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Your search keyword '"Nicolae, Gheorghe"' showing total 2 results
Start Over Author "Nicolae, Gheorghe" Publisher mdpi
2 results on '"Nicolae, Gheorghe"'

1. Biomolecular Dynamics of Nitric Oxide Metabolites and HIF1α in HPV Infection.

Author

Matei, Clara, Nicolae, Ilinca, Mitran, Madalina Irina, Mitran, Cristina Iulia, Ene, Corina Daniela, Nicolae, Gheorghe, Georgescu, Simona Roxana, and Tampa, Mircea

Subjects
HUMAN papillomavirus, VIRUS diseases, NITRIC oxide, WARTS, METABOLITES, RESPIRATION
Abstract

Introduction: Viral infections cause oxygen deprivation, leading to hypoxia or anoxia in certain tissues. The limitation of mitochondrial respiration is one of the major events during hypoxia that induces alternative metabolic activities and increased levels of certain biomolecules such as nitric oxide (NO) metabolites. In this study, we aimed to investigate the role of NO metabolites and hypoxia in HPV infection. Materials and Methods: We included 36 patients with palmoplantar warts and 36 healthy subjects and performed serum determinations of NO metabolites (direct nitrite, total nitrite, nitrate, and 3-nitrotyrosine) and HIF1α, a marker of hypoxia. Results: We found elevated serum levels in NO metabolites and HIF1α, and decreased direct nitrite/nitrate ratios in patients with warts versus controls. Additionally, we identified statistically significant positive correlations between NO metabolites and HIF1α levels, except for 3-nitrotyrosine. Conclusions: Our findings show that HPV infection causes hypoxia and alterations in NO metabolism and suggest a link between wart development and cellular stress. Our research could provide new insights for a comprehensive understanding of the pathogenesis of cutaneous HPV infections. [ABSTRACT FROM AUTHOR]

Published
2024
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2. Non-Surgical Periodontal Therapy Could Improve the Periodontal Inflammatory Status in Patients with Periodontitis and Chronic Hepatitis C

Author

Claudiu Marinel Ionele, Alex Ioan Sălan, Cristina Florescu, Adrian Camen, Mihail Virgil Boldeanu, Dora Maria Popescu, Allma Pitru, Petra Surlin, Adina Turcu-Stiolica, Ion Rogoveanu, and Dorin Nicolae Gheorghe

Subjects
medicine.medical_specialty, Inflammatory response, gingival fluid, Gastroenterology, Article, Chronic hepatitis, c-reactive protein, Internal medicine, Quantitative assessment, Medicine, chronic hepatitis C, In patient, periodontitis, non-surgical periodontal therapy, Pentraxin-3, Periodontitis, biology, business.industry, C-reactive protein, General Medicine, medicine.disease, Gingival fluid, pentraxin-3, biology.protein, enzyme-linked immunosorbent assay, business
Abstract

Non-surgical periodontal therapy (NSPT) is the first essential step for the management of any periodontitis patient. This study aims to evaluate the impact of NSPT on pro-inflammatory mediators’ regulation and on clinical parameters in periodontitis patients who suffer from chronic hepatitis C. At baseline, selected patients were clinically evaluated for their periodontal status. A subsequent quantitative assessment of C-reactive protein and pentraxin-3 in samples of gingival fluid was performed by Enzyme-Linked Immunosorbent Assay (ELISA). Afterwards, NSPT was performed. Three months after NSPT, the clinical and ELISA assessments were repeated. The results show an improvement of the clinical parameters in periodontitis patients at the three-month recall. In chronic hepatitis C patients with periodontitis, the gingival fluid levels of pro-inflammatory markers reduced significantly. The targeted markers also expressed significant correlations with the clinical parameters used for the assessment of periodontitis’ severity. The results suggest that, while chronic hepatitis C patients exhibited a more negative periodontal status at baseline as compared to non-hepatitis ones, NSPT is effective in decreasing the local periodontal inflammatory reaction and in proving the periodontal status of this type of patients. Given the limitation of the study, periodontal screening and NSPT should be included in the integrated therapeutical approach of chronic hepatitis C patients, for its impact on the local inflammatory response.

Published
2021

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