1. N-oxide alkaloids from Crinum amabile (Amaryllidaceae)
- Author
-
Laura Torras-Claveria, Luciana R. Tallini, Marcel Kaiser, Francesc Viladomat, Warley de Souza Borges, Jose Angelo Silveira Zuanazzi, and Jaume Bastida
- Subjects
Pharmaceutical Science ,Context (language use) ,01 natural sciences ,Article ,buphanisine N-oxide ,Analytical Chemistry ,lcsh:QD241-441 ,lcsh:Organic chemistry ,Drug Discovery ,Crinum ,Crinum amabile ,heterocyclic compounds ,Physical and Theoretical Chemistry ,Amaryllidaceae Alkaloids ,Natural products ,biology ,Traditional medicine ,010405 organic chemistry ,Chemistry ,Amaril·lidàcies ,augustine N-oxide ,biological activities ,Biological activities ,Organic Chemistry ,Amaryllidaceae ,Drugs ,Farmácia ,biology.organism_classification ,0104 chemical sciences ,010404 medicinal & biomolecular chemistry ,Chemistry (miscellaneous) ,Augustine N-oxide ,Molecular Medicine ,Productes naturals ,Buphanisine N-oxide ,Medicaments - Abstract
Natural products play an important role in the development of new drugs. In this context, the Amaryllidaceae alkaloids have attracted considerable attention in view of their unique structural features and various biological activities. In this study, twenty-three alkaloids were identified from; Crinum amabile; by GC-MS and two new structures (augustine; N; -oxide and buphanisine; N; -oxide) were structurally elucidated by NMR. Anti-parasitic and cholinesterase (AChE and BuChE) inhibitory activities of six alkaloids isolated from this species, including the two new compounds, are described herein. None of the alkaloids isolated from; C. amabile; gave better results than the reference drugs, so it was possible to conclude that the; N; -oxide group does not increase their therapeutic potential.
- Published
- 2018