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Purpose: This study investigated the impact of four weeks of age-dependent detraining on army soldiers' cardiorespiratory fitness and maximal and explosive strength. Methods: Fourteen volunteer tactical athletes participated, divided into two age groups (20 to 29 and 30 to 40 years). Before and after the detraining period, we assessed their anthropometric measurements (weight, height, body mass index, fat mass, and fat-free mass), cardiorespiratory fitness (maximal oxygen uptake [VO2max] and ventilatory thresholds [VT1 and VT2]), and kinematic properties during a single-leg counter-moving jump (CMJ) test for both the dominant and non-dominant legs. Two-way ANOVA followed by the Holm–Sidak post hoc test was used. Results: The anthropometric and cardiovascular variables did not show significant differences between the groups. However, both groups exhibited a significantly reduced maximum time and speed at the VO2max. Furthermore, the flight time and maximum height during the CMJ significantly decreased in the non-dominant leg for both age groups. Notably, the dominant leg's concentric impulse (CI) significantly reduced during the CMJ, but this effect was observed only in the 30–40 age group. There were significant differences between the two age groups. Conclusions: Our findings suggest that four weeks of detraining negatively impacts aerobic fitness and muscular strength, independently of age. However, the dominant leg may be more susceptible to detraining effects in army soldiers aged 30–40. Furthermore, as a perspective, our results strongly suggest that a detraining period could affect successful missions (aerobic performance deterioration), as well as promote a muscle imbalance between the legs, which could encourage muscle injuries and endanger combat missions. [ABSTRACT FROM AUTHOR]

Burnout is a primary psychosocial risk factor in the workplace. Mental health stigma, which includes negative cognitions, emotions, and behaviors, also undermines the performance of social healthcare professionals. This study aimed to explore the levels of burnout in a sample of community social healthcare workers as well as its relationships with variables such as stigma towards mental health problems, professional skills, and job characteristics. An online assessment was conducted with 184 social healthcare professionals (75.5% female, mean age = 40.82 years, SD = 9.9). Medium levels of burnout and stigma and high levels of professional skills were observed. Multiple linear regression analyses revealed that stigma towards mental health problems and professional skills predicted emotional exhaustion (R2 = 0.153, F(4, 179) = 9.245, p < 0.001), depersonalization (R2 = 0.213, F(3, 180) = 17.540, p < 0.001), and personal accomplishment (R2 = 0.289, F(5, 178) = 15.87, p < 0.001). These findings suggest that social healthcare systems could benefit from taking care of the mental health of their workers by addressing burnout, tackling negative attitudes towards mental health problems, and providing professional skills training. This would help to make social healthcare systems more inclusive and of higher quality, thereby reducing health costs. [ABSTRACT FROM AUTHOR]

The fruits of the nopal (Opuntia spp.), cactus pears, are considered functional foods due to their content of nutritive and bioactive substances. Its pulp is generated by numerous seeds that limit their consumption due to their size and hardness and detract from their quality. Other undesirable fruit characteristics are its inedible peel and its short shelf life. In the case of the cactus pear cactus (Opuntia spp.), no cultivar has been reported that produces quality parthenocarpic fruits, nor have they been obtained by artificially inducing parthenocarpy. The objectives of this research were to evaluate the response of 11 genotypes to the induction of parthenocarpy, to characterize the fruits of the genotypes with the best response, and to determine their postharvest life. To induce parthenocarpy, floral buds were used in the pre-anthesis stage, from which the style-stigma, stamens, and tepals were removed, generating a cavity in which a solution of growth regulators was applied (250 mg L−1 AG3 + 75 mg L −1 BA + 15 mg L−1 of AIB). A similar number of buds was used as a control, without treatment, and in free pollination. Only two genotypes, MX CP-30 Red and MX CP-40 Yellow, produced parthenocarpic fruits since their empty integuments produced pulp, remaining small, empty, and soft. Their peel was sweet (10–14 °Brix) and edible, and they had a longer shelf life than the corresponding fruits with seeds. [ABSTRACT FROM AUTHOR]

Brandy de Jerez is a grape-derived spirit produced in Southern Spain with specific characteristics that come from the casks where it is produced, which must have previously contained some type of Sherry wine for at least 12 months. These casks are known as Sherry Cask®. In this work, Brandies de Jerez aged for different aging times (0, 3, 6 and 12 months) in casks seasoned with three different types of Sherry wines (Fino, Oloroso and Amontillado) have been studied. The samples have been analyzed using FT-Raman spectroscopy, and their chemical characterization has also been realized by studying their total content of organic acid, volatile compounds, and phenolic and furanic compounds. Their chemical study showed that the main differences between the studied samples were due to the duration and the type of seasoning performed. However, the spectra obtained through FT-Raman presented noticeable differences according to cask seasoning time and the Sherry wine used for the process. A PCA (Principal Component Analysis) confirmed that the Brandies de Jerez presented significant differences depending on the seasoning time and type that the casks were subjected to. A PLS-R (Partial Least Squares Regression) study enabled establishing a close correlation between specific regions of the FT-Raman spectra and cask seasoning time. [ABSTRACT FROM AUTHOR]

Cyclooxygenase (COX) is the key enzyme in prostanoid synthesis from arachidonic acid (AA). Two isoforms, named COX-1 and COX-2, are expressed in mammalian tissues. The expression of COX-2 isoform is induced by several stimuli including cytokines and mitogens, and this induction is inhibited by glucocorticoids (GCs). We have previously shown that the transcriptional induction of COX-2 occurs early after T cell receptor (TCR) triggering, suggesting functional implications of this enzyme in T cell activation. Here, we show that dexamethasone (Dex) inhibits nuclear factor of activated T cells (NFAT)-mediated COX-2 transcriptional induction upon T cell activation. This effect is dependent on the presence of the GC receptor (GR), but independent of a functional DNA binding domain, as the activation-deficient GRLS7 mutant was as effective as the wild-type GR in the repression of NFAT-dependent transcription. Dex treatment did not disturb NFAT dephosphorylation, but interfered with activation mediated by the N-terminal transactivation domain (TAD) of NFAT, thus pointing to a negative cross-talk between GR and NFAT at the nuclear level. These results unveil the ability of GCs to interfere with NFAT activation and the induction of pro-inflammatory genes such as COX-2, and explain some of their immunomodulatory properties in activated human T cells. [ABSTRACT FROM AUTHOR]

Genome-wide association studies (GWAS) constitute a powerful tool to identify the different biochemical pathways associated with disease. This knowledge can be used to prioritize drugs targeting these routes, paving the road to clinical application. Here, we describe DAGGER (Drug Repositioning by Analysis of GWAS and Gene Expression in R), a straightforward pipeline to find currently approved drugs with repurposing potential. As a proof of concept, we analyzed a meta-GWAS of 1.6 × 107 single-nucleotide polymorphisms performed on Alzheimer's disease (AD). Our pipeline uses the Genotype-Tissue Expression (GTEx) and Drug Gene Interaction (DGI) databases for a rational prioritization of 22 druggable targets. Next, we performed a two-stage in vivo functional assay. We used a C. elegans humanized model over-expressing the Aβ1-42 peptide. We assayed the five top-scoring candidate drugs, finding midostaurin, a multitarget protein kinase inhibitor, to be a protective drug. Next, 3xTg AD transgenic mice were used for a final evaluation of midostaurin's effect. Behavioral testing after three weeks of 20 mg/kg intraperitoneal treatment revealed a significant improvement in behavior, including locomotion, anxiety-like behavior, and new-place recognition. Altogether, we consider that our pipeline might be a useful tool for drug repurposing in complex diseases. [ABSTRACT FROM AUTHOR]

Iron deficiency (ID) and iron deficiency anemia (IDA) are highly prevalent worldwide. Oral iron salts, especially ferrous sulfate, are commonly used for the treatment of iron deficiency (ID). However, its use is associated with gastrointestinal side effects, thus compromising treatment compliance. Intravenous iron administration is a more costly and logistically complex alternative and is not risk-free, as infusion and hypersensitivity reactions may occur. Sucrosomial® iron is an oral formulation consisting of ferric pyrophosphate conveyed by a phospholipid and sucrester matrix (sucrosome®). Intestinal Sucrosomial® iron absorption is mediated by enterocytes and M cells, through the paracellular and transcellular routes, and occurs mostly as intact particles. These pharmacokinetic properties of Sucrosomial® iron result in higher iron intestinal absorption and excellent gastrointestinal tolerance compared to oral iron salts. The evidence derived from clinical studies supports the use of Sucrosomial® iron as a valid first option for the treatment of ID and IDA, especially for subjects who are intolerant or refractory to conventional iron salts. Newer evidence also demonstrates the effectiveness of Sucrosomial® iron, with a lower cost and fewer side effects, in certain conditions usually treated with IV iron in current clinical practice. [ABSTRACT FROM AUTHOR]

Pedro Ximénez is a naturally sweet sherry wine produced in southern Spain from raisined Pedro Ximénez grape must and aged using a traditional Criaderas y Solera system. Complete analytical characterization has been useful in determining which parameters are the most influential in the aging of this wine. The organic acids, volatile compounds (higher alcohols, esters, aldehydes, and acetals), and phenolic compounds of this wine evolve during its aging, mainly through physico-chemical reactions and the contributions of wood compounds. During their aging, Pedro Ximénez sherry wines develop their organoleptic profiles, as tasting sessions have confirmed. A strong correlation between the aging of a wine and the parameters analyzed has also been corroborated through an MLR analysis. This allowed for the development of a model that, by using just 8 of the variables considered in the study, led to the determination of wine samples' ages at over 97% confidence. This constitutes a rather useful tool for wineries to control Pedro Ximénez sherry wine aging processes. [ABSTRACT FROM AUTHOR]

Brandy stabilization is an important step aimed at decanting the suspended organic and inorganic particles that may cause undesirable turbidity (cloudiness or haze) in brandies, affecting the physico-chemical stability, the organoleptic characteristics, and the consumer's quality perception of the brandy. This phenomenon originates from insoluble salts, volatile compounds (higher alcohols, fatty acid esters, and others), and ethanol-soluble lignins. Among them, ethyl esters of long-chain fatty acids are considered the main cause of haze formation, due to a decrease in their solubility when brandies are stored at low temperatures. For this reason, producers are recommended to intentionally encourage the formation of haze and then to remove it before releasing the brandy to the market. The purpose of this work was to study the influence of two methods of stabilization, the traditional method at room temperature for 1 year, and cold stabilization for 7 days at −10 °C, on the ester profile of "Brandy de Jerez". The results were compared with non-stabilized samples, to determine the main changes in the volatile composition. The use of multivariate statistical analyses made it possible to identify the esters (potential markers) most impacted by the stabilization process. It was observed that traditional stabilization yielded the most distinct ester profile, while brandies stabilized at cold temperature displayed a lower impact on their volatile composition. Furthermore, both stabilization processes produced a significant decrease in ethyl esters of long-chain fatty acids, which are the compounds responsible for haze formation. [ABSTRACT FROM AUTHOR]

Commercial fructans (inulin and oligofructose) are generally obtained from crops such as chicory, Jerusalem artichoke or agave. However, there are agricultural by-products, namely asparagus roots, which could be considered potential sources of fructans. In this work, the fructans extracted from asparagus roots and three commercial ones from chicory and agave were studied in order to compare their composition, physicochemical characteristics, and potential health effects. Asparagus fructans had similar chemical composition to the others, especially in moisture, simple sugars and total fructan contents. However, its contents of ash, protein and phenolic compounds were higher. FTIR analysis confirmed these differences in composition. Orafti®GR showed the highest degree of polymerization (DP) of up to 40, with asparagus fructans (up to 25) falling between Orafti®GR and the others (DP 10–11). Although asparagus fructan powder had a lower fructan content and lower DP than Orafti®GR, its viscosity was higher, probably due to the presence of proteins. The existence of phenolic compounds lent antioxidant activity to asparagus fructans. The prebiotic activity in vitro of the four samples was similar and, in preliminary assays, asparagus fructan extract presented health effects related to infertility and diabetes diseases. All these characteristics confer a great potential for asparagus fructans to be included in the prebiotics market. [ABSTRACT FROM AUTHOR]

Oloroso and Palo Cortado are two types of sherry wines, produced in the Sherry Wine Region in Southern Spain, known as Marco de Jerez, where it is aged following the traditional Criaderas y Solera system. All of them are aged through oxidative ageing, even though the peculiar Palo Cortado Sherry wine is also aged biologically under a veil of flor yeasts in the first stage. Total dry extract, organic acids, aldehydes, esters, higher alcohols and phenolic compounds in these sherry wines evolve during their ageing as a consequence of evaporation and/or perspiration processes, chemical reactions, extraction of compounds from oakwood and microbiological activity. Sherry wines develop their characteristic organoleptic profile during their ageing, as could be proven through their tasting sessions. According to the sherry type, some natural groupings of the wines could be observed after their principal component analysis. Furthermore, by multiple linear regression methods, an important correlation between the parameters that were analyzed and the ageing of each specific wine has been confirmed, which allowed us to establish two different models, each corresponding to the sherry type in question. Only five of the variables that were investigated were required to successfully estimate each wine's age at over 99% confidence. This represents a rather convenient tool for wineries to monitor the ageing of these sherry wines. [ABSTRACT FROM AUTHOR]

Brandy is a unique alcoholic beverage obtained from wine distillates. Numerous studies have been published on its physicochemical traits and the effect of certain elaboration variables on them, but not many studies have been carried out from a sensory point of view or that have followed standardized methods applicable to this discipline. This study intends to determine the effect that certain production variables have on the sensory characteristics of brandy. These variables are the following: The use of sulphur dioxide during the fermentation of the base wine, the subsequent distillation system, the alcohol content during aging, the botanical origin of the aging casks, and their toasting degree. For this purpose, the guidelines provided by the ISO standards for sensory analysis have been followed, and chromatic parameters have also been determined. Heavy extractions from Quercus petraea casks resulted in brandies with widely varying colors, although these were hard to distinguish using the olfactory and gustatory properties associated with the factors under study. Conversely, those brandies aged in Quercus alba casks presented very consistent greenish shades that are not traditionally associated with aged brandy. This lower extraction could explain why the aromatic traits that are found in the fresh spirit are better preserved when this type of oak is used. The spirit obtained through the distillation of SO2-free wines aged in Quercus robur presented average sensory characteristics: Good color, smooth in the mouth, and medium-intensity oak notes. The distillates that were aged at 55% ABV were later perceived as more aromatically intense with a greater oak note on the palate. On the other hand, the brandies obtained from wines without SO2 added were perceived as less alcoholic, sweeter, and more balanced, with a softer oak note. [ABSTRACT FROM AUTHOR]

RPB1, the major and catalytic subunit of human RNA Polymerase II (RNAPII), is specifically degraded by the ubiquitin–proteasome system upon induction of DNA damage by different agents, such as ultraviolet (UV) light. The "last resort" model of RNAPII degradation states that a persistently stalled RNAPII is degraded at the site of the DNA lesion in order to facilitate access to Nucleotide Excision Repair (NER) factors, thereby promoting repair in template strands of active genes. Recent identification and mutation of the lysine residue involved in RPB1 ubiquitylation and degradation unveiled the relevance of RNAPII levels in the control of gene expression. Inhibition of RNAPII degradation after UV light exposure enhanced RNAPII loading onto chromatin, demonstrating that the mere concentration of RNAPII shapes the gene expression response. In this review, we discuss the role of RNAPII ubiquitylation in NER-dependent repair, recent advances in RPB1 degradation mechanisms and its consequences in gene expression under stress, both in normal and repair deficient cells. [ABSTRACT FROM AUTHOR]

The COVID-19 lockdown has had a massive psychological impact on mental health in the general population, with increases in anxiety, depression, and post-traumatic stress disorder. Spiritual well-being, specifically peace and meaning, has already been identified as one of the main protective factors for these disorders in the COVID-19 context. The aim of the present study is to identify facilitating elements for peace and meaning during the COVID-19 lockdown in Spain. Online surveys were used to obtain data from a sample of 3480 Spanish people. Self-compassion and social support were positively related with peace and meaning, while loneliness and perceived discrimination were negatively related. The model for peace and meaning was statistically significant, explaining 47% of the variance. The significant variables were self-kindness, family support, mindfulness, and sense of belonging having a positive association and loneliness a negative one. [ABSTRACT FROM AUTHOR]

Fino and Amontillado are Sherry wines, produced in Marco de Jerez area (southern Spain), and aged in Criaderas y Solera system. Fino Sherry wine follows a biological aging process, under a veil of flor yeasts, while Amontillado Sherry wine shares the same biological aging firstly, followed by oxidative aging, which gives them special features. Organic acids, esters, higher alcohols, phenolic compounds and total dry extract of Sherries evolve during aging due to evaporation processes, physical-chemical reactions, wood contributions and microbiological activity. During aging, Sherry wines improve their organoleptic profile, as could be proved in the tasting sessions. Hierarchical Cluster Analysis and Factor Analysis with factor extraction using Principal Components of Sherry wines studied were carried out and natural groupings of the wines according to the type of aging and their age were observed. A strong correlation between the parameters analyzed and the aging of each wine has been seen in the Multiple Linear Regression studies, establishing two different models, one for each type of Sherry wine, that, with only four of all the variables studied estimated the wine age with more than 99% of confidence. This constitutes a useful tool to control the age of these Sherry wines in the winery. [ABSTRACT FROM AUTHOR]

Crop sustainability is essential for balancing economic development and environmental care, mainly in strong and very competitive regions in the agri-food sector, such as the Region of Murcia in Spain, considered to be the orchard of Europe, despite being a semi-arid area with an important scarcity of fresh water. In this region, farmers apply efficient techniques to minimize supplies and maximize quality and productivity; however, the effects of climate change and the degradation of significant natural environments, such as, the "Mar Menor", the most extent saltwater lagoon of Europe, threatened by resources overexploitation, lead to the search of even better irrigation management techniques to avoid certain effects which could damage the quaternary aquifer connected to such lagoon. This paper describes the Irriman Platform, a system based on Cloud Computing techniques, which includes low-cost wireless data loggers, capable of acquiring data from a wide range of agronomic sensors, and a novel software architecture for safely storing and processing such information, making crop monitoring and irrigation management easier. The proposed platform helps agronomists to optimize irrigation procedures through a usable web-based tool which allows them to elaborate irrigation plans and to evaluate their effectiveness over crops. The system has been deployed in a large number of representative crops, located along near 50,000 ha of the surface, during several phenological cycles. Results demonstrate that the system enables crop monitoring and irrigation optimization, and makes interaction between farmers and agronomists easier. [ABSTRACT FROM AUTHOR]

In potato (Solanum tuberosum L.), protoplast techniques are limited to a few genotypes; thus, the use of regular regeneration procedures of multicellular explants causes us to face complexities associated to CRISPR/Cas9 gene editing efficiency and final identification of individuals. Geminivirus-based replicons contained in T-DNAs could provide an improvement to these procedures considering their cargo capability. We built a Bean yellow dwarf virus-derived replicon vector, pGEF-U, that expresses all the editing reagents under a multi-guide RNA condition, and the Green Fluorescent Protein (GFP) marker gene. Agrobacterium-mediated gene transfer experiments were carried out on 'Yagana-INIA', a relevant local variety with no previous regeneration protocol. Assays showed that pGEF-U had GFP transient expression for up to 10 days post-infiltration when leaf explants were used. A dedicated potato genome analysis tool allowed for the design of guide RNA pairs to induce double cuts of genes associated to enzymatic browning (StPPO1 and 2) and to cold-induced sweetening (StvacINV1 and StBAM1). Monitoring GFP at 7 days post-infiltration, explants led to vector validation as well as to selection for regeneration (34.3% of starting explants). Plant sets were evaluated for the targeted deletion, showing individuals edited for StPPO1 and StBAM1 genes (1 and 4 lines, respectively), although with a transgenic condition. While no targeted deletion was seen in StvacINV1 and StPPO2 plant sets, stable GFP-expressing calli were chosen for analysis; we observed different repair alternatives, ranging from the expected loss of large gene fragments to those showing punctual insertions/deletions at both cut sites or incomplete repairs along the target region. Results validate pGEF-U for gene editing coupled to regular regeneration protocols, and both targeted deletion and single site editings encourage further characterization of the set of plants already generated. [ABSTRACT FROM AUTHOR]

Brandy de Jerez is a European Geographical Indication for grape-derived spirits aged in oak casks that have previously contained any kind of Sherry wine and, therefore, are known as Sherry Casks®. Wood compounds have a substantial influence in the quality of the brandies that are aged in the barrels. In the cellar, the barrels that have been used for many years to keep Sherry wine or other wine spirits are often used for this purpose. When wooden barrels are used for the first time, they release a large amount of compounds into the liquid contained in them. Such amount decreases over time but casks life cycle has remained unexplored until now. The present work has the aim to study the brandies obtained from the same wine spirit after two years ageing in three differently oak casks: namely new, 7 years of use (4 years containing Oloroso wine and 3 years containing wine spirits) and 32 years of use (8 years containing Oloroso wine and 24 years containing wine spirits). According to the results from our experiments, even after 32 years of use, the wood barrels still contribute to modify the organoleptic characteristics of brandy. Moreover, the brandies aged in used barrels were judged more balanced than those aged in new barrels. [ABSTRACT FROM AUTHOR]

Wooden barrels and wood chips are usually used in the ageing of spirits and wines to improve their sensorial profile. Oak wood is the most popular material used in cooperage, but there are other interesting woods, such as cherry or chestnut, that could be considered for this purpose. In this study, a novel method for the determination of the aromatic profile of wood powder by Direct Thermal Desorption-Gas Chromatography-Mass Spectrometry (DTD-GC-MS) was optimized by experimental design. The volatile composition of five different types of wood chips was determined by direct analysis of wood powder by DTD-GC-MS method developed. Thirty-one compounds from wood were identified through this analysis, allowing the differentiation between woods. The aromatic and phenolic compound profile of the 50% hydroalcoholic extract of each type of wood studied was analyzed by Stir-bar Sorptive Extraction-Gas Chromatography-Mass Spectrometry (SBSE-GC-MS) and Ultra-High-Performance Liquid Chromatography (UHPLC) to determine which wood compounds are transferred to spirits and wine after ageing. Different phenolic profiles were found by UHPLC in each wood extract, allowing their differentiation. However, results obtained by SBSE-GC-MS did not allow distinguishing between wood extracts. The analysis of wood in solid state, without any type of previous treatment except grinding, by DTD-GC-MS does not imply any loss of information of the aromatic compounds present in wood as other techniques. This is a potential method to identify aromas in wood that, in addition, allows different types of wood to be differentiated. [ABSTRACT FROM AUTHOR]

The current agricultural water panorama in many Mediterranean countries is composed by desalination facilities, wells (frequently overexploited), the water public utility network, and several consumer agents with different water needs. This distributed water network requires centralized management methods for its proper use, which are difficult to implement as the different agents are usually geographically separated. In this sense, the use of enabling technologies such as the Internet of Things can be essential to the proper operation of these agroindustrial systems. In this paper, an Internet of Things cloud architecture based on the FIWARE standard is proposed for interconnecting the several agents that make up the agroindustrial system. In addition, this architecture includes an efficient management method based on a model predictive control technique, which is aimed at minimizing operating costs. A case study inspired by three real facilities located in Almería (southeast of Spain) is used as the simulation test bed. The obtained results show how around 75% of the total operating costs can be saved with the application of the proposed approach, which could be very significant to decrease the costs of desalinated water and, therefore, to maintain the sustainability of the agricultural system. [ABSTRACT FROM AUTHOR]

Enterohemorrhagic Escherichia coli (EHEC) strains are food-borne pathogens that can cause different clinical conditions. Shiga toxin 2a and/or 2c (Stx2)-producing E. coli O157:H7 is the serotype most frequently associated with severe human disease. In this work we analyzed the hypothesis that host cells participate in Stx2 production, cell damage, and inflammation during EHEC infection. With this aim, macrophage-differentiated THP-1 cells and the intestinal epithelial cell line HCT-8 were incubated with E. coli O157:H7. A time course analysis of cellular and bacterial survival, Stx2 production, stx2 transcription, and cytokine secretion were analyzed in both human cell lines. We demonstrated that macrophages are able to internalize and kill EHEC. Simultaneously, Stx2 produced by internalized bacteria played a major role in macrophage death. In contrast, HCT-8 cells were completely resistant to EHEC infection. Besides, macrophages and HCT-8 infected cells produce IL-1β and IL-8 inflammatory cytokines, respectively. At the same time, bacterial stx2-specific transcripts were detected only in macrophages after EHEC infection. The interplay between bacteria and host cells led to Stx production, triggering of inflammatory response and cell damage, all of which could contribute to a severe outcome after EHEC infections. [ABSTRACT FROM AUTHOR]

In the context of increasing online health misinformation, several new approaches have been deployed to reduce the spread and increase the quality of information consumed. This systematic review examines how source credibility labels and other nudging interventions impact online health information choices. PubMed, Embase, Scopus, and Web of Science were searched for studies that present empirical evidence on the impact of interventions designed to affect online health-information-seeking behavior. Results are mixed: some interventions, such as content labels identifying misinformation or icon arrays displaying information, proved capable of impacting behavior in a particular context. In contrast, other reviewed strategies around signaling the source's credibility have failed to produce significant effects in the tested circumstances. The field of literature is not large enough to draw meaningful conclusions, suggesting that future research should explore how differences in design, method, application, and sources may affect the impact of these interventions and how they can be leveraged to combat the spread of online health misinformation. [ABSTRACT FROM AUTHOR]

Iron deficiency (ID) is usually treated with oral iron salts, but up to 50% of patients complain of gastrointestinal side effects, leading to reduced compliance with treatment. Intravenous (IV) iron formulations are increasingly safe, but there is still a risk of infusion, hypersensitivity reactions and the need for venous access and infusion monitoring. Sucrosomial® Iron (SI) is an innovative oral iron formulation in which ferric pyrophosphate is protected by a phospholipid bilayer plus a sucrester matrix (sucrosome), which is absorbed through para-cellular and trans-cellular routes (M cells). This confers SI's unique structural, physicochemical and pharmacokinetic characteristics, together with its high iron bioavailability and excellent gastrointestinal tolerance. The analysis of the available evidence supports oral SI iron as a valid option for ID treatment, which is more efficacious and tolerable than oral iron salts. SI has also demonstrated a similar effectiveness, with lower risks, in patients usually receiving IV iron (e.g., chronic kidney disease, cancer, bariatric surgery). Thus, oral SI emerges as a valuable first option for treating ID, especially for subjects with intolerance to iron salts or those for whom iron salts are inefficacious. Moreover, SI should also be considered as an alternative to IV iron for initial and/or maintenance treatment in different patient populations. [ABSTRACT FROM AUTHOR]

Starting in the middle of March 2020, various lockdown measures and degrees of confinement were put in place in most European countries as a result of the COVID-19 pandemic. Although this situation meant that more people were likely to experience poorer mental health, largely due to the imposition of social distancing measures, many individuals incorporated music into their coping routines to help improve their psychological well-being. Using a gender perspective, this study analyzes how individuals used music during lockdown and explores the differences between men's and women's views on the impact that listening to and making music has on their perceived level of well-being. A questionnaire, MUSIVID19, was administered to a sample of 1868 participants from all the autonomous regions in Spain. The results reveal that in the uses and perceptions of music, the stereotypes underlying the patriarchal system were also reproduced during confinement. [ABSTRACT FROM AUTHOR]

This study explores the relationship between religiosity, spirituality, and loneliness in the United States, using the 2018 General Social Survey to assess their interactions against a backdrop of declining traditional religious affiliation and a rise in "spiritual but not religious" identification. It examines religion and spirituality's capacity to counteract loneliness, a condition with significant health implications. The analysis uncovers complex relationships between aspects of religious life and loneliness, showing no mitigating role of spirituality when controlling for other factors, with complex and varied negative relationships of religious service attendance and self-rate religiosity to different aspects of loneliness. Yet, any potentially protective effect of religion varies, with minority religious groups reporting feelings of increased loneliness. These findings underscore religion and spirituality's nuanced roles in emotional well-being, indicating that their benefits (or not) against loneliness are complex, varied, and depend on the aspect of religion or loneliness observed, along with non-religious factors. The paper contributes to the literature on societal loneliness, changing religious and spiritual engagements, and highlighting the need for a comprehensive approach to explore the role of religion and spirituality in understanding loneliness specifically, and personal and social well-being more generally. [ABSTRACT FROM AUTHOR]

The COVID-19 pandemic introduced unprecedented challenges for households globally, serving as a precursor to and trigger for financial stress. This study examined the associations across various factors thought to be associated with financial stress (a psychological syndrome) resulting from the COVID-19 pandemic. Using survey data collected in 2019 (n = 997) and 2021 (n = 988), propensity score matching and hierarchical linear modeling were employed to identify the association between financial stress and the pandemic. Results indicated that financial stress increased during the COVID-19 pandemic. Three covariate groups, including financial characteristics, health status, and socio-demographic characteristics, were found to be associated with financial stress levels. The primary contribution of this paper lies in offering a comprehensive understanding of how the dynamics of financial stress evolve with shifting macroeconomic events. This paper serves as a framework to employ a comprehensive financial stress measure and matched samples at various data points. Findings from this study contribute to the existing literature on financial well-being, financial stress, and societal outcomes associated with global health events while providing implications for policy and practice. [ABSTRACT FROM AUTHOR]

Zinc is an essential element for plant nutrition, but it may cause toxicity depending on its bioavailability and potential transformation in soil. In vineyard soils, high concentrations of Zn are usually found, mainly due to agricultural practices. However, a great abandonment of vineyards has recently occurred, leading to changes in the total and bioavailable Zn concentrations, as well as Zn fractionation. We analyzed Zn concentrations (total, ZnT, and bioavailable, ZnED) and fractionation in the soil of three paired sites (PM, PT, and AR) up to depths of 50 cm in active and adjacent abandoned vineyards that were already transformed into forests. The ZnT averaged at 210 mg kg−1 among all studied vineyards. The results showed changes in the vertical pattern ZnT concentrations after vineyard abandonment at the PM and PT sites, while at the AR site, no great variation occurred. The ZnED (mean values = 7 mg kg−1) decreased after abandonment at PM and AR in the uppermost surface layers, while it increased in the top 10 cm at the PT site, reaching up to 60 mg kg−1. Regarding Zn fractionation in active vineyards, the residual fraction (ZnR) was the most abundant, followed by Zn bound to crystalline Fe and Al oxy-hydroxides (ZnC) and Zn bound to soil organic matter (ZnOM). After abandonment, the ZnR slightly increased and the ZnC slightly decreased at the PM and AR sites at all depths, while the ZnOM showed a noticeable variation in the uppermost 10 cm of the PT site. These results suggest that the soil organic matter that is provided during afforestation may play an important role in Zn fractionation and mobilization, depending on its humification degree and chemical stability. Zn mobilization could result in a positive nutrient supply for plants, but caution must be taken, since an excess of Zn could cause toxicity in long-term abandoned vineyards. [ABSTRACT FROM AUTHOR]

The landscape of financial credit risk models is changing rapidly. This study takes a brief look into the future of predictive modelling by considering some factors that influence financial credit risk modelling. The first factor is machine learning. As machine learning expands, it becomes necessary to understand how these techniques work and how they can be applied. The second factor is financial crises. Where predictive models view the future as a reflection of the past, financial crises can violate this assumption. This creates a new field of research on how to adjust predictive models to incorporate forward-looking conditions, which include future expected financial crises. The third factor considers the impact of financial technology (Fintech) on the future of predictive modelling. Fintech creates new applications for predictive modelling and therefore broadens the possibilities in the financial predictive modelling field. This changing landscape causes some challenges but also creates a wealth of opportunities. One way of exploiting these opportunities and managing the associated risks is via industry collaboration. Academics should join hands with industry to create industry-focused training and industry-focused research. In summary, this study made three novel contributions to the field of financial credit risk models. Firstly, it conducts an investigation and provides a comprehensive discussion on three factors that contribute to rapid changes in the credit risk predictive models' landscape. Secondly, it presents a unique discussion of the challenges and opportunities arising from these factors. Lastly, it proposes an innovative solution, specifically collaboration between academic and industry partners, to effectively manage the challenges and take advantage of the opportunities for mutual benefits. [ABSTRACT FROM AUTHOR]

Emerging antibiotic contaminants in water is a global problem because bacterial strains resistant to these antibiotics arise, risking human health. This study describes the use of poly[(4-vinylbenzyl) trimethylammonium chloride] and N-alkylated chitosan, two cationic polymers with different natures and structures to remove nalidixic acid. Both contain ammonium salt as a functional group. One of them is a synthetic polymer, and the other is a modified artificial polymer. The removal of the antibiotic was investigated under various experimental conditions (pH, ionic strength, and antibiotic concentration) using the technique of liquid-phase polymer-based retention (LPR). In addition, a stochastic algorithm provided by Fukui's functions is used. It was shown that alkylated N-chitosan presents 65.0% removal at pH 7, while poly[(4-vinylbenzyl)trimethylammonium chloride] removes 75.0% at pH 9. The interaction mechanisms that predominate the removal processes are electrostatic interactions, π–π interactions, and hydrogen bonding. The polymers reached maximum retention capacities of 1605 mg g−1 for poly[(4-vinylbenzyl) trimethylammonium chloride] and 561 mg g−1 of antibiotic per gram for alkylated poly(N-chitosan). In conclusion, the presence of aromatic groups improves the capacity and polymer–antibiotic interactions. [ABSTRACT FROM AUTHOR]

The introduction of forests in cities has been an observable trend in recent years, with planned forest management projects proliferating around the world. The fact that many urban forests in the public space are traditionally managed by top-down bureaucratic procedures and guided by expert knowledge raises questions about whether green areas should follow the same management approach as other urban infrastructures, such as mobility infrastructures, or whether they should explore a collaborative approach designed to engage diverse stakeholders. This article examines the challenges of innovating in urban forests, changing the management rules that may limit participatory and deliberative processes to support decision-making. In particular, we analyzed how introducing a co-creation stage impacted the traditional competitive public tender procedure in the Madrid Metropolitan Forest project, using the Institutional Analysis and Development (IAD) framework. Results showed that the costs and benefits of innovation differ among involved actors, generating unintended deterrent effects for experimentation. To mitigate these decoupling effects, we suggest a strategic design of working rules and updating the shared incentive to move from a competitive and transactional logic to a more collaborative and co-creative form of connection. [ABSTRACT FROM AUTHOR]

Banks are exposed to climate risks through stranded assets. This risk can be substantial in the banking sector, as it can spawn systemic risk. After the Great Recession, macro-prudential instruments effectively addressed systemic risk. However, climatic risks raise the research question of how feasible it is to address them by adopting macro-prudential instruments. The researchers, therefore, investigate how banks can respond to the risk posed by stranded assets through the framework of using macro-prudential instruments. A semi-systematic review of the related literature is carried out based on the researchers' aim to evaluate theory evidence in the effectiveness of macro-prudential instruments in addressing climate-related risks. The adaptability of macro-prudential instruments to address climatic risks and, by implication, systemic risk is demonstrated in the findings. The researchers develop a framework constituting climate transparency disclosures, climate capital requirement ratio, climate capital conservation, carbon countercyclical buffer and macro-prudential climate stress tests to mitigate the effects of climate risks in banking. [ABSTRACT FROM AUTHOR]

Small companies face significant difficulties in accessing finance, and the use of bank credit and trade credit are the primary sources of financing, specifically in small countries, with little market liquidity, and focused on the banking system, as is the case of Portugal. The main objective of this article is to identify significant drivers of bank and trade credit, as well as investigate the complementary or substitutive relationship between them, considering that both constitute an essential source of financing for small and medium-sized enterprises (SMEs). The sample comprises 5860 companies, and the analysis was performed using panel data methodology (2010–2019). The results suggest that, during the period in which the financial crisis was most felt in the country (2010–2013), companies intensified their demand for trade credit, and in the following years for bank credit. Our evidence does support the substitution hypothesis between trade and bank credit. [ABSTRACT FROM AUTHOR]

From a gender perspective, the persistence of the habitus of masculinity in Chilean male miners in their family relationships, relationships with their partners, sexuality, and work was analyzed, delving into a construction that drives them toward the satisfaction of desires and consumption. The discourses of 13 workers between 25 and 62 years old were obtained through individual and group interviews. The findings constitute an axis of the research Fondecyt 1180079 carried out in Antofagasta, the region with the highest mining production in Chile and the third largest in the world. The conclusions reveal notions of bodily habitus, mediated by gender hierarchies, where binary masculinity is accentuated, reproducing the extractive logic of the industry in the workers themselves. Men recognize a self-demand between fulfilling the mandate of economic provider vs. a relentless disciplining of male bodies in favor of efficiency, control, and exacerbated consumption, which underlies the industry. [ABSTRACT FROM AUTHOR]

In order to stress test loan portfolios for the impacts of climate change, historical events need to be analyzed to create templates to stress test for future events. Using the 2012 Midwestern US drought as an example, this work creates a stress-testing template for future droughts. The analysis connects weather and crop yield data to impacts on local macroeconomic conditions by comparing drought-impacted agricultural counties with nearby urban counties. After measuring the net macroeconomic impacts of the drought, this was used as an overlay with existing macroeconomic stress models to stress test a lender in a different part of the US for possible drought impacts. Having a library of such climate events would allow lenders to stress test their portfolios for a wide range of possible impacts. [ABSTRACT FROM AUTHOR]

Reports show that phytohormone abscisic acid (ABA) is involved in reducing zucchini postharvest chilling injury. During the storage of harvested fruit at low temperatures, chilling injury symptoms were associated with cell damage through the production of reactive oxygen species. In this work, we have studied the importance of different non-enzymatic antioxidants on tolerance to cold stress in zucchini fruit treated with ABA. The application of ABA increases the antioxidant capacity of zucchini fruit during storage through the accumulation of ascorbate, carotenoids and polyphenolic compounds. The quantification of specific phenols was performed by UPLC/MS-MS, observing that exogenous ABA mainly activated the production of flavonoids. The rise in all these non-enzymatic antioxidants due to ABA correlates with a reduction in oxidative stress in treated fruit during cold stress. The results showed that the ABA mainly induces antioxidant metabolism during the first day of exposure to low temperatures, and this response is key to avoiding the occurrence of chilling injury. This work suggests an important protective role of non-enzymatic antioxidants and polyphenolic metabolism in the prevention of chilling injury in zucchini fruit. [ABSTRACT FROM AUTHOR]

This paper studies an attribute control chart for monitoring the number of nonconforming items using a triple sampling (TS-np) which has not yet been applied to attribute control charts. The chart design and procedure for the decision about the state of the process are given. Mathematical expressions for the average run length (ARL) for in-control and out-of-control processes and the average sample number (ASN) are given. A bi-objective genetic algorithm that seeks to minimize the ASN and the probability of type 2 error is implemented in order to optimize the design of the TS-np control chart. A comparison between TS-np, single sampling np (SS-np), double sampling np (DS-np), and multiple dependent state repetitive sampling (MDSRS) control charts is carried out in terms of the out-of-control average run length ( A R L 1 ). Tables of A R L 1 values for TS-np are presented in comparison with MDSRS and DS-np for various scenarios. The operation of the proposed control chart is shown through simulated data. Finally, it is concluded that the proposed TS-np chart has a better performance in terms of A R L 1 detecting small and moderate shifts in the process nonconforming rate in-control ( p 0 ) compared with MDSRS and DS-np. [ABSTRACT FROM AUTHOR]

The Tinto and Odiel rivers (SW Spain) drain from a vast sulfide mining district and join at a 20-km-long estuary that enters the Atlantic Ocean. In this work, the contents of rare earth elements (REE) and fractionation in Neogene–Holocene sediment cores from La Fontanilla cove (Tinto estuary) were studied. The sediments were collected from a depth of 18 m at different distances from the recent river flow and were analyzed for new information on the temporal development of the REE load in the sediment column. Results show that the ∑ REE is higher in the finer sediments and during periods of mining activity from prehistoric to recent times. Marine influence appears to increase the light REE (LREE) relative to the heavy REE (HREE). The REE patterns of these estuarine sediments show convex curvatures in the MREE relative to the LREE and HREE, indicating the presence of acid-mixing processes between the fluvial waters affected by acid mine drainage (AMD) and seawater, as well as the precipitation of poorly crystalline mineral phases. Significant positive Eu anomalies were found in ebb-tide channels and marsh deposits, which can reflect the mineralogical composition and/or a strong localized salinity gradient combined with organic matter degradation. Sedimentological characteristics of the deposits appear to play the main role in accumulation and fractionation of the REE. [ABSTRACT FROM AUTHOR]

Featured Application: A cellular concrete design for building walls to promote the reduction of heat transfer on the envelope and the energy-related CO2 emissions without compromising the mechanical performance of the material. The thermal performance of economical housing located in hot climates remains a pending subject, especially in emerging economies. A cellular concrete mixture was designed, considering its thermophysical properties, to apply the new material into building envelopes. The proposed materials have low density and thermal conductivity to be used as a nonstructural lightweight construction element. From the design stage, a series of wall systems based on cellular concrete was proposed. Whereas in the second phase, the materials were analyzed to obtain the potential energy savings using dynamic simulations. It is foreseen that the energy consumption in buildings located in these climates will continue to increase critically due to the temperature increase associated with climate change. The temperatures predicted mean vote (PMV), electric energy consumption, and CO2 emissions were calculated for three IPCC scenarios. These results will help to identify the impact of climate change on the energy use of the houses built under these weather conditions. The results show that if the conventional concrete blocks continue to be used, the air conditioning energy requirements will increase to 49% for 2030 and 61% by 2050. The proposed cellular concrete could reduce energy consumption between 15% and 28%, and these saving rates would remain in the future. The results indicate that it is necessary to drive the adoption of lightweight materials, so the impact of energy use on climate change can be reduced. [ABSTRACT FROM AUTHOR]