Search

Groundwater resources from the volcanic aquifers of northern Latium (central Italy) are widely used to supply local water needs and are mainly captured through wells. Nevertheless, despite the detailed hydrogeological knowledge of these aquifers, not enough information is available on the long-term pumping yield necessary to define the sustainable yield of a well. In this study, data from about 230 pumping tests (mainly step-drawdown and a few constant-flow-rate tests) performed in the volcanic aquifers of the Latium region were analyzed. Specifically, the aquifer formations intercepted by the wells are the fall and flow pyroclastic deposits of the Vico, Vulsini, and Sabatini volcanic districts; lava from the Vico, Cimino, and Vulsini volcanic districts; and Ignimbrite Cimina, one of the main pyroclastic products of the Cimino eruptions. These aquifers were grouped and analyzed by considering the type of permeability, hydrostratigraphic succession, and frequency and thickness of the aquifer horizons intercepted by wells. The results obtained in terms of specific capacity and transmissivity values are comparable among the identified different aquifer formations, showing a good correlation between the two parameters, a strong hydraulic heterogeneity (variability within five orders of magnitude), and variable responses regarding drawdown to pumping. This study highlights that the analysis of drawdown over time at a constant flow is fundamental in heterogeneous hydrogeological environments such as volcanic ones, where the trend in drawdown is often affected by the reduced spatial continuity of the most productive aquifer formations. Knowledge of the trend in drawdown over time, the thickness of the aquifer intercepted by the well, and the operating time of the well is an essential element in defining the sustainable yield of a well. [ABSTRACT FROM AUTHOR]

Carbonate and karst aquifers are of great importance for human water supplies, for supporting aquatic habitats and providing ecosystem services. Optimizing the groundwater withdrawals is therefore essential for obtaining the maximum flow rate for human purposes while minimizing the negative effects on the environment. In particular, when the abstraction of groundwater occurs through wells, the problem of defining the sustainable yield arises. This study analyzes pumping tests conducted in carbonate and karst aquifers in southern Italy to derive indications for defining the sustainable yield of yields. The four examined cases concern the Mesozoic–Cenozoic platform and transition pelagic carbonate rocks characterized by different degree of fracturing and karstification and hosting a carbonate aquifer with variable average groundwater yields. The analysis compared drawdown–time trends and their derivatives for 35 pumping tests with theoretical curves to identify the flow dimension. Parameters useful for examining the well yields were then determined. The results show that the response to the pumping of the investigated aquifers is very variable, both among the different sites and within the same site. Well yields are very different due to aquifer heterogeneity, local hydrostratigraphy and structural setting, and position of the pumping center within the groundwater flow system. To determine the operational pumping rate for a well in this environment, this study emphasizes the importance of analyzing drawdown trends over time to correctly predict the well's long-term response to pumping. Specifically, when pumping induces a steady-state drawdown response, the focus for defining the sustainable abstraction shifts to the basin or aquifer scale. Conversely, when a transient drawdown response to pumping results, the well's capacity to capture groundwater becomes the primary factor for well yield and its sustainability. [ABSTRACT FROM AUTHOR]

Quarrying has great importance for economic development and, at the same time, can have several adverse environmental impacts; specifically, it may have a significant influence on water resources. There are approximately 4000 quarries in Italy, and knowledge of their potential impact on water resources is limited. To this end, a procedure for categorizing Italian quarries was devised by combining the methods of Geographic Information Systems and Multi-Criteria Decision Aiding, selecting the potentially impactful criteria, and parametrizing the latter through the available databases. Using the ELECTRE models (ELECTRE TRI and ELECTRE III), the impact category of each quarry was assessed separately for surface water and groundwater and then the overall impact on water resources was assessed. The simulations were carried out by varying the weights of the various selected criteria, which allowed the grouping of Italian quarries into five categories with increasing potential impact on water resources. The ranking of quarries falling into the two highest-impact categories was further refined using ascending and descending distillations. The categorization can be interpreted as a first national assessment of the sustainability of quarrying activities with reference to water resources. The methodological approach of the study proved to be appropriate for the quarry-sorting and -ranking processes, lending itself to the introduction of other criteria and weights, including those arising from the participation of different stakeholders. [ABSTRACT FROM AUTHOR]

In recent years, there has been a significant increase in the diagnosis of asymptomatic Late-Onset Pompe Disease (LOPD) patients, who are detected via family screening or Newborn Screening (NBS). The dilemma is when to start Enzyme Replacement Therapy (ERT) in patients without any clinical sign of the disease, considering its important benefits in terms of loss of muscle but also its very high cost, risk of side effects, and long-term immunogenicity. Muscle Magnetic Resonance Imaging (MRI) is accessible, radiation-free, and reproducible; therefore, it is an important instrument for the diagnosis and follow-up of patients with LOPD, especially in asymptomatic cases. European guidelines suggest monitoring in asymptomatic LOPD cases with minimal MRI findings, although other guidelines consider starting ERT in apparently asymptomatic cases with initial muscle involvement (e.g., paraspinal muscles). We describe three siblings affected by LOPD who present compound heterozygosis and wide phenotypic variability. The three cases differ in age at presentation, symptoms, urinary tetrasaccharide levels, and MRI findings, confirming the significant phenotypic variability of LOPD and the difficulty in deciding when to start therapy. [ABSTRACT FROM AUTHOR]

Background: the study of paraspinal muscles is pivotal for the diagnosis and staging of Amyotrophic Lateral Sclerosis (ALS), and is usually performed by electromyography. Objective: to evaluate the role of paraspinal muscle MRI as a diagnostic biomarker in ALS. Methods: we evaluated T1-w images of newly diagnosed ALS patients (n = 14), age-matched healthy controls (n = 11), patients affected by inflammatory myopathy (n = 10), and lumbar radiculopathy (n = 19), and compared them semiquantitatively by using the Mercuri Scale. Results: a significant difference in the appearance of the psoas muscle was observed between ALS patients and patients with radiculopathy (p = 0.003); after stratifying ALS patients into spinal and bulbar onsets, we found a significant difference in the appearance of the longissimus dorsi muscle between the spinal onset ALS subgroup and bulbar onset ALS subgroup (p = 0.0245), while no difference was found for multifidus (p = 0.1441), iliocostal (p = 0.0655), and psoas muscles (p = 0.0813) between the cohort subgroups. Conclusions: paraspinal T1-w MRI could help to distinguish spinal ALS patients from healthy and pathological controls. Specifically, the study of longissimus dorsi could play the role of a diagnostic ALS biomarker. [ABSTRACT FROM AUTHOR]