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5 results on '"Nens"'

1. Improvement of in-school physical activity with active school-based interventions to interrupt prolonged sitting: a systematic review and meta-analysis

Author

Andoni Carrasco-Uribarren, Anna Ortega-Martínez, Marta Amor-Barbosa, Aida Cadellans-Arróniz, Sara Cabanillas-Barea, and Maria Caridad Bagur-Calafat

Subjects
Escola, School, Physical activity, Health, Toxicology and Mutagenesis, Public Health, Environmental and Occupational Health, Comportament sedentari, Interrupción de sesión, Comportamiento sedentario, Adolescents, Interrupció asseguda, Sedentary behavior, Nens, Actividad física, Actividad física de moderada a vigorosa, Escuela, Moderate-to-vigorous physical activity, Activitat física, Sitting interruption, Niños, Adolescentes, Children, Activitat física de moderada a vigorosa
Abstract

Background: Sedentary behaviors have increased in recent years and their consequences have led the World Health Organization to make recommendations for promoting a more active lifestyle. The school environment has been defined as a key place for achieving this objective for children and adolescents. This systematic review and meta-analysis aims to analyze the effect of active-break interventions for interrupting prolonged sitting times during school-time on physical activity (PA) and sedentary behavior (SB), at school, in childhood and youth. Methods: A systematic review and meta-analysis were carried out, including clinical trials aimed at assessing the effects of interrupting prolonged sitting at school with active breaks on in-school PA and/or SB. Multimodal and static interventions were excluded. Six databases were analyzed: Medline, WOS, Cochrane Library, SPORT Discus, CINAHL and EMBASE. PA, SB; moderate-to-vigorous physical activity (MVPA) were the variables considered. Results: Nine studies were included, with a total of 2145 children between 6 and 12 years old. The heterogeneity in the duration (five–sixty min), the frequency (one–three times per-day up to three times per week), and duration (five days to three years) of the interventions was detected. The meta-analyses for in-school PA, MVPA, and SB were performed, showing a significant improvement in both PA and MVPA. Conclusions: Interrupting prolonged sitting with active-based school interventions could improve PA and MVPA levels during school time. (PROSPERO: CRD42022358933).

Published
2023

2. Active school-based interventions to interrupt prolonged sitting improve daily physical activity: a systematic review and meta-analysis

Author

Anna Ortega I Martínez, Caritat Bagur-Calafat, Andoni Carrasco-Uribarren, and Marta Amor-Barbosa

Subjects
School, Adolescent, Health, Toxicology and Mutagenesis, Libraries, Comportament sedentari, Interrupción de sesión, Adolescents, Interrupció asseguda, Nens, Actividad física de moderada a vigorosa, Humans, Moderate-to-vigorous physical activity, Child, Exercise, Life Style, Niños, Adolescentes, Children, Escola, Schools, Actividad física diaria, Public Health, Environmental and Occupational Health, Comportamiento sedentario, Sedentary behavior, Daily physical activity, Escuela, Activitat física diària, Sitting interruption, Activitat física de moderada a vigorosa
Abstract

Background: Sedentary behavior (SB) is a negative routine for health, especially during advancing age. Promoting an active lifestyle and reducing SB is a global endeavor. The aim of this study was to analyze the effects of active school-based programs to interrupt prolonged sitting for daily physical activity (PA) and daily SB in children and adolescents. Methods: A systematic review was conducted. Clinical trials analyzing the effect of interrupting prolonged sitting with active breaks and classroom-based PA were included. Studies that implemented PA in class without interrupting prolonged sitting or those that implemented multimodal interventions were excluded. A systematic search was conducted in 6 databases: Medline, WOS, Cochrane Library, SPORTDiscus, CINAHL and EMBASE. Primary outcomes were daily PA and daily SB, while moderate-to vigorous physical activity (MVPA) was considered a secondary outcome. Results: Six studies were included, with a total of 976 participants between 6–14 years. The interventions were heterogeneous in duration of the sitting time interruption (5–30 min), frequency (1–3 times per-day up to three times per-week) and total duration (five days to three years). 50% of the studies scored “high risk” of bias. Three meta-analyses were performed for daily PA, MVPA and SB, showing a significant improvement in the daily PA and MVPA. Conclusions: School-based programs aimed to interrupt prolonged sitting could be a good strategy to improve daily PA and MVPA levels. (Registration number: CRD42022358933). info:eu-repo/semantics/publishedVersion

Published
2022

3. Carcinoid Syndrome and Hyperinsulinemic Hypoglycemia Associated with Neuroendocrine Neoplasms: A Critical Review on Clinical and Pharmacological Management

Author

Manila Rubino, Franco Grimaldi, Francesca Spada, Alice Laffi, Elda Kara, Sara Massironi, Roberta Elisa Rossi, Nicola Fazio, and Sherrie Bhoori

Subjects
Pancreatic Insulinoma, Oncology, medicine.medical_specialty, medicine.medical_treatment, Pharmaceutical Science, carcinoid syndrome, 030209 endocrinology & metabolism, Review, Neuroendocrine tumors, insulinoma, medicine.disease_cause, Serotonin secretion, 03 medical and health sciences, Pharmacy and materia medica, 0302 clinical medicine, Quality of life, NENs, Internal medicine, Drug Discovery, medicine, Hyperinsulinemic hypoglycemia, Insulinoma, business.industry, Insulin, medicine.disease, RS1-441, 030220 oncology & carcinogenesis, Medicine, Molecular Medicine, neuroendocrine tumors, business, Carcinoid syndrome
Abstract

The carcinoid syndrome (CS) and hyperinsulinemic hypoglycemia (HH) represent two of the most common clinical syndromes associated with neuroendocrine neoplasms (NENs). The former is mainly related to the serotonin secretion by a small bowel NEN, whereas the latter depends on an insulin hypersecretion by a pancreatic insulinoma. Both syndromes/conditions can affect prognosis and quality of life of patients with NENs. They are often diagnosed late when patients become strongly symptomatic. Therefore, their early detection and management are a critical step in the clinical management of NEN patients. A dedicated and experienced multidisciplinary team with appropriate therapeutic strategies is needed and should be encouraged to optimize clinical outcomes. This review aims to critically analyze clinical features, evidence and treatment options of CS and HH and therefore to improve their management.

Published
2021

4. Sarcopenia and Ghrelin System in the Clinical Outcome and Prognosis of Gastroenteropancreatic Neuroendocrine Neoplasms.

Author

Herrera-Martínez, Yiraldine, Alzas Teomiro, Carlos, León Idougourram, Soraya, Molina Puertas, María José, Calañas Continente, Alfonso, Serrano Blanch, Raquel, Castaño, Justo P., Gálvez Moreno, María Ángeles, Gahete, Manuel D., Luque, Raúl M., and Herrera-Martínez, Aura D.

Subjects
*PANCREATIC tumors, *ANTHROPOMETRY, *NUTRITION, *SARCOPENIA, *GHRELIN, *GASTROINTESTINAL tumors, *TREATMENT effectiveness, *CANCER patients, *NEUROENDOCRINE tumors, *MALNUTRITION, *SYMPTOMS, *COMPUTED tomography
Abstract

Simple Summary: Malnutrition and sarcopenia affect clinical outcomes in cancer patients. Nutritional evaluation in patients with neuroendocrine neoplasms (NENs) is not routinely performed. Currently, the evaluation of sarcopenia using CT scans is the gold standard in cancer patients, additionally, anthropometric, biochemical and molecular analysis of patients with gastroenteropancreatic NENs at diagnosis was perfomed. The expression levels of key ghrelin system components were assessed in 63 tumor samples. Results: Nutritional parameters were similar in GEP-NEN tumors of different origin. Relapsed disease was associated with decreased BMI. Patients who presented with weight loss at diagnosis had significantly lower overall survival (108 (25–302) vs. 263 (79–136) months). Ghrelin O-acyltransferase (GOAT) enzyme expression was higher in these patients. The prevalence of sarcopenia using CT images reached 87.2%. Mortality was observed only in patients with sarcopenia. Muscle evaluation was correlated with biochemical parameters but not with the expression of ghrelin system components. Conclusion: Survival is related to the nutritional status of patients with GEP-NENs and also to the molecular expression of some relevant ghrelin system components. Routine nutritional evaluation should be performed in these patients, in order to prescribe appropriate nutritional support, when necessary, for increasing quality of life and improving clinical outcomes. Background: Malnutrition and sarcopenia affect clinical outcomes and treatment response in cancer patients. Patients with neuroendocrine neoplasms (NENs) may present with additional symptoms related to tumor localization in the gastrointestinal tract and hormone secretion, increasing the risk and effects of sarcopenia. Aim: To explore the presence of malnutrition and sarcopenia in gastroenteropancreatic (GEP)-NEN patients, their relation to tumor characteristics, patient outcomes, survival and the molecular expression of ghrelin system components in the tumor. Patients and methods: One-hundred-and-four patients were included. Anthropometric, biochemical and CT-scans at diagnosis were evaluated. The expression levels of key ghrelin system components were assessed in 63 tumor samples. Results: Nutritional parameters were similar in GEP-NEN tumors of different origin. Relapsed disease was associated with decreased BMI. Patients who presented with weight loss at diagnosis had significantly lower overall survival (108 (25–302) vs. 263 (79–136) months). Ghrelin O-acyltransferase (GOAT) enzyme expression was higher in these patients. The prevalence of sarcopenia using CT images reached 87.2%. Mortality was observed only in patients with sarcopenia. Muscle evaluation was correlated with biochemical parameters but not with the expression of ghrelin system components. Conclusion: Survival is related to the nutritional status of patients with GEP-NENs and also to the molecular expression of some relevant ghrelin system components. Routine nutritional evaluation should be performed in these patients, in order to prescribe appropriate nutritional support, when necessary, for increasing quality of life and improving clinical outcomes. [ABSTRACT FROM AUTHOR]

Published
2022
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5. Carcinoid Syndrome and Hyperinsulinemic Hypoglycemia Associated with Neuroendocrine Neoplasms: A Critical Review on Clinical and Pharmacological Management.

Author

Spada, Francesca, Rossi, Roberta E., Kara, Elda, Laffi, Alice, Massironi, Sara, Rubino, Manila, Grimaldi, Franco, Bhoori, Sherrie, and Fazio, Nicola

Subjects
*CARCINOID, *HYPOGLYCEMIA, *SMALL intestine, *TUMORS, *SYNDROMES, *ONE-way analysis of variance
Abstract

The carcinoid syndrome (CS) and hyperinsulinemic hypoglycemia (HH) represent two of the most common clinical syndromes associated with neuroendocrine neoplasms (NENs). The former is mainly related to the serotonin secretion by a small bowel NEN, whereas the latter depends on an insulin hypersecretion by a pancreatic insulinoma. Both syndromes/conditions can affect prognosis and quality of life of patients with NENs. They are often diagnosed late when patients become strongly symptomatic. Therefore, their early detection and management are a critical step in the clinical management of NEN patients. A dedicated and experienced multidisciplinary team with appropriate therapeutic strategies is needed and should be encouraged to optimize clinical outcomes. This review aims to critically analyze clinical features, evidence and treatment options of CS and HH and therefore to improve their management. [ABSTRACT FROM AUTHOR]

Published
2021
Full Text
View/download PDF

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