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This study explored the combined administration of docetaxel (DOC) and erlotinib (ERL) using nanostructured lipid carriers (NLCs), with folic acid (FA) conjugation to enhance their synergistic anticancer efficacy against triple-negative breast cancer. NLCs were developed through hot melt homogenization–ultrasound dispersion, and optimized by a quality-by-design (QbD) approach using Plackett–Burman design and Box–Behnken design. Plots were generated based on maximum desirability. Spherical, nanosized dispersions (<200 nm) with zeta potential ranging from −16.4 to −14.15 mV were observed. These nanoformulations demonstrated ~95% entrapment efficiency with around 5% drug loading. Stability tests revealed that the NLCs remained stable for 6 months under storage conditions at 4 °C. In vitro release studies indicated sustained release over 24 h, following Higuchi and Korsmeyer–Peppas models for NLCs and FA NLCs, respectively. Additionally, an in vitro pH-stat lipolysis model exhibited a nearly fivefold increase in bioaccessibility compared to drug-loaded suspensions. The DOC–ERL-loaded formulations exhibited dose- and time-dependent cytotoxicity, revealing synergism at a 1:3 molar ratio in MDA-MB-231 and 4T1 cells, with combination indices of 0.35 and 0.37, respectively. Co-treatment with DOC–ERL-loaded FA NLCs demonstrated synergistic anticancer effects in various in vitro assays. [ABSTRACT FROM AUTHOR]

With the rapid advancements of the internet of things (IoT), several applications have evolved with completely dissimilar structures and requirements. However, the fifth generation of mobile cellular networks (5G) is unable to successfully support the dissimilar structures and requirements. The sixth generation of mobile cellular networks (6G) is likely to enable new and unidentified applications with varying requirements. Therefore, 6G not only provides 10 to 100 times the speed of 5G, but 6G can also provide dynamic services for advanced IoT applications. However, providing security to 6G networks is still a significant problem. Therefore, in this paper, a hybrid image encryption technique is proposed to secure multimedia data communication over 6G networks. Initially, multimedia data are encrypted by using the proposed model. Thereafter, the encrypted data are then transferred over the 6G networks. Extensive experiments are conducted by using various attacks and security measures. A comparative analysis reveals that the proposed model achieves remarkably good performance as compared to the existing encryption techniques. [ABSTRACT FROM AUTHOR]