1. Post-Translational Modifications of Cytochrome c in Cell Life and Disease
- Author
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Universidad de Sevilla. Departamento de Bioquímica Vegetal y Biología Molecular, European Commission (EC). Fondo Europeo de Desarrollo Regional (FEDER), Junta de Andalucía, Guerra Castellano, Alejandra, Márquez Escudero, Inmaculada, Pérez Mejías, Gonzalo, Díaz Quintana, Antonio Jesús, Rosa Acosta, Miguel Ángel de la, Díaz Moreno, Irene, Universidad de Sevilla. Departamento de Bioquímica Vegetal y Biología Molecular, European Commission (EC). Fondo Europeo de Desarrollo Regional (FEDER), Junta de Andalucía, Guerra Castellano, Alejandra, Márquez Escudero, Inmaculada, Pérez Mejías, Gonzalo, Díaz Quintana, Antonio Jesús, Rosa Acosta, Miguel Ángel de la, and Díaz Moreno, Irene
- Abstract
Mitochondria are the powerhouses of the cell, whilst their malfunction is related to several human pathologies, including neurodegenerative diseases, cardiovascular diseases, and various types of cancer. In mitochondrial metabolism, cytochrome c is a small soluble heme protein that acts as an essential redox carrier in the respiratory electron transport chain. However, cytochrome c is likewise an essential protein in the cytoplasm acting as an activator of programmed cell death. Such a dual role of cytochrome c in cell life and death is indeed fine-regulated by a wide variety of protein post-translational modifications. In this work, we show how these modifications can alter cytochrome c structure and functionality, thus emerging as a control mechanism of cell metabolism but also as a key element in development and prevention of pathologies
- Published
- 2020