1. Neuroadaptive Biochemical Mechanisms of Remote Ischemic Conditioning.
- Author
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Baranova, Ksenia, Nalivaeva, Natalia, and Rybnikova, Elena
- Subjects
ISCHEMIC conditioning ,HYPOXIA-inducible factors ,BRAIN damage ,COGNITION disorders ,STEROID hormones - Abstract
This review summarizes the currently known biochemical neuroadaptive mechanisms of remote ischemic conditioning. In particular, it focuses on the significance of the pro-adaptive effects of remote ischemic conditioning which allow for the prevention of the neurological and cognitive impairments associated with hippocampal dysregulation after brain damage. The neuroimmunohumoral pathway transmitting a conditioning stimulus, as well as the molecular basis of the early and delayed phases of neuroprotection, including anti-apoptotic, anti-oxidant, and anti-inflammatory components, are also outlined. Based on the close interplay between the effects of ischemia, especially those mediated by interaction of hypoxia-inducible factors (HIFs) and steroid hormones, the involvement of the hypothalamic–pituitary–adrenocortical system in remote ischemic conditioning is also discussed. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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