1. Immature Immunoglobulin Gene Rearrangements Are Recurrent in B Precursor Adult Acute Lymphoblastic Leukemia Carrying TP53 Molecular Alterations.
- Author
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Salmoiraghi S, Cavagna R, Guinea Montalvo ML, Ubiali G, Tosi M, Peruta B, Intermesoli T, Oldani E, Salvi A, Pavoni C, Giussani U, Bassan R, Rambaldi A, and Spinelli O
- Subjects
- Adolescent, Adult, Aged, Clinical Trials as Topic, Female, Follow-Up Studies, Gene Expression Regulation, Neoplastic, Humans, Male, Middle Aged, Prognosis, Retrospective Studies, Young Adult, Biomarkers, Tumor genetics, Gene Rearrangement, Genes, Immunoglobulin genetics, Precursor B-Cell Lymphoblastic Leukemia-Lymphoma genetics, Precursor B-Cell Lymphoblastic Leukemia-Lymphoma pathology, Tumor Suppressor Protein p53 genetics
- Abstract
Here, we describe the immunoglobulin and T cell receptor (Ig/TCR) molecular rearrangements identified as a leukemic clone hallmark for minimal residual disease assessment in relation to TP53 mutational status in 171 Ph-negative Acute Lymphoblastic Leukemia (ALL) adult patients at diagnosis. The presence of a TP53 alterations, which represents a marker of poor prognosis, was strictly correlated with an immature DH/JH rearrangement of the immunoglobulin receptor ( p < 0.0001). Furthermore, TP53 -mutated patients were classified as pro-B ALL more frequently than their wild-type counterpart (46% vs. 25%, p = 0.05). Although the reasons for the co-presence of immature Ig rearrangements and TP53 mutation need to be clarified, this can suggest that the alteration in TP53 is acquired at an early stage of B-cell maturation or even at the level of pre-leukemic transformation.
- Published
- 2020
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