Search

Your search keyword '"Mihandoust, A"' showing total 5 results
Start Over Author "Mihandoust, A" Publisher mdpi
5 results on '"Mihandoust, A"'

1. High-Throughput Particle Concentration Using Complex Cross-Section Microchannels

Author

Robert A. Taylor, Majid Alizadeh, Asma Mihandoust, Nahid Maleki-Jirsaraei, Sajad Razavi Bazaz, and Majid Ebrahimi Warkiani

Subjects
Materials science, lcsh:Mechanical engineering and machinery, Microfluidics, 02 engineering and technology, Concentrator, 01 natural sciences, Article, Cross section (physics), Optics, lcsh:TJ1-1570, Electrical and Electronic Engineering, Spiral, Inertial microfluidics, Microchannel, 1007 Nanotechnology, business.industry, Mechanical Engineering, 010401 analytical chemistry, 021001 nanoscience & nanotechnology, complex cross-section, 0104 chemical sciences, Vortex, Control and Systems Engineering, Line (geometry), Particle, particle/cell concentrator, 0210 nano-technology, business
Abstract

High throughput particle/cell concentration is crucial for a wide variety of biomedical, clinical, and environmental applications. In this work, we have proposed a passive spiral microfluidic concentrator with a complex cross-sectional shape, i.e., a combination of rectangle and trapezoid, for high separation efficiency and a confinement ratio less than 0.07. Particle focusing in our microfluidic system was observed in a single, tight focusing line, in which higher particle concentration is possible, as compared with simple rectangular or trapezoidal cross-sections with similar flow area. The sharper focusing stems from the confinement of Dean vortices in the trapezoidal region of the complex cross-section. To quantify this effect, we introduce a new parameter, complex focusing number or CFN, which is indicative of the enhancement of inertial focusing of particles in these channels. Three spiral microchannels with various widths of 400 &micro, m, 500 &micro, m, and 600 &micro, m, with the corresponding CFNs of 4.3, 4.5, and 6, respectively, were used. The device with the total width of 600 &micro, m was shown to have a separation efficiency of ~98%, and by recirculating, the output concentration of the sample was 500 times higher than the initial input. Finally, the investigation of results showed that the magnitude of CFN relies entirely on the microchannel geometry, and it is independent of the overall width of the channel cross-section. We envision that this concept of particle focusing through complex cross-sections will prove useful in paving the way towards more efficient inertial microfluidic devices.

Published
2020

2. High-Throughput Particle Concentration Using Complex Cross-Section Microchannels.

Author

Mihandoust, A, Razavi Bazaz, S, Maleki-Jirsaraei, N, Alizadeh, M, A Taylor, R, Ebrahimi Warkiani, M, Mihandoust, A, Razavi Bazaz, S, Maleki-Jirsaraei, N, Alizadeh, M, A Taylor, R, and Ebrahimi Warkiani, M

Abstract

High throughput particle/cell concentration is crucial for a wide variety of biomedical, clinical, and environmental applications. In this work, we have proposed a passive spiral microfluidic concentrator with a complex cross-sectional shape, i.e., a combination of rectangle and trapezoid, for high separation efficiency and a confinement ratio less than 0.07. Particle focusing in our microfluidic system was observed in a single, tight focusing line, in which higher particle concentration is possible, as compared with simple rectangular or trapezoidal cross-sections with similar flow area. The sharper focusing stems from the confinement of Dean vortices in the trapezoidal region of the complex cross-section. To quantify this effect, we introduce a new parameter, complex focusing number or CFN, which is indicative of the enhancement of inertial focusing of particles in these channels. Three spiral microchannels with various widths of 400 µm, 500 µm, and 600 µm, with the corresponding CFNs of 4.3, 4.5, and 6, respectively, were used. The device with the total width of 600 µm was shown to have a separation efficiency of ~98%, and by recirculating, the output concentration of the sample was 500 times higher than the initial input. Finally, the investigation of results showed that the magnitude of CFN relies entirely on the microchannel geometry, and it is independent of the overall width of the channel cross-section. We envision that this concept of particle focusing through complex cross-sections will prove useful in paving the way towards more efficient inertial microfluidic devices.

Published
2020

5. High-Throughput Particle Concentration Using Complex Cross-Section Microchannels.

Author

Mihandoust, Asma, Razavi Bazaz, Sajad, Maleki-Jirsaraei, Nahid, Alizadeh, Majid, A. Taylor, Robert, and Ebrahimi Warkiani, Majid

Subjects
MICROELECTROMECHANICAL systems, MICROFLUIDIC devices, DIFFERENTIAL cross sections, COMPLEX numbers, PARTICLES, RECTANGLES
Abstract

High throughput particle/cell concentration is crucial for a wide variety of biomedical, clinical, and environmental applications. In this work, we have proposed a passive spiral microfluidic concentrator with a complex cross-sectional shape, i.e., a combination of rectangle and trapezoid, for high separation efficiency and a confinement ratio less than 0.07. Particle focusing in our microfluidic system was observed in a single, tight focusing line, in which higher particle concentration is possible, as compared with simple rectangular or trapezoidal cross-sections with similar flow area. The sharper focusing stems from the confinement of Dean vortices in the trapezoidal region of the complex cross-section. To quantify this effect, we introduce a new parameter, complex focusing number or CFN, which is indicative of the enhancement of inertial focusing of particles in these channels. Three spiral microchannels with various widths of 400 µm, 500 µm, and 600 µm, with the corresponding CFNs of 4.3, 4.5, and 6, respectively, were used. The device with the total width of 600 µm was shown to have a separation efficiency of ~98%, and by recirculating, the output concentration of the sample was 500 times higher than the initial input. Finally, the investigation of results showed that the magnitude of CFN relies entirely on the microchannel geometry, and it is independent of the overall width of the channel cross-section. We envision that this concept of particle focusing through complex cross-sections will prove useful in paving the way towards more efficient inertial microfluidic devices. [ABSTRACT FROM AUTHOR]

Published
2020
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results