems of dis-synergy among multi-stakeholders engaged in the integrated MSW management evolution, then contribute strategies to coordinated development of integrated MSW management system by bettering the engagement and interaction of different stakeholders combined with the region characteristics. From the perspective of the stakeholder theory and synergy theory, we constructed an integrated MSW management system with four stakeholder subsystems: governments, enterprises, residents, and NGO subsystems. We used integrated MSW management in Harbin as a case study and used the synergy degree model to estimate the system synergy degree from 2010 to 2019. Then, the synergetic development trend of integrated MSW management was studied, providing a feasible approach to boost the coordinated development of integrated MSW management in Harbin. The results were in concordance with the factual situation and pointed to integrated MSW management in Harbin and, although there is movement towards a more harmonious and orderly state over time, the government subsystem needs to be further reinforced. [ABSTRACT FROM AUTHOR]

Promoting the use of straw returning technology in rural areas is of great value to improve the use of agricultural technology and to reduce agricultural carbon emissions. However, the low proportion of straw recycling has also attracted more attention all over the world. An effective measure to solve this problem is to increase farmers' internet use to encourage them to participate in straw recycling. Based on micro survey data from 2126 households obtained from China, this paper uses an ordered probability model (OPM) and seeks to measure the impact of internet use on farmers' active use of straw returning and its heterogeneity. It aims to answer two questions: what the impact of internet use on farmers' willingness to participate in straw recycling is, and whether there is heterogeneity. The study found that the use of the internet can significantly drive farmers to use straw to return to the field. Specifically, farmers using the internet are less likely to become non-adoption (−2.95%) or non-voluntary (3.09%), but have a greater probability of becoming voluntary (6.04%). Moreover, the heterogeneity analysis showed that older groups and lower income groups could improve their willingness to actively adopt straw returning technology after using the internet. According to this research, it is suggested to improve local network resources, guide farmers to effectively entertain, study, live, and better enjoy the dividends brought by the internet. In terms of environmental publicity and education, the government should make policy adjustments for older groups and low-income groups to promote the use of technology. [ABSTRACT FROM AUTHOR]

This study aimed to investigate the effects of long-term nitrogen fertilization on non-structural carbohydrates (NSC) and nitrogen (N) status and their interaction in mature trees at the whole-tree scale. Ten g N m−2 yr−1 of ammonium nitrate fertilizer were applied to 26-year-old Larix gmelinii Rupr. (larch) and Fraxinus mandschurica Rupr. (ash) trees in Northeastern China from 2002 to 2012. NSC, total carbon (C) and total N concentrations in different compartments were examined. For both species, concentrations of NSC and their components (soluble sugars and starch) tended to increase in aboveground organs but decrease in fine roots following N fertilization, with significant (p < 0.05) changes only observed in ash stems and larch roots. N fertilization increased N concentrations and decreased the C:N ratio in all organs, especially in foliage and roots, while the effects of fertilization on total C concentrations varied with tree species and organs. Concentrations of NSC (mainly reflected in soluble sugar) were generally negatively correlated with N concentration in fine roots but positively related to N concentration in aboveground woody organs in both control and fertilized treatments. However, fertilization strengthened this correlation in fine roots and weakened this relationship in aboveground organs. This study provides a decade-long insight into the effect of currently increasing N deposition on tree growth and function. [ABSTRACT FROM AUTHOR]

Root hypodermis passage cells (PCs) lack suberin and lignin deposition, responsible for nutrient absorption and arbuscular mycorrhizal colonization, which are crucial for root resource acquisition. Nevertheless, their quantitative variability across diverse woody species and their relationships with root morphology and anatomy, as well as arbuscular mycorrhizal colonization, are still not well understood. Herein, the number and proportion of PCs in the root cross-section, root morphology, anatomy, and arbuscular mycorrhizal colonization rate were quantified across 10 temperate and 12 tropical woody species. The objectives of this study were to determine how PCs vary across contrasting environmental conditions and to explore their relationships with arbuscular mycorrhizal colonization rate and other root functional traits. The results showed that tropical species possessed 56% more PCs than temperate species; by contrast, they had similar proportions of PCs. In both biomes, the number of PCs had a tightly positive correlation with arbuscular mycorrhizal colonization rate (R2 = 0.35–0.87), root diameter (R2 = 0.84–0.93), and cortex thickness (R2 = 0.87–0.89), but the proportion of PCs was mostly independent of root morphological and anatomical traits. Our results suggest that variation in passage cells could well explain the tight linkage between arbuscular mycorrhizal colonization and root diameter across species and biomes, which provides insight into the collaboration gradient between plant roots and mycorrhizal fungi that dominates the root economics space. [ABSTRACT FROM AUTHOR]

The weighted surplus division value is defined in this paper, which allocates to each player his individual worth and then divides the surplus payoff with respect to the weight coefficients. This value can be characterized from three different angles. First, it can be obtained analogously to the scenario of getting the procedural value whereby the surplus is distributed among all players instead of among the predecessors. Second, endowing the exogenous weight to the surplus brings about the asymmetry of the distribution. We define the disweighted variance of complaints to remove the effect of the weight and prove the weighted surplus division value is the unique solution of an optimization model. Lastly, the paper offers axiomatic characterizations of the weighted surplus division value through proposing new properties, including the ω -symmetry for zero-normalized game and individual equity. [ABSTRACT FROM AUTHOR]