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Donepezil patch was developed to replace the original oral formulation. To accurately describe the pharmacokinetics of donepezil and investigate compatible doses between two formulations, a population pharmacokinetic model for oral and transdermal patches was built based on a clinical study. Plasma donepezil levels were analyzed via liquid chromatography/tandem mass spectrometry. Non-compartmental analyses were performed to derive the initial parameters for compartmental analyses. Compartmental analysis (CA) was performed with NLME software NONMEM assisted by Perl-speaks-NONMEM, and R. Model evaluation was proceeded via visual predictive checks (VPC), goodness-of-fit (GOF) plotting, and bootstrap method. The bioequivalence test was based on a 2 × 2 crossover design, and parameters of AUC and Cmax were considered. We found that a two-compartment model featuring two transit compartments accurately describes the pharmacokinetics of nine subjects administered in oral, as well as of the patch-dosed subjects. Through evaluation, the model was proven to be sufficiently accurate and suitable for further bioequivalence tests. Based on the bioequivalence test, 114 mg/101.3 cm2–146 mg/129.8 cm2 of donepezil patch per week was equivalent to 10 mg PO donepezil per day. In conclusion, the pharmacokinetic model was successfully developed, and acceptable parameters were estimated. However, the size calculated by an equivalent dose of donepezil patch could be rather large. Further optimization in formulation needs to be performed to find appropriate usability in clinical situations. [ABSTRACT FROM AUTHOR]

This paper proposes the design of a dual-band integrated rectenna. The rectenna has compact size of 0.4 × 0.3 × 0.25 cm 3 and operates at 925 MHz and 2450 MHz bands. In general, the rectenna consists of two main parts, the metal-rimmed dual-band antenna used for harvesting the radio frequency (RF) signals from the environment and the rectifier circuit to convert these receiving powers to the direct current (DC). Because of the dual resonant structure of the antenna, the rectifier circuit can be optimized in terms of size and the frequency bandwidth, while the conversion efficiencies are always obtained 60% at the RF input power −2.5 dBm and −1 dBm for the lower band and the higher band, respectively. Measured results show that the metal-rimmed antenna exhibits −10 dB reflection coefficient in both desired frequency bands. Moreover, the antenna achieves 47% and 89% of total efficiency respectively at 925 MHz and 2450 MHz, which confirms that the proposed rectenna is well applicable in most of the miniaturized wireless sensor networks and IoT systems. [ABSTRACT FROM AUTHOR]