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Your search keyword '"Rancoita P. M. V."' showing total 2 results
Start Over Author "Rancoita P. M. V." Publisher mdpi
2 results on '"Rancoita P. M. V."'

1. The Experience of COVID-19 in a Sample of Gynecological Cancer Patients Undergoing Chemotherapy: A Focus on the Psychological Implications

Author

Perego, G, Di Mattei, V, Mazzetti, M, Milano, F, Gatti, C, Rancoita, P, Taranto, P, Rabaiotti, E, Cioffi, R, Candiani, M, Perego G., Di Mattei V. E., Mazzetti M., Milano F., Gatti C., Rancoita P. M. V., Taranto P., Rabaiotti E., Cioffi R., Candiani M., Perego, G, Di Mattei, V, Mazzetti, M, Milano, F, Gatti, C, Rancoita, P, Taranto, P, Rabaiotti, E, Cioffi, R, Candiani, M, Perego G., Di Mattei V. E., Mazzetti M., Milano F., Gatti C., Rancoita P. M. V., Taranto P., Rabaiotti E., Cioffi R., and Candiani M.

Abstract

Cancer patients are at an increased risk of developing severe consequences due to the COVID-19 infection. However, psychological outcomes in this population have been overlooked in the literature. The present study aims to identify significant psychological differences between gynecological cancer patients undergoing chemotherapy before and during the pandemic. Additionally, we explore the correlations between COVID-19-related concerns and anxiety, depression, distress, and quality of life levels. Forty-two patients completed the STAI-Y, the EORTC QLQ-C30, the BDI II, the DT, and an ad-hoc questionnaire that investigated COVID-19-related concerns. The analyses did not show significant differences in the psychometric scales between the two groups, highlighting a considerable resilience against mental health and quality of life deterioration during the COVID-19 pandemic in gynecologic cancer patients. However, COVID-19-related concerns were positively associated with anxiety and inversely related to emotional functioning levels. These results emphasize the importance of a comprehensive patient care and the need to implement a multidisciplinary approach that includes psychological support in the treatment plan. Moreover, it is essential to encourage clear communication to convey comprehensive information about the impact of the pandemic on physical and psychological levels, as well as to offer psychoeducational tools to face the pandemic.

Published
2023

2. Dual Tracer 68Ga-DOTATOC and 18F-FDG PET Improve Preoperative Evaluation of Aggressiveness in Resectable Pancreatic Neuroendocrine Neoplasms

Author

Joniada Doraku, Carolina Bezzi, Maria Picchio, Valentina Andreasi, Matteo Salgarello, Francesca Muffatti, Paola M.V. Rancoita, Luigi Gianolli, Stefano Pasetto, Paola Mapelli, Massimo Falconi, Valentino Bettinardi, Stefano Partelli, Marco Schiavo Lena, Mapelli, P., Partelli, S., Salgarello, M., Doraku, J., Muffatti, F., Schiavo Lena, M., Pasetto, S., Bezzi, C., Bettinardi, V., Andreasi, V., Rancoita, P. M. V., Gianolli, L., Picchio, M., and Falconi, M.

Subjects
Staging, PET/CT, Clinical Biochemistry, Population, Standardized uptake value, Dual tracer, risk stratification, Article, 030218 nuclear medicine & medical imaging, Lesion, surgery, 03 medical and health sciences, 0302 clinical medicine, Interquartile range, Medicine, prognostic value, resection, education, Pancreatic neuroendocrine neoplasms, pancreatic neuroendocrine neoplasms, NEN, 68Ga-DOTA, 18F-FDG, dual tracer, staging, Risk stratification, education.field_of_study, PET-CT, lcsh:R5-920, Receiver operating characteristic, Somatostatin receptor, business.industry, Retrospective cohort study, Resection, 030220 oncology & carcinogenesis, Surgery, medicine.symptom, business, Nuclear medicine, lcsh:Medicine (General), Prognostic value
Abstract

Purpose: To define an imaging risk profile in a population of patients affected by Pancreatic neuroendocrine neoplasms (PanNENs) candidates to surgery, by assessing the predictive role of 68Ga-DOTATOC and 18F-FDG PET/CT and PET/MR derived parameters in risk stratification, particularly regarding histological features of aggressive behaviour. Patients and methods: Retrospective study including 83 patients (53 males, 30 females; median age: 60 years, interquartile range 52–66.5), who underwent to 68Ga-DOTATOC (PET/CT: n = 77; PET/MR: n = 6) and, 68/83 patients, also to 18F-FDG PET (PET/CT: n = 65; PET/MR: n = 3) before surgery for PanNEN between 2011 and 2019, with available histological and follow-up data. The PET scans were interpreted with both qualitative (positive vs. negative) and semiquantitative measurements as follows: maximum and mean standardized uptake value (SUVmax and SUVmean) for both 18F-FDG and 68Ga-DOTATOC scans, metabolic tumour volume (MTV) and tumour lesion glycolysis (TLG) for 18F-FDG scans and somatostatin receptor density (SRD) and total lesion somatostatin receptor density (TLSRD) for 68Ga-DOTATOC PET. Receiver Operating Characteristics (ROC) curve analysis was used to investigate the performance of several PET parameters in predicting tumour stage or characteristic. For each PET parameter, the optimal cut-off was derived. Logistic regression analysis was used to assess if the PET parameters, categorized with the optimal cut-off values, were able to predict significantly the corresponding tumour stage or characteristic. Results: Overall, 29 (35%) patients had G1, 49 (59%) a G2 and five (6%) had a G3 PanNEN. The median Ki-67 index was 4% (interquartile range: 1–8%). SRD and TLSRD significantly discriminated between pT3 or pT4 PanNEN versus pT1 or pT2, as well as 18F-FDG MTV and TLG. 68Ga-DOTATOC SUVmax was able to significantly predict the presence of distant metastases with a threshold of 51.27 (sensitivity and specificity of 85.7 and 68.1%, respectively). 18F-FDG MTV and TLG were predictors of angioinvasion. The cut-off threshold for MTV was 7.98 (sensitivity and specificity of 69.7 and 82.4%, respectively) (p = 0.0004) whereas the cut-off for TLG was 32.4 (sensitivity and specificity of 69.7% and 82.4%, respectively) (p = 0.0004). Conclusion: Dual tracer 68Ga-DOTATOC and 18F-FDG PET scans provide relevant information regarding tumour behaviour and aggressiveness, implementing the diagnostic preoperative work-up.

Published
2021

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