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In this study the exposure levels from Quercus pollen in the greater area of Thessaloniki are estimated. The estimation is implemented with a modeling system, comprising the meteorological model WRF, the Natural Emissions Model (NEMO) for the calculation of the Quercus pollen emissions and the chemistry-transport model CAMx for the advection and the deposition of the pollen particles. The period of 2016 with the highest potential is selected, based on the available measurements for the area of interest. The modeling system is evaluated with meteorological and pollen measurements, as well on the expected exposure levels, indicating a satisfactory overall performance. The modeling system is finally utilized for the estimation of exposure levels in the greater area of Thessaloniki, showing that the city of is not going to experience significant number of days with high Quercus pollen concentrations, although other, smaller cities and towns might be affected.