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Type-A γ-aminobutyric acid (GABAA) receptors are channel proteins crucial to mediating neuronal balance in the central nervous system (CNS). The structure of GABAA receptors allows for multiple binding sites and is key to drug development. Yet the formation mechanism of the receptor's distinctive pentameric structure is still unknown. This study aims to investigate the role of three predominant subunits of the human GABAA receptor in the formation of protein pentamers. Through purifying and refolding the protein fragments of the GABAA receptor α1, β2, and γ2 subunits, the particle structures were visualised with negative staining electron microscopy (EM). To aid the analysis, AlphaFold2 was used to compare the structures. Results show that α1 and β2 subunit fragments successfully formed homo-oligomers, particularly homopentameric structures, while the predominant heteropentameric GABAA receptor was also replicated through the combination of the three subunits. However, homopentameric structures were not observed with the γ2 subunit proteins. A comparison of the AlphaFold2 predictions and the previously obtained cryo-EM structures presents new insights into the subunits' modular structure and polymerization status. By performing experimental and computational studies, a deeper understanding of the complex structure of GABAA receptors is provided. Hopefully, this study can pave the way to developing novel therapeutics for neuropsychiatric diseases. [ABSTRACT FROM AUTHOR]

Incorporating AC-type flying capacitors (FC) between series-connected devices is an effective way to enhance the rated voltage for high-power applications based on current source converters (CSCs). Through appropriate modulation and FC voltage control, it is possible to achieve improved DC bus voltage quality with reduced common-mode voltage (CMV) and low dv/dt. On the other hand, the parallel CSC is a popular choice for increasing the system's rated current to accommodate higher power applications. The use of interleaved modulation techniques can improve the harmonic performance of parallel converters while reducing the need for passive filters. The modular flying capacitor clamped (FCC)-CSC structure can combine these advantages, achieving higher rated power along with improved power quality on both the DC and AC sides. Moreover, the enhanced AC quality contributes to the regulation of FC voltage and further improves the DC-side voltage quality. This paper analyzes the operation principle of the parallel FCC-CSC structure and proposes an interleaved space vector modulation (SVM) method to enhance the harmonic performance of the AC output. Additionally, an optimized zero-state replacement (ZSR) based FC voltage control and a DC-link current balance strategy built on this control are introduced. Simulation and experimental results validate the effectiveness of the proposed methods. [ABSTRACT FROM AUTHOR]

In order to study the influence of modular filled and composite material forms on the axial crushing and energy absorption properties of structures, modular filled composite structures were constructed, and innovatively applied to the inner side of double-hat beam (DHB) structures in automobiles. The modular filled structures comprise hexagonal, quadrilateral, and triangular sections. By analyzing the collision performance of modular filled DHB structures, significant enhancements were observed in both the sectional characteristics and the specific Mean Crushing Force of modular filled DHBs compared to the conventional double-hat beam structure. These advancements notably improved the plastic deformation characteristics of the structures. Additionally, dynamic weightlessness experiments were conducted to validate the accuracy of the simulation model. Among the proposed schemes, namely QU-5, HE-5, and TR-5, notable improvements in crashworthiness were identified. Specifically, crashworthiness indicators increased by 32.54%, 78.9%, and 116.53%. Compared with other thin-walled structures, modular filled composite DHBs have advantages in axial crushing and energy absorption. By optimizing layout characteristics, the modular filled structures will achieve significant lightweight and energy absorption performance improvements. This work has clear reference value for automotive engineers and scholars to further explore the axial crash safety, platform modularization, and lightweight design of vehicles. [ABSTRACT FROM AUTHOR]

Artificial reefs featuring different shapes and functions have been deployed around the world, causing impacts on marine ecosystems. However, the approaches typically used to deliver topological complexity, flexibility and expanding requirements to prospective structures during the initial design stages are not well established. The aim of this study was to highlight the advantages and provide evidence on how modularity and parametric design can holistically leverage the performance of multifunctional artificial reefs (MFARs). In particular, the goal was to develop a parametric design for MFAR and establish a direct relationship between specific design parameters and the MFAR target functions or design requirements. The idea of implementing the parametric design for generating the initial biomimetic geometry of the individual modular unit was explored. Furthermore, possible ways of manipulating the geometric parameters of the individual module and the whole assembly were proposed. The findings suggest that, by adopting the developed procedure and the examples studied, several functions may be reached within a single assembly: the promotion of marine biodiversity restoration, the support of scientific platforms with various sensors, as well as the development of recreational diving and of touristic attraction areas. Acquired knowledge suggests that the concept of a nature-like design approach was developed for artificial reefs with varying scales, complexity and functions, which widens the range of possibilities of how smart design of human-made underwater structures may contribute to benefiting the near shore ecosystems. [ABSTRACT FROM AUTHOR]

In high-power applications, achieving adequate power quality in power converter design is accomplished by utilizing multilevel inverters instead of using two-level and three-level inverters. The device generates a sinusoidal output voltage, which results in reduced total harmonic distortion and lower voltage stress on the switches and leads to lower electromagnetic interference, making it suitable for use in renewable energy applications. However, to illustrate the advantages mentioned above, a significant number of switching devices and DC sources are necessary while raising the voltage levels. This article proposes an asymmetrical voltage generation method, which operates in a ratio of 1:5 and generates 25 levels using 11 power switches. The topology is modular in structure, and each module has a lower component count, which significantly reduces the overall cost. The proposed topology is capable of generating negative output voltage levels without the use of an H-bridge configuration, where only three switches are used to generate any voltage levels. The functionality of the developed module is amended by fixing different voltage values in DC sources. This article also presents a comprehensive examination of the circuit and the functioning of various voltage levels. The advantages of the proposed inverter have been demonstrated by comparative research with the currently existing MLI topologies. Ultimately, both the simulation and experimental findings validated the practical capabilities. [ABSTRACT FROM AUTHOR]

Relearning to walk requires progressive training in real scenarios—overground—along with assistance in basic tasks, such as balancing. In addition, user ability must be maximized through compliant robotic assistance as needed. Despite decades of research, gait rehabilitation robotic devices yield controversial results. This article presents the conceptual design of a novel walking assistance and rehabilitation robot, the NIMBLE robot, aimed at providing ambulatory, bodyweight-supported gait training, assisting the user's center of mass trajectory to aid weight transfer and dynamic balance during walking. NIMBLE consists of a robotic mobile frame, a partial bodyweight support (PBWS) system, an ambulatory lower-limb exoskeleton (Exo-H3) and a cable-driven pelvis-assisting robot. Designed as a modular structure, it differentiates hierarchical communication levels through a Robot Operating System (ROS) 2 network. We present the mechatronic design and experimental results assessing the impact of the mechatronic coupling between the robotic modules on the walking kinematics and the frame movement control performance. The robotic frame hardly affects the walking kinematics up to 2 degrees in both the sagittal and frontal planes, making it feasible for lateral balance and weight translation training. Moreover, it successfully tracks and follows user trajectories. The NIMBLE robotic frame assessment shows promising results for ambulatory gait rehabilitation. [ABSTRACT FROM AUTHOR]

Though refugee camps are by definition "temporary", many camps endure for decades, where individuals live full lives through childhood, marriage, children, grandchildren, and death. These settlements function no differently than cities in their social life, density, zoning, and operation, yet are "planned" through UNHCR (United Nations High Commissioner for Refugees) templates for camps. The Zaatari camp in Jordan for Syrian asylum seekers, for example, holds a population of 80,000. Rather than viewing refugee camps as temporary human warehouses, this article demonstrates that camps are spaces where individuals build social networks and economic activities flourish. As such, the camp planning templates should include adaptive Construction 4.0 technologies for more socially flexible settlements, even if the camps are considered "temporary". This case study research on the Zaatari camp illustrates how refugees adapt their built environment, identifying adaptation patterns that enhance both livability and sustainability. The work illustrates social and environmental changes that require adaptive housing configurations. The conclusion suggests linking modern tools in the construction industry to empirically derived planning objectives to be efficiently executed in moments of crisis. [ABSTRACT FROM AUTHOR]

The study aims to identify and categorise the deterrents to adopting modular construction (MC) in affordable housing (AH), revealing their interconnections, and proposing strategies to overcome them. A systematic literature review (SLR) was conducted, followed by Pareto analysis and total interpretive structural modelling (TISM). A total of 75 deterrents were identified from 46 studies, spanning 7 categories: environmental, social and cultural, technical and construction, industry and market, administrative and bureaucratic, economic, and regulatory and policy. The top deterrent category was found to be economic, specifically high initial investment costs and financing challenges. Significant deterrents, particularly economic ones, that impede the adoption of MC in AH are revealed. The interconnectedness of these deterrents highlights the need for comprehensive strategies addressing multiple categories simultaneously. Mitigation strategies and countermeasures are proposed to facilitate the adoption of MC. The study is based on the existing literature, which may have limitations in terms of capturing all possible deterrents. Further empirical research is needed to validate and expand upon these findings. A critical gap is filled by this study, which systematically categorises and analyses deterrents to MC in AH and proposes actionable strategies to mitigate them, thereby contributing to more effective and widespread adoption of MC. The findings are valuable to both global audiences and Australian stakeholders and provide insights that allow the barriers to MC in AH to be overcome. [ABSTRACT FROM AUTHOR]

The development of new chiral ligands with simple and modular structure represents a challenging direction in the design of efficient homogeneous transition metal catalysts. Herein, we report on the asymmetric hydrogenation of prochiral ketones catalyzed by the iridium complexes of simple alkane-diyl-based P,N,O-type chiral ligands with a highly modular structure. The role of (i) the P-N and N-O backbone in the potentially tridentate ligands, (ii) the number, position and relative configuration of their stereogenic elements and (iii) the effect of their NH and OH subunits on the activity and enantioselectivity of the catalytic reactions are studied. The systematic variation in the ligand structure and the comparative catalytic experiments shed light on different mechanistic aspects of the iridium-catalyzed reaction. The catalysts containing the simple alkane-diyl-based ligands with central chirality provided high enantioselectivities (up to 98% ee) under optimized reaction conditions and proved to be active and selective even at very high substrate concentrations (100 mmol substrate/mL solvent). [ABSTRACT FROM AUTHOR]

A topological interlocking assembly (TIA) is an assembly of blocks together with a non-empty subset of blocks called the frame such that every non-empty set of blocks is kinematically constrained and can therefore not be removed from the assembly without causing intersections between blocks of the assembly. TIA provides a wide range of real-world applications, from modular construction in architectural design to potential solutions for sound insulation. Various methods to construct TIA have been proposed in the literature. In this paper, the approach of constructing TIA by applying the Escher trick to tilings of orientable surfaces is discussed. First, the strengths of this approach are highlighted for planar tilings, and the Escher trick is then exploited to construct a planar TIA that is based on the truncated square tiling, which is a semi-regular tiling of the Euclidean plane. Next, the Escher-Like approach is modified to construct TIAs that are based on arbitrary orientable surfaces. Finally, the capabilities of this modified construction method are demonstrated by constructing TIAs that are based on the unit sphere, the truncated icosahedron, and the deltoidal hexecontahedron. [ABSTRACT FROM AUTHOR]

The urban landscape is undergoing significant transformations due to economic shifts, urban planning initiatives, technological advancements, and sociopolitical changes. Almost 89% of the U.S. population is projected to reside in urban areas by 2050, which increases a pressing need for innovative and efficient urban revitalization strategies. Modular construction is an extensively researched topic with potential promise for addressing these challenges; however, there is a lack of comprehensive understanding of its specific opportunities and challenges within the context of urban revitalization. This paper explores the potential of modular construction methods as a viable solution in densely populated areas with limited space and competing land uses. This study employs a systematic literature review using PRISMA and mixed methods analysis with NVivo to identify the opportunities and challenges associated with implementing modular construction in urban settings. The findings highlight the advantages of modular construction, including reduced construction time, enhanced quality control, and improved sustainability. However, challenges such as land scarcity, restrictive zoning laws, and the need for innovative planning and collaboration among stakeholders are also emphasized. This paper provides valuable insights for policymakers, urban planners, and developers to effectively leverage modular construction methods for sustainable and efficient urban renewal efforts. [ABSTRACT FROM AUTHOR]

Modular integrated construction (MiC) is now widely adopted by industry and governments. However, its fragile and delicate logistics are still a concern for impeding project performance. MiC logistic operations involve rigorous multimode transportation, loading-unloading, and stacking during storage. Such processes may induce latent and intrinsic damage to the module. This damage causes safety hazards during assembly and deteriorates the module's structural health during the building use phase. Also, additional inspection and repairs before assembly cause uncertainties and can delay the whole supply chain. Therefore, continuous monitoring of the module's structural response during MiC logistics and the building use phase is vital. An IoT-based multi-sensing system is developed, integrating an accelerometer, gyroscope, and strain sensors to measure the module's structural response. The compact, portable, wireless sensing devices are designed to be easily installed on modules during the logistics and building use phases. The system is tested and calibrated to ensure its accuracy and efficiency. Then, a detailed field experiment is demonstrated to assess the damage, safety, and structural health during MiC logistic operations. The demonstrated damage assessment methods highlight the application for decision-makers to identify the module's structural condition before it arrives on site and proactively avoid any supply chain disruption. The developed sensing system is directly helpful for the industry in monitoring MiC logistics and module structural health during the use phase. The system enables the researchers to investigate and improve logistic strategies and module design by accessing detailed insights into the dynamics of MiC logistic operations. [ABSTRACT FROM AUTHOR]

This paper considers the design, manufacture, and testing of a prototype "soft–stiff" worm-inspired robot referred to herein, as the PneumaticallyActuated PeristaLtic Advancing Modular (PALAM) robot. The robot has a modular structure, mimicking the segmented nature of earthworms, and each segment is individually actuated by a set of three pneumatic artificial muscles (PAMs). The PAMs contract when inflated by pressurised air, generating a pulling force and fulfilling the role of biological muscles in the robot. The PAMs are made from the elastomer silicone rubber, which affords the robot flexibility and enables a wide range of real-life applications. A control-system is designed which can inflate any PAM on demand, and hence replicate the peristaltic motion of earthworms in the PALAM robot. Finally, this paper discusses a successful, low-cost, and widely accessible approach for the manufacture of the PAMs utilised herein. The PAMs can be scaled dimensionally and made from different materials with varying mechanical properties and behaviours, meaning that they are suitable for use in a wide range of robotics applications. [ABSTRACT FROM AUTHOR]

The study presents an integration of cob with robotic processes. By challenging conventional monolithic earth-building methods, the study proposes the use of spatial nonplanar formations that are robotically fabricated, presenting an alternative geometric language for earth construction. The research methodology is derived from existing factors within the robotic lab, encompassing both constant and variable parameters. Through an experimental approach, the variables are systematically manipulated while observing the outcomes to identify patterns and relationships. Incremental refinements to the research conditions result in an optimal equilibrium state within the defined lab parameters. An empirical investigation approach serves as the foundation for controlling the printing process; wherein an iterative adjustment of the robot extrusion parameters is based on the behaviour of the deposited material. The outcome is several robotically printed cob nonplanar prototypes. Depending on their geometric formations and complexity, the printing process combined three variations: continuous, intervals, and modular. The latter enabled the production of a cob arch, serving as proof of feasibility for the creation of modular cob structures through a segmented assembly process. The study contributes to expanding the possibilities of cob construction by leveraging robotic technologies and paving the way for innovative applications of cob in contemporary architecture practices. [ABSTRACT FROM AUTHOR]

The construction industry is constantly evolving through government policies, technologies, and innovative processes. BIM and modular construction are innovative concepts aimed at achieving sustainable smart cities by enhancing cost performance, efficiency, and sustainability. Despite growing global interest in their integration, there is a notable knowledge gap in sub-Saharan Africa. As a result, this research aims to explore the barriers to integrating BIM into modular construction in sub-Saharan Africa. The study adopted a non-experimental design, using a four-stage methodological framework. Initially, a literature review was carried out to conceptualize the study. Stage two involves a pilot survey to create an adequate data collection instrument. In the third stage, 81 registered companies were purposely selected, and data was collected through an online survey. Finally, the fourth stage uses descriptive and inferential techniques to make logical and informed conclusions. The top-ranked barriers are high initial costs, insufficient cross-field expertise, stakeholder collaboration problems, limited software interoperability, and skills shortages. Recommendations include early stakeholder collaboration, BIM execution plan development by modular companies, improved staff training, and increasing financial support from the government. Future research should explore country-specific barriers and case studies to aid the integration of the two innovative solutions in the region. [ABSTRACT FROM AUTHOR]

During emergencies, healthcare is generally provided by tents and temporary shelters, without considering the environmental and social impact of the structures as a priority, in favor of swift response. The resultant constructions intended as a temporary solution often persist for a long time. This paper aims to analyze an alternative and innovative modular structure designed as a transitory solution in emergencies and everyday life. The aim of this study is to assess and compare the energetic performance of a modular adaptive model for basic healthcare for people who are not subscribed to the Italian National Health System. The main goal is to challenge standard models by proposing a new model able to diminish the weaknesses of the current sanitary models, to improve the social conditions, flexibility and energy efficiency, and the thermal comfort of the occupants. In the first part of the paper, the conceptual framework and the preliminary design of the model are described by investigating the benefits of a safe space as a generator space for care services and the community. In the second part, the technological requirements of the system are defined by comparing the use of different panel structures and low-impact technologies. The energy efficiency and environmental impact of the model are assessed by comparing several panel structures in two different climatic areas in Italy (northern and Mediterranean areas) using SketchUp and EnergyPlus simulation. As a result, different configurations of the model are proposed according to the different climatic areas in order to optimize the model, from both an architectural and a technological point of view (box and panel composition). [ABSTRACT FROM AUTHOR]

Modular housing represents an opportunity for the mass provision of housing of an appropriate standard, implemented sustainably. We analyzed the theoretical basis of this type of housing for refugee populations. We identified several generations of housing provision, from tented camps to container settlements, and ultimately to units resembling traditional housing estates. The latter is feasible due to technological advancements. Our research contributes to the implementation of the principles of the New European Bauhaus initiative, which underpins the European Green Deal policy on space design. Using the Research through Design (RtD) method within the framework of a settlement project for the Ukrainian population migrating from war zones (Modular Refugees Settlement Project "ProModSe"), we tested the suitability of these principles in extreme and critical war-related situations. The most important criteria were speed of implementation, the prospect of long-term residence, and ensuring safety. We analyzed the social, environmental, and aesthetic–functional aspects, comparing them with existing practices in the design of settlements for displaced persons, modular settlements, and quality standards in residential environments. The results demonstrate, at multiple scales, the critical interdependence of sustainable development, aesthetics and functionality, and community creation. We emphasize the need to include security as an essential fourth axis within the New European Bauhaus concept. This study contributes to addressing the complex housing problem for refugee populations. The generalizations formulated based on empirical research complement the knowledge of housing and the functioning of the sociotechnological system. [ABSTRACT FROM AUTHOR]

This paper discusses the design and implementation of a portable IoT station. Communication and data synchronization issues in several installations are addressed here, making possible a detailed analysis of the entire system during its operation. The system operator requires a synchronized data stream, combining multiple communication protocols into one single time stamp. The hardware selected for the portable IoT station complies with the International Electrotechnical Commission (IEC) industrial standards. A short discussion regarding interface customization shows how easily the hardware can be modified so that it is integrated with almost any system. A programmable logic controller enables the Node-RED to be utilized. This open-source middleware defines operations for each global variable nominated in the Modbus register. Two applications are presented and discussed in this paper; each application has a distinct methodology utilized to publish and visualize the acquired data. The portable IoT station is highly customizable, consisting of a modular structure and providing the best platform for future research and development of dedicated algorithms. This paper also demonstrates how the portable IoT station can be implemented in systems where time-based data synchronization is essential while introducing a seamless implementation and operation. [ABSTRACT FROM AUTHOR]

Traditional approaches to modular construction progress monitoring and quality control with stringent and tight tolerances for on-site and off-site assembly processes are usually based on 3D laser scanning, but the high equipment costs associated with acquiring point clouds have economic ramifications. This paper provides the details of a new and inexpensive method through the integration of AprilTags and an ordinary phone. By using AprilTags instead of QR codes to label modules, progress management is achieved through the rapid identification and association of multiple modules based on a single image. Moreover, a virtual multi-view vision algorithm based on AprilTags is proposed to generate 3D reverse models of the construction site; the quality result can be acquired by comparing the offset and rotation values of the reverse model and the BIM model. Finally, all the algorithms are validated through comparing the reverse models with the reference models made with 3D printing and 3D laser scanning, which verifies the accuracy and efficiency of the proposed method. [ABSTRACT FROM AUTHOR]

Shear-keyed inter-modular connections (IMCs) are integral components of high-rise modular steel structures (MSSs), providing robust interconnectivity to support grouped tubular columns across modules, thereby introducing column discontinuities and distinctive structural behavior. This study conducted a comprehensive numerical assessment and theoretical analysis of the axial compression behavior of grouped tubular columns based on a validated finite element model (FEM), which captured the member-to-structural level behavior of steel hollow section (SHS) columns and accommodated geometric imperfections. An FEM was initially developed and validated using 28 axial compression tests documented in the literature, comprising 15 tests on cold-formed and 13 on hot-rolled steel hollow section (SHS) columns. The primary parameters explored in tests included material properties (stainless/carbon), processing methods (cold-formed/hot-rolled), cross-section sizes (D/B), cross-sectional or member slenderness ratios (D/tc, B/tc, or Lc/r), and the number of columns (1, 7, and 11). A comprehensive parametric numerical study involving 103 grouped tubular column FEMs then investigated the influence of initial imperfection, shear-key height (Lt), thickness (tt), steel tube length (D), width (B), thickness (tc), and height (Lc) alongside the effects of space between tube and key, and the gap between tubes. The results indicated that the load-shortening behavior of the grouped columns consists of linear elastic, inelastic, and recession stages. The failure modes observed primarily displayed an S-shaped pair of inward and outward local buckling on the outer sides and double S-shaped local buckling on the interior sides. The buckling arose near the shear key or at 1/4 or 1/2 of the column height. None of the considered models experienced global buckling. Increasing tt, Lt, tc, D, or B enhances strength and stiffness, while Lc or Lc/r linearly affects stiffness and ductility. The columns' nominal axial strength was reduced because of the shear keys, which decreased compression yielding and caused localized elastic buckling. Subsequently, the theoretical analysis revealed that the design codes do not capture this behavior, and thus, their capacity estimate yields inaccurate findings. This discrepancy renders existing code prediction equations, including those from Indian (IS800), New Zealand (NZS400), European (EC3:1-1), Canadian (CSA S16), American (AISC360-16), and Chinese (GB50017) standards, as well as the model proposed by Li et al., non-conservative. To assure conservative results, the paper recommended modification of existing standards and proposed prediction equations based on a fourth-order differential equation that describes the actual behavior of modular steel columns grouped with shear keys. The proposed design approach accurately predicted the axial compression capacity of modular steel-grouped columns, proving conservative yet effective. This provides valuable data that could transform design and construction techniques for MSSs, extending to various column and IMC forms through adaptable design parameters. This enhancement in structural performance and safety significantly contributes to the advancement of modular construction practices. [ABSTRACT FROM AUTHOR]

This paper aims to address the problems of safety and durability in China's ballastless track structures, particularly the lack of accurate analysis and methods for predicting the reliability of the new type of prefabricated track structure during the design phase. We propose a reliability prediction method for a new prefabricated track structure, the modular assembled track structure with built-in position retention. By adopting the fuzzy Failure Modes, Effects, and Criticality Analysis (fuzzy FMECA) method, a comprehensive assessment of fault severity, fault occurrence probability, and fault detection difficulty is conducted on the CRTS II slab track structure and the modular assembled track structure with built-in position retention. Consequently, a fault mode hazard assessment model for the new prefabricated track structure is constructed. Based on the assessment model and using a similar product method, a reliability prediction model for the new prefabricated track structure is established, and reliability prediction for the track structure is conducted. The research results indicate that the modular assembled track structure with built-in position retention has lower hazard levels and higher reliability compared to the CRTS II slab track structure. This study provides a scientific basis for the design optimization of new prefabricated track structures, helping to improve their safety and reliability, reduce operating and maintenance costs, and thereby promote the green and low-carbon development of the railway. [ABSTRACT FROM AUTHOR]

The shift from traditional on-site to off-site construction marks a significant evolution in the construction industry, characterized by increasing levels of prefabrication. These advancements enhance construction efficiency, reduce lead times, and mitigate environmental impacts, leading to modular integrated construction (MiC). However, MiC presents complex supply chain challenges, particularly in the transportation of prefabricated components and fully integrated modules. This study addresses these challenges by employing a multi-agent simulation using AnyLogic to optimize MiC transport logistics. The simulation models the interactions of various agents involved in the MiC process to improve operational efficiency and reduce costs. Results demonstrate that using three vehicles per supplier minimizes total transport costs, effectively balancing fixed and variable expenses while eliminating penalties for project delays. The findings highlight the cost efficiency of MiC, showing potential savings due to centralized assembly and optimized logistics. These significantly reduce material transportation and related costs, contributing to the overall efficiency and sustainability of construction projects. These insights underscore the value of multi-agent simulation in addressing the complexities of MiC supply chains. [ABSTRACT FROM AUTHOR]

In today's TEST interconnected world, the security of 5G Medical IoT networks is of paramount concern. The increasing number of connected devices and the transmission of vast amounts of data necessitate robust measures to protect information integrity and confidentiality. However, securing Medical IoT edge nodes poses unique challenges due to their limited resources, making the implementation of cryptographic protocols a complex task. Within these protocols, modular multiplication assumes a crucial role. Therefore, careful consideration must be given to its implementation. This study focuses on developing a resource-efficient hardware implementation of the Montgomery modular multiplication algorithm over GF( 2 l ), which is a critical operation in cryptographic algorithms. The proposed solution introduces a bit-serial systolic array layout with a modular structure and local connectivity between processing elements. This design, inspired by the principles of symmetry, allows for efficient utilization of resources and optimization of area and delay management. This makes it well-suited for deployment in compact Medical IoT edge nodes with limited resources. The suggested bit-serial processor structure was evaluated through ASIC implementation, which demonstrated substantial improvements over competing designs. The results showcase an average area reduction of 24.5% and significant savings in the area–time product of 26.2%. [ABSTRACT FROM AUTHOR]

This paper proposes a heuristic approach for managing complex construction projects. The tool incorporates Primavera P6 EPPM and Synchro 4D, enabling proactive clash detection and resolution of spatial conflicts during concurrent tasks. Additionally, it performs resource verification for sufficient allocation before task initiation. This integrated approach facilitates the generation of conflict-free and feasible construction schedules. By adhering to project constraints and seamlessly integrating with existing industry tools, the proposed solution offers a comprehensive and robust approach to construction project management. This constitutes, to our knowledge, the first dynamic digital twin for the delivery of a complex project. [ABSTRACT FROM AUTHOR]

In recent years, the topic of climate change has been increasingly noticed by the public, and carbon emission reduction is one of the primary targets for various industries worldwide. The construction industry has a profound influence in this field, so it is significant to consider what kind of efforts can be made in building projects. Many scholars agree to promote prefabrication technology for construction, but its application still faces several challenges. By undertaking desk research, this paper explores the motivation and barriers to adopting modular techniques in construction projects under the lifecycle analysis. The preliminary information of the literature review is collated from dozens of peer-reviewed academic papers. Under the whole lifecycle thought, the PEST analysis tools also present the analytical results. This research finds that the top five barriers are the attitudinal resistance to using modular constructions, lack of sufficient modular expertise and practice, increasing costs and risks on supply chain management, insufficient government support and policy making, and high design and planning requirements. Moreover, the lifecycle analysis can divide the collated barriers into each stage, and adequate government support can assist in promoting the prefabrication in building projects in financial, legal, and technical aspects. The current findings can facilitate the broader use of prefabrication in building projects, improving the environmental sustainability of stakeholders. The process of proposed desk research can also be considered a referenced pattern for other related studies. More first-hand data should be collected and evaluated in further research to improve accuracy and adapt to the newest research field and industrial situations. [ABSTRACT FROM AUTHOR]

This study focuses on evaluating modular house construction projects, which is a critical segment within sustainable building practices. Despite the significant advantages of modular construction, such as enhanced resource efficiency and reduced environmental impact, existing research often overlooks its unique attributes and constraints. Our objectives were to identify crucial parameters for a comprehensive evaluation of modular construction, particularly emphasizing sustainability, and to explore how an advanced conversational AI tool, ChatGPT, can assist in modular building assessments. We employed the Delphi method to define these parameters and integrated ChatGPT to develop a robust assessment methodology. This approach allowed us to harness AI-driven insights to enrich the evaluation process. Our findings suggest that ChatGPT delivers high-quality results comparable to those produced by experts in modular building assessments. ChatGPT formulated a detailed description of the evaluation scale for each criterion, effectively outlining the guidelines for evaluating modular house projects. To illustrate the effectiveness of our proposed methodology, we applied it to a real-world modular house project in Lithuania, demonstrating how this approach can significantly contribute to advancing sustainable construction practices. [ABSTRACT FROM AUTHOR]

As construction projects become increasingly complex, modular integrated construction (MiC) has emerged as a pivotal solution, driving integrated development in complex projects. However, the reliance on prefabricated modules underscores the crucial role of supply chain management (SCM) in MiC, necessitating strategic planning and operational control. This study aimed to use bibliometric analysis to map the SCM knowledge domain within MiC. Through the use of keywords related to "supply chain" and "MiC", 196 relevant papers were extracted from the Web of Science database. These papers were subjected to co-citation analysis, keyword co-occurrence analysis, and time span analysis to elucidate the historical evolution, multidisciplinary domains, and future directions in planning and control within SCM-MiC. The research identified two milestones in SCM-MiC's historical trajectory, enhancing our understanding of its foundations. Moreover, 11 clusters were identified, illustrating the multidisciplinary nature of SCM-MiC. Dividing the literature into seven stages of the supply chain, the research outlined four research directions aligned with project complexity and technological development, highlighting current hotspots and gaps of the strategic planning and control. These directions bridge the construction management and information technology domains, guiding future SCM-MiC research within complex project management. [ABSTRACT FROM AUTHOR]

In the aftermath of the COVID-19 pandemic, the urgent need for the rapid deployment of healthcare facilities propelled the rise of modular construction using an infill approach. In these modular, negative-pressure wards, the design of indoor airflow and pressure plays a crucial role in meeting the ventilation strategies required for isolation facilities. Accordingly, this paper focuses on modular negative-pressure wards employing an infill construction method and proposes an appropriate spatial pressure distribution to address the problem of air tightness degradation due to leakage. This study analyzed the indoor airflow and pressure distribution of a unit module corresponding to an infill. It aimed to examine whether the pressure difference with the adjacent room is maintained and to assess its effectiveness in isolating contaminated air. First, the airflow rate of the heating, ventilation, and air conditioning system in the unit module was calculated to ensure that it would meet the performance criteria of the negative-pressure ward. Afterward, based on the calculated rate, the study assessed the airflow and room-specific pressure within a typical floor, encompassing both the unit module and associated nursing support facilities. Here, the airflow in the external corridor of the typical floor was divided into two cases according to the pressure distribution: negative pressure and atmospheric pressure. The calculation results were compared using a computational fluid dynamics tool. The analysis results confirm that the air isolation performance is adequate as the pressure difference between adjacent rooms in the unit module and the typical floor was maintained at 2.5 Pa. Additionally, the indoor airflow in the negative-pressure isolation room formed a stable flow at a slow speed of 0.1–0.2 m/s, minimizing the possibility of air contamination from outside the isolation room. In particular, Case B of the typical floor design proposes a method to optimize the pressure distribution in the modular negative-pressure ward by designing the ventilation flow rate at atmospheric pressure level. Thus, this study emphasizes that atmospheric pressure design is appropriate when designing pressure in areas where negative-pressure control is difficult and can contribute to the design and improvement of similar medical facilities in the future. [ABSTRACT FROM AUTHOR]

Modular construction is gaining worldwide attention. Building services are the systems that make buildings comfortable and efficient. Mechanical, electrical, and plumbing (MEP) systems provide heating, cooling, lighting, energy distribution, and water services. Modular construction integrates building services into prefabricated modules at the manufacturing site, which are then transported to the construction site. A systematic review (SR) of building services integration within modular construction is thus necessary. Prior to the SR, a quantitative analysis of the retrieved 115 publications from the Scopus database was explored. Using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guide, 13 relevant publications from the Scopus database and via the Research Rabbit application were profiled. MEP systems integration approaches and research needs were examined. Recent literature emphasizes technology integration and sustainability, while early studies laid the framework for modular approaches. The findings highlight the potential of digital technologies like building information modeling (BIM) and recommend a holistic framework for the entire building's lifetime, from design to operation. Future research directions include performance studies, modular building service adaptation, and industry-wide standards building. Researchers and practitioners seeking to improve modular construction methods and integrate complex building services will gain insights from this study. [ABSTRACT FROM AUTHOR]

Multiport converters (MCs) are widely adopted in many applications, from renewable energy sources and storage integration to automotive applications and distribution systems. They are used in order to interface different energy sources, storage devices and loads with one single, simple converter topology in contrast to the traditional approach, which can require different solutions made by two-port converters. MCs allow for a reduction in the number of components and cascaded conversion stages with respect to an equivalent system of two-port converters, resulting in reduced complexity, dimensions and costs, as well as in improved reliability and enhanced efficiency. Nevertheless, some aspects related to the design of MCs are still worth further discussion when MCs are applied to hybrid AC/DC distribution systems. First, most converters are developed for one specific application and are not modular in structure. Furthermore, many of the proposed solutions are not equally suitable for AC and DC applications and they can introduce significant issues in hybrid distribution systems, with earthing management being particularly critical. Even though most available solutions offer satisfying steady-state and dynamic performances, fault behavior is often not considered and the possibility of maintaining controllability during faults is overlooked. Building on these three aspects, in this paper, a new MC for hybrid distribution systems is presented. An innovative circuit topology integrating three-phase AC ports and three-wire DC ports and characterized by a unique connection between the AC neutral wire and the DC midpoint neutral wire is presented. Its control principles and properties during external faults are highlighted, and extensive numerical simulations support the presented discussion. [ABSTRACT FROM AUTHOR]

The transformation formula under the action of a general linear fractional transformation for a generalized Dedekind eta function has been the subject of intensive study since the works of Rademacher, Dieter, Meyer, and Schoenberg et al. However, the (Hecke) modular relation structure was not recognized until the work of Goldstein-de la Torre, where the modular relations mean equivalent assertions to the functional equation for the relevant zeta functions. The Hecke modular relation is a special case of this, with a single gamma factor and the corresponding modular form (or in the form of Lambert series). This has been the strongest motivation for research in the theory of modular forms since Hecke's work in the 1930s. Our main aim is to restore the fundamental work of Rademacher (1932) by locating the functional equation hidden in the argument and to reveal the Hecke correspondence in all subsequent works (which depend on the method of Rademacher) as well as in the work of Rademacher. By our elucidation many of the subsequent works will be made clear and put in their proper positions. [ABSTRACT FROM AUTHOR]

The integration of the Arduino board into educational settings has penetrated across various educational levels. The teaching of this subject can be accomplished by (a) using real components in breadboards, (b) prefabricated modular boards that snap together, and (c) utilizing computer simulations. Yet, it is unknown which interface offers a more effective learning experience. Therefore, this experimental study aims to compare the effectiveness of these interfaces in a series of three laboratory exercises involving 110 university students, who were divided into three groups: (a) the first group used a tangible user interface, implementing circuits on breadboards, (b) the second group also used a tangible interface but with modular boards, and (c) the third group used a graphical user interface to simulate circuits using Tinkercad. For each laboratory exercise, students completed both pretests and posttests. Also, they provided feedback through five Likert-type attitude questions regarding their experiences. In terms of data analysis, t-tests, ANOVA, and ANCOVA, along with bootstrapping, and principal component analysis were employed. The results suggest that among the participants, those who used a graphical user interface stated that their understanding of the interconnection of components in microcontroller circuits was enhanced, while students with previous experience in microcontroller labs found the circuit creation process easier than students without experience. [ABSTRACT FROM AUTHOR]

This paper presents a novel approach to developing fully automated intelligent control systems for use within production-based organizations, with a specific focus on advancing research into intelligent production systems. This analysis underscores a prevailing deficiency in control operations preceding assembly, where single-purpose control machines are commonly utilized, thus presenting inherent limitations. Conversely, while accurate multipurpose measurement centers exist, they often fail to deliver comprehensive quality control for manufactured parts due to cost and time constraints associated with the measuring process. The primary aim in this study was to develop an intelligent modular control system capable of overseeing the production of diverse components effectively. The modular intelligent control system is designed to meticulously monitor the quality of each module during the pre-assembly phase. By integrating sophisticated sensors, diagnostic tools, and intelligent control mechanisms, this system ensures precise control over module production processes. It facilitates the monitoring of multiple parameters and critical quality features, while integrated sensors and diagnostic methods promptly identify discrepancies and inaccuracies, enabling the swift diagnosis of issues within specific modules. The system's intelligent control algorithms optimize production processes and ensure synchronization among individual modules, thereby ensuring consistent quality and performance. Notably, the implementation of this solution reduces inspection time by an average of 40 to 60% compared to manual inspection methods. Moreover, the system enables the comprehensive archiving of measurement data, eliminating the substantial error rates introduced by human involvement in the inspection process. Furthermore, the system enhances overall project efficiency, predictability, and safety, while allowing for rapid adjustments in order to meet standards and requirements. This innovative approach represents a significant advancement in intelligent control systems for use in production organizations, offering substantial benefits in terms of efficiency, accuracy, and adaptability. [ABSTRACT FROM AUTHOR]

Modular timber construction embodies a pioneering and eco-friendly methodology within the building sector. With the notable progress made in manufacturing technologies and the advent of engineered wood products, timber has evolved into a promising substitute for conventional materials such as concrete, masonry, and steel. Beyond its structural attributes, timber brings environmental advantages, including its inherent capacity for carbon sequestration and a reduced carbon footprint compared to conventional materials. Timber's lightweight nature, coupled with its versatility and efficiency in factory-based production, accelerates modular construction processes, providing a sustainable solution to the growing demands of the building industry. This work thoroughly explores contemporary modular construction using wood as the primary material. The investigation spans various aspects, from the fundamentals of modularity and the classification of modular timber solutions to considerations of layout design, structural systems, and stability at both the building and module levels. Moreover, inter-module joining techniques, MEP (mechanical, electrical, and plumbing) integration, and designs for disassembly are scrutinized. The investigation led to the conclusion that timber modular construction, drawing inspiration from the steel modular concept, consistently utilizes a structural approach based on linear members (timber frame, post-and-beam, etc.), incorporating stability configurations and diverse joint techniques. Despite the emphasis on modularization and prefabrication for adaptability, a significant portion of solutions still concentrate on the on-site linear assembly process of those linear members. Regarding modularity trends, the initial prevalence of 2D and 3D systems has given way to a recent surge in the utilization of post-and-beam structures, congruent with the ascending verticality of buildings. In contrast to avant-garde and bold trends, timber structures typically manifest as rectilinear, symmetric plans, characterized by regular and repetitive extrusions, demonstrating a proclivity for centrally located cores. This work aims to offer valuable insights into the current utilization of modular timber construction while identifying pivotal gaps for exploration. The delineation of these unexplored areas seeks to enable the advancement of modular timber projects and systems, fully leveraging the benefits provided by prefabrication and modularity. [ABSTRACT FROM AUTHOR]

On-orbit assembling space telescope (OAST) is one of the most feasible methods to implement a large-scale space telescope. Unlike a monolithic space telescope (such as Hubble Space Telescope, HST) or a deployable space telescope (such as James Webb Space Telescope, JWST), OAST can be assembled in the spatial environment. To ensure proper telescope performance, OAST must be equipped with a large deployable sunshade. In order to verify the technology of the OAST, the authors propose a modular space telescope on the China Space Station (CSS) and design a deployable sunshade. The deployable mechanism of the sunshade is made up of a radial deployable mechanism and an axial deployable mechanism. The paper describes the overall design approach, the key component technologies, and the design and preliminary testing of a part of the deployable sunshade assembly. [ABSTRACT FROM AUTHOR]

Autonomous driving navigation relies on diverse approaches, each with advantages and limitations depending on various factors. For HD maps, modular systems excel, while end-to-end methods dominate mapless scenarios. However, few leverage the strengths of both. This paper innovates by proposing a hybrid architecture that seamlessly integrates modular perception and control modules with data-driven path planning. This innovative design leverages the strengths of both approaches, enabling a clear understanding and debugging of individual components while simultaneously harnessing the learning power of end-to-end approaches. Our proposed architecture achieved first and second place in the 2023 CARLA Autonomous Driving Challenge's SENSORS and MAP tracks, respectively. These results demonstrate the architecture's effectiveness in both map-based and mapless navigation. We achieved a driving score of 41.56 and the highest route completion of 86.03 in the MAP track of the CARLA Challenge leaderboard 1, and driving scores of 35.36 and 1.23 in the CARLA Challenge SENSOR track with route completions of 85.01 and 9.55 , for, respectively, leaderboard 1 and 2. The results of leaderboard 2 raised the hybrid architecture to the first position, winning the edition of the 2023 CARLA Autonomous Driving Competition. [ABSTRACT FROM AUTHOR]

Soil fungal communities play a critical role in the promotion of nutrient cycling and the stabilization of ecosystem functions in subtropical forests. Yet, clarifying the relationships between soil fungal diversity and microclimate variability along an elevational gradient, as well as understanding the driving mechanisms of their variations in subtropical forests, remains insufficiently understood. In this study, we recorded the composition and soil fungal diversity along an elevational gradient in Daiyun Mountain of China, aiming to elucidate the primary factors influencing the structure of the dominant soil fungal along an elevational gradient in subtropical forests. The results showed that (1) the dominant phylum of soil fungi at different elevations were Basidiomycota, Ascomycota (relative abundance > 10%) and Zygomycota (relative abundance > 1%). The Simpson index of soil fungi showed a clear upward trend along the elevational gradient, while no significant difference was observed in the other indices, and both overall reached their maximum value at the elevation of 1200 m. (2) The mean annual soil temperature and moisture, soil pH and available phosphorus were the main factors driving the dominant soil fungal along the elevational gradient. (3) Co–occurrence network analyses revealed a distinct modular structure of dominant soil fungal communities at different elevations, with Ascomycetes identified as the key taxa in fungi network relationships. Our research holds ecological significance in understanding the pivotal role of soil environmental factors in shaping the complex composition and interactions within soil fungal communities. [ABSTRACT FROM AUTHOR]

Construction professionals work in silos and use traditional design and construction methods. The growing demand for rapidly built and high-quality construction is making off-site manufacturing mainstream. Studies have shown that collaboration among all stakeholders is a necessary component for success in the construction of such buildings. This multidisciplinary study of an existing concrete hotel aims to explore an alternative structural design in mass timber or volumetric modular construction. To this end, the reinforced concrete floor plan of Club Med de Charlevoix in Quebec, Canada, was used as a benchmark for two different structural systems. The first strategy investigated CLT (cross-laminated timber) and glulam columns to replicate the reinforced concrete system (column–slab), while the second involved maximum prefabrication (volumetric modular construction). Both mass timber and volumetric modular strategies can lead to a smaller carbon footprint. The main conclusion is that the plan should be designed from the outset to be either traditional or prefabricated since major changes are required if the choice is made to switch from one system to the other. Moreover, when structural systems maximize off-site construction, such as volumetric modular construction, the various professions need to be included during early planning. This is necessary to avoid task duplication and prevent the neglect of considerations such as manufacturable dimensions and partition organization. [ABSTRACT FROM AUTHOR]

Modular construction is becoming famous for buildings because it allows a high degree of prefabrication, with individual modules easily transported and installed. Building envelope optimization is vital as it protects buildings from undesirable external environments by expressly preventing the incursion of outside elements. This research uses a systematic literature review to appraise the characteristics of modular envelope panels, focusing on hygrothermal and energy performance. A total of 265 articles were subjected to rigorous filtering and screening measures. The findings reveal notable inconsistencies in modular envelope terminologies and a lack of consistent performance measures, which present significant challenges for research and development efforts. Furthermore, the results indicate a predominant focus on hygrothermal and energy performance in existing studies, with limited attention to environmental impacts and other performance factors. Moreover, the existing literature primarily addresses modular envelope solutions in temperate climates, offering inadequate information for hot and hot–humid climate contexts. To address these gaps, this study proposes categorizing modular envelope panels into four distinct categories: active, passive, smart, and green/vegetated wall panels. These findings will benefit researchers, architects, building envelope designers, policymakers, and organizations developing building performance-related assessment ratings, standards, and codes. The study suggests adopting the categorization of modular envelope panels provided in this study and developing modular panels suitable for hot and humid climates to fill the existing knowledge gap. [ABSTRACT FROM AUTHOR]

In modular structures, inaccuracies of the modules superimpose over the entire structure. Depending on the placement of the modules, these inaccuracies have (different) effects on stresses and total deformations. Especially for structures with many individual modules, it is favorable to place them according to their influence. To cover structural diversity, column-, beam-, and wall-like modular structures made from plane modules are investigated. In numerical simulation, geometric inaccuracies are applied via an equivalent temperature approach, which allows almost arbitrary nodal deviations of the modules. With the elementary effects method, the sensitivities of the modules' inaccuracies regarding their structural impact can be determined with minimal computational effort. On a predefined control node, the overall structural inaccuracies are examined in a simplified manner. Column-like structures experience higher deformations due to inclination than beam-like or wall-like structures. For column-like, the bottommost modules are decisive for the overall inaccuracy, as they contribute significantly to the inclination. By contrast, modules at the supports are identified as particularly sensitive for beam- and wall-like structures. Controlling module placement towards their mean absolute influence, the deformation at the control node is mathematically reduced by at least 43% compared to random placement. Thereby, even modules that do not comply with tolerance requirements for structural components can be used in areas of low influence for a sustainable and low-waste design. [ABSTRACT FROM AUTHOR]

Prompt optimization is a crucial task for improving the performance of large language models for downstream tasks. In this paper, a prompt is a sequence of n-grams selected from a vocabulary. Consequently, the aim is to select the optimal prompt concerning a certain performance metric. Prompt optimization can be considered as a combinatorial optimization problem, with the number of possible prompts (i.e., the combinatorial search space) given by the size of the vocabulary (i.e., all the possible n-grams) raised to the power of the length of the prompt. Exhaustive search is impractical; thus, an efficient search strategy is needed. We propose a Bayesian Optimization method performed over a continuous relaxation of the combinatorial search space. Bayesian Optimization is the dominant approach in black-box optimization for its sample efficiency, along with its modular structure and versatility. We use BoTorch, a library for Bayesian Optimization research built on top of PyTorch. Specifically, we focus on Hard Prompt Tuning, which directly searches for an optimal prompt to be added to the text input without requiring access to the Large Language Model, using it as a black-box (such as for GPT-4 which is available as a Model as a Service). Albeit preliminary and based on "vanilla" Bayesian Optimization algorithms, our experiments with RoBERTa as a large language model, on six benchmark datasets, show good performances when compared against other state-of-the-art black-box prompt optimization methods and enable an analysis of the trade-off between the size of the search space, accuracy, and wall-clock time. [ABSTRACT FROM AUTHOR]

Thuja sutchuenensis Franch., an endangered species sparsely distributed in the mountainous and arid regions of southwest China, faces the critical challenge of adapting to these harsh conditions. Understanding the plant's strategies for survival and the precise roles played by soil fungal communities in this adaptation remains an area of limited knowledge. Our investigation centers on the fungal communities associated with T. sutchuenensis and their interactions with soil water content. Notably, we identified unique fungal communities in the low soil moisture group, and these communities exhibited lower coverage but higher phylogenetic diversity (PD), Chao1, and Shannon indices compared to other groups. Network analysis revealed a modular structure within the fungal communities, with key hub nodes identified, particularly in the arid group. This group demonstrated higher levels of soil saprotrophs and ectomycorrhizal fungi and a reduced presence of plant pathogens. Linear discriminant analysis highlighted the significance of genera such as Russula, Myxotrichaceae, and Sebacina, emphasizing their roles in supporting the plant in arid environments. Random forest analysis indicated that soil moisture content emerged as the primary driver in determining fungal composition and diversity and contributed to the variables of several fungal genera. Collectively, this study provides valuable insights into the fungal communities associated with T. sutchuenensis, shedding light on their adaptation to extreme arid conditions. [ABSTRACT FROM AUTHOR]

This paper delineates the design and realization of a Wheelchair-Mounted Robotic Arm (WMRA), envisioned as an autonomous assistance apparatus for individuals encountering motor difficulties and/or upper limb paralysis. The proposed design solution is based on employing a 3D printing process coupled with optimization design techniques to achieve a cost-oriented and user-friendly solution. The proposed design is based on utilizing commercial Arduino control hardware. The proposed device has been named Pick&Eat. The proposed device embodies reliability, functionality, and cost-effectiveness, and features a modular structure housing a 4-degrees-of-freedom robotic arm with a fixing frame that can be attached to commercial wheelchairs. The arm is integrated with an interchangeable end-effector facilitating the use of various tools such as spoons or forks tailored to different food types. Electrical and sensor components were meticulously designed, incorporating sensors to ensure user safety throughout operations. Smooth and secure operations are achieved through a sequential procedure that is depicted in a specific flowchart. Experimental tests have been carried out to demonstrate the engineering feasibility and effectiveness of the proposed design solution as an innovative assistive solution for individuals grappling with upper limb impairment. Its capacity to aid patients during the eating process holds promise for enhancing their quality of life, particularly among the elderly and those with disabilities. [ABSTRACT FROM AUTHOR]

This paper investigates the robustness of a single 3D volumetric corner-supported module made of square hollow-section (SHS) columns. Typically, the moment–rotation (M-θ) behaviour of connections within the module (intra-module) is assumed to be fully rigid rather than semi-rigid, resulting in inaccurate assessment (i.e., overestimated vertical stiffness) during extreme loading events, such as progressive collapse. The intra-module connections are not capable of rigidly transferring the moment from the beams to the SHS columns. In this paper, a computationally intensive shell element model (SEM) of the module frame is created. The M-θ relationship of the intra-module connections in the SEM is firstly validated against test results by others and then replicated in a new simplified phenomenological beam element model (BEM), using nonlinear spring elements to capture the M-θ relationship. Comparing the structural behaviour of the SEM and BEM, under notional support removal, shows that the proposed BEM with semi-rigid connections (SR-BEM) agrees well with the validated SEM and requires substantially lower modelling time (98.7% lower) and computational effort (97.4% less RAM). When compared to a BEM with the typically modelled fully rigid intra-module connections (FR-BEM), the vertical displacement in the SR-BEM is at least 16% higher. The results demonstrate the importance of an accurate assessment of framing rotational stiffness and the benefits of a computationally efficient model. [ABSTRACT FROM AUTHOR]

Featured Application: Inelastic analysis of RC slender beam elements under cyclic loading. A mathematical model for RC beam elements is presented that falls into the category of distributed inelasticity models discretizing the cross-section in polygons (trapezoids, triangles). The models falling into these categories are considered to be able to describe in the best manner the inelastic behavior of the element across its whole clear length, since its response results from the numerical integration of the stiffnesses of its cross-sections, while presenting an ideal combination of accuracy, simplicity, and computational cost. The behavior of the cross-section is described through the constitutive relationships σ–ε of its materials for cyclic loading. The main objectives for the development of the proposed mathematical model are as follows: (a) the increased accuracy of the results compared to existing experimental ones; (b) the limitless generalization of its application, regarding of the cross-section shape; and (c) the elimination of the numerical problems presented by the application of other related models, a fact that leads to their impractical use in real three-dimensional structures. The proposed model falls under the category of distributed inelasticity models. This paper focuses on its initial version, which targets slender beam elements with negligible shear and bond-slip effects (i.e., with ribbed bars, sufficiently anchored). Thus, it is applicable to 2D and 3D framed structures that fulfill these conditions, while its modular structure allows for future adjustments for the inclusion of other effects. [ABSTRACT FROM AUTHOR]

Despite the growing rich and fragmented literature focusing on quality assurance (QA) and Industry 4.0, the implementation of associated individual digital technologies has not been fully evaluated and synthesised to achieve adequate QA in the construction industry; hence, it has received limited focus. This study, thus, aimed to organise, evaluate, and synthesise the current literature on individual digital technology applications in QA in the construction industry and propose future research directions. A literature review approach was adopted for this study along with Deming's cycle framework to address four research questions: (1) What is the status of the state-of-the-art in the literature? (2) What digital technologies have been applied for QA in the construction industry? (3) Which areas in QA processes have experienced digital technology applications, and what are the applications? (4) What are the limitations of the existing studies and future research directions of digital technologies for QA in the construction industry? The findings showed an increasing trend of research on digital technology for QA in construction since 2017. This cuts across 23 countries with six different research methods published across 18 different publication sources. Four categories of digital technologies were revealed to have been adopted for QA in construction based on the functionality of the technologies: data collection technologies, decision-oriented technologies, collaborative technologies, and transparency and security-related technologies. Evaluation with Deming's cycle framework revealed that digital technologies have a high level of application at the "do" phase, improving the quality management process during construction towards achieving pre-stated quality requirements. This includes mostly collaborative technologies, consisting of BIM technologies. Limitations of the existing studies were further identified, and this led to five research directions: interoperability of technology development, integrated digital technologies for QA of prefabricated and modular construction, integrated digital technologies for QA of cross-border construction logistics and supply chain, digital innovation for sustainable QA, and moving beyond the technical solution. The study showed a significant contribution to both academia and the industry in the built environment. [ABSTRACT FROM AUTHOR]

As an innovative building system, the modular steel structure demonstrates a high degree of industrialization and assembly efficiency. However, no linkage exists between the components of modular units, leading to issues such as diminished load capacity and excessive steel usage in modular construction. In order to tackle these challenges, finite element numerical simulations are employed to examine the inter-column connectors and the cooperative modular steel buildings. This simulation calculates the initial stiffness across various degrees of freedom in these connectors. In addition, it analyzes the displacement response, changes in internal forces, and height of cooperative modular steel structures under varying seismic precautionary intensities. The results revealed that cooperative modular steel buildings substantially improve overall stiffness and lateral performance compared to their non-cooperative counterparts. There is a maximum reduction in the inter-story displacement angle of up to 36.1%, and the maximum reduction of the top displacement can reach 16.2%. This enhancement also increases structural stiffness, a shortened natural vibration period, and an augmented bottom shear force. Based on these findings, it is advised that the height of cooperative modular steel buildings should not exceed 21 m at 7 degrees (0.10 g), 21 m at 7 degrees (0.15 g), and 12 m at 8 degrees (0.20 g). [ABSTRACT FROM AUTHOR]

Based on the elastic–plastic contact theory, elastic–plastic contact finite element models for the integrated modular house by flat pack are established. The structural stress and displacement distributions are obtained. An experimental test is conducted to study the performance of the corner fitting joint of the house. The finite element analysis and experimental test comprehensively demonstrated the safety and reliability of the house structure. The results show that the most unfavorable stress point of the house is located at the corner fitting joint. When the end plate connection holes of the corner column seal are designed with through holes and internal screw holes, respectively, the fastening effect of bolting between the corner fitting and corner column using the internal screw hole is better. The reliability of the repeated disassembly and assembly of the house is verified via multiple loading–unloading simulation cycle experiments of the corner fitting joint. The results of the study provide technical support and a reference basis for the optimal design and ensuring the service performance of the integrated modular house by flat pack. [ABSTRACT FROM AUTHOR]

Prefabricated installation, a pivotal study in the realm of contemporary construction practices, delves into the utilization of prefabrication within mechanical, electrical, and plumbing (MEP) systems. Despite its ascending prominence, the domain grapples with ambiguities in application pathways, uncertain developmental trajectories, and the absence of a holistic technical paradigm. This research endeavors to bridge these gaps by conducting a thorough and multidimensional investigation into the current landscape of prefabricated MEP installation initiatives. This study meticulously dissects the paradigm from five critical vantage points: historical evolution, standards and regulations, life cycle analysis, technological applications, and corporate implementation strategies. At present, there is still a lack of standards and specifications specifically for the field of assembled MEP installation. The analysis reveals a trend towards intelligent and sustainable installation practices in prefabricated MEP projects. The research predominantly focuses on the design, production, and installation stages. Notably, building information modeling (BIM) emerges as the most prominent technology, followed by the Internet of Things (IoT) and 3D laser scanning, with extended reality (XR) technologies gaining traction. Large, state-owned construction firms are spearheading innovative applications in this realm. In summary, this paper provides an overview and outlook for the development direction and the application of cutting-edge technologies in prefabricated MEP installation projects, with the aim of supporting the industry's advancement. [ABSTRACT FROM AUTHOR]

Human T-cell Leukemia Virus type 1 (HTLV-1) is a human retrovirus responsible for leukaemia in 5 to 10% of infected individuals. Among the viral proteins, Tax has been described as directly involved in virus-induced leukemogenesis. Tax is therefore an interesting therapeutic target. However, its 3D structure is still unknown and this hampers the development of drug-design-based therapeutic strategies. Several algorithms are available that can be used to predict the structure of proteins, particularly with the recent appearance of artificial intelligence (AI)-driven pipelines. Here, we review how the structure of Tax is predicted by several algorithms using distinct modelling strategies. We discuss the consequences for the understanding of Tax structure/function relationship, and more generally for the use of structure models for modular and/or flexible proteins, which are frequent in retroviruses. [ABSTRACT FROM AUTHOR]