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3 results on '"Torres do Rego, A."'

1. Diurnal Triglyceridemia in Relation to Alcohol Intake in Men

Author

Manuel Castro Cabezas, Erwin Birnie, Ana Torres do Rego, B. Klop, Victoria Cachofeiro Ramos, Luis Antonio Alvarez-Sala Walther, Jan Willem F. Elte, Cardiology, and Socio-Medical Sciences (SMS)

Subjects
Adult, Male, medicine.medical_specialty, Time Factors, Adolescent, Alcohol Drinking, Dietética y nutrición, lcsh:TX341-641, postprandial, Alcohol, Bedtime, Article, Body Mass Index, Young Adult, chemistry.chemical_compound, lipemia, Surveys and Questionnaires, Internal medicine, Humans, Medicine, triglyceride, Triglycerides, Aged, Aged, 80 and over, Hypertriglyceridemia, Nutrition and Dietetics, Ethanol, Triglyceride, business.industry, Middle Aged, Postprandial Period, medicine.disease, Postprandial, Endocrinology, chemistry, Alcohol intake, ethanol, business, lcsh:Nutrition. Foods and food supply, Body mass index, Food Science
Abstract

Fasting and postprandial triglyceride concentrations largely depend on dietary and lifestyle factors. Alcohol intake is associated with triglycerides, but the effect of alcohol on diurnal triglyceridemia in a free living situation is unknown. During three days, 139 men (range: 18–80 years) measured their own capillary triglyceride (cTG) concentrations daily on six fixed time-points before and after meals, and the total daily alcohol intake was recorded. The impact of daily alcohol intake (none, low, &lt, 10 g/day, moderate, 10–30 g/day, high, &gt, 30 g/day) on diurnal triglyceridemia was analyzed by the incremental area under the cTG curve (∆cTG-AUC) reflecting the mean of the six different time-points. Fasting cTG were similar between the alcohol groups, but a trend of increased cTG was observed in men with moderate and high alcohol intake after dinner and at bedtime (p for trend &lt, 0.001) which persisted after adjustment for age, smoking and body mass index. The ∆cTG-AUC was significantly lower in males with low alcohol intake (3.0 ± 1.9 mmol·h/L) (n = 27) compared to males with no (7.0 ± 1.8 mmol·h/L) (n = 34), moderate (6.5 ± 1.8 mmol·h/L) (n = 54) or high alcohol intake (7.2 ± 2.2 mmol·h/L) (n = 24), when adjusted for age, smoking and body mass index (adjusted p value &lt, 0.05). In males, low alcohol intake was associated with decreased diurnal triglyceridemia, whereas moderate and high alcohol intake was associated with increased triglycerides after dinner and at bed time.

Published
2013

2. Diurnal Triglyceridemia in Relation to Alcohol Intake in Men

Author

Torres do Rego, Ana, Klop, Boudewijn, Birnie, Erwin, Elte, Jan, Cachofeiro Ramos, María Victoria, Álvarez-Sala Walther, Luis Antonio, Cabezas, Manuel, Torres do Rego, Ana, Klop, Boudewijn, Birnie, Erwin, Elte, Jan, Cachofeiro Ramos, María Victoria, Álvarez-Sala Walther, Luis Antonio, and Cabezas, Manuel

Abstract

Fasting and postprandial triglyceride concentrations largely depend on dietary and lifestyle factors. Alcohol intake is associated with triglycerides, but the effect of alcohol on diurnal triglyceridemia in a free living situation is unknown. During three days, 139 men (range: 18–80 years) measured their own capillary triglyceride (cTG) concentrations daily on six fixed time-points before and after meals, and the total daily alcohol intake was recorded. The impact of daily alcohol intake (none; low, <10 g/day; moderate, 10–30 g/day; high, >30 g/day) on diurnal triglyceridemia was analyzed by the incremental area under the cTG curve (∆cTG-AUC) reflecting the mean of the six different time-points. Fasting cTG were similar between the alcohol groups, but a trend of increased cTG was observed in men with moderate and high alcohol intake after dinner and at bedtime (p for trend <0.001) which persisted after adjustment for age, smoking and body mass index. The ∆cTG-AUC was significantly lower in males with low alcohol intake (3.0 ± 1.9 mmol·h/L) (n = 27) compared to males with no (7.0 ± 1.8 mmol·h/L) (n = 34), moderate (6.5 ± 1.8 mmol·h/L) (n = 54) or high alcohol intake (7.2 ± 2.2 mmol·h/L) (n = 24), when adjusted for age, smoking and body mass index (adjusted p value < 0.05). In males, low alcohol intake was associated with decreased diurnal triglyceridemia, whereas moderate and high alcohol intake was associated with increased triglycerides after dinner and at bed time., Instituto de Salud Carlos III (ISCIII), Depto. de Fisiología, Depto. de Medicina, Fac. de Medicina, TRUE, pub

Published
2013

3. Identification of a Plasma Microrna Signature as Biomarker of Subaneurysmal Aortic Dilation in Patients with High Cardiovascular Risk.

Author

Torres-Do Rego, Ana, Barrientos, María, Ortega-Hernández, Adriana, Modrego, Javier, Gómez-Gordo, Rubén, Álvarez-Sala, Luis A., Cachofeiro, Victoria, and Gómez-Garre, Dulcenombre

Subjects
*ABDOMINAL aortic aneurysms, *BIOMARKERS, *MICRORNA, *RECEIVER operating characteristic curves
Abstract

Patients with subaneurysmal aortic dilation (SAD; 25–29 mm diameter) are likely to progress to true abdominal aortic aneurysm (AAA). Despite these patients having a higher risk of all-cause mortality than subjects with aortic size <24 mm, early diagnostic biomarkers are lacking. MicroRNAs (miRs) are well-recognized potential biomarkers due to their differential expression in different tissues and their stability in blood. We have investigated whether a plasma miRs profile could identify the presence of SAD in high cardiovascular risk patients. Using qRT-PCR arrays in plasma samples, we determined miRs differentially expressed between SAD patients and patients with normal aortic diameter. We then selected 12 miRs to be investigated as biomarkers by construction of ROC curves. A total of 82 significantly differentially expressed miRs were found by qPCR array, and 12 were validated by qRT-PCR. ROC curve analyses showed that seven selected miRs (miR-28-3p, miR-29a-3p, miR-93-3p, miR-150-5p, miR-338-3p, miR-339-3p, and miR-378a-3p) could be valuable biomarkers for distinguishing SAD patients. MiR-339-3p showed the best sensitivity and specificity, even after combination with other miRs. Decreased miR-339-3p expression was associated with increased aortic abdominal diameter. MiR-339-3p, alone or in combination with other miRs, could be used for SAD screening in high cardiovascular risk patients, helping to the early diagnosis of asymptomatic AAA. [ABSTRACT FROM AUTHOR]

Published
2020
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